JP2002212067A - Composition for treating cold - Google Patents
Composition for treating coldInfo
- Publication number
- JP2002212067A JP2002212067A JP2001006659A JP2001006659A JP2002212067A JP 2002212067 A JP2002212067 A JP 2002212067A JP 2001006659 A JP2001006659 A JP 2001006659A JP 2001006659 A JP2001006659 A JP 2001006659A JP 2002212067 A JP2002212067 A JP 2002212067A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cold
- treating
- group
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 18
- 150000003839 salts Chemical class 0.000 claims abstract description 9
- YWGDOWXRIALTES-NRFANRHFSA-N bepotastine Chemical compound C1CN(CCCC(=O)O)CCC1O[C@H](C=1N=CC=CC=1)C1=CC=C(Cl)C=C1 YWGDOWXRIALTES-NRFANRHFSA-N 0.000 claims abstract description 8
- 229960002071 bepotastine Drugs 0.000 claims abstract description 8
- 206010039083 rhinitis Diseases 0.000 claims abstract description 7
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960005405 methoxyphenamine Drugs 0.000 claims abstract description 6
- OEHAYUOVELTAPG-UHFFFAOYSA-N methoxyphenamine Chemical compound CNC(C)CC1=CC=CC=C1OC OEHAYUOVELTAPG-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960001802 phenylephrine Drugs 0.000 claims abstract description 6
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims abstract description 6
- 229960000395 phenylpropanolamine Drugs 0.000 claims abstract description 6
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims abstract description 6
- FMCGSUUBYTWNDP-ONGXEEELSA-N (1R,2S)-2-(dimethylamino)-1-phenyl-1-propanol Chemical compound CN(C)[C@@H](C)[C@H](O)C1=CC=CC=C1 FMCGSUUBYTWNDP-ONGXEEELSA-N 0.000 claims description 5
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- 239000002552 dosage form Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 208000024891 symptom Diseases 0.000 abstract description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 9
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- 229940108858 belladonna total alkaloid Drugs 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
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- 229910002651 NO3 Inorganic materials 0.000 description 1
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- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
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- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
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- NTCYWJCEOILKNG-ROLPUNSJSA-N [(1r,2s)-1-hydroxy-1-phenylpropan-2-yl]-dimethylazanium;chloride Chemical compound Cl.CN(C)[C@@H](C)[C@H](O)C1=CC=CC=C1 NTCYWJCEOILKNG-ROLPUNSJSA-N 0.000 description 1
- QDPOOGQUCJJZAO-FCXRPNKRSA-N [(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate Chemical compound C1=C(O)C(O)=CC=C1\C=C\C(=O)OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QDPOOGQUCJJZAO-FCXRPNKRSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
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- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、風邪による鼻炎症
状に対する効果が増強された風邪治療用組成物に関す
る。TECHNICAL FIELD The present invention relates to a composition for treating a cold, which has an enhanced effect on rhinitis caused by a cold.
【0002】[0002]
【従来の技術及び発明が解決しようとする課題】風邪症
候群はウイルス性の呼吸器感染症である。一般に、上気
道を中心とする局所炎症性症状に発熱、倦怠感等の種々
の全身症状を伴う疾患である。風邪の治療法として、そ
の原因となるウイルスの感染及び増殖を抑制する抗ウイ
ルス作用を有する薬剤の開発が原因療法として望まれて
いるが、依然として有効なものがなく、個々の風邪症状
の改善を目的とする対症療法が中心となっている。多岐
に亘る風邪症状の治療には種々の薬効成分を含む配合剤
が有効とされるが、薬物の使用頻度を減らしかつ副作用
の発生を防止するためには、その成分として何を選ぶ
か、その成分を如何に配合して処方するかがポイントと
なっていた。BACKGROUND OF THE INVENTION The cold syndrome is a viral respiratory infection. Generally, it is a disease accompanied by various systemic symptoms such as fever, malaise, and local inflammatory symptoms centering on the upper respiratory tract. As a treatment for the common cold, the development of a drug having an antiviral effect that suppresses the infection and proliferation of the virus that causes the cold has been desired as a causal treatment. The main symptomatic treatment is aimed at. Combination preparations containing various medicinal ingredients are effective in treating a wide variety of cold symptoms.However, in order to reduce the frequency of drug use and prevent the occurrence of side effects, what kind of ingredients should be selected should be selected. The point was how to mix and formulate the components.
【0003】ベポタスチン、フェキソフェナジンは抗ア
レルギー薬として用いられており、また、フェニルプロ
パノールアミン、メチルエフェドリン、フェニレフリ
ン、メトキシフェナミンは交感神経興奮薬として長い間
汎用されている薬剤である。[0003] Bepotastine and fexofenadine are used as antiallergic drugs, and phenylpropanolamine, methylephedrine, phenylephrine and methoxyphenamine have been widely used as sympathomimetics for a long time.
【0004】しかし、(a)ベポタスチン又はフェキソ
フェナジンと(b)フェニルプロパノールアミン、メチ
ルエフェドリン、フェニレフリン又はメトキシフェナミ
ンを組み合わせた組成物は知られていない。当然、この
(a)と(b)の組成物が鼻炎症状に対する強い効果を
有することは知られていない。However, there is no known composition in which (a) bepotastine or fexofenadine is combined with (b) phenylpropanolamine, methylephedrine, phenylephrine or methoxyphenamine. Naturally, it is not known that the compositions (a) and (b) have a strong effect on rhinitis symptoms.
【0005】本発明の目的は、風邪による鼻炎症状に対
する効果が増強された風邪治療用組成物を提供すること
である。It is an object of the present invention to provide a composition for treating a cold, which has an enhanced effect on rhinitis symptoms caused by the cold.
【0006】[0006]
【課題を解決するための手段】本発明者らは、上記を目
的とし鋭意研究した結果、有効成分として、ある特定の
抗アレルギー薬と特定の交感神経興奮薬を配合した組成
物が鼻粘膜の炎症症状(充血、鼻閉など)の除去あるい
は軽減に対し優れた効果を示すことを見い出し、その知
見に基づき本発明を完成した。Means for Solving the Problems The inventors of the present invention have conducted intensive studies for the above purpose, and as a result, have found that a composition comprising a specific antiallergic drug and a specific sympathomimetic as the active ingredients has been applied to the nasal mucosa. The present inventors have found that they show an excellent effect on removing or reducing inflammatory symptoms (such as hyperemia and nasal congestion), and completed the present invention based on the findings.
【0007】本発明の組成物の有効成分の一つとして配
合する抗アレルギー薬はベポタスチン、フェキソフェナ
ジン及びこれらの塩類からなる群より選ばれる1種以上
である。[0007] The antiallergic drug to be incorporated as one of the active ingredients of the composition of the present invention is at least one selected from the group consisting of bepotastine, fexofenadine and salts thereof.
【0008】本発明の組成物の有効成分の一つとして配
合する交感神経興奮薬はフェニルプロパノールアミン、
メチルエフェドリン、フェニレフリン、メトキシフェナ
ミン及びこれらの塩類からなる群より選ばれる1種以上
である。[0008] Sympathomimetics incorporated as one of the active ingredients of the composition of the present invention include phenylpropanolamine,
One or more selected from the group consisting of methylephedrine, phenylephrine, methoxyphenamine and salts thereof.
【0009】本発明において塩類とは、塩酸塩、硝酸
塩、硫酸塩、リン酸塩、シュウ酸塩、マレイン酸塩、フ
マル酸塩、トシル酸塩、臭化水素酸塩等が挙げられる。In the present invention, the salts include hydrochloride, nitrate, sulfate, phosphate, oxalate, maleate, fumarate, tosylate, hydrobromide and the like.
【0010】[0010]
【発明の実施の形態】本発明の風邪治療用組成物は、通
常、成人に対して1日当たり1回ないし数回に分けて経
口投与することができる。この投与量は年齢、体重、病
状により適宜増減することができる。各成分の投与量
は、それぞれ成人に対して1日当たり、(a)ベポタス
チン(その塩類は有効部分)は2〜20mgがよく、フ
ェキソフェナジン(その塩類は有効部分)は15〜12
0mgがよい。また、同様に、(b)フェニルプロパノ
ールアミンは20〜100mgがよく、メチルエフェド
リン(l体、dl体を含む)は22〜110mgがよ
く、フェニレフリンは6〜40mgがよく、メトキシフ
ェナミンは30〜150mgがよい。BEST MODE FOR CARRYING OUT THE INVENTION The composition for treating a cold of the present invention can be usually orally administered to an adult once or several times a day. This dose can be appropriately increased or decreased depending on the age, weight, and medical condition. The dose of each component is preferably 2 to 20 mg per day for adult (a) bepotastine (the salt is an effective portion) and 15 to 12 mg for fexofenadine (the salt is an effective portion) per adult.
0 mg is good. Similarly, (b) phenylpropanolamine is preferably 20 to 100 mg, methylephedrine (including l-form and dl-form) is preferably 22 to 110 mg, phenylephrine is preferably 6 to 40 mg, and methoxyphenamine is 30 to 100 mg. 150 mg is good.
【0011】本発明の風邪治療用組成物は、剤型として
錠剤、カプセル剤、顆粒剤、細粒剤、粉剤、チュアブル
剤、発泡剤、ドロップ剤、口中溶解剤、ドライシロップ
剤、内服液剤等の経口投与形態の製剤として用いる。こ
れらの製剤は、常法により調製することができる。[0011] The composition for treating a cold of the present invention may be used in the form of tablets, capsules, granules, fine granules, powders, chewables, foaming agents, drops, mouth dissolving agents, dry syrups, oral liquids and the like. It is used as an oral dosage form. These preparations can be prepared by a conventional method.
【0012】固形剤においては製剤の調製に使用する担
体としては、乳糖、デンプン、砂糖、マンニトール、結
晶セルロースなどの賦形剤、ヒドロキシプロピルセルロ
ース、ヒドロキシプロピルメチルセルロース、ゼラチ
ン、PVPなどの結合剤、カルボキシメチルセルロース
カルシウム、低置換度ヒドロキシプロピルセルロースな
どの崩壊剤、ステアリン酸マグネシウム、硬化ヒマシ
油、タルクなどの滑沢剤があり、この他必要に応じて溶
解補助剤、緩衝剤、保存剤、香料、色素、矯味剤等を使
用することができる。In the case of solid preparations, the carriers used in the preparation of preparations include excipients such as lactose, starch, sugar, mannitol, crystalline cellulose, binders such as hydroxypropylcellulose, hydroxypropylmethylcellulose, gelatin, PVP, and carboxy. There are disintegrants such as methylcellulose calcium and low-substituted hydroxypropylcellulose, lubricating agents such as magnesium stearate, hydrogenated castor oil, and talc.In addition, if necessary, dissolution aids, buffering agents, preservatives, fragrances, and pigments And flavoring agents can be used.
【0013】また、内服液剤においては製剤の調製に使
用する担体としては、ショ糖脂肪酸エステル類、ステア
リン酸ポリオキシル類、ポリオキシエチレンポリオキシ
プロピレングリコール類、ポリオキシエチレンモノ脂肪
酸エステル類等の界面活性剤、合成ケイ酸アルミニウ
ム、ケイ酸マグネシウム、炭酸マグネシウム、酸化マグ
ネシウム、メタケイ酸アルミン酸マグネシウム等の増粘
剤、クエン酸緩衝液、リン酸緩衝液等の有機酸系・無機
酸系のpH調整剤があり、この他必要に応じて溶解補助
剤、緩衝剤、保存剤、香料、色素、甘味剤等を使用する
ことができる。[0013] In the liquid preparation for internal use, the carrier used for the preparation of the preparation includes sucrose fatty acid esters, polyoxyl stearate, polyoxyethylene polyoxypropylene glycols, and polyoxyethylene mono fatty acid esters. Agents, thickeners such as synthetic aluminum silicate, magnesium silicate, magnesium carbonate, magnesium oxide, and magnesium aluminate metasilicate; organic acid and inorganic acid pH adjusters such as citrate buffer and phosphate buffer In addition, if necessary, a solubilizing agent, a buffer, a preservative, a flavor, a pigment, a sweetener, and the like can be used.
【0014】本発明の風邪治療用組成物は、以上の成分
の他に必要に応じて非ステロイド性抗炎症薬、消炎酵素
薬類、気管支拡張薬、他の中枢神経興奮薬、鎮咳薬、去
痰薬、抗ヒスタミン薬、他の抗アレルギー薬、抗コリン
薬、ビタミン類、制酸薬、生薬等から選ばれる少なくと
も1つの薬剤を適宜に配合しても良い。なお、これらの
成分は単独または相互に混合して用いることができ、通
常は一般用医薬品製造指針(2000年版・薬事審査研
究会監修、株式会社じほう発行)に収載されているかぜ
薬基準、鼻炎用内服薬基準等に準拠して配合される。The composition for treating a cold according to the present invention may further comprise, if necessary, a nonsteroidal anti-inflammatory drug, an anti-inflammatory enzyme drug, a bronchodilator, another central nervous stimulant, an antitussive, an expectorant. At least one drug selected from drugs, antihistamines, other antiallergic drugs, anticholinergic drugs, vitamins, antacids, crude drugs and the like may be appropriately compounded. These components can be used singly or as a mixture of each other. Usually, cold medicine standards and rhinitis listed in the over-the-counter drug manufacturing guidelines (2000 edition, supervised by the Pharmaceutical Affairs Committee, published by Jiho Co., Ltd.) It is compounded in accordance with the standard for internal use.
【0015】[0015]
【実施例】以下に実施例及び試験例を挙げて本発明をさ
らに詳しく説明するが、本発明はその例に限定されるも
のではない。The present invention will be described in more detail with reference to examples and test examples, but the present invention is not limited to these examples.
【0016】実施例1 下記の各成分及び分量を秤量し充分混合した後、打錠機
(クリーンプレス コレクト19;菊水製作所社製)を
用いて錠剤を製した。なお、1錠重量200mgとし、
8mm径の隅角平面の杵を使用した。 ベシル酸ベポタスチン 10g 塩酸フェニルプロパノールアミン 100g 塩化リゾチーム 100g(力価) 無水カフェイン 75g 乳糖 295g 微結晶セルロース(アビセルPH201) 290g ステアリン酸マグネシウム 10gExample 1 After the following components and amounts were weighed and thoroughly mixed, tablets were produced using a tableting machine (Clean Press Collect 19; manufactured by Kikusui Seisakusho). The weight of one tablet is 200 mg.
An 8 mm-diameter corner flat punch was used. Bepotastine besylate 10 g Phenylpropanolamine hydrochloride 100 g Lysozyme chloride 100 g (titer) Anhydrous caffeine 75 g Lactose 295 g Microcrystalline cellulose (Avicel PH201) 290 g Magnesium stearate 10 g
【0017】実施例2 下記の各成分及び分量を秤量し充分混合した後、実施例
1と同様にして、200mgの錠剤を得た。 ベシル酸ベポタスチン 20g 塩酸フェニルプロパノールアミン 100g ベラドンナ総アルカロイド 0.4g 塩化リゾチーム 90g(力価) 無水カフェイン 75g 乳糖 233.6g 微結晶セルロース 226g ステアリン酸マグネシウム 20gExample 2 The following components and amounts were weighed and thoroughly mixed, and a tablet of 200 mg was obtained in the same manner as in Example 1. Bepotastine besylate 20 g Phenylpropanolamine hydrochloride 100 g Belladonna total alkaloid 0.4 g Lysozyme chloride 90 g (titer) Anhydrous caffeine 75 g Lactose 233.6 g Microcrystalline cellulose 226 g Magnesium stearate 20 g
【0018】実施例3 下記の各成分及び分量を秤量し充分混合した後、実施例
1と同様にして、200mgの錠剤を得た。 塩酸フェキソフェナジン 60g dl−塩酸メチルエフェドリン 60g ベラドンナ総アルカロイド 0.3g ブロメライン 100000単位 タブレトーズ 90g 低置換度ヒドロキシプロピルセルロース 82.7g ステアリン酸マグネシウム 17gExample 3 The following components and amounts were weighed and thoroughly mixed, and a tablet of 200 mg was obtained in the same manner as in Example 1. Fexofenadine hydrochloride 60 g dl-Methylephedrine hydrochloride 60 g Belladonna total alkaloid 0.3 g Bromelain 100,000 units Tabretase 90 g Low-substituted hydroxypropylcellulose 82.7 g Magnesium stearate 17 g
【0019】実施例4 下記の各成分及び分量を秤量し均一に混合した後、実施
例1と同様にして、150mgの錠剤を得た。 塩酸フェキソフェナジン 120g 塩酸メトキシフェナミン 150g ヨウ化イソプロパミド 7.5g グリチルリチン酸ジカリウム(グリチルリチン酸として200g) 無水カフェイン 75g 乳糖 182.5g 微結晶セルロース 182g ステアリン酸マグネシウム 20g 硬化ヒマシ油 5gExample 4 The following components and amounts were weighed and uniformly mixed, and a 150 mg tablet was obtained in the same manner as in Example 1. Fexofenadine hydrochloride 120 g Methoxyphenamine hydrochloride 150 g Isopropamide iodide 7.5 g Dipotassium glycyrrhizinate (200 g as glycyrrhizic acid) Caffeic anhydride 75 g Lactose 182.5 g Microcrystalline cellulose 182 g Magnesium stearate 20 g Hardened castor oil 5 g
【0020】試験例[日本白色雄性ウサギの鼻粘膜炎症
に対する作用] (試験検体の調製方法)表1に示す各成分を採取し、結
晶セルロース100mg、ステアリン酸マグネシウム1
5mg、乳糖50mg及び硬化ヒマシ油5mgと均一に
混合し、各群の試験検体とした。なお、コントロール群
の検体は上記基剤成分のみで製した。Test Example [Effect on Nasal Mucosal Inflammation of Japanese White Male Rabbit] (Preparation Method of Test Specimen) Each component shown in Table 1 was collected, and 100 mg of crystalline cellulose, 1 mg of magnesium stearate 1
5 mg, lactose 50 mg and hydrogenated castor oil 5 mg were uniformly mixed to prepare a test sample for each group. In addition, the sample of the control group was manufactured only from the above-mentioned base components.
【0021】[0021]
【表1】単位:mg [Table 1] Unit: mg
【0022】(試験方法)12週齢の日本白色雄性ウサ
ギを1群3匹として用いた。各ウサギに、1鼻腔当た
り、2.0%カプサイシン水溶液の10μLを4時間間
隔で3回鼻腔内に噴霧し、鼻粘膜炎症反応を惹起した。
続いて、各試験検体の半量を8時間間隔で2回経口投与
し、2回目投与後1時間における症状を鼻腔内視鏡にて
観察した。評価法としては、0点;ほとんど充血してい
ない、1点;充血が認められる、2点;ほぼ全面が充血
している、3点;充血と粘液が認められる、4点;浮腫
が認められる、5点;浮腫により鼻腔が狭窄している、
の6段階で評価し、各群3匹の平均点を比較した。(Test Method) Japanese white male rabbits, 12 weeks old, were used as 3 rabbits per group. To each rabbit, 10 μL of a 2.0% aqueous solution of capsaicin was sprayed into the nasal cavity three times at 4-hour intervals per nasal cavity to induce an inflammatory reaction in the nasal mucosa.
Subsequently, a half amount of each test sample was orally administered twice at an interval of 8 hours, and symptoms at 1 hour after the second administration were observed with a nasal endoscope. Evaluation method: 0 point; hardly congested, 1 point; congestion observed, 2 points; almost congested, 3 points; congestion and mucus, 4 points, edema 5 points; nasal cavity narrowed due to edema;
And the average score of 3 mice in each group was compared.
【0023】(結果)図1に示す通り、組合せ処方群
(A〜B群)の方が単味群(C〜E群)及びコントロー
ル群より評価点が著しく低く,組合せ処方に鼻粘膜炎症
に対する優れた効果があることが示された。(Results) As shown in FIG. 1, the combination prescription group (groups A and B) had a significantly lower evaluation score than the plain group (groups C to E) and the control group. It was shown to have excellent effects.
【0024】[0024]
【発明の効果】本発明は、鼻粘膜の炎症症状の除去・軽
減に対し優れた効果を有する組成物であり、風邪による
鼻炎等に対して有効な薬剤を提供することができた。Industrial Applicability The present invention is a composition having an excellent effect on the removal and reduction of inflammatory symptoms of the nasal mucosa, and was able to provide a drug effective against rhinitis due to a cold.
【0025】[0025]
【図1】は各試験検体の鼻粘膜炎症に対する効果の比較
を示す。FIG. 1 shows a comparison of the effect of each test sample on nasal mucosal inflammation.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 中神 浄二 東京都豊島区高田3丁目24番1号 大正製 薬株式会社内 (72)発明者 中川 泰緒 東京都豊島区高田3丁目24番1号 大正製 薬株式会社内 (72)発明者 相川 勝義 東京都豊島区高田3丁目24番1号 大正製 薬株式会社内 Fターム(参考) 4C206 AA01 AA02 FA10 FA11 FA14 MA03 MA04 MA72 NA14 ZA34 ZA59 ZC54 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Joji Nakagami 3- 24-1, Takada, Toshima-ku, Tokyo Inside Taisho Seiyaku Co., Ltd. (72) Inventor Yasushi Nakagawa 3--24, Takada, Toshima-ku, Tokyo No. 1 Taisho Pharmaceutical Co., Ltd. (72) Inventor Katsuyoshi Aikawa 3-24-1, Takada, Toshima-ku, Tokyo F-term (reference) 4C206 AA01 AA02 FA10 FA11 FA14 MA03 MA04 MA72 NA14 ZA34 ZA59 ZC54
Claims (3)
及びこれらの塩類 (b)フェニルプロパノールアミン、メチルエフェドリ
ン、フェニレフリン、メトキシフェナミン及びこれらの
塩類において、(a)の群から選ばれる1種以上及び
(b)の群から選ばれる1種以上を配合した風邪治療用
組成物。(A) Bepotastine, fexofenadine and salts thereof (b) phenylpropanolamine, methylephedrine, phenylephrine, methoxyphenamine and salts thereof, wherein at least one selected from the group (a) and A composition for treating a cold, comprising one or more members selected from the group (b).
の風邪治療用組成物。2. The composition for treating a cold according to claim 1, wherein the dosage form is an oral administration form.
を用いる鼻炎症状の治療方法。3. A method for treating rhinitis using the composition for treating a cold according to claim 1 or 2.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001006659A JP2002212067A (en) | 2001-01-15 | 2001-01-15 | Composition for treating cold |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001006659A JP2002212067A (en) | 2001-01-15 | 2001-01-15 | Composition for treating cold |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002212067A true JP2002212067A (en) | 2002-07-31 |
Family
ID=18874514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2001006659A Withdrawn JP2002212067A (en) | 2001-01-15 | 2001-01-15 | Composition for treating cold |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2002212067A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1314400C (en) * | 2004-12-29 | 2007-05-09 | 杭州容立医药科技有限公司 | Solid preparation taken through oral cavity of compound MEthoxyphEnaminE and preparation method |
WO2008123701A1 (en) * | 2007-04-05 | 2008-10-16 | Hanmi Pharm. Co., Ltd. | Novel crystalline bepotastine metal salt hydrate, method for preparing same, and pharmaceutical composition comprising same |
JP2016222657A (en) * | 2015-06-01 | 2016-12-28 | ロート製薬株式会社 | Anti-allergic composition |
JP6286096B1 (en) * | 2017-08-01 | 2018-02-28 | ロート製薬株式会社 | Pharmaceutical tablets |
JP2019147797A (en) * | 2018-02-26 | 2019-09-05 | ロート製薬株式会社 | Granule containing fexofenadine hydrochloride |
JP2020070285A (en) * | 2017-12-27 | 2020-05-07 | 興和株式会社 | Pharmaceutical product |
JP2021091623A (en) * | 2019-12-09 | 2021-06-17 | 興和株式会社 | Pharmaceutical |
-
2001
- 2001-01-15 JP JP2001006659A patent/JP2002212067A/en not_active Withdrawn
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1314400C (en) * | 2004-12-29 | 2007-05-09 | 杭州容立医药科技有限公司 | Solid preparation taken through oral cavity of compound MEthoxyphEnaminE and preparation method |
WO2008123701A1 (en) * | 2007-04-05 | 2008-10-16 | Hanmi Pharm. Co., Ltd. | Novel crystalline bepotastine metal salt hydrate, method for preparing same, and pharmaceutical composition comprising same |
JP2016222657A (en) * | 2015-06-01 | 2016-12-28 | ロート製薬株式会社 | Anti-allergic composition |
JP6286096B1 (en) * | 2017-08-01 | 2018-02-28 | ロート製薬株式会社 | Pharmaceutical tablets |
JP2019026609A (en) * | 2017-08-01 | 2019-02-21 | ロート製薬株式会社 | Pharmaceutical tablet |
JP2020070285A (en) * | 2017-12-27 | 2020-05-07 | 興和株式会社 | Pharmaceutical product |
JP7274288B2 (en) | 2017-12-27 | 2023-05-16 | 興和株式会社 | pharmaceuticals |
JP2019147797A (en) * | 2018-02-26 | 2019-09-05 | ロート製薬株式会社 | Granule containing fexofenadine hydrochloride |
JP2021091623A (en) * | 2019-12-09 | 2021-06-17 | 興和株式会社 | Pharmaceutical |
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