JP2001524948A - 疎水性テトラサイクリンによるセリンプロテイナーゼ阻害活性 - Google Patents
疎水性テトラサイクリンによるセリンプロテイナーゼ阻害活性Info
- Publication number
- JP2001524948A JP2001524948A JP53959398A JP53959398A JP2001524948A JP 2001524948 A JP2001524948 A JP 2001524948A JP 53959398 A JP53959398 A JP 53959398A JP 53959398 A JP53959398 A JP 53959398A JP 2001524948 A JP2001524948 A JP 2001524948A
- Authority
- JP
- Japan
- Prior art keywords
- tetracycline
- activity
- leukocyte elastase
- dimethylamino
- deoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.生体系において過度の白血球エラスターゼ活性を阻害する方法であって、 過度の白血球エラスターゼ活性に感受性の生体系に対し、白血球エラスターゼ 活性阻害量の疎水性テトラサイクリンを投与することを含む該方法。 2.テトラサイクリンが4−デ(ジメチルアミノ)テトラサイクリンである請求 項1記載の方法。 3.生体系が哺乳類である請求項1記載の方法。 4.テトラサイクリンが、6−デメチル−6−デオキシ−4−デ(ジメチルアミ ノ)テトラサイクリン、6−デオキシ−5α−ヒドロキシ−4−デ(ジメチル アミノ)テトラサイクリン、4−デ(ジメチルアミノ)ミノサイクリン、及び それらの組み合せを含む請求項1記載の方法。 5.テトラサイクリンが6−デメチル−6−デオキシ−4−デ(ジメチルアミノ )テトラサイクリンを含む請求項1記載の方法。 6.テトラサイクリンが、更に、化粧品を含む請求項1記載の方法。 7.テトラサイクリンが、更に、医薬製剤を含む請求項1記載の方法。 8.過度の白血球エラスターゼ活性により生じた組織ダメージに罹患した被験体 を治療する方法であって、該被験体に対し、白血球エラスターゼ阻害量の疎水 性テトラサイクリンを投与することを含む該方法。 9.テトラサイクリンが4−デ(ジメチルアミノ)テトラサイクリンである請求 項8記載の方法。 10.被験体が哺乳類である請求項8記載の方法。 11.テトラサイクリンが、6−デメチル−6−デオキシ−4−デ(ジメチルアミ ノ)テトラサイクリン、6−デオキシ−5α−ヒドロキシ−4−デ(ジメチル アミノ)テトラサイクリン、4−デ(ジメチルアミノ)ミノサイクリン、及び それらの組み合せを含む請求項8記載の方法。 12.テトラサイクリンが6−デメチル−6−デオキシ−4−デ(ジメチルアミノ) テトラサイクリンを含む請求項8記載の方法。 13.過度の白血球エラスターゼ活性により生じた組織ダメージが肺疾患である請 求項8記載の方法。 14.肺疾患が、嚢胞性繊維症、気腫、成人呼吸窮迫症候群、又は毒性物質の吸入 により生じる急性灰損傷である請求項13記載の方法。 15.呼吸窮迫症候群が、複数外傷、手術侵襲、セプシスの合併症として、又は多 臓器疾患の1部としてのものである請求項14記載の方法。 16.毒性物質が、酸性物質、化学物質、工業的及び軍事的毒性物質及び煙及び他 の燃焼毒性生成物である請求項14記載の方法。 17.過度の白血球エラスターゼ活性による組織ダメージが、腎疾患である請求項 8記載の方法。 18.腎疾患が、糸球体腎炎、複数外傷又はセプシスの合併症としての急性腎不全 、又は多臓器疾患の1部としての急性腎不全である請求項17記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/816,551 | 1997-03-13 | ||
US08/816,551 US5773430A (en) | 1997-03-13 | 1997-03-13 | Serine proteinase inhibitory activity by hydrophobic tetracycline |
PCT/US1998/003782 WO1998040079A1 (en) | 1997-03-13 | 1998-02-26 | Serine proteinase inhibitory activity by hydrophobic tetracycline |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001524948A true JP2001524948A (ja) | 2001-12-04 |
JP2001524948A5 JP2001524948A5 (ja) | 2005-12-02 |
JP4339411B2 JP4339411B2 (ja) | 2009-10-07 |
Family
ID=25220936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53959398A Expired - Fee Related JP4339411B2 (ja) | 1997-03-13 | 1998-02-26 | 疎水性テトラサイクリンによるセリンプロテイナーゼ阻害活性 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5773430A (ja) |
EP (1) | EP0975349B1 (ja) |
JP (1) | JP4339411B2 (ja) |
KR (1) | KR100530683B1 (ja) |
AT (1) | ATE292972T1 (ja) |
AU (1) | AU733308B2 (ja) |
CA (1) | CA2283071C (ja) |
DE (1) | DE69829748T2 (ja) |
DK (1) | DK0975349T3 (ja) |
ES (1) | ES2241124T3 (ja) |
NZ (1) | NZ337578A (ja) |
PT (1) | PT975349E (ja) |
WO (1) | WO1998040079A1 (ja) |
Families Citing this family (48)
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WO1998052575A1 (en) * | 1997-05-20 | 1998-11-26 | The Trustees Of Columbia University In The City Of New York | Use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema |
US5977091A (en) * | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
US6946453B2 (en) | 1998-11-18 | 2005-09-20 | Collagenex Pharmaceuticals, Inc. | 4-dedimethylaminotracycline derivatives |
US6506740B1 (en) | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
US6887678B2 (en) * | 1998-12-02 | 2005-05-03 | Cindy L. Bristow | Method for the quantitative determination of proteinase inhibitors |
EP1175216A2 (en) * | 1999-04-30 | 2002-01-30 | APT Pharmaceutical, L.L.C. | Antimalarian agents for the treatment of asthma |
GB0004531D0 (en) * | 2000-02-25 | 2000-04-19 | Richards Andrew J M | The treatment of respiratory diseases |
US6627785B1 (en) * | 2000-02-29 | 2003-09-30 | Virginia Commwealth University | Wound dressings with protease-lowering activity |
US6503892B2 (en) | 2000-04-26 | 2003-01-07 | New England Medical Center Hospitals Inc. | Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US7247704B2 (en) * | 2000-12-18 | 2007-07-24 | Arriva Pharmaceuticals, Inc. | Multifunctional protease inhibitors and their use in treatment of disease |
EP1383483A4 (en) * | 2001-04-05 | 2006-08-09 | Collagenex Pharm Inc | CONTROLLED RELEASE OF TETRACYCLIN COMPOUNDS AND TETRACYCLINE DERIVATIVES |
WO2002099134A1 (en) * | 2001-06-05 | 2002-12-12 | Auckland Uniservices Limited | Methods and compositions for assessment of pulmonary function and disorders |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
EP2332548A1 (en) | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of stroke |
US20030181371A1 (en) * | 2001-12-28 | 2003-09-25 | Angiotech Pharmaceuticals, Inc. | Compositions and methods of using collajolie |
AU2003235759A1 (en) | 2002-01-08 | 2003-07-24 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
EP1482926A4 (en) | 2002-03-08 | 2006-04-12 | Paratek Pharm Innc | AMINO METHYL SUBSTITUTED TETRACYCLINE COMPOUNDS |
KR101025400B1 (ko) | 2002-03-21 | 2011-03-28 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
AU2003261161B2 (en) | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
US20040092491A1 (en) * | 2002-11-09 | 2004-05-13 | The Research Foundation Of State University Of New York | Method of treating sepsis-induced ARDS |
CA2803922C (en) | 2003-04-07 | 2015-09-15 | Supernus Pharmaceuticals, Inc. | Once daily formulations of tetracyclines |
CA2526222A1 (en) * | 2003-05-16 | 2004-12-02 | Arriva Pharmaceuticals, Inc. | Treatment of respiratory disease associated with matrix metalloprotease inhibitors |
US20050137174A1 (en) | 2003-07-09 | 2005-06-23 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
EP2319829A1 (en) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | 9-substituted tetracycline compounds |
CA2553510C (en) | 2004-01-15 | 2012-09-25 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
CA2585418A1 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
EP2284151A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
US20060269946A1 (en) * | 2005-05-10 | 2006-11-30 | Young Robert P | Methods and compositions for assessment of pulmonary function and disorders |
CA2608161A1 (en) * | 2005-05-19 | 2006-11-23 | Synergenz Bioscience Limited | Methods for the assesssment of risk of developing lung cancer using analysis of genetic polymorphisms |
WO2006123943A1 (en) * | 2005-05-20 | 2006-11-23 | Synergenz Bioscience Limited | Methods of analysis of polymorphisms and uses thereof |
AU2006272698B2 (en) * | 2005-07-21 | 2012-11-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
US8795730B2 (en) * | 2006-01-31 | 2014-08-05 | David John Vachon | Compositions and methods for promoting the healing of tissue of multicellular organisms |
US8513223B2 (en) * | 2006-12-21 | 2013-08-20 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
BRPI0720569B8 (pt) | 2006-12-21 | 2021-05-25 | Paratek Pharm Innc | compostos de tetraciclina substituída e uso dos ditos compostos para o tratamento de uma infecção bacteriana, viral ou parasitária |
JP2010525069A (ja) | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
ES2386926T3 (es) * | 2007-07-06 | 2012-09-06 | Paratek Pharmaceuticals, Inc. | Métodos para sintetizar minociclina9-sustituida |
TW202216656A (zh) * | 2008-05-23 | 2022-05-01 | 美商Prtk Spv2公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
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BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
SG11201903327PA (en) | 2016-10-19 | 2019-05-30 | Tetraphase Pharmaceuticals Inc | Crystalline forms of eravacycline |
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US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
USRE34656E (en) * | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
US4925833A (en) * | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
US4666897A (en) * | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
US4935412A (en) * | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
US5045538A (en) * | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
US5223248A (en) * | 1991-02-11 | 1993-06-29 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing antiplaque properties |
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-
1997
- 1997-03-13 US US08/816,551 patent/US5773430A/en not_active Expired - Lifetime
-
1998
- 1998-02-26 KR KR10-1999-7008325A patent/KR100530683B1/ko not_active IP Right Cessation
- 1998-02-26 CA CA002283071A patent/CA2283071C/en not_active Expired - Fee Related
- 1998-02-26 EP EP98908747A patent/EP0975349B1/en not_active Expired - Lifetime
- 1998-02-26 NZ NZ337578A patent/NZ337578A/en not_active IP Right Cessation
- 1998-02-26 AU AU66698/98A patent/AU733308B2/en not_active Ceased
- 1998-02-26 WO PCT/US1998/003782 patent/WO1998040079A1/en active IP Right Grant
- 1998-02-26 DE DE69829748T patent/DE69829748T2/de not_active Expired - Lifetime
- 1998-02-26 JP JP53959398A patent/JP4339411B2/ja not_active Expired - Fee Related
- 1998-02-26 AT AT98908747T patent/ATE292972T1/de active
- 1998-02-26 DK DK98908747T patent/DK0975349T3/da active
- 1998-02-26 ES ES98908747T patent/ES2241124T3/es not_active Expired - Lifetime
- 1998-02-26 PT PT98908747T patent/PT975349E/pt unknown
Also Published As
Publication number | Publication date |
---|---|
DE69829748D1 (de) | 2005-05-19 |
DE69829748T2 (de) | 2006-03-09 |
KR100530683B1 (ko) | 2005-11-24 |
JP4339411B2 (ja) | 2009-10-07 |
NZ337578A (en) | 2001-08-31 |
DK0975349T3 (da) | 2005-08-01 |
US5773430A (en) | 1998-06-30 |
ATE292972T1 (de) | 2005-04-15 |
EP0975349B1 (en) | 2005-04-13 |
EP0975349A1 (en) | 2000-02-02 |
CA2283071A1 (en) | 1998-09-17 |
ES2241124T3 (es) | 2005-10-16 |
EP0975349A4 (en) | 2002-10-30 |
AU733308B2 (en) | 2001-05-10 |
PT975349E (pt) | 2005-08-31 |
CA2283071C (en) | 2009-01-27 |
KR20000076231A (ko) | 2000-12-26 |
AU6669898A (en) | 1998-09-29 |
WO1998040079A1 (en) | 1998-09-17 |
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