JP2001507217A - 細胞標本およびこの種のものの検査を実施するための装置 - Google Patents
細胞標本およびこの種のものの検査を実施するための装置Info
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- JP2001507217A JP2001507217A JP52210198A JP52210198A JP2001507217A JP 2001507217 A JP2001507217 A JP 2001507217A JP 52210198 A JP52210198 A JP 52210198A JP 52210198 A JP52210198 A JP 52210198A JP 2001507217 A JP2001507217 A JP 2001507217A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/147—Employing temperature sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.細胞標本およびこの種の標本の検査を実施するための装置であって、該装 置は、細胞標本に対する多数の個別容器を備えたマイクロタイタープレートまた はこの種の収容装置と、個別標本における変質を検出するための測定装置とを有 しており、それぞれの収容容器(3,10)に少なくとも1つのセンサ(7)が 設けられている形式のものにおいて、 前記測定装置は1つまたは複数のサブストレートプレート上に存在している複数 の半導体センサ(7)を有している ことを特徴とする装置。 2.前記センサは、少なくとも唯一の収容容器に対して、1つの共通の、ウエ ハ形状の半導体サブストレートプレート(2)上に存在している 請求項1記載の装置。 3.個別収容容器に、種々異なったセンサが配置されている 請求項1または2記載の装置。 4.測定ストラクチャを有する測定装置が収容装置の下面に設けられておりか つそれぞれの収容容器(3,10)は底面および/または側壁に少なくとも1つ のセンサ(7)を支持している 請求項1から3までのいずれか1項記載の装置。 5.前記マイクロタイタープレートまたはこの種の収容装置は下面に、有利に は前記サブストレートプレートないし前記測定ストラクチャの下面に、温度調節 装置(12)を有しており、該温度調節装置は有利には、サーモスタット式に制 御可能である 請求項1から4までのいずれか1項記載の装置。 6.前記半導体サブストレートプレート(2)上に、蜂の巣形状の管ストラク チャ、有利には市販のマイクロタイタープレートの底なしの上部(11a)が載 着されておりかつ前記サブストレートプレート(2)に有利には超音波溶接によ ってシール結合されている 請求項1から5までのいずれか1項記載の装置。 7.当該装置は、中に容器としてセル形状の収容用ウェル(3)を多数個持っ ている半導体サブストレートプレート(2)を有しておりかつそれぞれのウェル (3)に配属されているセンサ(7)を有している測定ストラクチャは前記サブ ストレートプレート(2)の構成部分である 請求項1から6までのいずれか1項記載の装置。 8.前記センサ(7)および場合によっては前記温度調節装置およびこの種の ものを有しているサブストレートプレートの壁厚は個別容器の領域において低減 されておりかつ透光式測定法に適うように設計されている 請求項1から7までのいずれか1項記載の装置。 9.前記サブストレートプレートは個別容器の領域において少なくとも1つの 光を通すことができる通路を有している 請求項1から8までのいずれか1項記載の装置。 10.個別容器(10)または収容用ウェル(3)の領域において、複数の、有 利には種々異なったセンサ(7)が例えばセンサアレイ(7a)として設けられ ている 請求項1から9までのいずれか1項記載の装置。 11.前記半導体サブストレートプレート(2)は測定ストラクチャとして少な くとも1つの電界効果トランジスタ、例えばISFETを有しており、該トラン ジスタのゲートは細胞に接触するために露出している 請求項1から10までのいずれか1項記載の装置。 12.センサ(7)として少なくとも1つのインターデジタルコンデンサが設け られており、該インターデジタルコンデンサは有利には、対毎に内側が噛み合っ ている電極を有している 請求項1から11までのいずれか1項記載の装置。 13.複数の、有利には種々異なった大きさのインターデジタルコンデンサが設 けられている 請求項12記載の装置。 14.前記インターデジタルコンデンサの電極の少なくとも1つの隔離された中 間室において、電気化学感応層が設けられている 請求項12または13記載の装置。 15.前記インターデジタルコンデンサの電極間に、光導波路が設けられており かつそれぞれの光導波路を走行する光を検出しかつ評価するための光検出器が前 記サブストレート中に配置されている 請求項12から14までのいずれか1項記載の装置。 16.前記サブストレートに、例えばCCDセルまたはCCDアレイの形のCC Dセンサが集積されている 請求項1から15までのいずれか1項記載の装置。 17.前記測定ストラクチャを有するサブストレート(2)に、少なくとも1つ の温度センサ、例えば温度測定ダイオードが設けられている 請求項1から16までのいずれか1項記載の装置。 18.前記サブストレートプレート(2)に制御および評価装置として少なくと も1つのマルチプレクサと、センサ制御部を有するAD/DA変換器と、マイク ロプロセッサと、10ユニットとが存在している 請求項1から17までのいずれか1項記載の装置。 19.センサ(7)として、光センサ、例えば表面波導体、格子カップラおよび 類似のものが設けられている 請求項1から18までのいずれか1項記載の装置。 20.個別容器に配属されているセンサは導線または導体マトリクスを介して制 御および評価装置に接続されており、該制御および評価装置は前記センサと一緒 に共通のサブストレートプレート上に配置されている 請求項1から19までのいずれか1項記載の装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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DE19646505.2 | 1996-11-12 | ||
DE19646505A DE19646505A1 (de) | 1996-11-12 | 1996-11-12 | Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen |
PCT/EP1997/005997 WO1998020974A1 (de) | 1996-11-12 | 1997-10-30 | Vorrichtung zur durchführung von untersuchungen an zellproben und dergleichen |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001507217A true JP2001507217A (ja) | 2001-06-05 |
JP3953528B2 JP3953528B2 (ja) | 2007-08-08 |
Family
ID=7811283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52210198A Expired - Lifetime JP3953528B2 (ja) | 1996-11-12 | 1997-10-30 | 細胞標本およびこの種のものの検査を実施するための装置 |
Country Status (5)
Country | Link |
---|---|
US (1) | US6376233B1 (ja) |
EP (1) | EP0938383B1 (ja) |
JP (1) | JP3953528B2 (ja) |
DE (2) | DE19646505A1 (ja) |
WO (1) | WO1998020974A1 (ja) |
Cited By (6)
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JP2005345243A (ja) * | 2004-06-02 | 2005-12-15 | Toshiba Corp | 核酸検出基板および該装置を使用する核酸検出方法 |
JP2010509577A (ja) * | 2006-11-09 | 2010-03-25 | ナノアイデント テクノロジーズ アクチェンゲゼルシャフト | 薄膜光センサを備えるタイタプレート |
JP2013535681A (ja) * | 2010-08-06 | 2013-09-12 | ディ・エヌ・エイ・エレクトロニクス・リミテッド | 無線で接続されたチップ上の流体センサ |
JP2014503347A (ja) * | 2010-11-29 | 2014-02-13 | ジーイー・ヘルスケア・ユーケイ・リミテッド | 生物学的サンプル保存装置 |
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JP2018510321A (ja) * | 2014-12-10 | 2018-04-12 | フラウンホーファー−ゲゼルシャフト ツル フェルデルング デル アンゲヴァンテン フォルシュング エー ファウFraunhofer−Gesellschaft zur Foerderung der angewandten Forschung e.V. | マルチウェル・プレート用の温度制御体、および生体試料を凍結させおよび/または解凍するための方法および装置 |
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Also Published As
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DE59702254D1 (de) | 2000-09-28 |
DE19646505A1 (de) | 1998-05-14 |
EP0938383B1 (de) | 2000-08-23 |
WO1998020974A1 (de) | 1998-05-22 |
EP0938383A1 (de) | 1999-09-01 |
US6376233B1 (en) | 2002-04-23 |
JP3953528B2 (ja) | 2007-08-08 |
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