JP2001131065A - Body fat-reducing accelerator and food composition for body fat-reducing acceleration - Google Patents

Body fat-reducing accelerator and food composition for body fat-reducing acceleration

Info

Publication number
JP2001131065A
JP2001131065A JP31469999A JP31469999A JP2001131065A JP 2001131065 A JP2001131065 A JP 2001131065A JP 31469999 A JP31469999 A JP 31469999A JP 31469999 A JP31469999 A JP 31469999A JP 2001131065 A JP2001131065 A JP 2001131065A
Authority
JP
Japan
Prior art keywords
body fat
creatine
reducing
food composition
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP31469999A
Other languages
Japanese (ja)
Inventor
Tokutsugu Ota
篤胤 太田
Misao Takasaki
みさお 高嵜
Katsumi Sugiura
克巳 杉浦
Mitsuru Igarashi
充 五十嵐
Kensuke Sakai
健介 酒井
Takahisa Tokunaga
隆久 徳永
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP31469999A priority Critical patent/JP2001131065A/en
Publication of JP2001131065A publication Critical patent/JP2001131065A/en
Pending legal-status Critical Current

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  • Non-Alcoholic Beverages (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)

Abstract

PROBLEM TO BE SOLVED: To obtain a medicine or beverage or food capable of reducing body fat without carrying out excessive diet restriction. SOLUTION: It is found for the first time that intake of creatine readily and efficiently reduces body fat by analyzing effect by intake of creatine to complete a body fat-reducing accelerator and a food composition for accelerating body fat-reducing according to the present invention.

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【0001】[0001]

【発明の属する技術分野】本発明は体脂肪の減少、いわ
ゆるダイエットを促進するために摂取される、クレアチ
ンを有効成分として含有することを特徴とする体脂肪減
少促進剤及び体脂肪減少促進用食品組成物に関する。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an agent for promoting body fat reduction and a food for promoting body fat reduction, which contains creatine as an active ingredient and is taken to promote reduction of body fat, so-called diet. Composition.

【0002】[0002]

【従来の技術】クレアチンは、動物の体内でオルニチン
とアルギニンから生合成されるアミノ酸の1種で、その
大部分が筋肉内に存在している。クレアチンはリンと反
応し、高エネルギーリン酸化合物であるクレアチンリン
酸となる。この化合物は筋肉内でのエネルギーの貯蔵型
であり、筋肉の収縮などの運動は、ATPがADPに代謝され
るエネルギーを使って行われるが、ADPをATPに再生する
際にクレアチンリン酸がクレアチニンに代謝されそのエ
ネルギーを供給する。このようなことから、筋肉内のク
レアチン量を高めることにより、筋の瞬発力や持久力を
高めることが期待されている。
2. Description of the Related Art Creatine is one of the amino acids biosynthesized from ornithine and arginine in the animal body, and most of it is present in muscle. Creatine reacts with phosphorus to produce creatine phosphate, a high-energy phosphate compound. This compound is a storage type of energy in muscle, and exercises such as muscle contraction are performed using the energy that ATP is metabolized into ADP. It is metabolized to supply its energy. Thus, it is expected that increasing the amount of creatine in the muscle will increase the instantaneous power and endurance of the muscle.

【0003】実際に、バルセロナ五輪の優勝者がクレア
チンを経口的に摂取するクレアチンローディングを行っ
ていたことから話題となっていた。現在では多くのアス
リートが競技力向上の目的でクレアチンローディングを
行っており、一定の成果が得られている。
[0003] Actually, it has been a topic of interest because the winner of the Barcelona Olympics was carrying out creatine loading in which creatine is taken orally. Many athletes are now loading creatine for the purpose of improving their competitiveness, with some success.

【0004】一方、あらゆる成人病の危険因子である肥
満の解消という目的で体脂肪を減少させようとする試み
が一般によく行われている。もっとも身近な方法は食事
制限であるが、単純に食事を減らすことによって体重を
減少させても、必ずしも体脂肪の減少が得られない場合
が多いと言われている。また、食事制限に加えて運動す
ることにより体脂肪を減少させた方がダイエット効果は
高いと言われているが、運動で消費されるエネルギーは
決して大きいものではないため、長時間の運動を行う必
要があることから、運動することによっても体脂肪を減
少させるのは容易なことではない。
[0004] On the other hand, attempts to reduce body fat for the purpose of eliminating obesity, which is a risk factor for any adult disease, are generally made. The most familiar method is dietary restriction, but it is said that in many cases, simply reducing the diet to reduce weight does not always result in a reduction in body fat. In addition, it is said that reducing body fat by exercising in addition to dietary restriction has a higher diet effect, but exercise for a long time because energy consumed by exercise is by no means large. Because of the need, it is not easy to lose body fat by exercising.

【0005】[0005]

【発明が解決しようとする課題】クレアチンローディン
グについては、競技力の向上に関する以外の効果につい
てはほとんど研究されていない。また、筋肉を中心とし
た除脂肪体重の増加についての報告(Earnest C.P.他.A
cta.Physiol.Scand.153,207-209,(1995))はあるもの
の、脂肪組織などその他の体構成に対する影響に関する
知見もほとんどなかった。
With respect to creatine loading, little research has been made on effects other than improvement of athletic ability. In addition, a report on the increase in lean body mass mainly in muscle (Earnest CP et al. A
cta. Physiol. Scand. 153, 207-209, (1995)), but little was known about the effects on other body composition such as adipose tissue.

【0006】[0006]

【課題を解決するための手段】本発明者らは、筋力の強
化はエネルギー代謝経路に生化学的な変化をもたらし、
ひいては体脂肪の減少に繋がるものと考え鋭意研究を進
めた。その結果、クレアチンを摂取することにより体脂
肪が著しく減少することを見出し、本発明を完成した。
SUMMARY OF THE INVENTION The present inventors have found that strengthening muscle strength results in a biochemical change in the energy metabolic pathway,
As a result, the research was devoted to the reduction of body fat. As a result, they found that body fat was significantly reduced by ingesting creatine, and completed the present invention.

【0007】すなわち、本発明は、体脂肪減少効果を向
上させる作用を有するクレアチンを含有する体脂肪減少
促進剤及び体脂肪減少促進用食品組成物に関する。ま
た、本発明は、クレアチンを有効成分として含有するこ
とを特徴とする食品組成物を摂取し、体脂肪の減少を促
進する方法に関する。
[0007] That is, the present invention relates to a body fat reduction promoting agent and a food composition for promoting body fat reduction containing creatine which has an action of improving the body fat reducing effect. In addition, the present invention relates to a method of ingesting a food composition containing creatine as an active ingredient, and promoting the reduction of body fat.

【0008】[0008]

【発明の実施の形態】本発明は体脂肪減少促進剤及び体
脂肪減少促進用食品組成物に関するものであり、クレア
チンを含有した剤あるいは食品組成物を摂取することに
より、有意に体脂肪を減少させることができることを見
出し、発明を完成したものである。
BEST MODE FOR CARRYING OUT THE INVENTION The present invention relates to a body fat reduction promoting agent and a food composition for promoting body fat reduction, wherein a body fat is significantly reduced by ingesting a creatine-containing agent or a food composition. The inventors have found that the invention can be performed and completed the invention.

【0009】本発明の体脂肪減少促進剤及び体脂肪減少
促進用食品組成物は、クレアチンを含有することを特徴
としている。本発明に使用するクレアチンの純度は特に
限定されないが、各種食品組成物及び薬剤の特性、嗜好
性、摂取量、安全性等を考慮すれば、比較的高純度のも
のがこのましい。
[0009] The body fat reduction promoting agent and the food composition for promoting body fat reduction of the present invention are characterized by containing creatine. The purity of creatine used in the present invention is not particularly limited, but relatively high purity is preferable in consideration of the characteristics, taste, intake, safety, etc. of various food compositions and drugs.

【0010】本発明における医薬品としての体脂肪減少
促進剤の形態は特に限定されるものではなく、一般に製
剤上使用できる各種賦形剤、安定剤、香味剤等と調合し
て錠剤、カプセル剤、顆粒剤、散剤等とすることができ
る。
[0010] The form of the body fat reduction promoter as a medicament in the present invention is not particularly limited, and is generally formulated with various excipients, stabilizers, flavors, etc., which can be used in pharmaceutical preparations, tablets, capsules, Granules and powders can be prepared.

【0011】本発明における体脂肪減少促進用食品組成
物の形態は特に限定されるものではなく、多くの飲食品
の形態をとることができる。例えばタブレットキャンデ
ィー、粉末飲料、ビスケット、ウエハーなどが適してい
る。
[0011] The form of the food composition for promoting body fat reduction in the present invention is not particularly limited, and can take the form of many foods and drinks. For example, tablet candies, powdered drinks, biscuits, wafers, and the like are suitable.

【0012】本食品組成物中のクレアチンの含有量は特
に限定されないが、各種飲食品の特性、嗜好性、摂取
量、安全性、経済性等を考慮すれば、その含有量として
は20重量%以下、好ましくは5〜15重量%程度であれば
よく、目的に応じて適当な製造工程の段階で適宜配合す
ればよい。
Although the content of creatine in the present food composition is not particularly limited, the content is preferably 20% by weight in consideration of the characteristics, taste, intake, safety, economy and the like of various foods and drinks. Hereinafter, the content is preferably about 5 to 15% by weight, and may be appropriately added at an appropriate stage of the manufacturing process according to the purpose.

【0013】1回あるいは1食当たりのクレアチン摂取
量は、1〜5グラム程度が適している。これは、クレア
チンを吸収できる量には限度があるものと予想されてお
り、1〜5グラム程度が無駄なく吸収されるのに適した
1回当たりの摂取量である。
[0013] The creatine intake per serving or per meal is suitably about 1 to 5 grams. It is expected that there is a limit to the amount of creatine that can be absorbed, and that it is a single intake that is suitable for about 1 to 5 grams to be absorbed without waste.

【0014】[0014]

【実施例】次に、本発明を実施例及び製造例によって更
に詳細に説明するが、これらは本発明を何ら限定するも
のではない。
Next, the present invention will be described in more detail with reference to Examples and Production Examples, which do not limit the present invention in any way.

【0015】実施例1 ラットにおける効果の確認試験 4週齢のSprague-Dawley系雄性ラット14個体を、一群7
個体づつ対照(対照飼料摂取)群、摂取(クレアチン含
有飼料摂取)群の2群に分けた。飼育期間を通じてラッ
トには、1周1mの外周を有する回転籠を装備した飼育
ケージ(シナノ製作所製)を用い自発運動を行わせた。
自発運動量は、1日約6kmで両運動群に差はなかった。
対照飼料はAIN−93G精製飼料(オリエンタル酵母製)を
用い、クレアチンは、対照飼料中のカゼイン 2.5%と置
換することにより添加した。実験に使用した対照飼料及
びクレアチン含有飼料の組成を表1に示す。ラットに
は、これらの飼料を28日間自由摂取させた。
Example 1 Test for Confirmation of Effect in Rats Fourteen 4-week-old Sprague-Dawley male rats were treated in groups of 7
Individuals were divided into two groups, a control (control feed intake) group and an intake (creatine-containing feed intake) group. Throughout the breeding period, the rats were allowed to exercise spontaneously using a breeding cage (manufactured by Shinano Seisakusho) equipped with a rotating cage having an outer circumference of 1 m per round.
Spontaneous locomotion was about 6 km per day, and there was no difference between the two groups.
As a control feed, AIN-93G purified feed (manufactured by Oriental Yeast) was used, and creatine was added by substituting 2.5% of casein in the control feed. Table 1 shows the compositions of the control feed and the creatine-containing feed used in the experiment. Rats had free access to these diets for 28 days.

【0016】[0016]

【表1】 [Table 1]

【0017】飼育最終日にラットは、エーテル麻酔科で
採血屠殺し、体脂肪量に正比例することが知られている
後腹壁脂肪及び副睾丸脂肪を摘出し、その組織重量を測
定した。また、血液を遠心分離して得られた血清につい
ては、エネルギー代謝の流れが糖質と脂質のいずれを主
体としているかを推定する目的で、血糖値及び血清中性
脂肪濃度の測定を行った。これらの測定の結果を表2に
示す。
On the last day of the breeding, the rats were bled and killed in an ether anesthesia department, and the posterior abdominal wall fat and epididymal fat, which is known to be directly proportional to the amount of body fat, were extracted, and the tissue weight was measured. For serum obtained by centrifuging blood, the blood glucose level and serum triglyceride concentration were measured for the purpose of estimating whether the flow of energy metabolism was mainly carbohydrate or lipid. Table 2 shows the results of these measurements.

【0018】[0018]

【表2】 [Table 2]

【0019】表2に示されたように、摂取群では対照群
に比して、いずれの脂肪組織においても重量の低下が認
められた。血糖値は群間に有意な差はなかったが、血清
中性脂肪濃度は、対照群に比して摂取群で低下した。こ
の現象は、クレアチンの摂取により、生体内でのエネル
ギー産生が糖質より脂質に依存する形に変化することを
示している。以上の結果のごとく、クレアチンの摂取
は、体脂肪減少効果を向上させることが明らかである。
As shown in Table 2, the weight of the adipose tissue was lower in the ingested group than in the control group. Although blood glucose levels did not differ significantly between the groups, serum triglyceride levels were lower in the intake group than in the control group. This phenomenon indicates that ingestion of creatine changes the energy production in vivo to a form that depends more on lipids than on carbohydrates. As is clear from the above results, it is clear that creatine intake improves the body fat reducing effect.

【0020】製造例1 錠剤 高純度クレアチンを使用した商品ザバスプロ・クレアチ
ン(明治製菓(株)製、クレアチン含有率99%以上)を用
い、常法に従って以下の配合で錠剤タイプの本発明の体
脂肪減少促進剤を作製した。 ザバスプロ・クレアチン 100部 トウモロコシデンプン 19部 結晶セルロース 30部 ステアリン酸マグネシウム 1部
Production Example 1 Tablets The body fat of the present invention in the form of a tablet is prepared using the following formulation using Zabaspro creatine (manufactured by Meiji Seika Co., Ltd., creatine content: 99% or more) using high-purity creatine. A reduction accelerator was made. Zabaspro Creatine 100 parts Corn starch 19 parts Microcrystalline cellulose 30 parts Magnesium stearate 1 part

【0021】上記成分を所定量採取し、均一に混合した
後、圧縮成型し直径7mm、1錠150mgの錠剤とする。こ
の1錠にはクレアチン100mgが含まれている。
A predetermined amount of the above components is collected, uniformly mixed, and then compression molded to form tablets each having a diameter of 7 mm and a tablet of 150 mg. One tablet contains 100 mg of creatine.

【0022】製造例2 錠菓タイプの食品組成物 ザバスプロ・クレアチン(明治製菓(株)製)を用い、常
法に従って以下の配合で錠菓タイプの本発明の体脂肪減
少促進用食品組成物を作製した。 グラニュー糖 718部 濃縮果汁 50部 クエン酸 60部 香料 20部 ゼラチン 10部 ザバスプロ・クレアチン 100部 炭酸カルシウム 15部 酸化マグネシウム 5部 リン酸二水素カリウム 22部
Production Example 2 A tablet confection type food composition for promoting body fat reduction of the present invention was prepared using tablet confection type food composition Zabaspro creatine (manufactured by Meiji Seika Co., Ltd.) in the following manner in accordance with a conventional method. Produced. Granulated sugar 718 parts Fruit juice concentrate 50 parts Citric acid 60 parts Flavor 20 parts Gelatin 10 parts Zabaspro creatine 100 parts Calcium carbonate 15 parts Magnesium oxide 5 parts Potassium dihydrogen phosphate 22 parts

【0023】製造例3 粉末飲料タイプの食品組成物 ザバスプロ・クレアチン(明治製菓(株)製)を用い、常
法に従って以下の配合で粉末飲料タイプの本発明の体脂
肪減少促進用食品組成物を作製した。 無水結晶ブドウ糖 650部 クエン酸顆粒 60部 酒石酸 60部 重曹顆粒 55部 フレーバー 25部 ザバスプロ・クレアチン 100部 ドロマイト 50部
Production Example 3 Powdered Beverage Type Food Composition The present invention provides a powdered beverage type food composition for promoting body fat reduction according to a conventional method using Zabaspro Creatine (manufactured by Meiji Seika Co., Ltd.) in the following formulation. Produced. Anhydrous crystalline glucose 650 parts Citric acid granules 60 parts Tartaric acid 60 parts Baking soda granules 55 parts Flavor 25 parts Zabaspro creatine 100 parts Dolomite 50 parts

【0024】製造例4 クッキータイプの食品組成物 ザバスプロ・クレアチン(明治製菓(株)製)を用い、常
法に従って以下の配合でクッキータイプの本発明の体脂
肪減少促進用食品組成物を作製した。 小麦粉 340部 砂糖 200部 マーガリン 200部 全卵粉 70部 バニラエッセンス 20部 ザバスプロ・クレアチン 150部 乳清カルシウム 20部
Production Example 4 Cookie-type food composition A cookie-type food composition for promoting body fat reduction of the present invention was prepared according to a conventional method using Zabaspro Creatine (manufactured by Meiji Seika Co., Ltd.) in the following manner. . Flour 340 parts Sugar 200 parts Margarine 200 parts Whole egg powder 70 parts Vanilla essence 20 parts Zabaspro creatine 150 parts Whey calcium 20 parts

【0025】[0025]

【発明の効果】クレアチンを含有することを特徴とする
本発明の体脂肪減少促進剤及び体脂肪減少促進用食品組
成物を摂取することにより、体脂肪を容易に且つ効率良
く減少させることができる。
The body fat can be easily and efficiently reduced by ingesting the body fat reduction promoting agent and the body fat reduction promoting food composition of the present invention characterized by containing creatine. .

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 FI テーマコート゛(参考) A23L 2/52 A23L 2/00 F 2/39 Q (72)発明者 五十嵐 充 東京都中央区京橋2−4−16 明治製菓株 式会社内 (72)発明者 酒井 健介 埼玉県坂戸市千代田5−3−1 明治製菓 株式会社生物科学研究所内 (72)発明者 徳永 隆久 埼玉県坂戸市千代田5−3−1 明治製菓 株式会社生物科学研究所内 Fターム(参考) 4B014 GB08 GK12 GL09 4B017 LC03 LK14 LL09 4B018 MD19 ME14 4B032 DB22 DK19 DL20 4C206 AA01 AA02 HA32 MA01 MA04 ZA70 ZC33 ──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A23L 2/52 A23L 2/00 F 2/39 Q (72) Inventor Mitsuru Igarashi 2-Kyobashi, Chuo-ku, Tokyo 4-16 Meiji Seika Co., Ltd. (72) Inventor Kensuke Sakai 5-3-1 Chiyoda, Sakado City, Saitama Prefecture Meiji Seika Co., Ltd., Biological Science Research Institute (72) Inventor Takahisa Tokunaga 5-3-Chiyoda, Sakado City, Saitama Prefecture 1 Meiji Seika Co., Ltd. Biological Science Laboratory F-term (reference) 4B014 GB08 GK12 GL09 4B017 LC03 LK14 LL09 4B018 MD19 ME14 4B032 DB22 DK19 DL20 4C206 AA01 AA02 HA32 MA01 MA04 ZA70 ZC33

Claims (3)

【特許請求の範囲】[Claims] 【請求項1】クレアチンを有効成分として含有すること
を特徴とする体脂肪減少促進剤
1. A body fat reduction promoting agent comprising creatine as an active ingredient.
【請求項2】クレアチンを有効成分として含有すること
を特徴とする体脂肪減少促進用食品組成物
2. A food composition for promoting body fat reduction, comprising creatine as an active ingredient.
【請求項3】クレアチンを有効成分として含有すること
を特徴とする食品組成物を摂取し、体脂肪の減少を促進
する方法
3. A method for ingesting a food composition containing creatine as an active ingredient to promote reduction of body fat.
JP31469999A 1999-11-05 1999-11-05 Body fat-reducing accelerator and food composition for body fat-reducing acceleration Pending JP2001131065A (en)

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Publications (1)

Publication Number Publication Date
JP2001131065A true JP2001131065A (en) 2001-05-15

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Country Status (1)

Country Link
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010521420A (en) * 2007-01-31 2010-06-24 アルツケム トロストベルク ゲゼルシャフト ミット ベシュレンクテル ハフツング Use of guanidinoacetic acid (salt) in combination with betaine and / or choline for the manufacture of health enhancers
JPWO2013069764A1 (en) * 2011-11-10 2015-04-02 広久 西澤 Intake method of creatine composition, creatine composition for oral intake used in the ingestion method, and creatine-containing food comprising the creatine composition
JP2017057175A (en) * 2015-09-18 2017-03-23 株式会社保健科学研究所 Muscle increasing agent

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WO1999000122A1 (en) * 1997-06-25 1999-01-07 Ipr-Institute For Pharmaceutical Research Ag Method for reducing body weight

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010521420A (en) * 2007-01-31 2010-06-24 アルツケム トロストベルク ゲゼルシャフト ミット ベシュレンクテル ハフツング Use of guanidinoacetic acid (salt) in combination with betaine and / or choline for the manufacture of health enhancers
JPWO2013069764A1 (en) * 2011-11-10 2015-04-02 広久 西澤 Intake method of creatine composition, creatine composition for oral intake used in the ingestion method, and creatine-containing food comprising the creatine composition
JP2015165803A (en) * 2011-11-10 2015-09-24 広久 西澤 Creatine composition for oral ingestion, and creatine-containing food with use of the creatine composition for oral ingestion
US9757347B2 (en) 2011-11-10 2017-09-12 Hirohisa Nishizawa Ingestion method of creatine composition, creatine composition for using in the ingestion method, and creatine-containing medicament and food each produced using the creatine composition
JP2017057175A (en) * 2015-09-18 2017-03-23 株式会社保健科学研究所 Muscle increasing agent

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