JP2000509486A - 1段階オールインワン乾燥試薬イムノアッセイ - Google Patents
1段階オールインワン乾燥試薬イムノアッセイInfo
- Publication number
- JP2000509486A JP2000509486A JP9535865A JP53586597A JP2000509486A JP 2000509486 A JP2000509486 A JP 2000509486A JP 9535865 A JP9535865 A JP 9535865A JP 53586597 A JP53586597 A JP 53586597A JP 2000509486 A JP2000509486 A JP 2000509486A
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9123—Phosphotransferases in general with a nitrogenous group as acceptor (2.7.3), e.g. histidine kinases
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/969—Multiple layering of reactants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/809—Multifield plates or multicontainer arrays
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.競合的又は非競合的イムノアッセイ法であって、以下の工程; −反応ウェル内の固相上にアッセイ特異的成分を固定化し; −標識されたアッセイ特異的成分を添加し; −上記成分を乾燥させ; −分析されるべきマーカーを含有するサンプルを添加し; −上記マーカーが上記アッセイ特異的成分と反応することを許容し;そして −上記標識からのシグナルを検出する、 を含む、前記イムノアッセイ法。 2.競合的又は非競合的イムノアッセイ法であって、以下の工程; −分析されるべきマーカーを含有するサンプルを、反応ウェル; 上記反応ウェル内の固相上に直接的に又はアフィニティー対を介して固定化され たアッセイ特異的成分;標識されたアッセイ特異的成分を含むデバイスに添加し 、ここで、そのデバイス内で、上記の固定化された成分と標識が乾燥されており ; −上記マーカーが上記アッセイ特異的成分と反応することを許容し;そして −上記標識からのシグナルを検出する、 を含む、前記イムノアッセイ法。 3.前記反応ウェルが、通常のマイクロタイトレーション・ウェルのサイズ又 はそれより小さなサイズを有する、請求項1又は2に記載のアッセイ法。 4.前記の免疫反応が1のインキュベーション手順内で行われる 、請求項1又は2に記載のアッセイ法。 5.抗体又は抗原であることができる、前記標識された成分から前記の固定化 された成分を分離する遮断層が、乾燥前に添加される、請求項1又は2に記載の アッセイ法。 6.前記の固定化された成分と標識された成分、抗体と抗原が、いずれの遮断 層を伴わずに前記乾燥ウェル内に存在する、請求項1又は2に記載の競合的アッ セイ法。 7.前記遮断層が、タンパク質及び/又は炭水化物、並びに前記の必要なアッ セイ特異的成分を含む、請求項5に記載のアッセイ法。 8.前記の事前に添加されたアッセイ特異的成分が風乾されている、請求項1 又は2に記載のアッセイ法。 9.前記のサンプルが、血清、血漿又は全血から成る群から選ばれた、請求項 1又は2に記載のアッセイ法。 10.前記ランタニド・キレートが、アッセイ特異的成分を標識するために使用 される、請求項1又は2に記載のアッセイ法。 11.前記ランタニド・キレートが、時間分解フルオロメトリーにより計測され る、請求項10に記載のアッセイ法。 12.前記ランタニド・キレートが、時間分解フルオロメトリーにより、 −溶液中で、又は −前記固相上で直接的に、 計測される、請求項10に記載のアッセイ法。 13.2以上の分析物が、異なる分析物について異なるランタニド・キレート標 識を使用することにより1の単反応ウェル内で計測されている、請求項10に記載 のアッセイ法。 14.前記反応ウェル内の乾燥成分が、 −ミオグロビン; −クレアチン・キナーゼ・アイソザイムMB; −心臓特異的トロポニンI; −ヒト・グリコーゲン・ホスホリラーゼ・アイソザイムBB; −ミオグロビン及びクレアチン・キナーゼ・アイソザイムMB;又は −ミオグロビン、クレアチン・キナーゼ・アイソザイムMB及び心臓特異的トロ ポニンI、 に特異的である、請求項1又は2に記載のアッセイ法。 15.競合的及び/又は非競合的イムノアッセイにおける使用のためのデバイス であって; −反応ウェル; −上記反応ウェルの表面上に、直接的にか又は第2の固定化試薬を介して、固 定化されたアッセイ特異的成分; −標識されたアッセイ特異的成分;及び −場合により、上記の標識された成分から上記の固定化された成分を分離する 遮断層、 を含み、このデバイス内で、上記の固定化された成分、上記の標識された成分及 び上記の任意的遮断層が全て乾燥されている、前記デバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/629,177 | 1996-04-08 | ||
US08/629,177 US6429026B1 (en) | 1996-04-08 | 1996-04-08 | One-step all-in-one dry reagent immunoassay |
PCT/FI1997/000153 WO1997038311A1 (en) | 1996-04-08 | 1997-03-07 | One-step all-in-one dry reagent immunoassay |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000509486A true JP2000509486A (ja) | 2000-07-25 |
JP3537829B2 JP3537829B2 (ja) | 2004-06-14 |
Family
ID=24521923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53586597A Expired - Lifetime JP3537829B2 (ja) | 1996-04-08 | 1997-03-07 | 1段階オールインワン乾燥試薬イムノアッセイ |
Country Status (6)
Country | Link |
---|---|
US (1) | US6429026B1 (ja) |
EP (1) | EP0892927B1 (ja) |
JP (1) | JP3537829B2 (ja) |
DE (1) | DE69729186T2 (ja) |
ES (1) | ES2217394T3 (ja) |
WO (1) | WO1997038311A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004361397A (ja) * | 2003-05-09 | 2004-12-24 | Japan Science & Technology Agency | 複数種のイオン測定用器具 |
WO2010092753A1 (ja) * | 2009-02-13 | 2010-08-19 | 大陽日酸株式会社 | 酵素反応試薬、酵素反応試薬キット及び酵素反応用の液の保存方法 |
JP2011072970A (ja) * | 2009-10-01 | 2011-04-14 | Sumitomo Bakelite Co Ltd | 糖鎖捕捉物質を含むタブレットおよびその用途 |
JP2017026635A (ja) * | 2005-12-21 | 2017-02-02 | メソ スケール テクノロジーズ エルエルシー | アッセイ試薬を具備するアッセイモジュールとその製造方法およびその使用方法 |
US10794914B2 (en) | 2005-12-21 | 2020-10-06 | Meso Scale Technologies, Llc | Assay apparatuses, methods and reagents |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPR005600A0 (en) * | 2000-09-12 | 2000-10-05 | University Of Sydney, The | Diagnostic assay |
JP2005510696A (ja) * | 2001-11-27 | 2005-04-21 | ダイアジェニクス インターナショナル コーポレーション | 患者サンプル中の生化学的標識の迅速同時検出のための免疫分析法および免疫分析キット |
US7211440B2 (en) * | 2002-03-08 | 2007-05-01 | Wallac Oy | Dissociative fluorescence enhancement assay |
NZ547177A (en) | 2003-11-14 | 2009-09-25 | Inverness Medical Switzerland | Rapid sample analysis and storage devices and methods of use |
FI20040205A (fi) | 2004-02-11 | 2005-08-12 | Reagena Ltd Oy | Menetelmä ja laite pikatestin valmistamiseksi |
FI20040768A0 (fi) * | 2004-06-04 | 2004-06-04 | Teemu Korpimaeki | Menetelmä määritysreagenssien stabiloimiseksi, stabilisoituja määritysreagensseja sisältävä reagenssisäiliö ja sen käyttö |
US20050283380A1 (en) * | 2004-06-18 | 2005-12-22 | Garduno Ramon S | Delivery service for a health management system |
CA2631025A1 (en) | 2005-11-30 | 2007-06-07 | Inverness Medical Switzerland Gmbh | A device for detecting the presence or amount of an analyte in a fluid sample and method thereof |
CA3006231C (en) | 2005-12-21 | 2022-04-12 | Meso Scale Technologies, Llc | Assay modules having assay reagents and methods of making and using same |
JP3157356U (ja) | 2006-07-26 | 2010-02-18 | インバーネス・メデイカル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 生物学的試料用の分析装置 |
EP1970711A1 (en) * | 2007-03-16 | 2008-09-17 | Radiometer Medical ApS | Reagent cup device |
KR101343035B1 (ko) * | 2008-12-22 | 2013-12-18 | 삼성전자 주식회사 | 제1수용체, 차단물질 및 제2수용체가 고정화된 고체 기판을포함하는 표적물질을 분석하기 위한 물품 및 그 용도 |
KR101314221B1 (ko) * | 2009-12-09 | 2013-10-02 | 한국전자통신연구원 | 호흡기 질환 진단용 진단 키트 |
CN102200536B (zh) | 2010-03-25 | 2015-05-27 | 艾博生物医药(杭州)有限公司 | 测试液体样本中被分析物的检测装置 |
US20110306148A1 (en) | 2010-06-14 | 2011-12-15 | Siemens Healthcare Diagnostics Inc. | Composition for use as an assay reagent |
US20120095369A1 (en) | 2010-10-15 | 2012-04-19 | Teixeira Scott M | System and Method for Sampling Device for Bodily Fluids |
US20120282681A1 (en) * | 2011-05-05 | 2012-11-08 | Teixeira Scott M | Rapid Identification of Organisms in Bodily Fluids |
US10024937B2 (en) | 2011-09-27 | 2018-07-17 | Koninklijke Philips N.V. | Gradient amplifier with compensation for dead time and forward voltage |
US9434977B2 (en) | 2013-02-27 | 2016-09-06 | Avent, Inc. | Rapid identification of organisms in bodily fluids |
CN103884844A (zh) * | 2014-04-03 | 2014-06-25 | 南方医科大学 | 测定柴胡皂苷a含量的时间分辨荧光免疫分析法及试剂盒 |
CN106053783A (zh) * | 2016-06-03 | 2016-10-26 | 广州市丰华生物工程有限公司 | 一种适用于结核感染t细胞检测的快速时间分辨荧光免疫分析试剂盒及其检测方法 |
CN106353505B (zh) * | 2016-08-08 | 2018-05-18 | 上海睿康生物科技有限公司 | 基于催化信号放大的ApoE试剂盒 |
CN108548919A (zh) * | 2018-04-04 | 2018-09-18 | 广州市雷德生物科技有限公司 | 一种预包被酶标板及其制备方法和应用 |
KR102568430B1 (ko) * | 2020-11-16 | 2023-08-24 | 바디텍메드(주) | 항 약물 항체의 신속 검출 방법 |
EP4363851A1 (en) | 2021-07-01 | 2024-05-08 | Radiometer Medical ApS | Method for calibrating an immunoassay device to determine the concentration of an analyte |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4017597A (en) * | 1974-10-30 | 1977-04-12 | Monsanto Company | Unitized solid phase immunoassay kit and method |
US4256725A (en) * | 1978-02-21 | 1981-03-17 | Becton, Dickinson And Company | Preparation of solid substrate containing receptor and labeled form of ligand for assays |
US4434236A (en) * | 1982-10-20 | 1984-02-28 | E. I. Du Pont De Nemours & Co. | Immunoassay wherein labeled antibody is displaced from immobilized analyte-analogue |
GB8500698D0 (en) * | 1985-01-11 | 1985-02-13 | Unilever Plc | Preparation of reagents |
US4857454A (en) * | 1987-04-09 | 1989-08-15 | a Division of Yeshiva University Albert Einstein College of Medicine of Yeshiva University | Spectrophotometric method for kinetic absorbance measurements in two-phase enzyme immunoassay and apparatus therefor |
JPS6447952A (en) * | 1987-05-06 | 1989-02-22 | Saibaafuruua Inc | Immunoassay, reagent used therefor and making thereof |
ATE179798T1 (de) * | 1988-12-12 | 1999-05-15 | Csl Ltd | Festphase-immuno-testverfahren mit etikettierten konjugaten |
JPH02213766A (ja) * | 1989-02-15 | 1990-08-24 | Mochida Pharmaceut Co Ltd | 免疫測定用試薬および免疫測定器具 |
DE4024544A1 (de) * | 1990-08-02 | 1992-02-06 | Boehringer Mannheim Gmbh | Analyseelement und verfahren zu seiner herstellung |
-
1996
- 1996-04-08 US US08/629,177 patent/US6429026B1/en not_active Expired - Lifetime
-
1997
- 1997-03-07 JP JP53586597A patent/JP3537829B2/ja not_active Expired - Lifetime
- 1997-03-07 EP EP97906208A patent/EP0892927B1/en not_active Expired - Lifetime
- 1997-03-07 DE DE69729186T patent/DE69729186T2/de not_active Expired - Lifetime
- 1997-03-07 WO PCT/FI1997/000153 patent/WO1997038311A1/en active IP Right Grant
- 1997-03-07 ES ES97906208T patent/ES2217394T3/es not_active Expired - Lifetime
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004361397A (ja) * | 2003-05-09 | 2004-12-24 | Japan Science & Technology Agency | 複数種のイオン測定用器具 |
JP2017026635A (ja) * | 2005-12-21 | 2017-02-02 | メソ スケール テクノロジーズ エルエルシー | アッセイ試薬を具備するアッセイモジュールとその製造方法およびその使用方法 |
JP2018112556A (ja) * | 2005-12-21 | 2018-07-19 | メソ スケール テクノロジーズ エルエルシー | アッセイ試薬を具備するアッセイモジュールとその製造方法およびその使用方法 |
US10794914B2 (en) | 2005-12-21 | 2020-10-06 | Meso Scale Technologies, Llc | Assay apparatuses, methods and reagents |
US11300571B2 (en) | 2005-12-21 | 2022-04-12 | Meso Scale Technologies, Llc. | Assay apparatuses, methods and reagents |
US11892455B2 (en) | 2005-12-21 | 2024-02-06 | Meso Scale Technologies, Llc. | Assay apparatuses, methods and reagents |
WO2010092753A1 (ja) * | 2009-02-13 | 2010-08-19 | 大陽日酸株式会社 | 酵素反応試薬、酵素反応試薬キット及び酵素反応用の液の保存方法 |
JP2011072970A (ja) * | 2009-10-01 | 2011-04-14 | Sumitomo Bakelite Co Ltd | 糖鎖捕捉物質を含むタブレットおよびその用途 |
Also Published As
Publication number | Publication date |
---|---|
DE69729186D1 (de) | 2004-06-24 |
ES2217394T3 (es) | 2004-11-01 |
US6429026B1 (en) | 2002-08-06 |
WO1997038311A1 (en) | 1997-10-16 |
JP3537829B2 (ja) | 2004-06-14 |
EP0892927A1 (en) | 1999-01-27 |
EP0892927B1 (en) | 2004-05-19 |
DE69729186T2 (de) | 2005-05-04 |
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