JP2000219699A5 - - Google Patents
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- Publication number
- JP2000219699A5 JP2000219699A5 JP1999022588A JP2258899A JP2000219699A5 JP 2000219699 A5 JP2000219699 A5 JP 2000219699A5 JP 1999022588 A JP1999022588 A JP 1999022588A JP 2258899 A JP2258899 A JP 2258899A JP 2000219699 A5 JP2000219699 A5 JP 2000219699A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polypeptide according
- pathogenic
- dna
- mycobacteriosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 6
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 3
- 230000001717 pathogenic Effects 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 206010024229 Leprosy Diseases 0.000 description 1
- 241000545499 Mycobacterium avium-intracellulare Species 0.000 description 1
- 102000004965 antibodies Human genes 0.000 description 1
- 108090001123 antibodies Proteins 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 229960005486 vaccines Drugs 0.000 description 1
Description
【特許請求の範囲】
【請求項1】 1又は複数個のアミノ酸が置換、付加又は欠失していてもよい配列番号1(205個のアミノ酸)で表される病原性抗酸菌に対する免疫原性を有するポリペプチド。
【請求項2】 リン酸化された請求項1に記載のポリペプチド。
【請求項3】 請求項1に記載のポリペプチドをコードしているDNA。
【請求項4】 請求項3に記載のDNAを含むベクター。
【請求項5】 請求項4に記載の該ベクターを含む形質転換体。
【請求項6】 請求項5に記載の形質転換体を培養することを特徴とする請求項1に記載のポリペプチドの製造法。
【請求項7】 請求項1に記載のポリペプチドまたは請求項3に記載のDNAを含むワクチン。
【請求項8】 請求項1に記載のポリペプチドに対する抗体を検出することを特徴とする病原性抗酸菌症の診断法。
【請求項9】 病原性抗酸菌症が結核、MAC(Mycobacterium avium-intracellulare complex)、ハンセン氏病からなる群から選ばれる請求項8に記載の診断法。
[Claims]
1. A polypeptide having immunogenicity against pathogenic mycobacteria represented by SEQ ID NO: 1 (205 amino acids) in which one or more amino acids may be substituted, added or deleted.
2. The polypeptide according to claim 1, which is phosphorylated.
3. A DNA encoding the polypeptide according to claim 1.
A vector comprising the DNA according to claim 3.
A transformant comprising the vector according to claim 4.
6. The method for producing a polypeptide according to claim 1, wherein the transformant according to claim 5 is cultured.
7. A vaccine comprising the polypeptide according to claim 1 or the DNA according to claim 3.
8. A method for diagnosing pathogenic mycobacteriosis, comprising detecting an antibody against the polypeptide according to claim 1.
9. The diagnostic method according to claim 8, wherein the pathogenic mycobacteriosis is selected from the group consisting of tuberculosis, MAC (Mycobacterium avium-intracellulare complex), and Hansen's disease.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP02258899A JP4415200B2 (en) | 1999-01-29 | 1999-01-29 | Late-growing mycobacterial polypeptide |
AU23207/00A AU2320700A (en) | 1999-01-29 | 2000-01-28 | Slow growing acid-fast bacterium polypeptide |
PCT/JP2000/000455 WO2000044905A1 (en) | 1999-01-29 | 2000-01-28 | Slow growing acid-fast bacterium polypeptide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP02258899A JP4415200B2 (en) | 1999-01-29 | 1999-01-29 | Late-growing mycobacterial polypeptide |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2000219699A JP2000219699A (en) | 2000-08-08 |
JP2000219699A5 true JP2000219699A5 (en) | 2006-03-09 |
JP4415200B2 JP4415200B2 (en) | 2010-02-17 |
Family
ID=12087024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP02258899A Expired - Lifetime JP4415200B2 (en) | 1999-01-29 | 1999-01-29 | Late-growing mycobacterial polypeptide |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP4415200B2 (en) |
AU (1) | AU2320700A (en) |
WO (1) | WO2000044905A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009066502A1 (en) * | 2007-11-20 | 2009-05-28 | Konica Minolta Medical & Graphic, Inc. | Solid support |
WO2010001841A1 (en) * | 2008-07-01 | 2010-01-07 | コニカミノルタホールディングス株式会社 | Method for aggregation and/or precipitation of microorganism using mdp1 |
JP5906019B2 (en) * | 2011-03-31 | 2016-04-20 | 国立大学法人福井大学 | Application of immunostimulation G9.1 to creation of anti-tuberculosis booster vaccine |
CN103304625B (en) * | 2012-03-14 | 2015-09-30 | 天津大学 | The extraction of protein group inside and outside Penicillium cell |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2104731T3 (en) * | 1990-11-08 | 1997-10-16 | Univ London | MICOBACTERIUM USED AS AN ADJUVANT FOR ANTIGENS. |
JP2002514385A (en) * | 1997-12-23 | 2002-05-21 | ジェネシス リサーチ アンド デベロップメント コーポレイション リミテッド | COMPOSITIONS DERIVED FROM MYCOBACTERIUM BACKEY AND USE THEREOF |
-
1999
- 1999-01-29 JP JP02258899A patent/JP4415200B2/en not_active Expired - Lifetime
-
2000
- 2000-01-28 AU AU23207/00A patent/AU2320700A/en not_active Abandoned
- 2000-01-28 WO PCT/JP2000/000455 patent/WO2000044905A1/en active Application Filing
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