JP2000219699A5 - - Google Patents

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Publication number
JP2000219699A5
JP2000219699A5 JP1999022588A JP2258899A JP2000219699A5 JP 2000219699 A5 JP2000219699 A5 JP 2000219699A5 JP 1999022588 A JP1999022588 A JP 1999022588A JP 2258899 A JP2258899 A JP 2258899A JP 2000219699 A5 JP2000219699 A5 JP 2000219699A5
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JP
Japan
Prior art keywords
polypeptide
polypeptide according
pathogenic
dna
mycobacteriosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1999022588A
Other languages
Japanese (ja)
Other versions
JP2000219699A (en
JP4415200B2 (en
Filing date
Publication date
Application filed filed Critical
Priority to JP02258899A priority Critical patent/JP4415200B2/en
Priority claimed from JP02258899A external-priority patent/JP4415200B2/en
Priority to AU23207/00A priority patent/AU2320700A/en
Priority to PCT/JP2000/000455 priority patent/WO2000044905A1/en
Publication of JP2000219699A publication Critical patent/JP2000219699A/en
Publication of JP2000219699A5 publication Critical patent/JP2000219699A5/ja
Application granted granted Critical
Publication of JP4415200B2 publication Critical patent/JP4415200B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Description

【特許請求の範囲】
【請求項１】 １又は複数個のアミノ酸が置換、付加又は欠失していてもよい配列番号１（２０５個のアミノ酸）で表される病原性抗酸菌に対する免疫原性を有するポリペプチド。
【請求項２】 リン酸化された請求項１に記載のポリペプチド。
【請求項３】 請求項１に記載のポリペプチドをコードしているＤＮＡ。
【請求項４】 請求項３に記載のＤＮＡを含むベクター。
【請求項５】 請求項４に記載の該ベクターを含む形質転換体。
【請求項６】 請求項５に記載の形質転換体を培養することを特徴とする請求項１に記載のポリペプチドの製造法。
【請求項７】 請求項１に記載のポリペプチドまたは請求項３に記載のＤＮＡを含むワクチン。
【請求項８】 請求項１に記載のポリペプチドに対する抗体を検出することを特徴とする病原性抗酸菌症の診断法。
【請求項９】 病原性抗酸菌症が結核、ＭＡＣ(Mycobacterium avium-intracellulare complex)、ハンセン氏病からなる群から選ばれる請求項８に記載の診断法。
[Claims]
1. A polypeptide having immunogenicity against pathogenic mycobacteria represented by SEQ ID NO: 1 (205 amino acids) in which one or more amino acids may be substituted, added or deleted.
2. The polypeptide according to claim 1, which is phosphorylated.
3. A DNA encoding the polypeptide according to claim 1.
A vector comprising the DNA according to claim 3.
A transformant comprising the vector according to claim 4.
6. The method for producing a polypeptide according to claim 1, wherein the transformant according to claim 5 is cultured.
7. A vaccine comprising the polypeptide according to claim 1 or the DNA according to claim 3.
8. A method for diagnosing pathogenic mycobacteriosis, comprising detecting an antibody against the polypeptide according to claim 1.
9. The diagnostic method according to claim 8, wherein the pathogenic mycobacteriosis is selected from the group consisting of tuberculosis, MAC (Mycobacterium avium-intracellulare complex), and Hansen's disease.

JP02258899A 1999-01-29 1999-01-29 Late-growing mycobacterial polypeptide Expired - Lifetime JP4415200B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP02258899A JP4415200B2 (en) 1999-01-29 1999-01-29 Late-growing mycobacterial polypeptide
AU23207/00A AU2320700A (en) 1999-01-29 2000-01-28 Slow growing acid-fast bacterium polypeptide
PCT/JP2000/000455 WO2000044905A1 (en) 1999-01-29 2000-01-28 Slow growing acid-fast bacterium polypeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP02258899A JP4415200B2 (en) 1999-01-29 1999-01-29 Late-growing mycobacterial polypeptide

Publications (3)

Publication Number Publication Date
JP2000219699A JP2000219699A (en) 2000-08-08
JP2000219699A5 true JP2000219699A5 (en) 2006-03-09
JP4415200B2 JP4415200B2 (en) 2010-02-17

Family

ID=12087024

Family Applications (1)

Application Number Title Priority Date Filing Date
JP02258899A Expired - Lifetime JP4415200B2 (en) 1999-01-29 1999-01-29 Late-growing mycobacterial polypeptide

Country Status (3)

Country Link
JP (1) JP4415200B2 (en)
AU (1) AU2320700A (en)
WO (1) WO2000044905A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009066502A1 (en) * 2007-11-20 2009-05-28 Konica Minolta Medical & Graphic, Inc. Solid support
WO2010001841A1 (en) * 2008-07-01 2010-01-07 コニカミノルタホールディングス株式会社 Method for aggregation and/or precipitation of microorganism using mdp1
JP5906019B2 (en) * 2011-03-31 2016-04-20 国立大学法人福井大学 Application of immunostimulation G9.1 to creation of anti-tuberculosis booster vaccine
CN103304625B (en) * 2012-03-14 2015-09-30 天津大学 The extraction of protein group inside and outside Penicillium cell

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2104731T3 (en) * 1990-11-08 1997-10-16 Univ London MICOBACTERIUM USED AS AN ADJUVANT FOR ANTIGENS.
JP2002514385A (en) * 1997-12-23 2002-05-21 ジェネシス リサーチ アンド デベロップメント コーポレイション リミテッド COMPOSITIONS DERIVED FROM MYCOBACTERIUM BACKEY AND USE THEREOF

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