JOP20210265A1 - الأجسام المضادة لبيروغلوتامات أميلويد بيتا واستخداماتها - Google Patents

الأجسام المضادة لبيروغلوتامات أميلويد بيتا واستخداماتها

Info

Publication number
JOP20210265A1
JOP20210265A1 JOP/2021/0265A JOP20210265A JOP20210265A1 JO P20210265 A1 JOP20210265 A1 JO P20210265A1 JO P20210265 A JOP20210265 A JO P20210265A JO P20210265 A1 JOP20210265 A1 JO P20210265A1
Authority
JO
Jordan
Prior art keywords
antibodies
antigen binding
binding fragments
amyloid
pyroglutamate
Prior art date
Application number
JOP/2021/0265A
Other languages
English (en)
Inventor
Wilson Edwards
Rajkumar Ganesan
Jinquan Luo
Marc Mercken
Sanjaya Singh
Chichi Huang
Broeck Bianca Van
Porte Sherry La
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of JOP20210265A1 publication Critical patent/JOP20210265A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

يوفر الاختراع أجسامًا مضادة أو أجزاء منها رابطًة للمستضد - ترتبط بالبيروغلوتامات في الثمالة الثالثة (3pE A?) وطرقًا لتحضيره واستخدامه، متضمنًا ذلك استخدام التركيبات والإعطاء والأدوات. ويعد الجسم المضاد - أو الجزء منه الرابط للمستضد - والطرق التي تم الكشف عنها مفيدة لتشخيص داء ألزهايمر أو الأمراض المرتبطة بأميلويد بيتا وتشخيصها وعلاجها.
JOP/2021/0265A 2019-03-26 2020-03-25 الأجسام المضادة لبيروغلوتامات أميلويد بيتا واستخداماتها JOP20210265A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962823785P 2019-03-26 2019-03-26
PCT/EP2020/058395 WO2020193644A1 (en) 2019-03-26 2020-03-25 ANTIBODIES TO PYROGLUTAMATE AMYLOID-ß AND USES THEREOF

Publications (1)

Publication Number Publication Date
JOP20210265A1 true JOP20210265A1 (ar) 2023-01-30

Family

ID=70008544

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0265A JOP20210265A1 (ar) 2019-03-26 2020-03-25 الأجسام المضادة لبيروغلوتامات أميلويد بيتا واستخداماتها

Country Status (21)

Country Link
US (3) US11236155B2 (ar)
EP (1) EP3946603A1 (ar)
JP (1) JP2022526528A (ar)
KR (1) KR20210143858A (ar)
CN (1) CN113891746A (ar)
AU (1) AU2020245031A1 (ar)
BR (1) BR112021019107A2 (ar)
CA (1) CA3134785A1 (ar)
CL (2) CL2021002473A1 (ar)
CO (1) CO2021014028A2 (ar)
CR (1) CR20210492A (ar)
DO (1) DOP2021000199A (ar)
EA (1) EA202192606A1 (ar)
EC (1) ECSP21079184A (ar)
IL (1) IL286634A (ar)
JO (1) JOP20210265A1 (ar)
MA (1) MA55491A (ar)
MX (1) MX2021011715A (ar)
PE (1) PE20212266A1 (ar)
SG (1) SG11202110504XA (ar)
WO (1) WO2020193644A1 (ar)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202216760A (zh) 2020-07-23 2022-05-01 愛爾蘭商歐薩爾普羅席納有限公司 抗類澱粉β (ABETA)抗體
EP4259657A1 (en) * 2021-10-28 2023-10-18 Abbvie Inc. Anti-amyloid beta antibodies and methods of using the same
TW202345899A (zh) * 2022-03-11 2023-12-01 比利時商健生藥品公司 多特異性抗體及其用途(三)
TW202346355A (zh) * 2022-03-11 2023-12-01 比利時商健生藥品公司 多特異性抗體及其用途(二)
WO2023170291A1 (en) * 2022-03-11 2023-09-14 Janssen Pharmaceutica Nv Multispecific antibodies and uses thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
US5642870A (en) 1992-08-05 1997-07-01 Sargis; Ike Switch stand
US5761894A (en) 1996-09-25 1998-06-09 Magic Circle Corporation Grass striping attachment for lawn mowers
US9907485B2 (en) 2004-10-15 2018-03-06 Brainlab Ag Targeted immunization and plaque destruction against Alzheimer's disease
WO2006066049A2 (en) * 2004-12-15 2006-06-22 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
CN117903302A (zh) 2005-11-30 2024-04-19 Abbvie 公司 抗-Aβ球聚体抗体，其相关产品，生产所述抗体的方法，所述抗体的应用以及使用方法
IL199534A (en) 2007-01-05 2013-01-31 Univ Zuerich An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses.
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
CA2730073A1 (en) 2008-07-09 2010-01-14 University Of Zurich Method of promoting neurogenesis
MX2011000875A (es) 2008-07-21 2011-04-05 Probiodrug Ag Ensayo de anticuerpo de diagnostico.
CN102574915B (zh) 2009-08-06 2014-10-22 伊缪纳斯制药株式会社 特异性结合Aβ寡聚体的抗体及其用途
PE20130214A1 (es) * 2010-02-23 2013-03-11 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumores
US8795664B2 (en) * 2010-06-04 2014-08-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Monoclonal antibodies targeting amyloid beta oligomers
EP3042917B1 (en) * 2010-08-12 2018-02-21 Eli Lilly and Company Anti-n3pglu amyloid beta peptide antibodies and uses thereof
WO2012021475A2 (en) 2010-08-12 2012-02-16 Eli Lilly And Company ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
EP2511296A1 (en) 2011-04-12 2012-10-17 Araclón Biotech, S. L. Antibody, kit and method for determination of amyloid peptides
ITRM20120383A1 (it) 2012-03-20 2013-09-21 Uni Degli Studi Di Milano B Icocca Metodo e kit per la rivelazione di anticorpi.
WO2015175769A1 (en) 2014-05-15 2015-11-19 Biogen Ma Inc. Methods for the detection of amyloid beta oligomers in biological samples
WO2015191825A1 (en) 2014-06-13 2015-12-17 Biogen Ma Inc. Methods for the detection and measurement of amyloid beta in biological samples
NZ728425A (en) * 2014-08-07 2022-05-27 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
EP3234611A1 (en) 2014-12-19 2017-10-25 Probiodrug AG Novel method for the detection of pglu-abeta peptides
JP7002811B2 (ja) 2015-07-16 2022-03-04 ビボリョン セラピューティクス エヌブイ 抗ピログルタミン酸化アミロイドβヒト化抗体
JOP20170004B1 (ar) 2016-01-15 2022-09-15 Lilly Co Eli الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته
TW201740954A (zh) 2016-03-16 2017-12-01 美國禮來大藥廠 組合療法
EP3249388A1 (en) 2016-05-23 2017-11-29 Raman Health Technologies, S.L Method for diagnosing alzheimer´s disease
KR20230165883A (ko) 2016-06-07 2023-12-05 바이오겐 인터내셔널 뉴로사이언스 게엠베하 알츠하이머병의 치료 방법
WO2018031361A2 (en) 2016-08-09 2018-02-15 Eli Lilly And Company Combination therapy
AR110470A1 (es) 2016-10-21 2019-04-03 Lilly Co Eli Terapia de combinación para tratar la enfermedad de alzheimer
TW201827467A (zh) * 2016-11-03 2018-08-01 比利時商健生藥品公司 焦穀胺酸類澱粉蛋白－β之抗體及其用途
JOP20190247A1 (ar) 2017-04-20 2019-10-20 Lilly Co Eli أجسام بيتا ببتيد النشوانية المضادة لـ N3pGlu واستخداماتها
KR20200030029A (ko) * 2017-05-02 2020-03-19 프로테나 바이오사이언시즈 리미티드 타우 인식 항체
CA3073066A1 (en) 2017-08-22 2019-02-28 Biogen Ma Inc. Pharmaceutical compositions containing anti-beta amyloid antibodies
CN113164777A (zh) * 2018-09-27 2021-07-23 马伦戈治疗公司 Csf1r/ccr2多特异性抗体

Also Published As

Publication number Publication date
KR20210143858A (ko) 2021-11-29
BR112021019107A2 (pt) 2021-11-30
CN113891746A (zh) 2022-01-04
CA3134785A1 (en) 2020-10-01
EA202192606A1 (ru) 2022-01-24
CL2022002670A1 (es) 2023-03-31
SG11202110504XA (en) 2021-10-28
CO2021014028A2 (es) 2021-10-29
AU2020245031A1 (en) 2021-10-21
EP3946603A1 (en) 2022-02-09
CR20210492A (es) 2021-11-19
MX2021011715A (es) 2021-12-10
PE20212266A1 (es) 2021-11-30
JP2022526528A (ja) 2022-05-25
US20200308261A1 (en) 2020-10-01
MA55491A (fr) 2022-02-09
US20220106387A1 (en) 2022-04-07
ECSP21079184A (es) 2021-11-30
DOP2021000199A (es) 2022-07-15
CL2021002473A1 (es) 2022-04-22
IL286634A (en) 2021-10-31
US11236155B2 (en) 2022-02-01
WO2020193644A1 (en) 2020-10-01
US20220177560A1 (en) 2022-06-09

Similar Documents

Publication Publication Date Title
JOP20210265A1 (ar) الأجسام المضادة لبيروغلوتامات أميلويد بيتا واستخداماتها
ZA202005259B (en) Anti-ctla4 antibodies and methods of making and using the same
UA109633C2 (uk) Антитіло людини проти тканинного фактора
MY194997A (en) Anti-ccr7 antibody drug conjugates
JOP20180117B1 (ar) أجسام مضادة انتقائية لـ tau فائق المعالجة بفوسفوريلات وطرق لاستخدامها
WO2006084075A3 (en) Adam-9 modulators
WO2008066691A3 (en) Tes7 and antibodies that bind thereto
MA37761A1 (fr) Protéines de liaison à un antigène antagoniste d'un double récepteur et leurs utilisations
WO2019186276A8 (en) Antibody-based methods of detecting and treating alzheimer's disease
AR069290A1 (es) Anticuerpos monoclonales que se unen al hgm -csf (factor estimulante de la colonia de granulocitos-macrofagos) y las composiciones medicas que los comprenden
BRPI0414513A (pt) kid3 e anticorpos de kid3 que se ligam a ele
WO2006084092A3 (en) Antibodies to oncostatin m receptor
MX2021004808A (es) Anticuerpos contra la epcam, anticuerpos activables e inmunoconjugados y usos de estos.
WO2006084078A3 (en) Jam-3 and antibodies that bind thereto
WO2006083852A3 (en) Luca2 and antibodies that bind thereto
WO2006076584A3 (en) Kid31 and antibodies that bind thereto
EA202192090A1 (ru) Антигенсвязывающие белки против гамма-цепи рецептора il2
WO2019234241A8 (en) ANTI-oxMIF/ANTI-CD3 ANTIBODY FOR CANCER TREATMENT
PH12020552006A1 (en) Antibodies specific for cd3 and uses thereof
MX2021006362A (es) Anticuerpos de dominio simple contra cll-1.
EA201492162A1 (ru) Антитела к трансглютаминазе 2
MX2022004194A (es) Anticuerpos contra el receptor de virus de la polio (pvr) y usos de los mismos.
EA202100199A1 (ru) Моноклональные антитела, специфически связывающиеся с trbv-9 человека
MA44917B1 (fr) Anticorps ou son fragment de liaison d’antigènes apte a se lier au récepteur d'interleukine-6 de l'humain.
MX2021007593A (es) Anticuerpos anti-pmel17 y conjugados de los mismos.