JOP20210197A1 - Methods of purifying an allergen extract - Google Patents

Methods of purifying an allergen extract

Info

Publication number
JOP20210197A1
JOP20210197A1 JOP/2021/0197A JOP20210197A JOP20210197A1 JO P20210197 A1 JOP20210197 A1 JO P20210197A1 JO P20210197 A JOP20210197 A JO P20210197A JO P20210197 A1 JOP20210197 A1 JO P20210197A1
Authority
JO
Jordan
Prior art keywords
allergen extract
purifying
methods
allergen
purified
Prior art date
Application number
JOP/2021/0197A
Other languages
Arabic (ar)
Inventor
Marta Rom?N-Escutia
Mar?A Teresa Gallego
S?Nchez Jer?Nimo Carnes
Mar?A Morales
Original Assignee
Leti Pharma S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leti Pharma S L filed Critical Leti Pharma S L
Publication of JOP20210197A1 publication Critical patent/JOP20210197A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/68—Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Insects & Arthropods (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to processes for producing semi-purified and purified allergen extracts and pharmaceutical compositions and vaccines for use in the diagnosis and treatment of allergy. In one aspect of the invention, a process for producing a depigmented allergen extract is provided, the process comprising: a) basifying a native allergen extract; and b) removing molecules having a molecular size of less than 3.5 kDa; and c) adjusting the pH to neutrality; thereby to produce a depigmented allergen extract.
JOP/2021/0197A 2019-01-17 2019-03-26 Methods of purifying an allergen extract JOP20210197A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19382030 2019-01-17
PCT/EP2019/057647 WO2020147985A1 (en) 2019-01-17 2019-03-26 Methods of purifying an allergen extract

Publications (1)

Publication Number Publication Date
JOP20210197A1 true JOP20210197A1 (en) 2023-01-30

Family

ID=65279503

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0197A JOP20210197A1 (en) 2019-01-17 2019-03-26 Methods of purifying an allergen extract

Country Status (16)

Country Link
US (1) US20220110983A1 (en)
EP (1) EP3911343A1 (en)
JP (1) JP2022523647A (en)
CN (1) CN113825518A (en)
AU (1) AU2019422413A1 (en)
BR (1) BR112021014064A2 (en)
CA (1) CA3126499A1 (en)
CL (1) CL2021001889A1 (en)
CO (1) CO2021010606A2 (en)
CR (1) CR20210432A (en)
EC (1) ECSP21060381A (en)
IL (1) IL284901A (en)
JO (1) JOP20210197A1 (en)
MX (1) MX2021008665A (en)
PE (1) PE20212105A1 (en)
WO (1) WO2020147985A1 (en)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0083497A3 (en) * 1982-01-06 1985-11-06 Beecham Group Plc Process for preparing modified allergens, their use in treating allergic conditions
WO1993001213A1 (en) * 1991-07-12 1993-01-21 Immulogic Pharmaceutical Corporation Allergenic proteins and peptides from japanese cedar pollen
JP3124344B2 (en) * 1991-11-06 2001-01-15 フマキラー株式会社 Polymerized mite allergen
JP3397791B2 (en) * 1992-09-21 2003-04-21 ラボラトリオス レティ ソシエダッド アノニマ Purification method of aqueous extract containing protein active as allergen, extract obtained by this method and use thereof
US5770698A (en) 1992-09-21 1998-06-23 C.B.F. Leti S.A. Process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use
BRPI0313613B1 (en) * 2002-08-19 2016-06-07 Merck Patent Ges Mit Beschränkter Haftung variants of the major timothy grass phl p 1 allergen, their folding forms lm and hm, their uses and their preparation and purification processes, DNA molecule, recombinant DNA expression vector and its use, and pharmaceutical compositions
RU2332986C2 (en) * 2003-04-04 2008-09-10 Дженентек, Инк. Highly concentrated compositions of antibodies and proteins
RU2706685C2 (en) * 2010-02-12 2019-11-20 Лабораториос Лети, С.Л. Method of producing allergen extract
FI20115374A0 (en) * 2011-04-18 2011-04-18 Teknologian Tutkimuskeskus Vtt Oy New hypoallergens
CN102552900A (en) * 2011-12-21 2012-07-11 北京新华联协和药业有限责任公司 Artemisia pollen allergen vaccine, and preparation method and application thereof
CN103966292A (en) * 2013-01-31 2014-08-06 中国食品发酵工业研究院 Industrial manufacturing method and use of allergen-eliminated partly appropriately-hydrolyzed casein peptide
ES2503516B1 (en) * 2013-04-03 2015-09-09 Inmunotek, S.L. IMMUNOGENIC COMPLEX FOR VACCINATION AND METHOD OF OBTAINING

Also Published As

Publication number Publication date
EP3911343A1 (en) 2021-11-24
IL284901A (en) 2021-08-31
CR20210432A (en) 2022-01-05
JP2022523647A (en) 2022-04-26
PE20212105A1 (en) 2021-11-04
US20220110983A1 (en) 2022-04-14
MX2021008665A (en) 2021-10-26
CN113825518A (en) 2021-12-21
CL2021001889A1 (en) 2022-01-21
AU2019422413A1 (en) 2021-08-26
CA3126499A1 (en) 2020-07-23
WO2020147985A1 (en) 2020-07-23
ECSP21060381A (en) 2021-11-18
BR112021014064A2 (en) 2021-09-21
CO2021010606A2 (en) 2021-10-29

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