JOP20210082A1 - تركيبات تآزرية تشتمل على (r)-2-(2-أوكسو بيروليدين-1-يل)بيوتان أميد و(s)-2-(2-أوكسو بيروليدين-1-يل)بيوتان أميد بنسبة غير راسيمية - Google Patents
تركيبات تآزرية تشتمل على (r)-2-(2-أوكسو بيروليدين-1-يل)بيوتان أميد و(s)-2-(2-أوكسو بيروليدين-1-يل)بيوتان أميد بنسبة غير راسيميةInfo
- Publication number
- JOP20210082A1 JOP20210082A1 JOP/2021/0082A JOP20210082A JOP20210082A1 JO P20210082 A1 JOP20210082 A1 JO P20210082A1 JO P20210082 A JOP20210082 A JO P20210082A JO P20210082 A1 JOP20210082 A1 JO P20210082A1
- Authority
- JO
- Jordan
- Prior art keywords
- oxopyrrolidin
- butanamide
- composition
- synergistic compositions
- seizure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
يتعلق الاختراع الحالي بتركيبة مصاوغات مرآتية من 2-(2-أوكسو بيروليدين-1-يل)بيوتان أميد وذوابات أو بلورات مشتركة مقبولة صيدلانيًا منها بنسبة معينة، وتركيبة صيدلانية تشتمل على التركيبة المذكورة، واستخدامها كدواء واستخدام التركيبات الابتكارية أو التركيبات الصيدلانية في علاج و/أو الوقاية من مرض أو اضطراب يتم اختياره بشكل نمطي ومفضل من الاضطرابات المتعلقة بالنوبات أو الاعتلال العصبي الحسي الطرفي، ويفضل ألم الاعتلال العصبي الطرفي، أو نوبة أو الاكتئاب أو القصور الإدراكي.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18210106 | 2018-12-04 | ||
PCT/EP2019/083594 WO2020115093A1 (en) | 2018-12-04 | 2019-12-04 | Synergistic compositions comprising (r)-2-(2-oxopyrrolidin-1-yl)butanamide and (s)-2-(2-oxopyrrolidin-1-yl)butanamide in a non-racemic ratio |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20210082A1 true JOP20210082A1 (ar) | 2023-01-30 |
Family
ID=64604549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2021/0082A JOP20210082A1 (ar) | 2018-12-04 | 2019-12-04 | تركيبات تآزرية تشتمل على (r)-2-(2-أوكسو بيروليدين-1-يل)بيوتان أميد و(s)-2-(2-أوكسو بيروليدين-1-يل)بيوتان أميد بنسبة غير راسيمية |
Country Status (20)
Country | Link |
---|---|
US (1) | US20220047548A1 (ar) |
EP (1) | EP3890833B1 (ar) |
JP (1) | JP2022510363A (ar) |
KR (1) | KR20210099567A (ar) |
CN (1) | CN113164767A (ar) |
AU (1) | AU2019391309A1 (ar) |
BR (1) | BR112021010739A2 (ar) |
CA (1) | CA3117350A1 (ar) |
CO (1) | CO2021007055A2 (ar) |
EA (1) | EA202191485A1 (ar) |
EC (1) | ECSP21040300A (ar) |
ES (1) | ES2953785T3 (ar) |
HU (1) | HUE062575T2 (ar) |
IL (1) | IL283441A (ar) |
JO (1) | JOP20210082A1 (ar) |
MX (1) | MX2021006243A (ar) |
PL (1) | PL3890833T3 (ar) |
SG (1) | SG11202105863PA (ar) |
WO (1) | WO2020115093A1 (ar) |
ZA (1) | ZA202102701B (ar) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8412358D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
EP1034826A1 (en) | 1999-03-05 | 2000-09-13 | Reuter Chemische Apparatebau | Co-crystallization process |
GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
ITMI20030573A1 (it) | 2003-03-24 | 2004-09-25 | Nikem Research Srl | Composti ad azione nootropica, loro preparazione, |
CA2488325C (en) * | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
WO2009058261A1 (en) | 2007-10-31 | 2009-05-07 | Merck & Co., Inc. | Modulation of sleep with nr2b receptor antagonists |
ES2454366T3 (es) | 2008-02-22 | 2014-04-10 | Neurotune Ag | Compuestos bicíclicos que contienen nitrógeno activos en afecciones de dolor crónico |
EP2671858A1 (en) * | 2012-06-08 | 2013-12-11 | Université Catholique De Louvain | Process for chiral resolution of etiracetam |
JOP20190251A1 (ar) * | 2017-05-31 | 2019-10-21 | Metys Pharmaceuticals AG | تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية |
-
2019
- 2019-12-04 JP JP2021531433A patent/JP2022510363A/ja active Pending
- 2019-12-04 KR KR1020217016689A patent/KR20210099567A/ko unknown
- 2019-12-04 MX MX2021006243A patent/MX2021006243A/es unknown
- 2019-12-04 CN CN201980076384.6A patent/CN113164767A/zh active Pending
- 2019-12-04 EP EP19813837.2A patent/EP3890833B1/en active Active
- 2019-12-04 PL PL19813837.2T patent/PL3890833T3/pl unknown
- 2019-12-04 HU HUE19813837A patent/HUE062575T2/hu unknown
- 2019-12-04 AU AU2019391309A patent/AU2019391309A1/en active Pending
- 2019-12-04 WO PCT/EP2019/083594 patent/WO2020115093A1/en unknown
- 2019-12-04 BR BR112021010739-8A patent/BR112021010739A2/pt unknown
- 2019-12-04 CA CA3117350A patent/CA3117350A1/en active Pending
- 2019-12-04 EA EA202191485A patent/EA202191485A1/ru unknown
- 2019-12-04 JO JOP/2021/0082A patent/JOP20210082A1/ar unknown
- 2019-12-04 ES ES19813837T patent/ES2953785T3/es active Active
- 2019-12-04 SG SG11202105863PA patent/SG11202105863PA/en unknown
- 2019-12-04 US US17/299,928 patent/US20220047548A1/en active Pending
-
2021
- 2021-04-22 ZA ZA2021/02701A patent/ZA202102701B/en unknown
- 2021-05-25 IL IL283441A patent/IL283441A/en unknown
- 2021-05-28 CO CONC2021/0007055A patent/CO2021007055A2/es unknown
- 2021-06-03 EC ECSENADI202140300A patent/ECSP21040300A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2021006243A (es) | 2021-08-11 |
SG11202105863PA (en) | 2021-07-29 |
CO2021007055A2 (es) | 2021-06-10 |
EP3890833B1 (en) | 2023-06-07 |
KR20210099567A (ko) | 2021-08-12 |
US20220047548A1 (en) | 2022-02-17 |
HUE062575T2 (hu) | 2023-11-28 |
IL283441A (en) | 2021-07-29 |
ES2953785T3 (es) | 2023-11-16 |
ZA202102701B (en) | 2023-10-25 |
ECSP21040300A (es) | 2021-07-30 |
AU2019391309A1 (en) | 2021-05-20 |
EP3890833A1 (en) | 2021-10-13 |
EP3890833C0 (en) | 2023-06-07 |
CN113164767A (zh) | 2021-07-23 |
CA3117350A1 (en) | 2020-06-11 |
PL3890833T3 (pl) | 2023-09-18 |
BR112021010739A2 (pt) | 2021-08-24 |
WO2020115093A1 (en) | 2020-06-11 |
JP2022510363A (ja) | 2022-01-26 |
EA202191485A1 (ru) | 2021-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2021004431A (es) | Procesos novedosos. | |
MX2021004110A (es) | Composiciones farmaceuticas que comprenden n-(3,5- dimetoxifenil)-n'-(1-metiletil)-n-[3-(1-metil-1h- pirazol-4-il)quinoxalin-6-il]etano-1,2-diamina. | |
MX2022002196A (es) | Composición de liberación retardada de niclosamida y uso antiviral de la misma. | |
PH12018500859A1 (en) | Crystalline form of 2-(2,6-dichlorophenyl)-1-[(1s,3r)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1h)-yl]ethanone for the treatment of parkinson`s disease | |
MX2023009685A (es) | Inhibidores de tyk2 y sus usos. | |
MX2021009539A (es) | Derivado del profarmaco 6-oxo-1,6-dihidropiridazina, metodo de preparacion del mismo y aplicacion del mismo en medicina. | |
MX2023006504A (es) | Compuesto de hidroxamato, metodo de preparacion del mismo y aplicacion del mismo. | |
PH12019502580A1 (en) | Synergistic compositions comprising (r)-dimiracetam (1) and (s)-dimiracetam (2) in a non-racemic ratio | |
WO2022175746A8 (en) | Tyk2 inhibitors and uses thereof | |
EP4039267A4 (en) | COMPOSITION, COMPRISING TMEM176B, OR AN EXPRESSION OR ACTIVITY REGULATOR THEREOF, USED AS AN ACTIVE SUBSTANCE, FOR THE PREVENTION OR TREATMENT OF A DEGENERATIVE BRAIN DISEASE | |
MX2021007142A (es) | Compuestos organicos. | |
ZA202102701B (en) | Synergistic compositions comprising (r)-2-(2-oxopyrrolidin-1-yl)butanamide and (s)-2-(2-oxopyrrolidin-1-yl)butanamide in a non-racemic ratio | |
UA89753C2 (ru) | Применение модафинила и антидепрессанта при лечении депрессии и для сокращения времени до начала действия антидепрессанта | |
MX2023009613A (es) | Terapia combinada de obicetrapib y ezetimiba para usarse en pacientes intolerantes a las estatinas que sufren hiperlipidemia o dislipidemia mixta. | |
PH12021551239A1 (en) | Synergistic compositions comprising r-2-(substituted-sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6(2h)-ones and s-2-(substituted-sulfonyl)-hexahydro-pyrrolo[1,2-a]pyrazin-6(2h)-ones in a non-racemic ratio | |
MX2020000834A (es) | Derivado de adamantilmetilamina y uso del mismo como producto farmaceutico. | |
MX2019013717A (es) | Plasma de origen animal o fracciones del mismo para usarse en el tratamiento contra trastornos del deterioro cognitivo en humanos y animales de compañia. | |
MX2023003725A (es) | Composiciones farmacéuticas y usos de las mismas para la prevención y/o tratamiento de la inflamación. | |
MX2021014673A (es) | Combinacion de dosis fija de liberacion inmediata de memantina y donepezil. | |
MX2022001159A (es) | Nueva formulacion farmaceutica. | |
MX2023010542A (es) | Uso de mevidaleno y otros moduladores alostéricos positivos d1 para ralentizar la progresión de la enfermedad de parkinson. | |
ZA202104167B (en) | Compounds for use in the treatment of parkinson's disease | |
MX2022000373A (es) | Combinacion de ibuprofeno y tramadol para aliviar el dolor. | |
MX2022001023A (es) | Compuestos de aminotiolester y usos de los mismos. | |
WO2021119327A3 (en) | Transpore delivery of cannabinoid and uses thereof |