JO3601B1 - مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 - Google Patents

مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2

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Publication number
JO3601B1
JO3601B1 JOP/2015/0178A JOP20150178A JO3601B1 JO 3601 B1 JO3601 B1 JO 3601B1 JO P20150178 A JOP20150178 A JO P20150178A JO 3601 B1 JO3601 B1 JO 3601B1
Authority
JO
Jordan
Prior art keywords
compounds
dihydropyrazolo
pyrazin
allosteric modulators
negative allosteric
Prior art date
Application number
JOP/2015/0178A
Other languages
English (en)
Inventor
José Ignacio Andrés-Gil
Gool Michiel Luc Maria Van
O'scar Delgado-Gonza'lez
Diego Sergio-Alvar Alonso-De
Lucas Olivares Ana Isabel De
Andrés Avelino Trabanco-Sua'rez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of JO3601B1 publication Critical patent/JO3601B1/ar

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

يتعلق الاختراع الحالي بمشتقات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون بصفتها منظمات الوسترية سلبية لمستقبل جلوتاميت ميتاتروبي نوع فرعي 2. كما يتعلق الاختراع بتركيبات صيدلانية تشتمل على هذه المركبات وبعمليات تحضير هذه المركبات والتركيبات واستخدام هذه المركبات والتركيبات لمنع أو معالجة الاضطرابات التي تتضمن مستقبل جلوتاميت ميتاتروبي نوع فرعي 2 .
JOP/2015/0178A 2014-08-01 2015-07-27 مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 JO3601B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14179599 2014-08-01

Publications (1)

Publication Number Publication Date
JO3601B1 true JO3601B1 (ar) 2020-07-05

Family

ID=51257438

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2015/0178A JO3601B1 (ar) 2014-08-01 2015-07-27 مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2

Country Status (15)

Country Link
US (1) US10112949B2 (ar)
EP (1) EP3174880B1 (ar)
JP (1) JP6615864B2 (ar)
KR (1) KR102531693B1 (ar)
CN (1) CN106573935B (ar)
AR (1) AR101393A1 (ar)
AU (1) AU2015295299B2 (ar)
BR (1) BR112017001998A2 (ar)
CA (1) CA2954218C (ar)
EA (1) EA031038B1 (ar)
ES (1) ES2702192T3 (ar)
JO (1) JO3601B1 (ar)
MX (1) MX2017001453A (ar)
TW (1) TWI696625B (ar)
WO (1) WO2016016381A1 (ar)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20150179B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
CA2967542C (en) 2014-12-03 2022-11-29 Janssen Pharmaceutica Nv Radiolabelled mglur2 pet ligands
EP3227295B1 (en) 2014-12-03 2019-02-20 Janssen Pharmaceutica NV 6,7-dihydropyrazolo[1,5- ]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglu2 receptors
SI3389727T1 (sl) * 2015-12-18 2020-10-30 Janssen Pharmaceutica Nv Radioaktivno označeni ligandi PET MGLUR2/3
ES2820823T3 (es) 2015-12-18 2021-04-22 Janssen Pharmaceutica Nv Ligandos PET mGluR2/3 radiomarcados
AU2018373464B2 (en) 2017-11-24 2022-12-08 Sumitomo Pharma Co., Ltd. 6,7-dihydropyrazolo[1,5-a] pyrazinone derivative and medical use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004054665A1 (de) * 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituierte bi- und tricyclische Pyrazol-Derivate Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
RU2412943C2 (ru) * 2005-03-23 2011-02-27 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-***并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
AU2011343477A1 (en) * 2010-12-17 2013-07-04 Vanderbilt University Bicyclic triazole and pyrazole lactams as allosteric modulators of mGluR5 receptors
WO2012172093A1 (en) * 2011-06-17 2012-12-20 Merz Pharma Gmbh & Co. Kgaa Dihydroindolizine derivate as metabotropic glutamate receptor modulators
MY167423A (en) 2011-11-03 2018-08-27 Merck Sharp & Dohme Quinoline carboxamide and quinoline carbonitrile derivatives as mglur2-negative allosteric modulators,compositions,and their use
EP2666775A1 (en) 2012-05-21 2013-11-27 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
CN104736156A (zh) 2012-06-20 2015-06-24 范德比尔特大学 作为mglur5受体变构调节剂的取代的双环烷氧基吡唑类似物
US20130345204A1 (en) 2012-06-20 2013-12-26 Vanderbilt University Substituted bicyclic cycloalkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors
US20130345205A1 (en) * 2012-06-20 2013-12-26 Vanderbilt University Substituted bicyclic aralkyl pyrazole lactam analogs as allosteric modulators of mglur5 receptors
EP2925292A1 (en) 2012-10-23 2015-10-07 F. Hoffmann-La Roche AG Mglu2/3 antagonists for the treatment of autistic disorders
CN107018661B (zh) * 2014-08-01 2020-01-03 詹森药业有限公司 6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其作为MGLUR2受体的负向别构调节剂的用途

Also Published As

Publication number Publication date
JP6615864B2 (ja) 2019-12-04
TW201609742A (zh) 2016-03-16
CA2954218C (en) 2022-11-29
EP3174880B1 (en) 2018-09-26
WO2016016381A1 (en) 2016-02-04
BR112017001998A2 (pt) 2017-12-12
EA031038B1 (ru) 2018-11-30
JP2017523201A (ja) 2017-08-17
EP3174880A1 (en) 2017-06-07
ES2702192T3 (es) 2019-02-27
EA201692496A1 (ru) 2017-06-30
KR102531693B1 (ko) 2023-05-10
US20180222908A1 (en) 2018-08-09
AU2015295299A1 (en) 2017-01-19
CN106573935A (zh) 2017-04-19
CN106573935B (zh) 2020-01-17
TWI696625B (zh) 2020-06-21
US10112949B2 (en) 2018-10-30
AU2015295299B2 (en) 2019-05-02
AR101393A1 (es) 2016-12-14
KR20170032464A (ko) 2017-03-22
CA2954218A1 (en) 2016-02-04
MX2017001453A (es) 2017-05-11

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