JO3446B1 - طريقة لمعالجة الأرق الأولي - Google Patents
طريقة لمعالجة الأرق الأوليInfo
- Publication number
- JO3446B1 JO3446B1 JOP/2002/0086A JOP20020086A JO3446B1 JO 3446 B1 JO3446 B1 JO 3446B1 JO P20020086 A JOP20020086 A JO P20020086A JO 3446 B1 JO3446 B1 JO 3446B1
- Authority
- JO
- Jordan
- Prior art keywords
- primary insomnia
- melatonin
- treating primary
- treating
- agents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
يتعلق هذا الاختراع بدواء لمعالجة وتحسين النوعية المعيدة للصحة للنوم في مريض يعاني من الأرق الأولي، يشتمل على مركب واحد على الأقل يختار من ميلاتونين، عوامل مولدة للميلاتونين، عوامل تألف الميلاتونين وعوامل ضادة للملايتونين بمقدار فعال ضمن المدى من 0.0025 الى 50مجج ويجوز أن يشتمل على عامل فعال علاجيا واحد أو كثر
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL144900A IL144900A (en) | 2001-08-14 | 2001-08-14 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3446B1 true JO3446B1 (ar) | 2020-07-05 |
Family
ID=11075696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2002/0086A JO3446B1 (ar) | 2001-08-14 | 2002-08-08 | طريقة لمعالجة الأرق الأولي |
Country Status (35)
Country | Link |
---|---|
US (1) | US8962024B2 (ar) |
EP (2) | EP3103443B1 (ar) |
JP (1) | JP2005501095A (ar) |
KR (1) | KR20040032917A (ar) |
CN (1) | CN100453078C (ar) |
AR (1) | AR034975A1 (ar) |
AU (1) | AU2002326114C1 (ar) |
BR (1) | BR0211855A (ar) |
CA (1) | CA2454699C (ar) |
CL (1) | CL2002001701A1 (ar) |
CR (1) | CR7271A (ar) |
CY (2) | CY1118924T1 (ar) |
DK (2) | DK3103443T3 (ar) |
EA (1) | EA200400302A1 (ar) |
ES (2) | ES2882584T3 (ar) |
GT (1) | GT200200164A (ar) |
HK (1) | HK1066161A1 (ar) |
HU (1) | HU230786B1 (ar) |
IL (1) | IL144900A (ar) |
IS (1) | IS3004B (ar) |
JO (1) | JO3446B1 (ar) |
LT (1) | LT1441702T (ar) |
MX (1) | MXPA04001372A (ar) |
NO (1) | NO334788B2 (ar) |
NZ (1) | NZ531318A (ar) |
PA (1) | PA8552301A1 (ar) |
PE (1) | PE20030331A1 (ar) |
PL (1) | PL367872A1 (ar) |
PT (2) | PT1441702T (ar) |
RU (1) | RU2560840C2 (ar) |
SI (1) | SI1441702T1 (ar) |
UA (1) | UA87262C2 (ar) |
UY (1) | UY27401A1 (ar) |
WO (1) | WO2003015690A2 (ar) |
ZA (1) | ZA200402005B (ar) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
IL149377A (en) * | 2002-04-28 | 2012-10-31 | Neurim Pharma 1991 | Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds |
AR056076A1 (es) * | 2005-09-20 | 2007-09-19 | Takeda Pharmaceutical | Agente profilactico o terapeutico para el desorden de sueno |
US20070088079A1 (en) * | 2005-09-20 | 2007-04-19 | Takeda Pharmaceutical Company Limited | Prophylactic or therapeutic agent for sleep disorder |
US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
EP2124907B1 (en) | 2007-03-19 | 2018-05-30 | Vita Sciences, Llc | Transdermal patch and method for delivery of vitamin b12 |
WO2008122102A1 (en) * | 2007-04-05 | 2008-10-16 | Iomedix Development International Srl | Melatonin-based composition for improved sleep |
US20080248106A1 (en) | 2007-04-05 | 2008-10-09 | Marvin Heuer | Melatonin-based composition for improved sleep |
WO2012103411A2 (en) * | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
US10849856B2 (en) | 2016-10-31 | 2020-12-01 | Neurim Pharmaceuticals Ltd. | Melatonin mini-tablets and method of manufacturing the same |
SI3337462T1 (sl) | 2016-10-31 | 2021-01-29 | Neurim Pharmaceuticals Ltd. | Melantonin mini-tablete in metoda za izdelavo le-teh |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
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US3126375A (en) | 1964-03-24 | Chioacyl | ||
US2789118A (en) | 1956-03-30 | 1957-04-16 | American Cyanamid Co | 16-alpha oxy-belta1, 4-pregnadienes |
US2990401A (en) | 1958-06-18 | 1961-06-27 | American Cyanamid Co | 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids |
US3048581A (en) | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
US3749712A (en) | 1970-09-25 | 1973-07-31 | Sigma Tau Ind Farmaceuti | Triamcinolone acetonide esters and process for their preparation |
SE378109B (ar) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
US3996359A (en) | 1972-05-19 | 1976-12-07 | Ab Bofors | Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith |
SE378110B (ar) | 1972-05-19 | 1975-08-18 | Bofors Ab | |
JPS6045513A (ja) * | 1983-05-18 | 1985-03-12 | モナシユ ユニバ−シテイ | 身体行動および機能の日周期の不調を軽減する薬剤 |
DE3466215D1 (en) | 1983-05-18 | 1987-10-22 | Univ Monash | The use of melatonin for the manufacture of a medicament |
US4600723A (en) * | 1983-05-18 | 1986-07-15 | Monash University | Method for minimizing disturbances in circadian rhythms of bodily performance and function |
US5151446A (en) | 1989-09-25 | 1992-09-29 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US5591768A (en) | 1990-12-04 | 1997-01-07 | State Of Oregan, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Methods for treating circadian rhythm phase disturbances |
US5707652A (en) | 1990-12-04 | 1998-01-13 | State Of Oregon | Methods of treating circadian rhythm phase disorders |
EP0518468B1 (en) | 1991-05-09 | 1999-06-30 | Neurim Pharmaceuticals (1991) Limited | Melatonin containing compositions |
IT1251544B (it) | 1991-05-13 | 1995-05-17 | Gabriele Biella | Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico |
FR2680507B1 (fr) | 1991-08-23 | 1993-10-08 | Adir Cie | Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
ATE141051T1 (de) * | 1992-04-07 | 1996-08-15 | Neurim Pharma 1991 | Verwendung von melatonin zur herstellung eines arzneimittels zur behandlung der gutartigen prostatahyperplasie |
US5449683A (en) | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
IL103411A (en) | 1992-10-11 | 1996-11-14 | Neurim Pharma 1991 | Melatonin Controlled Pharmacy Preparation for the Correction of Melatonin Deficiency or Distortion in Melatonin in Human Plasma |
TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
JP2781661B2 (ja) | 1992-12-17 | 1998-07-30 | フアイザー・インコーポレイテツド | Crfアンタゴニストとしての置換ピラゾール |
TW370529B (en) | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
WO1994013643A1 (en) | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Pyrazoles and pyrazolopyrimidines having crf antagonist activity |
JP2895961B2 (ja) | 1992-12-17 | 1999-05-31 | フアイザー・インコーポレイテツド | Crfアンタゴニストとしてのピロロピリミジン |
WO1995003043A1 (en) | 1993-07-26 | 1995-02-02 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Sustained release oral compositions containing melatonin |
US5654325A (en) * | 1993-11-18 | 1997-08-05 | Eli Lilly And Company | Melatonin derivatives for use in treating sleep disorders |
US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
US6469044B1 (en) * | 1995-02-01 | 2002-10-22 | Neurim Pharmaceuticals (1991) Ltd. | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
US5688520A (en) * | 1995-03-29 | 1997-11-18 | Minnesota Mining And Manufacturing Company | Transmucosal delivery of melatonin for prevention of migraine |
EP0748627A3 (en) | 1995-06-14 | 1997-05-21 | Lilly Co Eli | Melatonin agonists for the treatment of benign forms of hyperplasia of the prostate |
NO981489L (no) * | 1995-10-03 | 1998-05-22 | Interneuron Pharma | Blandinger av melatonin og analgetika samt anvendelser derav |
WO1998002158A1 (en) * | 1996-07-17 | 1998-01-22 | Merck & Co., Inc. | Alteration of circadian rhythmicity with a tachykinin antagonist |
US5776969A (en) | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
US5826408A (en) * | 1997-05-08 | 1998-10-27 | Riverwood International Corporation | Rotary flap tucker for a cartoning machine |
US6472421B1 (en) | 1998-11-13 | 2002-10-29 | Nymox Corporation | Methods for treating, preventing, and reducing the risk of the onset of alzheimer's disease using an HMG CoA reductase inhibitor |
SK287508B6 (sk) * | 2000-01-05 | 2010-12-07 | Neurim Pharmaceuticals (1991) Ltd. | Použitie a formulácia prípravku na liečbu rezistencie voči antihypertenzívam a podobných stavov |
IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
US6703412B1 (en) | 2002-09-27 | 2004-03-09 | Holly A. Rosenthal | Method of treating sleeplessness with melatonin on an acute basis |
AU2012316159A1 (en) | 2011-09-27 | 2014-04-17 | IBIS Medical, Inc. | Intragastric implant devices |
-
2001
- 2001-08-14 IL IL144900A patent/IL144900A/en active IP Right Grant
-
2002
- 2002-07-29 UY UY27401A patent/UY27401A1/es not_active Application Discontinuation
- 2002-07-31 CL CL2002001701A patent/CL2002001701A1/es unknown
- 2002-08-05 AR ARP020102964A patent/AR034975A1/es not_active Application Discontinuation
- 2002-08-08 JO JOP/2002/0086A patent/JO3446B1/ar active
- 2002-08-09 PA PA20028552301A patent/PA8552301A1/es unknown
- 2002-08-12 LT LTEP02760523.7T patent/LT1441702T/lt unknown
- 2002-08-12 CA CA2454699A patent/CA2454699C/en not_active Expired - Lifetime
- 2002-08-12 RU RU2011131532/15A patent/RU2560840C2/ru active
- 2002-08-12 ES ES16172415T patent/ES2882584T3/es not_active Expired - Lifetime
- 2002-08-12 EA EA200400302A patent/EA200400302A1/ru unknown
- 2002-08-12 PT PT2760523T patent/PT1441702T/pt unknown
- 2002-08-12 JP JP2003520451A patent/JP2005501095A/ja active Pending
- 2002-08-12 EP EP16172415.8A patent/EP3103443B1/en not_active Expired - Lifetime
- 2002-08-12 CN CNB028158326A patent/CN100453078C/zh not_active Ceased
- 2002-08-12 HU HU0401042A patent/HU230786B1/hu unknown
- 2002-08-12 SI SI200231087T patent/SI1441702T1/sl unknown
- 2002-08-12 US US10/486,688 patent/US8962024B2/en active Active
- 2002-08-12 DK DK16172415.8T patent/DK3103443T3/da active
- 2002-08-12 PL PL02367872A patent/PL367872A1/xx not_active Application Discontinuation
- 2002-08-12 WO PCT/IL2002/000662 patent/WO2003015690A2/en active Application Filing
- 2002-08-12 BR BR0211855-6A patent/BR0211855A/pt not_active Application Discontinuation
- 2002-08-12 AU AU2002326114A patent/AU2002326114C1/en not_active Expired
- 2002-08-12 NZ NZ531318A patent/NZ531318A/en not_active IP Right Cessation
- 2002-08-12 DK DK02760523.7T patent/DK1441702T3/en active
- 2002-08-12 IS IS7136A patent/IS3004B/is unknown
- 2002-08-12 ES ES02760523.7T patent/ES2626591T3/es not_active Expired - Lifetime
- 2002-08-12 PT PT161724158T patent/PT3103443T/pt unknown
- 2002-08-12 KR KR10-2004-7002245A patent/KR20040032917A/ko active Search and Examination
- 2002-08-12 EP EP02760523.7A patent/EP1441702B1/en not_active Revoked
- 2002-08-12 MX MXPA04001372A patent/MXPA04001372A/es unknown
- 2002-08-13 GT GT200200164A patent/GT200200164A/es unknown
- 2002-08-13 PE PE2002000731A patent/PE20030331A1/es not_active Application Discontinuation
- 2002-12-08 UA UA2004031856A patent/UA87262C2/uk unknown
-
2004
- 2004-01-09 NO NO20040087A patent/NO334788B2/no not_active IP Right Cessation
- 2004-03-03 CR CR7271A patent/CR7271A/es unknown
- 2004-03-12 ZA ZA2004/02005A patent/ZA200402005B/en unknown
- 2004-11-15 HK HK04109022.9A patent/HK1066161A1/xx not_active IP Right Cessation
-
2017
- 2017-05-31 CY CY20171100561T patent/CY1118924T1/el unknown
-
2021
- 2021-08-31 CY CY20211100776T patent/CY1124763T1/el unknown
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