JO1758B1 - Therapeutic agents - Google Patents

Abstract

Tetrahydroisoquinoline compounds of formula I And pharmaceutically acceptable salts thereof, in which:- R1 represents one or more substituents selected from H, halo, hydroxy, alkyl(optionally substituted by hydroxy) alkoxy, alkylthio, alkylsulphinyl, alkyl-sulphonyl, nitro, cyano, polyhaloalkyl, polyhaloalkoxy, phenyl(optionally substituted by one or more of halo, alkyl or alkoxy) or R1 is optionally alkylated carbamoyl R2 represents an aliphatic group optionally substituted by hydroxyl or alkoxy; E represents an alkylene chain optionally substituted by one or more alkyl groups; And G represents phenyl or phenyl substituted by one or more of alkyl, alkoxy, halo, hyroxy, polyhaloalkyl, polyhaloalkoxy, cyano, alkylthio, alkylsulphinyl, alkylsulphonyl, phenyl (optionally substituted by one or more of halo, alkyl or alkoxy) optionally alkylated carbamoyl, or G represents a phenyl ring having fused thereto a heterocyclic or aromatic carbocyclic ring ;and Q- acylated derivatives thereof which provide lipophilic esters have utility in analgesia and in the treatment of psychoses(e.g Schizophrenia) parkinson’s disease, lesch-Nyan syndrome, attention deficit disorder or cognitive impairment or in the relief of drug dependence or tardive dyskinesia.