JO1683B1 - Therapeutic AGENTS - Google Patents

Abstract

Compounds of formula 1 In which x represent oxygen or sulphur Z represents – CH- or –N- when X represents oxygen Z represents –CH= when X represents sulphur R5 represents hydrogen when R3 represents methyl, or R5 represents CH- R6 When R3 represents a bond together with either one of R2 and R4 R6 represents hydrogen, halo, S(O)Y1, carboxy, carbamoyl, a carboxylic acyl group, an esterified carboxyl group or CONR12 R13, R6 represents hydrogen or methyl, or R6 and R6 , together with the carbon atom to which they are attached represent cyclopropyl, R9 and R 10 which may be the same or different , represent , halo,or R9 represents hydrogen and R10 represents hydrogen, halo, trifluoromethyl, nitro , c1-6 alkyl,C1-6 alkoxy, hydroxyl or a carboxylic acyloxy group, R12 represents methyl, ethyl or C3-8 cycloalkyl and R13 represents C1-6 alkyl optionally substituted by cyano, Phenyl, a 3-8 member non-aromtic heterocylic group, a 5 or 6 membered heterocyclic aryl group or C3-8 cycloalkyl or R13 represnts phenyl optionally substituted by C2-6 alkoxycarbonyl or halo, or R12 and R13 together with the nitrogen to which they are attached represent a 3-8 memered non-aromatic heterocylic group which may be substituted by a C2-6 acyloxy (C1-6) alkyl group, Y1 represents C1-6 alkyl, n is 0.1.or 2 , and R1.R2.R4.R7.R8 and R8 and R8. are as defined , for use immunomodulatroy agents