JO1606B1 - New compounds - Google Patents

Abstract

Compounds having a renin inhibitory effect and having the formula where R H; lower alkyl (1-3 carbons) R2 straight or branched lower alkyl or alkenyl (1—6 carbons), optionally substituted with lower alkoxy, cyano, fluoro, lower thicalkyl; cycloalkyl (3—7 carbons); aryl (6-10 carbons); cycloalkylalkyl (4-9 carbons); arylalkyl (7-11 carbons) R3 straight or branched lower alkyl (3—6 carbons); cycloalkylalkyl (4-11 carbons); arylalkyl (7-11 carbons) R4 H; straight or branched lower alkyl (1-5 carbons) R5 straight or branched lower alkyl (1—5 carbons); cycloalkyl (3-7 carbons); aryl (6-10 carbons); arylalkyl (7-11 carbons); cycloalkylalkyl (4-8 carbons) q = 0-2 O = 0-2 p= 0-2 n =0—2 X= CH; N Z= 0; CH(R8); absent W =0; CH(R8); absent