ITUB20153108A1 - Varianti del recettore delle cellule T e loro uso nella terapia tumorale - Google Patents

Varianti del recettore delle cellule T e loro uso nella terapia tumorale

Info

Publication number
ITUB20153108A1
ITUB20153108A1 ITUB2015A003108A ITUB20153108A ITUB20153108A1 IT UB20153108 A1 ITUB20153108 A1 IT UB20153108A1 IT UB2015A003108 A ITUB2015A003108 A IT UB2015A003108A IT UB20153108 A ITUB20153108 A IT UB20153108A IT UB20153108 A1 ITUB20153108 A1 IT UB20153108A1
Authority
IT
Italy
Prior art keywords
variants
cell receptor
tumor therapy
tumor
therapy
Prior art date
Application number
ITUB2015A003108A
Other languages
English (en)
Inventor
Berardinis Piergiuseppe De
Luciana D'apice
Umberto Oreste
Original Assignee
Immures S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immures S R L filed Critical Immures S R L
Priority to ITUB2015A003108A priority Critical patent/ITUB20153108A1/it
Priority to PCT/EP2015/075607 priority patent/WO2016071343A1/en
Priority to US15/523,925 priority patent/US20190030071A1/en
Priority to EP15790529.0A priority patent/EP3215164A1/en
Publication of ITUB20153108A1 publication Critical patent/ITUB20153108A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47B—TABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
    • A47B3/00—Folding or stowable tables
    • A47B3/06—Folding or stowable tables with separable parts
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47B—TABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
    • A47B13/00—Details of tables or desks
    • A47B13/02—Underframes
    • A47B13/021—Fastening devices of the feet or legs
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47B—TABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
    • A47B21/00—Tables or desks for office equipment, e.g. typewriters, keyboards
    • A47B21/06—Tables or desks for office equipment, e.g. typewriters, keyboards characterised by means for holding, fastening or concealing cables
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47B—TABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
    • A47B13/00—Details of tables or desks
    • A47B13/02—Underframes
    • A47B13/021—Fastening devices of the feet or legs
    • A47B2013/022—Fastening devices of the feet or legs with detachable connection of a tubular leg
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47B—TABLES; DESKS; OFFICE FURNITURE; CABINETS; DRAWERS; GENERAL DETAILS OF FURNITURE
    • A47B2200/00—General construction of tables or desks
    • A47B2200/0011—Underframes
    • A47B2200/0019—Auxiliary use of table underframes, e.g. incorporating: cooling, drainage, air supply or wires

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
ITUB2015A003108A 2014-11-03 2015-08-13 Varianti del recettore delle cellule T e loro uso nella terapia tumorale ITUB20153108A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITUB2015A003108A ITUB20153108A1 (it) 2015-08-13 2015-08-13 Varianti del recettore delle cellule T e loro uso nella terapia tumorale
PCT/EP2015/075607 WO2016071343A1 (en) 2014-11-03 2015-11-03 T cell receptors
US15/523,925 US20190030071A1 (en) 2014-11-03 2015-11-03 T cell receptors
EP15790529.0A EP3215164A1 (en) 2014-11-03 2015-11-03 T cell receptors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUB2015A003108A ITUB20153108A1 (it) 2015-08-13 2015-08-13 Varianti del recettore delle cellule T e loro uso nella terapia tumorale

Publications (1)

Publication Number Publication Date
ITUB20153108A1 true ITUB20153108A1 (it) 2017-02-13

Family

ID=54884144

Family Applications (1)

Application Number Title Priority Date Filing Date
ITUB2015A003108A ITUB20153108A1 (it) 2014-11-03 2015-08-13 Varianti del recettore delle cellule T e loro uso nella terapia tumorale

Country Status (1)

Country Link
IT (1) ITUB20153108A1 (it)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696545B1 (en) * 1997-04-11 2004-02-24 Sangstat Medical Corporation Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696545B1 (en) * 1997-04-11 2004-02-24 Sangstat Medical Corporation Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AGGEN D H ET AL: "Single-chain V alpha V beta T-cell receptors function without mispairing with endogenous TCR chains", GENE THERAPY, vol. 19, no. 4, April 2012 (2012-04-01), pages 365 - 374, XP002754589 *
MORLEY B J ET AL: "THE LYSINE RESIDUE IN THE MEMBRANE-SPANNING DOMAIN OF THE BETA CHAIN IS NECESSARY FOR CELL SURFACE EXPRESSION OF THE T CELL ANTIGEN RECEPTOR", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 168, no. 6, 1988, pages 1971 - 1978, XP002754591, ISSN: 0022-1007 *
OKAMOTO SACHIKO ET AL: "Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogenous TCR", CANCER RESEARCH, vol. 69, no. 23, December 2009 (2009-12-01), pages 9003 - 9011, XP002754590, ISSN: 0008-5472 *
VARRIALE S ET AL: "An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane", MOLECULAR PHYLOGENETICS AND EVOLUTION, ORLANDO, FL, US, vol. 57, no. 3, 1 December 2010 (2010-12-01), pages 1238 - 1244, XP027534534, ISSN: 1055-7903, [retrieved on 20101016] *
Z. SEBESTYEN ET AL: "Human TCR That Incorporate CD3 Induce Highly Preferred Pairing between TCR and Chains following Gene Transfer", THE JOURNAL OF IMMUNOLOGY, vol. 180, no. 11, 19 May 2008 (2008-05-19), pages 7736 - 7746, XP055118197, ISSN: 0022-1767, DOI: 10.4049/jimmunol.180.11.7736 *

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