ITRM910518A0 - Agenti bloccanti neuromuscolari e procedimento di preparazione - Google Patents

Agenti bloccanti neuromuscolari e procedimento di preparazione

Info

Publication number: ITRM910518A0
Authority: IT; Italy
Prior art keywords: blocking agents; preparation procedure; neuromuscular blocking; neuromuscular; procedure
Prior art date: 1990-07-13

Application number

IT91RM518A

Other languages

English (en)

Inventor

Derek Anthony Hill

Geoffrey Lloyd Turner

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-13

Filing date

1991-07-12

Publication date

1991-07-12

1991-07-12 Application filed by Wellcome Found filed Critical Wellcome Found

1991-07-12 Publication of ITRM910518A0 publication Critical patent/ITRM910518A0/it

1992-01-14 Publication of ITRM910518A1 publication Critical patent/ITRM910518A1/it

1995-03-09 Application granted granted Critical

1995-03-09 Publication of IT1249677B publication Critical patent/IT1249677B/it

Links

239000000842 neuromuscular blocking agent Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Semiconductor Lasers (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Led Devices (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Paper (AREA)

ITRM910518A 1990-07-13 1991-07-12 Agenti bloccanti neuromuscolari e procedimento di preparazione IT1249677B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909015473A GB9015473D0 (en)	1990-07-13	1990-07-13	Neuromuscular blocking agents

Publications (3)

Publication Number	Publication Date
ITRM910518A0 true ITRM910518A0 (it)	1991-07-12
ITRM910518A1 ITRM910518A1 (it)	1992-01-14
IT1249677B IT1249677B (it)	1995-03-09

Family

ID=10679071

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITRM910518A IT1249677B (it)	1990-07-13	1991-07-12	Agenti bloccanti neuromuscolari e procedimento di preparazione

Country Status (40)

Country	Link
EP (1)	EP0539470B1 (it)
JP (3)	JP2823356B2 (it)
KR (1)	KR0174284B1 (it)
AT (1)	ATE138369T1 (it)
AU (2)	AU8190491A (it)
BE (1)	BE1003407A3 (it)
CA (1)	CA2087104C (it)
CH (1)	CH683427A5 (it)
CY (1)	CY1985A (it)
CZ (1)	CZ284645B6 (it)
DE (2)	DE4191541T1 (it)
DK (2)	DK0539470T3 (it)
ES (2)	ES2088009T3 (it)
FI (2)	FI103507B1 (it)
FR (1)	FR2665701B1 (it)
GB (2)	GB9015473D0 (it)
GE (1)	GEP19981163B (it)
GR (1)	GR3020792T3 (it)
HK (1)	HK80196A (it)
HU (2)	HU218766B (it)
IE (1)	IE912440A1 (it)
IL (1)	IL98814A (it)
IT (1)	IT1249677B (it)
LT (1)	LT3317B (it)
LU (1)	LU88198A1 (it)
LV (1)	LV10432B (it)
MX (1)	MX9203220A (it)
MY (1)	MY113017A (it)
NL (1)	NL9120017A (it)
NZ (1)	NZ238964A (it)
PA (1)	PA8401801A1 (it)
PL (1)	PL167302B1 (it)
PT (1)	PT98306B (it)
RU (1)	RU2104005C1 (it)
SA (1)	SA91120073B1 (it)
SE (1)	SE9300052D0 (it)
SK (1)	SK383392A3 (it)
UA (1)	UA32536C2 (it)
WO (1)	WO1992000965A1 (it)
ZA (1)	ZA915468B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5453510A (en) *	1990-07-13	1995-09-26	Burroughs Wellcome Co.	Neuromuscular blocking agents
DE19535762A1 (de) *	1995-09-26	1997-03-27	Basf Ag	Verfahren zur Racematspaltung
US5684154A (en) *	1996-02-16	1997-11-04	Abbott Laboratories	Process for the preparation and isolation of atracurium besylate
US6177445B1 (en) *	1997-03-25	2001-01-23	Glaxo Wellcome Inc.	Substituted isoquinolines as ultra short acting neuromuscular blockers
BRPI0808272A2 (pt)	2007-03-08	2014-07-08	Chemagis Ltd	"método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
BRPI0808581A2 (pt) *	2007-03-26	2014-09-16	Chemagis Ltd	"método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
WO2008132748A1 (en)	2007-05-01	2008-11-06	Chemagis Ltd.	Process for producing cisatracurium compounds and associated intermediates
BRPI0809892A2 (pt)	2007-05-01	2014-09-30	Chemagis Ltd	Composto de isoquinolínio, forma cristalina, composto cristalino (vii) e método para preparar cis-atracúrio
EP2132181A1 (en) *	2007-06-18	2009-12-16	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
CN101337936B (zh) *	2007-07-06	2011-03-23	江苏恒瑞医药股份有限公司	一种用柱色谱法纯化苯磺酸阿曲库铵的方法
CN101337935B (zh) *	2007-07-06	2011-01-12	江苏恒瑞医药股份有限公司	一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CA2702535A1 (en)	2007-10-29	2009-05-07	Chemagis Ltd.	Novel r,r'-atracurium salts
IT1396543B1 (it)	2008-07-16	2012-12-14	Farmabios Spa	Processo per la purificazione di bloccanti neuromuscolari
WO2010128518A2 (en) *	2009-05-04	2010-11-11	Gland Pharma Limited	Novel process for the preparation of cisatracurium besylate
CN107056700A (zh) *	2017-04-18	2017-08-18	哈尔滨医科大学	一种四氢异喹啉类化合物外消旋体的半量拆分法
CN112939862B (zh) *	2021-02-03	2023-01-10	江苏诚信药业有限公司	一种苯磺顺阿曲库铵杂质h的分离制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3004031A (en) *	1958-07-03	1961-10-10	Allen & Hauburys Ltd	Diquaternary salts of papaverino esters
GB1579822A (en) *	1976-10-29	1980-11-26	Wellcome Found	Tetrahydroisoquinolinium muscle relaxants
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
ES454090A1 (es) *	1976-12-09	1978-01-16	Wellcome Found	Un metodo para preparar compuestos heterociclicos.
DE3328664A1 (de) *	1983-08-09	1985-02-21	Robert Bosch Gmbh, 7000 Stuttgart	Zuckerziehmaschine
BG41897A1 (en) *	1985-07-19	1987-09-15	Ivanov	Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation

1990
- 1990-07-13 GB GB909015473A patent/GB9015473D0/en active Pending
1991
- 1991-07-12 DE DE19914191541 patent/DE4191541T1/de not_active Withdrawn
- 1991-07-12 SK SK3833-92A patent/SK383392A3/sk not_active IP Right Cessation
- 1991-07-12 NL NL9120017A patent/NL9120017A/nl not_active Application Discontinuation
- 1991-07-12 AU AU81904/91A patent/AU8190491A/en not_active Abandoned
- 1991-07-12 ZA ZA915468A patent/ZA915468B/xx unknown
- 1991-07-12 NZ NZ238964A patent/NZ238964A/en not_active IP Right Cessation
- 1991-07-12 BE BE9100665A patent/BE1003407A3/fr not_active IP Right Cessation
- 1991-07-12 PT PT98306A patent/PT98306B/pt not_active IP Right Cessation
- 1991-07-12 FR FR9108805A patent/FR2665701B1/fr not_active Expired - Lifetime
- 1991-07-12 CH CH857/92A patent/CH683427A5/fr not_active IP Right Cessation
- 1991-07-12 IT ITRM910518A patent/IT1249677B/it active IP Right Grant
- 1991-07-12 RU RU93004869A patent/RU2104005C1/ru active
- 1991-07-12 WO PCT/GB1991/001150 patent/WO1992000965A1/en active IP Right Grant
- 1991-07-12 KR KR1019930700072A patent/KR0174284B1/ko not_active IP Right Cessation
- 1991-07-12 DE DE69119768T patent/DE69119768T2/de not_active Expired - Lifetime
- 1991-07-12 IE IE244091A patent/IE912440A1/en not_active IP Right Cessation
- 1991-07-12 ES ES91913479T patent/ES2088009T3/es not_active Expired - Lifetime
- 1991-07-12 DK DK91913479.1T patent/DK0539470T3/da active
- 1991-07-12 EP EP91913479A patent/EP0539470B1/en not_active Expired - Lifetime
- 1991-07-12 UA UA93101147A patent/UA32536C2/uk unknown
- 1991-07-12 CZ CS923833A patent/CZ284645B6/cs not_active IP Right Cessation
- 1991-07-12 ES ES09250007A patent/ES2083315B1/es not_active Expired - Lifetime
- 1991-07-12 PL PL91297606A patent/PL167302B1/pl unknown
- 1991-07-12 IL IL9881491A patent/IL98814A/en not_active IP Right Cessation
- 1991-07-12 CA CA002087104A patent/CA2087104C/en not_active Expired - Fee Related
- 1991-07-12 HU HU9300052A patent/HU218766B/hu unknown
- 1991-07-12 MY MYPI91001260A patent/MY113017A/en unknown
- 1991-07-12 AT AT91913479T patent/ATE138369T1/de not_active IP Right Cessation
- 1991-07-12 JP JP3512229A patent/JP2823356B2/ja not_active Expired - Lifetime
- 1991-08-18 SA SA91120073A patent/SA91120073B1/ar unknown
1992
- 1992-06-24 MX MX9203220A patent/MX9203220A/es unknown
- 1992-11-26 GB GB9224764A patent/GB2260763B/en not_active Expired - Lifetime
- 1992-12-09 LU LU88198A patent/LU88198A1/fr unknown
- 1992-12-14 DK DK149692A patent/DK149692A/da not_active Application Discontinuation
- 1992-12-18 LV LVP-92-334A patent/LV10432B/lv unknown
- 1992-12-28 FI FI925894A patent/FI103507B1/fi not_active IP Right Cessation
- 1992-12-30 LT LTIP274A patent/LT3317B/lt not_active IP Right Cessation
1993
- 1993-01-12 SE SE9300052A patent/SE9300052D0/xx not_active Application Discontinuation
- 1993-07-26 GE GEAP19931161A patent/GEP19981163B/en unknown
1995
- 1995-01-23 AU AU11346/95A patent/AU687481B2/en not_active Expired
- 1995-05-12 HU HU95P/P00131P patent/HU211169A9/hu unknown
1996
- 1996-05-09 HK HK80196A patent/HK80196A/xx not_active IP Right Cessation
- 1996-08-14 GR GR960402172T patent/GR3020792T3/el unknown
- 1996-11-14 PA PA19968401801A patent/PA8401801A1/es unknown
1997
- 1997-09-05 CY CY198597A patent/CY1985A/xx unknown
- 1997-09-08 JP JP9242598A patent/JPH10139763A/ja active Pending
1998
- 1998-10-28 FI FI982342A patent/FI982342A0/fi unknown
2000
- 2000-09-05 JP JP2000268819A patent/JP3462165B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
UA32536C2 (uk)	2001-02-15
AU687481B2 (en)	1998-02-26
CH683427A5 (fr)	1994-03-15
FR2665701B1 (fr)	1995-03-03
LV10432A (lv)	1995-02-20
EP0539470B1 (en)	1996-05-22
FI103507B (fi)	1999-07-15
BE1003407A3 (fr)	1992-03-17
AU1134695A (en)	1995-03-30
EP0539470A1 (en)	1993-05-05
CA2087104C (en)	1998-08-18
PL297606A1 (it)	1992-07-13
DK0539470T3 (da)	1996-08-05
DK149692D0 (da)	1992-12-14
PT98306B (pt)	1999-01-29
HU9300052D0 (en)	1993-04-28
GB9015473D0 (en)	1990-08-29
CY1985A (en)	1997-09-05
LT3317B (en)	1995-06-26
ZA915468B (en)	1993-03-31
MX9203220A (es)	1992-07-01
ATE138369T1 (de)	1996-06-15
SA91120073B1 (ar)	2002-10-26
DK149692A (da)	1992-12-14
IL98814A (en)	1995-12-08
PA8401801A1 (es)	1997-01-03
ES2083315B1 (es)	1997-11-16
LV10432B (en)	1995-08-20
WO1992000965A1 (en)	1992-01-23
HUT67613A (en)	1995-04-28
GB2260763B (en)	1994-01-05
ITRM910518A1 (it)	1992-01-14
FI925894A (fi)	1992-12-28
LU88198A1 (fr)	1993-05-17
LTIP274A (en)	1994-10-25
JP2001058981A (ja)	2001-03-06
DE69119768D1 (de)	1996-06-27
GR3020792T3 (en)	1996-11-30
SE9300052L (sv)	1993-01-12
JP2823356B2 (ja)	1998-11-11
FI982342A (fi)	1998-10-28
FI103507B1 (fi)	1999-07-15
PT98306A (pt)	1992-06-30
JPH10139763A (ja)	1998-05-26
HU218766B (hu)	2000-11-28
GB2260763A (en)	1993-04-28
GB9224764D0 (en)	1993-02-03
IT1249677B (it)	1995-03-09
ES2083315A1 (es)	1996-04-01
DE4191541T1 (de)	1993-05-13
CZ284645B6 (cs)	1999-01-13
GEP19981163B (en)	1998-07-06
FI982342A0 (fi)	1998-10-28
NZ238964A (en)	1992-06-25
FR2665701A1 (fr)	1992-02-14
MY113017A (en)	2001-11-30
NL9120017A (nl)	1993-04-01
KR0174284B1 (ko)	1999-02-18
CZ383392A3 (en)	1994-02-16
SK279907B6 (sk)	1999-05-07
CA2087104A1 (en)	1992-01-14
RU2104005C1 (ru)	1998-02-10
PL167302B1 (en)	1995-08-31
IL98814A0 (en)	1992-07-15
SE9300052D0 (sv)	1993-01-12
DE69119768T2 (de)	1996-10-02
JP3462165B2 (ja)	2003-11-05
HK80196A (en)	1996-05-17
IE912440A1 (en)	1992-01-15
AU8190491A (en)	1992-02-04
HU211169A9 (en)	1995-11-28
SK383392A3 (en)	1999-05-07
FI925894A0 (fi)	1992-12-28
ES2088009T3 (es)	1996-08-01
JPH05508648A (ja)	1993-12-02

Legal Events

Date	Code	Title	Description
1995-03-09	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970730

Publication	Publication Date	Title
BR9106438A (pt)	1993-05-18	Composicoes terapeuticas sinergisticas e processos
DE69329842D1 (de)	2001-02-15	Bildverfahren-und Geräte
BR1100824A (pt)	1999-08-31	Composto e composição farmacêutica
IT9022032A0 (it)	1990-11-13	L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
NO933601D0 (no)	1993-10-08	Forbedret ligningsbasert treklebemiddel
BR9103582A (pt)	1992-05-12	Derivados de pirimidina e composicao herbicida
ITRM910518A0 (it)	1991-07-12	Agenti bloccanti neuromuscolari e procedimento di preparazione
ITTO910114A1 (it)	1992-08-19	Composizioni e procedimento di placcatura
ITTO910643A0 (it)	1991-08-09	Procedimento di galvanostegia
DE69131802D1 (de)	1999-12-30	Verschlussmechanismen und Sperrvorrichtung
DE69307754D1 (de)	1997-03-13	Gewebe
DE69130722D1 (de)	1999-02-18	Arbeitsstation und dazugehöriges Konfigurationsverfahren
BR9104279A (pt)	1992-06-02	Composicao e composto
BR9106742A (pt)	1993-08-03	Preparacao de pentafluoretos de niobio e de tantalo anidros
BR9103730A (pt)	1992-05-19	Trampolim e esteira de trampolim
FI923862A (fi)	1992-08-28	Anordning foer reducerad effektmatning
IT1247290B (it)	1994-12-12	Procedimento e dispositivo di disaccoppiamento
AU7982091A (en)	1991-11-27	Clot imaging agents and use thereof
BR9205281A (pt)	1993-07-27	Pentapeptideos imuno-reguladores e neuro-reguladores
FI1031U1 (fi)	1993-11-19	En troakar
IT219116Z2 (it)	1992-12-10	"siringa di sicurezza"
NO923082L (no)	1992-08-05	Terapeutiske midler
ZA902030B (en)	1990-12-28	Agents against keratin pests
DK0439244T3 (da)	1997-11-03	Nodulariseringsfremgangsmåde
BR9002261A (pt)	1991-11-12	Termokit-aquecedor e microsecadora