ITRM20030596A1 - Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3. - Google Patents

Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3.

Info

Publication number: ITRM20030596A1
Authority: IT; Italy
Prior art keywords: ptx3; pentraxine; pathologies; reply; medication
Prior art date: 2003-12-23

Application number

IT000596A

Other languages

English (en)

Inventor

Barbara Bottazzi

Paolo Carminati

Cecilia Garlanda

Alberto Mantovani

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-23

Filing date

2003-12-23

Publication date

2005-06-24

2003-12-23 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2003-12-23 Priority to IT000596A priority Critical patent/ITRM20030596A1/it

2004-12-01 Priority to TW093137054A priority patent/TW200526246A/zh

2004-12-21 Priority to ARP040104816A priority patent/AR047159A1/es

2004-12-21 Priority to JP2006546487A priority patent/JP2007517021A/ja

2004-12-21 Priority to MXPA06007080A priority patent/MXPA06007080A/es

2004-12-21 Priority to AU2004305341A priority patent/AU2004305341A1/en

2004-12-21 Priority to EP04806879A priority patent/EP1706144A2/en

2004-12-21 Priority to PCT/IT2004/000714 priority patent/WO2005060997A2/en

2004-12-21 Priority to KR1020067012245A priority patent/KR20070000415A/ko

2004-12-21 Priority to US10/584,292 priority patent/US20070098722A1/en

2004-12-21 Priority to BRPI0418017-8A priority patent/BRPI0418017A/pt

2004-12-21 Priority to CA002548452A priority patent/CA2548452A1/en

2004-12-21 Priority to CNA2004800371947A priority patent/CN1893975A/zh

2005-06-24 Publication of ITRM20030596A1 publication Critical patent/ITRM20030596A1/it

Links

101001082142 Homo sapiens Pentraxin-related protein PTX3 Proteins 0.000 title 2
BFHAYPLBUQVNNJ-UHFFFAOYSA-N Pectenotoxin 3 Natural products OC1C(C)CCOC1(O)C1OC2C=CC(C)=CC(C)CC(C)(O3)CCC3C(O3)(O4)CCC3(C=O)CC4C(O3)C(=O)CC3(C)C(O)C(O3)CCC3(O3)CCCC3C(C)C(=O)OC2C1 BFHAYPLBUQVNNJ-UHFFFAOYSA-N 0.000 title 2
102100027351 Pentraxin-related protein PTX3 Human genes 0.000 title 2
230000004071 biological effect Effects 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
230000002265 prevention Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4737—C-reactive protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Environmental Sciences (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Husbandry (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)

IT000596A 2003-12-23 2003-12-23 Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3. ITRM20030596A1 (it)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
IT000596A ITRM20030596A1 (it)	2003-12-23	2003-12-23	Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3.
TW093137054A TW200526246A (en)	2003-12-23	2004-12-01	Medicament comprising inhibitors of long pentraxin PTX3
ARP040104816A AR047159A1 (es)	2003-12-23	2004-12-21	Medicamento que comprende inhibidores de pentraxina larga ptx3
JP2006546487A JP2007517021A (ja)	2003-12-23	2004-12-21	長いペントラキシンｐｔｘ３の阻害剤を含む医薬
MXPA06007080A MXPA06007080A (es)	2003-12-23	2004-12-21	Medicamento que comprende inhibidores de pentraxina de cadena larga ptx3.
AU2004305341A AU2004305341A1 (en)	2003-12-23	2004-12-21	Medicament comprising inhibitors of long pentraxin PTX3
EP04806879A EP1706144A2 (en)	2003-12-23	2004-12-21	Medicament comprising inhibitors of long pentraxin ptx3
PCT/IT2004/000714 WO2005060997A2 (en)	2003-12-23	2004-12-21	Medicament comprising inhibitors of long pentraxin ptx3
KR1020067012245A KR20070000415A (ko)	2003-12-23	2004-12-21	긴 펜트락신 ｐｔｘ３의 억제제를 포함하는 약제
US10/584,292 US20070098722A1 (en)	2003-12-23	2004-12-21	Medicament comprising inhibitors of long pentraxin ptx3
BRPI0418017-8A BRPI0418017A (pt)	2003-12-23	2004-12-21	medicamento compreendendo inibidores de pentraxina ptx3 longa
CA002548452A CA2548452A1 (en)	2003-12-23	2004-12-21	Medicament comprising inhibitors of long pentraxin ptx3
CNA2004800371947A CN1893975A (zh)	2003-12-23	2004-12-21	包含长正五聚蛋白ptx3抑制剂的药物

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000596A ITRM20030596A1 (it)	2003-12-23	2003-12-23	Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3.

Publications (1)

Publication Number	Publication Date
ITRM20030596A1 true ITRM20030596A1 (it)	2005-06-24

Family

ID=34708534

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT000596A ITRM20030596A1 (it)	2003-12-23	2003-12-23	Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3.

Country Status (13)

Country	Link
US (1)	US20070098722A1 (it)
EP (1)	EP1706144A2 (it)
JP (1)	JP2007517021A (it)
KR (1)	KR20070000415A (it)
CN (1)	CN1893975A (it)
AR (1)	AR047159A1 (it)
AU (1)	AU2004305341A1 (it)
BR (1)	BRPI0418017A (it)
CA (1)	CA2548452A1 (it)
IT (1)	ITRM20030596A1 (it)
MX (1)	MXPA06007080A (it)
TW (1)	TW200526246A (it)
WO (1)	WO2005060997A2 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1298487B1 (it) *	1997-12-19	2000-01-10	Sigma Tau Ind Farmaceuti	Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale,
ITRM20020109A1 (it) *	2002-02-28	2003-08-28	Sigma Tau Ind Farmaceuti	Derivati funzionali della pentraxina lunga ptx3 per preparare un vaccino autologo per la cura dei tumori.
EP1832295A1 (en) *	2006-03-10	2007-09-12	Tecnogen S.P.A.	Use of PTX3 for the treatment of viral diseases
ES2389452T3 (es)	2006-05-02	2012-10-26	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Uso de timosina 1, sola o en combinación con PTX3 o ganciclovir, para el tratamiento de infección por citomegalovirus
CN107080845A (zh) *	2007-12-11	2017-08-22	科达治疗公司	受损伤口愈合的组合物和治疗
KR101305515B1 (ko) *	2011-06-10	2013-09-06	경북대학교 산학협력단	펜트락신 3 단백질의 파킨슨 질환 진단 용도
AU2013361106B2 (en)	2012-12-21	2017-06-01	Teikoku Pharma Usa, Inc.	Compositions and methods for transdermal delivery of hormones and other medicinal agents
JP6959913B2 (ja) *	2016-05-13	2021-11-05	国立大学法人東京大学	肝分泌型代謝制御因子阻害作用による肥満関連疾患治療剤
CN106950366B (zh) *	2017-02-15	2019-03-22	中国医学科学院北京协和医院	一种acpa阴性的ra诊断标志物及其应用
WO2019056991A1 (zh) *	2017-09-19	2019-03-28	臻崴生物科技有限公司	单克隆抗体或其抗原结合片段及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1298487B1 (it) *	1997-12-19	2000-01-10	Sigma Tau Ind Farmaceuti	Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale,
IT1317927B1 (it) *	2000-11-03	2003-07-15	Sigma Tau Ind Farmaceuti	Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patologie autoimmuni.
IT1317930B1 (it) *	2000-11-08	2003-07-15	Sigma Tau Ind Farmaceuti	Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patalogie associate ad una alterata attivazione
US20030195167A1 (en) *	2002-04-15	2003-10-16	Kowa Co., Ltd.	PTX3-gene expression inhibitor

2003
- 2003-12-23 IT IT000596A patent/ITRM20030596A1/it unknown
2004
- 2004-12-01 TW TW093137054A patent/TW200526246A/zh unknown
- 2004-12-21 KR KR1020067012245A patent/KR20070000415A/ko not_active Application Discontinuation
- 2004-12-21 WO PCT/IT2004/000714 patent/WO2005060997A2/en active Application Filing
- 2004-12-21 CA CA002548452A patent/CA2548452A1/en not_active Abandoned
- 2004-12-21 US US10/584,292 patent/US20070098722A1/en not_active Abandoned
- 2004-12-21 AR ARP040104816A patent/AR047159A1/es not_active Application Discontinuation
- 2004-12-21 JP JP2006546487A patent/JP2007517021A/ja active Pending
- 2004-12-21 MX MXPA06007080A patent/MXPA06007080A/es not_active Application Discontinuation
- 2004-12-21 AU AU2004305341A patent/AU2004305341A1/en not_active Abandoned
- 2004-12-21 CN CNA2004800371947A patent/CN1893975A/zh active Pending
- 2004-12-21 BR BRPI0418017-8A patent/BRPI0418017A/pt not_active IP Right Cessation
- 2004-12-21 EP EP04806879A patent/EP1706144A2/en not_active Ceased

Also Published As

Publication number	Publication date
AU2004305341A1 (en)	2005-07-07
WO2005060997A2 (en)	2005-07-07
WO2005060997A3 (en)	2005-09-09
CN1893975A (zh)	2007-01-10
JP2007517021A (ja)	2007-06-28
TW200526246A (en)	2005-08-16
CA2548452A1 (en)	2005-07-07
BRPI0418017A (pt)	2007-04-17
EP1706144A2 (en)	2006-10-04
AR047159A1 (es)	2006-01-11
US20070098722A1 (en)	2007-05-03
KR20070000415A (ko)	2007-01-02
MXPA06007080A (es)	2006-09-04

Publication	Publication Date	Title
BR0313371A (pt)	2005-07-05	Composto, uso de um composto e método de tratamento de doença
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PT1230230E (pt)	2003-12-31	Derivados de indeno-di-hidrotiazole sua preparacao e sua utilizacao como medicamentos anorexigenico
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ATE356994T1 (de)	2007-04-15	Screeningverfahren mit pim1-kinase oder pim3- kinase
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ITMI20020773A1 (it)	2003-10-13	Farmaci per il trattamento dell'artrite
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TW200503666A (en)	2005-02-01	Treatment of type 1 diabetes with pde5 inhibitors
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