ITMI991715A0 - Uso di agonisti dei recettori gabab per la terapia di mantenimento del l'astinenza da nicotina in soggetti nicotino-dipendenti - Google Patents

Uso di agonisti dei recettori gabab per la terapia di mantenimento del l'astinenza da nicotina in soggetti nicotino-dipendenti

Info

Publication number
ITMI991715A0
ITMI991715A0 IT99MI001715A ITMI991715A ITMI991715A0 IT MI991715 A0 ITMI991715 A0 IT MI991715A0 IT 99MI001715 A IT99MI001715 A IT 99MI001715A IT MI991715 A ITMI991715 A IT MI991715A IT MI991715 A0 ITMI991715 A0 IT MI991715A0
Authority
IT
Italy
Prior art keywords
nicotine
receptor agonists
maintenance therapy
gabab receptor
dependent subjects
Prior art date
Application number
IT99MI001715A
Other languages
English (en)
Inventor
Giancarlo Colombo
Gian Luigi Gessa
Luca Pani
Walter Fratta
Original Assignee
Neuroscienze S C A R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuroscienze S C A R L filed Critical Neuroscienze S C A R L
Publication of ITMI991715A0 publication Critical patent/ITMI991715A0/it
Priority to IT1999MI001715A priority Critical patent/IT1313585B1/it
Priority to DE60017147T priority patent/DE60017147T2/de
Priority to ES00947901T priority patent/ES2235913T3/es
Priority to AT00947901T priority patent/ATE285763T1/de
Priority to PCT/EP2000/006120 priority patent/WO2001008675A1/en
Priority to PL353373A priority patent/PL196334B1/pl
Priority to AU61534/00A priority patent/AU6153400A/en
Priority to CA002379752A priority patent/CA2379752C/en
Priority to DK00947901T priority patent/DK1202727T3/da
Priority to PT00947901T priority patent/PT1202727E/pt
Priority to SI200030632T priority patent/SI1202727T1/xx
Priority to RU2002105375/15A priority patent/RU2262352C2/ru
Priority to EP00947901A priority patent/EP1202727B1/en
Priority to IL14787600A priority patent/IL147876A0/xx
Priority to CNB00811031XA priority patent/CN1176650C/zh
Publication of ITMI991715A1 publication Critical patent/ITMI991715A1/it
Priority to IL147876A priority patent/IL147876A/en
Application granted granted Critical
Publication of IT1313585B1 publication Critical patent/IT1313585B1/it
Priority to HK02107911.9A priority patent/HK1046849B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IT1999MI001715A 1999-07-30 1999-07-30 Uso di agonisti dei recettori gabab per la terapia di mantenimentodell'astinenza da nicotina in soggetti nicotino-dipendenti. IT1313585B1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT1999MI001715A IT1313585B1 (it) 1999-07-30 1999-07-30 Uso di agonisti dei recettori gabab per la terapia di mantenimentodell'astinenza da nicotina in soggetti nicotino-dipendenti.
DK00947901T DK1202727T3 (da) 1999-07-30 2000-06-30 Anvendelse af agonister af GABAB-receptorer og farmaceutisk acceptable derivater deraf til behandling for at opnå fortsat nikotinafholdenhed hos nikotinafhængige patienter
SI200030632T SI1202727T1 (it) 1999-07-30 2000-06-30
AT00947901T ATE285763T1 (de) 1999-07-30 2000-06-30 Verwendung von gabab-rezeptor agonisten und deren pharmazeutisch akzeptierbaren derivate bei der therapie zur erhaltung von nikotinabstinenz bei nikotinabhängigen patienten
PCT/EP2000/006120 WO2001008675A1 (en) 1999-07-30 2000-06-30 Use of agonists of gabab receptors and pharmaceutically acceptable derivates thereof, in the therapy of maintaining nicotine abstinence-dependent patients
PL353373A PL196334B1 (pl) 1999-07-30 2000-06-30 Zastosowanie agonistów receptorów GABA B i ich farmaceutycznie dopuszczalnych pochodnych w terapii abstynencji nikotynowej u uzależnionych od nikotyny pacjentów
AU61534/00A AU6153400A (en) 1999-07-30 2000-06-30 Use of agonists of gabab receptors and pharmaceutically acceptable derivates thereof, in the therapy of maintaining nicotine abstinence-dependent patients
CA002379752A CA2379752C (en) 1999-07-30 2000-06-30 Use of agonists of gabab receptors and pharmaceutically acceptable derivates thereof, in the therapy of maintaining nicotine abstinence-dependent patients
DE60017147T DE60017147T2 (de) 1999-07-30 2000-06-30 Verwendung von gabab-rezeptor agonisten und deren pharmazeutisch akzeptierbaren derivate bei der therapie zur erhaltung von nikotinabstinenz bei nikotinabhängigen patienten
PT00947901T PT1202727E (pt) 1999-07-30 2000-06-30 Utilizacao de agonistas de receptores gabab e seus derivados farmaceuticamente aceitaveis, na terapia para manter a abstinencia de nicotina em pacientes dependentes de nicotina
ES00947901T ES2235913T3 (es) 1999-07-30 2000-06-30 Utilizacion de antiinductores de receptores de gabab y de sus derivados aceptables farmaceuticamente, en la terapia de mantenimiento de la abstinencia de nicotina en pacientes dependientes de la nicotina.
RU2002105375/15A RU2262352C2 (ru) 1999-07-30 2000-06-30 Применение агонистов рецепторов b-типа гамма-аминомасляной кислоты и их фармацевтически приемлемых производных при лечении никотиновой зависимости
EP00947901A EP1202727B1 (en) 1999-07-30 2000-06-30 Use of agonists of gabab receptors and pharmaceutically acceptable derivatives thereof, in the therapy of maintaining nicotine abstinence in nicotine-dependent patients
IL14787600A IL147876A0 (en) 1999-07-30 2000-06-30 Use of agonists of gabab receptors and pharmaceutically acceptable derivatives thereof, in the therapy of maintaining nicotine abstinence-dependent patients
CNB00811031XA CN1176650C (zh) 1999-07-30 2000-06-30 巴氯芬在制备治疗烟碱依赖药物中的用途
IL147876A IL147876A (en) 1999-07-30 2002-01-28 Use of agonists of gabab receptors or pharmaceutically acceptable derivatives thereof for the preparation of pharmaceutical compositions for reducing the wish of smoking in nicotine-dependent patients
HK02107911.9A HK1046849B (zh) 1999-07-30 2002-10-31 Gabab受體激動劑及其可藥用衍生物在治療烟碱依賴者保持烟碱戒除的用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001715A IT1313585B1 (it) 1999-07-30 1999-07-30 Uso di agonisti dei recettori gabab per la terapia di mantenimentodell'astinenza da nicotina in soggetti nicotino-dipendenti.

Publications (3)

Publication Number Publication Date
ITMI991715A0 true ITMI991715A0 (it) 1999-07-30
ITMI991715A1 ITMI991715A1 (it) 2001-01-30
IT1313585B1 IT1313585B1 (it) 2002-09-09

Family

ID=11383467

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999MI001715A IT1313585B1 (it) 1999-07-30 1999-07-30 Uso di agonisti dei recettori gabab per la terapia di mantenimentodell'astinenza da nicotina in soggetti nicotino-dipendenti.

Country Status (16)

Country Link
EP (1) EP1202727B1 (it)
CN (1) CN1176650C (it)
AT (1) ATE285763T1 (it)
AU (1) AU6153400A (it)
CA (1) CA2379752C (it)
DE (1) DE60017147T2 (it)
DK (1) DK1202727T3 (it)
ES (1) ES2235913T3 (it)
HK (1) HK1046849B (it)
IL (2) IL147876A0 (it)
IT (1) IT1313585B1 (it)
PL (1) PL196334B1 (it)
PT (1) PT1202727E (it)
RU (1) RU2262352C2 (it)
SI (1) SI1202727T1 (it)
WO (1) WO2001008675A1 (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101140559B1 (ko) 2003-08-20 2012-07-05 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2006050472A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
WO2006050471A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2008033572A1 (en) 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
JP4498407B2 (ja) 2006-12-22 2010-07-07 キヤノン株式会社 プロセスカートリッジ、電子写真画像形成装置、及び、電子写真感光体ドラムユニット
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
WO2009094563A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use
ES2601852T3 (es) 2008-01-25 2017-02-16 Xenoport, Inc. Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso
US8299291B2 (en) 2008-08-07 2012-10-30 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
WO2010017498A1 (en) 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing n-hydroxysuccinimidyl carbonates
NZ594648A (en) 2009-03-03 2013-12-20 Xenoport Inc Sustained release oral dosage forms of an r-baclofen prodrug
CA2758245A1 (en) 2009-04-17 2010-10-21 Xenoport, Inc. Gamma-amino-butyric acid derivatives as gabab receptor ligands
WO2011081558A1 (ru) * 2009-08-21 2011-07-07 Komissarov Jury Vladimirovich Курительное устройство для отказа от табачного курения
US8580850B2 (en) 2011-08-11 2013-11-12 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
CN112601524A (zh) * 2018-04-06 2021-04-02 奥维德医疗公司 加波沙朵在治疗物质使用障碍中的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126684A (en) * 1976-02-11 1978-11-21 Ciba-Geigy Corporation 4-amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse
US5073539A (en) * 1990-01-22 1991-12-17 Ciba-Geigy Corporation Transdermal administration of zwitterionic drugs
US5760049A (en) * 1997-02-21 1998-06-02 Synapse Pharmaceuticals International, Inc. Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use
US6541520B1 (en) * 1998-08-05 2003-04-01 Brookhaven Science Associates Treatment of addiction and addiction-related behavior

Also Published As

Publication number Publication date
PL353373A1 (en) 2003-11-17
ITMI991715A1 (it) 2001-01-30
SI1202727T1 (it) 2005-08-31
ES2235913T3 (es) 2005-07-16
DK1202727T3 (da) 2005-05-09
CA2379752A1 (en) 2001-02-08
AU6153400A (en) 2001-02-19
IL147876A (en) 2007-06-17
ATE285763T1 (de) 2005-01-15
WO2001008675A1 (en) 2001-02-08
PT1202727E (pt) 2005-05-31
EP1202727B1 (en) 2004-12-29
RU2262352C2 (ru) 2005-10-20
HK1046849B (zh) 2005-07-15
CN1176650C (zh) 2004-11-24
PL196334B1 (pl) 2007-12-31
DE60017147T2 (de) 2006-01-12
EP1202727A1 (en) 2002-05-08
HK1046849A1 (en) 2003-01-30
IT1313585B1 (it) 2002-09-09
CN1377265A (zh) 2002-10-30
CA2379752C (en) 2008-05-27
IL147876A0 (en) 2002-08-14
DE60017147D1 (de) 2005-02-03

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