ITMI20042098A1 - Processo per la purificazione di tacrolimus - Google Patents

Processo per la purificazione di tacrolimus

Info

Publication number
ITMI20042098A1
ITMI20042098A1 IT002098A ITMI20042098A ITMI20042098A1 IT MI20042098 A1 ITMI20042098 A1 IT MI20042098A1 IT 002098 A IT002098 A IT 002098A IT MI20042098 A ITMI20042098 A IT MI20042098A IT MI20042098 A1 ITMI20042098 A1 IT MI20042098A1
Authority
IT
Italy
Prior art keywords
tacrolimus
purification
tacrolimus purification
Prior art date
Application number
IT002098A
Other languages
English (en)
Inventor
Walter Cabri
Luca Morra
Paolo Paissoni
Jacopo Roletto
Original Assignee
Antibioticos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos Spa filed Critical Antibioticos Spa
Priority to IT002098A priority Critical patent/ITMI20042098A1/it
Publication of ITMI20042098A1 publication Critical patent/ITMI20042098A1/it
Priority to EP05807586A priority patent/EP1812447A1/en
Priority to CA002586193A priority patent/CA2586193A1/en
Priority to PCT/EP2005/011393 priority patent/WO2006048145A1/en
Priority to CNA2005800370313A priority patent/CN101048415A/zh
Priority to US11/718,415 priority patent/US20080160586A1/en
Priority to JP2007539497A priority patent/JP2008518984A/ja
Priority to KR1020077010048A priority patent/KR20070083930A/ko

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00Purification; Separation; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/322Normal bonded phase
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/325Reversed phase

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
IT002098A 2004-11-03 2004-11-03 Processo per la purificazione di tacrolimus ITMI20042098A1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT002098A ITMI20042098A1 (it) 2004-11-03 2004-11-03 Processo per la purificazione di tacrolimus
EP05807586A EP1812447A1 (en) 2004-11-03 2005-10-24 Process for the purification of tacrolimus
CA002586193A CA2586193A1 (en) 2004-11-03 2005-10-24 Process for the purification of tacrolimus
PCT/EP2005/011393 WO2006048145A1 (en) 2004-11-03 2005-10-24 Process for the purification of tacrolimus
CNA2005800370313A CN101048415A (zh) 2004-11-03 2005-10-24 藤霉素的纯化方法
US11/718,415 US20080160586A1 (en) 2004-11-03 2005-10-24 Process for the Purification of Tacrolimus
JP2007539497A JP2008518984A (ja) 2004-11-03 2005-10-24 タクロリムスの精製方法
KR1020077010048A KR20070083930A (ko) 2004-11-03 2005-10-24 타크롤리무스 정제 방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002098A ITMI20042098A1 (it) 2004-11-03 2004-11-03 Processo per la purificazione di tacrolimus

Publications (1)

Publication Number Publication Date
ITMI20042098A1 true ITMI20042098A1 (it) 2005-02-03

Family

ID=35542958

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002098A ITMI20042098A1 (it) 2004-11-03 2004-11-03 Processo per la purificazione di tacrolimus

Country Status (8)

Country Link
US (1) US20080160586A1 (it)
EP (1) EP1812447A1 (it)
JP (1) JP2008518984A (it)
KR (1) KR20070083930A (it)
CN (1) CN101048415A (it)
CA (1) CA2586193A1 (it)
IT (1) ITMI20042098A1 (it)
WO (1) WO2006048145A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013017A1 (en) * 2005-07-29 2007-02-01 Ranbaxy Laboratories Limited A process for purification of macrolides
ITMI20051549A1 (it) * 2005-08-05 2007-02-06 Antibioticos Spa Purificazione del tacrolimus su supporti dimorigine vegetale
KR100891313B1 (ko) * 2007-08-17 2009-03-31 (주) 제노텍 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법
KR101033845B1 (ko) * 2008-09-18 2011-05-16 (주) 제노텍 은 이온 용액 결정화에 의한 불포화 알킬기를 가진 락톤 화합물 정제방법
CN101712685B (zh) * 2009-06-22 2012-07-04 鲁南制药集团股份有限公司 一种他克莫司粗品的精制方法
KR101261131B1 (ko) 2010-08-24 2013-05-06 이화여자대학교 산학협력단 신규 타크롤리무스 유도체, 상기 유도체를 포함하는 신경 보호용 조성물, 상기 유도체를 포함하는 면역 억제용 조성물, 상기 유도체의 생산 방법 및 상기 유도체의 생산 균주
WO2012026665A1 (en) * 2010-08-24 2012-03-01 Ewha University - Industry Collaboration Foundation Novel tacrolimus derivatives, a neuroprotective composition comprising the same, an immunosuppressive composition comprising the same, a method for preparing the same, and a mutant for producing the same
WO2013177466A1 (en) * 2012-05-23 2013-11-28 Lanzatech New Zealand Limited A fermentation and simulated moving bed process
CN107556327A (zh) * 2017-10-31 2018-01-09 无锡福祈制药有限公司 一种分离纯化他克莫司的方法
KR102645011B1 (ko) 2023-10-17 2024-03-07 주식회사 라이프슈티컬 고상 추출법을 이용한 타크롤리무스의 정제방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
GB8430455D0 (en) * 1984-12-03 1985-01-09 Fujisawa Pharmaceutical Co Fr-900506 substance
CA2018710A1 (en) * 1989-06-13 1990-12-13 Shieh-Shung T. Chen L-683,590 microbial transformation product
JPH03275689A (ja) * 1990-03-23 1991-12-06 Fujisawa Pharmaceut Co Ltd Fr900506物質の脱メチル体およびヒドロキシ体
JP3067183B2 (ja) * 1990-09-18 2000-07-17 藤沢薬品工業株式会社 Fr900506物質の製造法
EP0480623A1 (en) * 1990-10-11 1992-04-15 Merck & Co. Inc. New halomacrolides and derivatives having immunosuppressive activity
US5194378A (en) * 1991-01-28 1993-03-16 Merck & Co., Inc. Process for producing fk-506
IL146285A0 (en) * 1999-05-25 2002-07-25 Fujisawa Pharmaceutical Co Method for separating analogous organic compounds
TW553946B (en) * 1999-09-08 2003-09-21 Fujisawa Pharmaceutical Co Method for separating lactone-containing high-molecular weight compounds
CA2548297C (en) * 2003-12-05 2011-06-14 Biocon Limited Process for the purification of macrolides
CA2562805C (en) * 2004-04-12 2014-03-11 Biocon Limited Process for the production of macrolides using a novel strain, streptomyces sp. bicc 7522

Also Published As

Publication number Publication date
WO2006048145A1 (en) 2006-05-11
US20080160586A1 (en) 2008-07-03
EP1812447A1 (en) 2007-08-01
JP2008518984A (ja) 2008-06-05
CA2586193A1 (en) 2006-05-11
KR20070083930A (ko) 2007-08-24
CN101048415A (zh) 2007-10-03

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