IT9019132A1 - THIOPHILIC ABSORBENTS - Google Patents

THIOPHILIC ABSORBENTS

Info

Publication number
IT9019132A1
IT9019132A1 IT019132A IT1913290A IT9019132A1 IT 9019132 A1 IT9019132 A1 IT 9019132A1 IT 019132 A IT019132 A IT 019132A IT 1913290 A IT1913290 A IT 1913290A IT 9019132 A1 IT9019132 A1 IT 9019132A1
Authority
IT
Italy
Prior art keywords
thiophilic
absorbents
adsorbents
silica
silanizing
Prior art date
Application number
IT019132A
Other languages
Italian (it)
Other versions
IT9019132A0 (en
IT1237997B (en
Inventor
Fortune Kohen
Bernard Nopper
Meir Wilchek
Original Assignee
Yeda Res And Developmentcompan Y Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res And Developmentcompan Y Ltd filed Critical Yeda Res And Developmentcompan Y Ltd
Publication of IT9019132A0 publication Critical patent/IT9019132A0/en
Publication of IT9019132A1 publication Critical patent/IT9019132A1/en
Application granted granted Critical
Publication of IT1237997B publication Critical patent/IT1237997B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
    • B01J20/3259—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
    • B01J20/3263—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. an heterocyclic or heteroaromatic structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

New silica-based thiophilic adsorbents are obtained by silanizing silica, cleaving the resulting epoxy groups and reacting the product with divinylsulfone, followed by treatment with mercaptoethanol. Adsorbents have utility in HPL chromatography and in purification of proteins e.g. monoclonal antibodies and immunoglobulins.
IT01913290A 1989-01-24 1990-01-23 THIOPHILIC ABSORBENTS IT1237997B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL89047A IL89047A0 (en) 1989-01-24 1989-01-24 Thiophilic adsorbents

Publications (3)

Publication Number Publication Date
IT9019132A0 IT9019132A0 (en) 1990-01-23
IT9019132A1 true IT9019132A1 (en) 1990-07-25
IT1237997B IT1237997B (en) 1993-06-21

Family

ID=11059628

Family Applications (1)

Application Number Title Priority Date Filing Date
IT01913290A IT1237997B (en) 1989-01-24 1990-01-23 THIOPHILIC ABSORBENTS

Country Status (5)

Country Link
DE (1) DE4002044A1 (en)
FR (1) FR2642072A1 (en)
GB (1) GB2230003A (en)
IL (1) IL89047A0 (en)
IT (1) IT1237997B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789578A (en) * 1996-01-11 1998-08-04 Massey University Methods for the preparation of resins with ligands attached thereto through a linking group comprising sulfide, sulfoxide or sulfone functionality
CN105542076B (en) * 2016-01-28 2017-12-15 安徽师范大学 thiophilic porous material and its preparation method and application

Also Published As

Publication number Publication date
IT9019132A0 (en) 1990-01-23
IT1237997B (en) 1993-06-21
FR2642072A1 (en) 1990-07-27
DE4002044A1 (en) 1990-07-26
GB2230003A (en) 1990-10-10
IL89047A0 (en) 1989-08-15
GB9001593D0 (en) 1990-03-21

Similar Documents

Publication Publication Date Title
MX9603637A (en) Antibody purification.
ATE431159T1 (en) HIGH AFFINITY HUMAN MONOCLONAL ANTIBODIES SPECIFIC FOR RSV F PROTEINS
IT8319234A0 (en) PROCEDURE FOR THE PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES.
EP0143423A3 (en) Polyethylenimide bound chromatographic packing
AU558931B2 (en) A process and apparatus for the recovery of immunoglobulins
ES8506902A1 (en) Method of affinity purification employing monoclonal antibodies.
DE59208982D1 (en) Methods for purifying IgG monoclonal antibodies
DK407987A (en) APOLIPOPROTEIN B-SPECIFIC MONOCLONAL ANTIBODIES AND HYBRIDOMES PRODUCING THESE ANTIBODIES
PT840620E (en) IL-8 ANTAGONISTS FOR ASTHMA TREATMENT
EP0087686A3 (en) Homogeneous human immune interferon and process therefor
CA2126182A1 (en) Humanized antibodies reactive with gpiib/iiia
IT1237997B (en) THIOPHILIC ABSORBENTS
EP0287397A3 (en) Monoclonal antibody specific to human pancreatic phospholipase a2
DE3579808D1 (en) ANTI-UROKINASE MONOCLONAL ANTIBODY, ITS PRODUCTION AND USE.
JPS643129A (en) Separating agent for optical isomer
DK134487A (en) MONOCLONAL ANTIBODY WITH AFFINITY FOR HUMANT INTERLEUKIN-2
HU895916D0 (en) Process for the preparation of monoclonal antibody recognaizing reg protein
AU4465489A (en) Monoclonal antibody specifically recognizing n-glycolyl type gm2 hybridoma producing the antibody and method for preparing the hybridoma
DE3881101D1 (en) MONOCLONAL ANTIBODIES AND METHOD FOR PREPARING HYBRIDOMA, PRODUCING THIS ANTIBODIES.
IT1178489B (en) CLONANT VECTOR, PROCEDURE FOR ITS CONSTRUCTION AND CONCENTRATION AND PURIFICATION PROCEDURE OF PRODUCED PROTEINS, FORMED BY THE CLONANT VECTOR
SE9404491D0 (en) Process for the production of human monoclonal antibodies
RU96124514A (en) METHOD FOR ISSUING ANGIOGENIN
ITMI932667A0 (en) METHOD FOR THE PRODUCTION OF MONOCLONAL ANTIBODIES SPECIFIC TO CHEMOKINES
EP0251186A3 (en) Monoclonal antibody to human plasminogen, method for production thereof, assay reagent and kit comprising said antibody, and hybridoma producing said antibody
GB9226928D0 (en) Novel immunoglobulin binding proteins,process for their production & recombinant dna molecules coding therefor

Legal Events

Date Code Title Description
0001 Granted