IT8547834A0 - Procedimento di trattamento di cellule con proteine ossee solubili per renderle idonee a stimolare la crescita di tessuti cartilaginei ed ossei,e prodotto ottenuto - Google Patents

Procedimento di trattamento di cellule con proteine ossee solubili per renderle idonee a stimolare la crescita di tessuti cartilaginei ed ossei,e prodotto ottenuto

Info

Publication number
IT8547834A0
IT8547834A0 IT8547834A IT4783485A IT8547834A0 IT 8547834 A0 IT8547834 A0 IT 8547834A0 IT 8547834 A IT8547834 A IT 8547834A IT 4783485 A IT4783485 A IT 4783485A IT 8547834 A0 IT8547834 A0 IT 8547834A0
Authority
IT
Italy
Prior art keywords
bone
cartilagine
stimulating
growth
cells
Prior art date
Application number
IT8547834A
Other languages
English (en)
Other versions
IT1209941B (it
Inventor
Arnold I Caplan
Glen T Syftestad
Original Assignee
Arnold I Caplan
Glen T Syftestad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arnold I Caplan, Glen T Syftestad filed Critical Arnold I Caplan
Publication of IT8547834A0 publication Critical patent/IT8547834A0/it
Application granted granted Critical
Publication of IT1209941B publication Critical patent/IT1209941B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT8547834A 1984-03-20 1985-03-20 Procedimento di trattamento di cellule con proteine ossee solubili per renderle idonee a stimolare la crescita di tessuti cartilaginei ed ossei,e prodotto ottenuto IT1209941B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/591,440 US4609551A (en) 1984-03-20 1984-03-20 Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites

Publications (2)

Publication Number Publication Date
IT8547834A0 true IT8547834A0 (it) 1985-03-20
IT1209941B IT1209941B (it) 1989-08-30

Family

ID=24366497

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8547834A IT1209941B (it) 1984-03-20 1985-03-20 Procedimento di trattamento di cellule con proteine ossee solubili per renderle idonee a stimolare la crescita di tessuti cartilaginei ed ossei,e prodotto ottenuto

Country Status (5)

Country Link
US (1) US4609551A (it)
EP (1) EP0175762A1 (it)
AU (1) AU4153985A (it)
IT (1) IT1209941B (it)
WO (1) WO1985004185A1 (it)

Families Citing this family (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902288A (en) * 1985-12-03 1990-02-20 Marylou Ingram Implantable immunotherapy system using stimulated cells
US5133755A (en) * 1986-01-28 1992-07-28 Thm Biomedical, Inc. Method and apparatus for diodegradable, osteogenic, bone graft substitute device
WO1987005931A1 (en) * 1986-04-03 1987-10-08 East Carolina University Extracellular matrix induction method to produce pancreatic islet tissue
US4935000A (en) * 1986-04-03 1990-06-19 East Carolina University Extracellular matrix induction method to produce pancreatic islet tissue
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US4743259A (en) * 1986-10-29 1988-05-10 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
US5041138A (en) * 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US5736372A (en) * 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US5804178A (en) * 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
CH676196A5 (it) * 1988-08-30 1990-12-28 Sulzer Ag
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US4996154A (en) * 1989-05-04 1991-02-26 Millipore Corporation Method for growing cellular tissue
WO1991001720A1 (en) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
ES2111566T3 (es) * 1990-04-24 1998-03-16 Mark Eisenberg Equivalentes compuestos de piel viva.
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5811094A (en) * 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5853746A (en) * 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5192312A (en) * 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
CA2363965C (en) * 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
DE69206693T2 (de) * 1991-05-24 1996-05-23 Synthes Ag Resorbierbare Sehnen- und Knochenverstärkungseinrichtung
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
KR950703052A (ko) * 1992-08-13 1995-08-23 안토니 메리트 뼈 조직의 시험관내 합성을 위한 생활성 물질 주형(bioactive material tem-plate for in vitro synthesis of bone tissue)
DE4306661C2 (de) * 1993-03-03 1995-04-20 Michael Dipl Biol Sittinger Verfahren zum Herstellen eines Implantates aus Zellkulturen
EP2025353A2 (en) * 1993-04-30 2009-02-18 Massachusetts Institute of Technology Injectable polysaccharide-cell compositions
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
AU722956B2 (en) * 1993-07-07 2000-08-17 Smith & Nephew Plc Prosthesis
EP0707498B1 (en) * 1993-07-07 2003-06-25 Smith & Nephew PLC Implantable prosthesis, kit and device for manufacturing the same
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US6280771B1 (en) 1997-02-20 2001-08-28 Therics, Inc. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
US5518680A (en) * 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
US6176874B1 (en) 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5736160A (en) * 1993-10-28 1998-04-07 Thm Biomedical, Inc. Process and device for treating and healing a bone void
US5591625A (en) * 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
WO1995024873A1 (en) * 1994-03-14 1995-09-21 Cryolife, Inc. Treated tissue for implantation and preparation methods
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5981825A (en) 1994-05-13 1999-11-09 Thm Biomedical, Inc. Device and methods for in vivo culturing of diverse tissue cells
US5837235A (en) * 1994-07-08 1998-11-17 Sulzer Medizinaltechnik Ag Process for regenerating bone and cartilage
US5769899A (en) * 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US20010011131A1 (en) * 1997-07-28 2001-08-02 Luyten Frank P. DNA molecules encoding cartilage-derived morphogenetic proteins
AU1120295A (en) 1994-11-07 1996-05-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Cartilage-derived morphogenetic proteins
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5716616A (en) * 1995-03-28 1998-02-10 Thomas Jefferson University Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects
US6974571B2 (en) * 1995-03-28 2005-12-13 Thomas Jefferson University Isolated stromal cells and methods of using the same
US6653134B2 (en) * 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US6123727A (en) * 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) * 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6132463A (en) * 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US5655546A (en) * 1995-06-07 1997-08-12 Halpern; Alan A. Method for cartilage repair
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5591444A (en) * 1995-07-28 1997-01-07 Isolagen Technologies, Inc. Use of autologous dermal fibroblasts for the repair of skin and soft tissue defects
US6200606B1 (en) 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US5788976A (en) * 1996-02-12 1998-08-04 Wbk, Inc. Method for effecting bone repair
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
EP0891421A4 (en) 1996-03-18 2001-07-25 Univ Pennsylvania SUBSTRATE OF BIOACTIVE MATERIAL FOR INCREASED CELLULAR FIXATION AND FUNCTION
US5824084A (en) * 1996-07-03 1998-10-20 The Cleveland Clinic Foundation Method of preparing a composite bone graft
DE19630034A1 (de) * 1996-07-25 1998-04-23 Huels Chemische Werke Ag Biohybrides Zahnimplantat
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8617242B2 (en) 2001-05-25 2013-12-31 Conformis, Inc. Implant device and method for manufacture
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8234097B2 (en) 2001-05-25 2012-07-31 Conformis, Inc. Automated systems for manufacturing patient-specific orthopedic implants and instrumentation
US7618451B2 (en) 2001-05-25 2009-11-17 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty
US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
DE19716098A1 (de) * 1997-04-17 1998-10-22 Univ Ludwigs Albert Fibroblasten mit einem Fremdgen enthaltende Zusammensetzung zur Behandlung von Wunden
US6432710B1 (en) 1998-05-22 2002-08-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
US6551355B1 (en) 1998-08-14 2003-04-22 Cambridge Scientific, Inc. Tissue transplant coated with biocompatible biodegradable polymer
WO2000035346A2 (en) 1998-09-14 2000-06-22 Stanford University Assessing the condition of a joint and preventing damage
US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
US6454811B1 (en) 1998-10-12 2002-09-24 Massachusetts Institute Of Technology Composites for tissue regeneration and methods of manufacture thereof
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
DE60138116D1 (de) 2000-09-14 2009-05-07 Univ R Beurteilung des zustandes eines gelenkes und planung einer behandlung
ATE414310T1 (de) 2000-09-14 2008-11-15 Univ Leland Stanford Junior Verfahren zur manipulation medizinischer bilder
CA2365376C (en) * 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US20020127265A1 (en) * 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6852330B2 (en) * 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6599323B2 (en) * 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7175336B2 (en) * 2001-01-26 2007-02-13 Depuy Acromed, Inc. Graft delivery system
US6723131B2 (en) 2001-02-28 2004-04-20 The Cleveland Clinic Foundation Composite bone marrow graft material with method and kit
US8951260B2 (en) 2001-05-25 2015-02-10 Conformis, Inc. Surgical cutting guide
US9308091B2 (en) 2001-05-25 2016-04-12 Conformis, Inc. Devices and methods for treatment of facet and other joints
WO2002096268A2 (en) 2001-05-25 2002-12-05 Imaging Therapeutics, Inc. Methods and compositions for articular resurfacing
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US9969980B2 (en) * 2001-09-21 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
EP1441762A1 (en) * 2001-09-28 2004-08-04 University Of South Florida Rsv gene expression vaccine
EP1448089A4 (en) * 2001-11-01 2008-06-04 Spine Wave Inc DEVICES AND METHODS FOR SPINACH RECOVERY
JP4125234B2 (ja) * 2001-11-01 2008-07-30 スパイン・ウェイブ・インコーポレーテッド 椎間板間の終板の前処理のための装置及び方法
AU2002343738A1 (en) * 2001-11-15 2003-05-26 University Of Medicine And Dentistry Of New Jersey A three-dimensional matrix for producing living tissue equivalents
US6852331B2 (en) * 2002-02-11 2005-02-08 Taipei Biotechnology Ltd., Inc. Fabrication of a cartilage implant
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US9969977B2 (en) 2002-09-20 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
CA2501041A1 (en) * 2002-10-07 2004-04-22 Conformis, Inc. Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
JP2006505366A (ja) 2002-11-07 2006-02-16 コンフォーミス・インコーポレイテッド 半月板サイズおよび形状の決定および工夫した処置の方法
US7468050B1 (en) 2002-12-27 2008-12-23 L. Vad Technology, Inc. Long term ambulatory intra-aortic balloon pump
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) * 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
EP1691727B1 (en) 2003-12-11 2011-07-06 Isto Technologies Inc. Particulate cartilage system
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8657881B2 (en) * 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
JP2008504895A (ja) * 2004-06-29 2008-02-21 スパイン・ウェイブ・インコーポレーテッド 椎間板の欠陥及び損傷を治療する方法
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20090319045A1 (en) 2004-10-12 2009-12-24 Truncale Katherine G Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
EP1916964A4 (en) 2005-08-26 2015-11-04 Zimmer Inc IMPLANTS AND METHODS FOR THE REPAIR, REPLACEMENT AND TREATMENT OF JOINT DISEASES
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
EP1764117A1 (en) * 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
EP1951158A4 (en) 2005-11-21 2010-03-31 Vertegen Inc DEVICES AND METHODS FOR TREATMENT OF FACE CHAINS, UNCOVERTEBRAL JOINTS, COSTOVERTEBRUSK JOINTS AND OTHER JOINTS
CN105030297A (zh) 2006-02-06 2015-11-11 康复米斯公司 患者可选择的关节成形术装置和手术器具
US8623026B2 (en) 2006-02-06 2014-01-07 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
US8357168B2 (en) * 2006-09-08 2013-01-22 Spine Wave, Inc. Modular injection needle and seal assembly
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US9045735B2 (en) * 2007-04-03 2015-06-02 The Cleveland Clinic Foundation Enrichment of tissue-derived adult stem cells based on retained extracellular matrix material
EP2134297B1 (en) 2007-04-12 2017-03-08 Zimmer, Inc. Apparatus for tissue repair
JP2010529987A (ja) * 2007-06-15 2010-09-02 ガーネット バイオセラピューティクス インコーポレイテッド ｉｎｖｉｔｒｏで培養および増殖させた自己複製性コロニー形成細胞を用いる疾患および障害の治療
US20090005868A1 (en) * 2007-06-27 2009-01-01 Depuy Products, Inc. Osteogenic prosthesis, associated instrument, and associated method
US8682052B2 (en) 2008-03-05 2014-03-25 Conformis, Inc. Implants for altering wear patterns of articular surfaces
US9616205B2 (en) * 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
CA2734254C (en) 2008-08-13 2018-06-05 Smed-Ta/Td, Llc Orthopaedic screws
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
WO2010019807A1 (en) * 2008-08-13 2010-02-18 Smed-Ta/Td, Llc Orthopaedic implant with spatially varying porosity
US20100042213A1 (en) * 2008-08-13 2010-02-18 Nebosky Paul S Drug delivery implants
WO2010025386A1 (en) * 2008-08-29 2010-03-04 Smed-Ta/Td, Llc Orthopaedic implant
US20100274362A1 (en) * 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct
US8808297B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US8808303B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
EP2419035B1 (en) 2009-04-16 2017-07-05 ConforMIS, Inc. Patient-specific joint arthroplasty methods for ligament repair
AU2010327987B2 (en) 2009-12-11 2015-04-02 Conformis, Inc. Patient-specific and patient-engineered orthopedic implants
EP2640429B1 (en) 2010-11-15 2016-12-21 Zimmer Orthobiologics, Inc. Bone void fillers
WO2012112698A2 (en) 2011-02-15 2012-08-23 Conformis, Inc. Patient-adapted and improved articular implants, procedures and tools to address, assess, correct, modify and/or accommodate anatomical variation and/or asymmetry
US9486226B2 (en) 2012-04-18 2016-11-08 Conformis, Inc. Tibial guides, tools, and techniques for resecting the tibial plateau
US9675471B2 (en) 2012-06-11 2017-06-13 Conformis, Inc. Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
WO2014159722A1 (en) * 2013-03-12 2014-10-02 Carol Livermore-Clifford Deterministic manufacturing process for creating 3d living tissues based on 2d directed assembly and origami techniques
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
AU2017204355B2 (en) 2016-07-08 2021-09-09 Mako Surgical Corp. Scaffold for alloprosthetic composite implant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456687A (en) * 1978-11-16 1984-06-26 President And Fellows Of Harvard College Agents for promoting growth of epithelial cells
US4299819A (en) * 1979-01-02 1981-11-10 Sloan-Kettering Institute For Cancer Research Process for treating burn victims
US4304866A (en) * 1979-11-14 1981-12-08 Massachusetts Institute Of Technology Transplantable sheets of living keratinous tissue
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process

Also Published As

Publication number Publication date
AU4153985A (en) 1985-10-11
WO1985004185A1 (en) 1985-09-26
EP0175762A1 (en) 1986-04-02
US4609551A (en) 1986-09-02
IT1209941B (it) 1989-08-30

Similar Documents

Publication Publication Date Title
IT8547834A0 (it) Procedimento di trattamento di cellule con proteine ossee solubili per renderle idonee a stimolare la crescita di tessuti cartilaginei ed ossei,e prodotto ottenuto
AU3393993A (en) Method of administering proteins to living skin cells
DE3777253D1 (de) Herzschrittmacher zur stimulierung des menschlichen herzens.
AU589438B2 (en) Transplantable artificial tissue and process
NO880193L (no) Vevveksthjelpemiddel og fremstilling derav.
AU576365B2 (en) Collagen and or fibrinogen as carrier of drugs for their introduction into cellular lesion areas
IL83899A0 (en) Yeast production of human tumor necrosis factor
IT1232827B (it) Proteine biologicamente attive, formulazioni che le contengono e metodo per prepararle ed applicarle
YU45724B (sh) Postupak za dobijanje kristalnog kalcijum pseudomonata ili njegovog hidrata
GB2187955B (en) Improvements in or relating to the treatment of sickle cell disease
DE3778585D1 (de) Herzschrittmacher zur stimulierung des menschlichen herzens.
IT1238348B (it) Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.
GB8828694D0 (en) Preparation for introducing active substance for regulating tanning into skin production & use thereof
AR243514A1 (es) Derivados de 5-oxazolil-3-hidroxi-2-ciclohexen 1-ona oxim-eteres,de aplicacion para combatir el crecimiento de plantas indeseadas y composiciones que los contienen para obtenerlos.
AU2644888A (en) Method of healing wounds in horses
DE3778587D1 (de) Herzschrittmacher zur stimulierung des menschlichen herzens.
NZ222089A (en) Endothelial cell harvester with irrigation means for enzyme treatment of blood vessel
FR2598591B1 (fr) Procede de culture des procaryoyes et eucaryotes et utilisation des cellules ainsi preparees dans les compositions cosmetiques, alimentaires et des supplements au fourrage
GB8602247D0 (en) Growth of plant tissue cultures
JPS56158651A (en) Preparation of hard protein implant tissue having high biological stability
IT1213100B (it) La produzione di prodotti sessuali impiego di sostanze stimolanti per da mammiferi,adatti per la fecondazione naturale ed artificiale e sostanze relative
AU1089983A (en) Interfacial growth of cells in tissue culture
DE2966082D1 (en) Process for growing human epidermal cells in tissue culture
DE3888053D1 (de) Implantierbare Elektrode zur Herzstimulation.
AU7661987A (en) Composition for inducing and stimulating hair growth and for decreasing their loss, bases on pyrimidine derivatives