IT7849175A0 - Derivati n-alchil-n-acilici della tienamicina - Google Patents

Derivati n-alchil-n-acilici della tienamicina

Info

Publication number
IT7849175A0
IT7849175A0 IT7849175A IT4917578A IT7849175A0 IT 7849175 A0 IT7849175 A0 IT 7849175A0 IT 7849175 A IT7849175 A IT 7849175A IT 4917578 A IT4917578 A IT 4917578A IT 7849175 A0 IT7849175 A0 IT 7849175A0
Authority
IT
Italy
Prior art keywords
thienamicin
alkyl
acylic
derivatives
acylic derivatives
Prior art date
Application number
IT7849175A
Other languages
English (en)
Other versions
IT1105291B (it
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IT7849175A0 publication Critical patent/IT7849175A0/it
Application granted granted Critical
Publication of IT1105291B publication Critical patent/IT1105291B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT49175/78A 1977-05-05 1978-05-03 Derivati n-alchil-n-acilici della tienamicina IT1105291B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/793,974 US4235917A (en) 1977-05-05 1977-05-05 N-Alkyl-N-acyl derivatives of thienamycin

Publications (2)

Publication Number Publication Date
IT7849175A0 true IT7849175A0 (it) 1978-05-03
IT1105291B IT1105291B (it) 1985-10-28

Family

ID=25161301

Family Applications (1)

Application Number Title Priority Date Filing Date
IT49175/78A IT1105291B (it) 1977-05-05 1978-05-03 Derivati n-alchil-n-acilici della tienamicina

Country Status (14)

Country Link
US (1) US4235917A (it)
JP (1) JPS53137992A (it)
BE (1) BE866660A (it)
CH (1) CH638209A5 (it)
DE (1) DE2819479A1 (it)
DK (1) DK170678A (it)
ES (1) ES469425A1 (it)
FR (1) FR2389629B1 (it)
GB (1) GB1604276A (it)
IE (1) IE46877B1 (it)
IT (1) IT1105291B (it)
LU (1) LU79597A1 (it)
NL (1) NL7804230A (it)
SE (1) SE7804446L (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839352A (en) * 1975-11-21 1989-06-13 Merck & Co., Inc. N-acyl derivatives of thienamycin
US4318912A (en) * 1979-01-02 1982-03-09 Merck & Co., Inc. 6-(1-Hydroxyethyl)-3-substituted-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid
US4376774A (en) * 1979-05-29 1983-03-15 Merck & Co., Inc. Antibiotic N-heterocyclyl thienamycin
EP0055990B1 (en) * 1979-08-10 1986-06-11 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
US4361512A (en) * 1980-11-26 1982-11-30 Merck & Co., Inc. 2-Substituted thio-6-substituted-carbapen-2-em-3-carboxylic acids
JPS5857392A (ja) * 1981-10-02 1983-04-05 Sanraku Inc 新規な抗生物質oa−6129のリン酸エステル
ZA832412B (en) * 1982-04-09 1983-12-28 Bristol Myers Co Carbapenem antibiotics
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4710568A (en) * 1982-04-09 1987-12-01 Bristol-Myers Company Carbapenem antibiotics
US4642341A (en) * 1982-04-09 1987-02-10 Bristol-Myers Company Carbapenem antibiotics
US4529597A (en) * 1982-04-19 1985-07-16 Merck & Co., Inc. Substituted 1-azabicyclo(3.2.0)hept-6-en-2-one-7-carboxylic acids
BE897086A (fr) * 1982-06-18 1983-12-19 Bristol Myers Co Produits nouveaux de la classe des carbapenems et leur application en tant qu'antibiotiques
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
US4665170A (en) * 1982-06-18 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4732977A (en) * 1982-09-28 1988-03-22 Bristol Myers Company Carbapenem antibiotics
US4746736A (en) * 1982-09-28 1988-05-24 Bristol-Myers Company Carbapenem antibiotics
ZA841643B (en) * 1983-03-08 1984-10-31 Bristol Myers Co Carbapenem process
US4992542A (en) * 1984-01-24 1991-02-12 Merck & Co., Inc. 2-substituted-6-carbadethiapen-2-em-3-carboxylic acids
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
CH632508A5 (de) * 1975-11-21 1982-10-15 Merck & Co Inc Verfahren zur herstellung von neuen estern des n-acylierten thienamycins.
US4150145A (en) * 1977-09-15 1979-04-17 Merck & Co., Inc. N-alkylated derivatives of thienamycin sulfoxide and sulfone

Also Published As

Publication number Publication date
FR2389629A1 (it) 1978-12-01
BE866660A (fr) 1978-11-03
IE780899L (en) 1978-11-05
US4235917A (en) 1980-11-25
IT1105291B (it) 1985-10-28
NL7804230A (nl) 1978-11-07
JPH0222076B2 (it) 1990-05-17
JPS53137992A (en) 1978-12-01
GB1604276A (en) 1981-12-09
DK170678A (da) 1979-01-16
DE2819479A1 (de) 1978-11-16
IE46877B1 (en) 1983-10-19
DE2819479C2 (it) 1992-04-30
CH638209A5 (de) 1983-09-15
LU79597A1 (fr) 1979-02-02
ES469425A1 (es) 1980-01-01
FR2389629B1 (it) 1980-06-20
SE7804446L (sv) 1978-11-06

Similar Documents

Publication Publication Date Title
IT1206635B (it) Composizioni diserbanti di derivati della pirimidina
IT1094469B (it) Derivati della guanidina
IT1092170B (it) Derivati della morfolina
IT1088554B (it) Procedimento sellettivo per la preparazione di derivati della 7-indrossi cumarina
IT7848808A0 (it) Derivati di mercaptoalchilsolfonilprolina e composti affini
IT1105291B (it) Derivati n-alchil-n-acilici della tienamicina
IT1160633B (it) Derivati 2-sostituiti della 5-idrossi-1h-imidazol-4-carbossammide
IT1110097B (it) Derivati della cumarina
IT7868754A0 (it) Derivati della maleinimmide e succinimmide e pr0cediment0 per la l0r0 preparazi0ne
IT1193842B (it) Derivati della cisteina
IT1096276B (it) Derivati di benzimmidazolo
IT1170641B (it) Derivati della bis-moranolina
IT1130292B (it) Derivati della teobromina e procedimento per produrli
IT1092333B (it) Derivati di ossadiazol-pirimidine
IT1092334B (it) Derivati della ossidiazolo-pirimidina
IT1068692B (it) Derivati della colesterina
IT1093710B (it) Derivati della chinazolina
IT1076900B (it) Derivati della chinolina
IT1102266B (it) Derivati del furano
IT1130248B (it) Derivati della chinolina
IT8147592A0 (it) Derivati della cinnamil moranolina
IT1098350B (it) Derivati prostaglandinici
IT1096628B (it) Derivati di 15-sostituita-w-pentanorprostaglandina
IT1101411B (it) Derivati naftalimidici
IT1089247B (it) 5-6-di idro-prostaciclina derivati