IT202100008465A1 - ANALGESIC COMPOSITION FOR NEWBORN - Google Patents
ANALGESIC COMPOSITION FOR NEWBORN Download PDFInfo
- Publication number
- IT202100008465A1 IT202100008465A1 IT102021000008465A IT202100008465A IT202100008465A1 IT 202100008465 A1 IT202100008465 A1 IT 202100008465A1 IT 102021000008465 A IT102021000008465 A IT 102021000008465A IT 202100008465 A IT202100008465 A IT 202100008465A IT 202100008465 A1 IT202100008465 A1 IT 202100008465A1
- Authority
- IT
- Italy
- Prior art keywords
- newborn
- composition
- analgesic composition
- sucrose
- analgesic
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 20
- 230000000202 analgesic effect Effects 0.000 title claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 229930006000 Sucrose Natural products 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 7
- 239000005720 sucrose Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000001814 pectin Substances 0.000 claims description 4
- 235000010987 pectin Nutrition 0.000 claims description 4
- 229920001277 pectin Polymers 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 230000002335 preservative effect Effects 0.000 claims description 3
- 230000008719 thickening Effects 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 239000002562 thickening agent Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 description 3
- 239000006193 liquid solution Substances 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Description
DESCRIZIONE DESCRIPTION
Annessa a domanda di brevetto per INVENZIONE INDUSTRIALE avente per titolo Attached to a patent application for INDUSTRIAL INVENTION having the title
?Composizione analgesica per neonato? ?Analgesic composition for newborn?
La presente invenzione riguarda una composizione analgesica per neonato. The present invention relates to an analgesic composition for newborns.
I neonati alla nascita, gi? ricoverati o che accedono per controlli e diagnosi in ambulatorio, sono spesso sottoposti a procedure invasive stressanti e dolorose. Punture ed esami diagnostici sono solo alcune di esse. Diversi studi hanno dimostrato che i neuroni che trasmettono stimoli dolorosi sono ben sviluppati nel cervello del neonato, e lo stress derivante da uno stimolo doloroso pu? influenzare negativamente i principali sistemi dell?organismo. Molteplici studi sottolineano come l?esposizione al dolore in et? neonatale porti con s? conseguenze negative, sia a breve termine come alterazione dei parametri vitali, fluttuazioni della pressione endocranica, aumento del rischio infettivo, sia a lungo termine con un alterato sviluppo del sistema nervoso. Babies at birth, right? hospitalized or who access for checks and diagnoses in the clinic, are often subjected to stressful and painful invasive procedures. Punctures and diagnostic tests are just some of them. Several studies have shown that the neurons that transmit painful stimuli are well developed in the brain of the newborn, and the stress resulting from a painful stimulus can negatively affect the main body systems. Multiple studies underline how exposure to pain in the age neonatal do you bring with you? negative consequences, both in the short term such as alteration of vital parameters, fluctuations in intracranial pressure, increased risk of infection, and in the long term with altered development of the nervous system.
Alcuni studi hanno dimostrato che la somministrazione di saccarosio ? un mezzo sicuro ed efficace per ridurre il dolore nel neonato. In molti ospedali, i protocolli prevedono l'immersione di un ciuccio o il dito di un medico guantato in una soluzione di saccarosio e l'inserimento nella bocca di un bambino. Some studies have shown that the administration of sucrose ? a safe and effective means of reducing pain in the newborn. In many hospitals, protocols involve dipping a pacifier or a gloved doctor's finger into a sucrose solution and inserting it into a baby's mouth.
Le soluzioni liquide hanno per? il difetto di scorrere senza permanere nella bocca del neonato esaurendo la propria funzione analgesica in breve tempo. Do liquid solutions have for? the defect of flowing without remaining in the mouth of the newborn, exhausting its analgesic function in a short time.
La presente invenzione mira a superare l?inconveniente sopra accennato. The present invention aims to overcome the above mentioned drawback.
Lo scopo principale della presente invenzione ? quello di fornire una composizione analgesica per neonati che permanga nella bocca per un tempo maggiore di una soluzione liquida. The main purpose of the present invention ? that of providing an analgesic composition for infants which remains in the mouth for a longer time than a liquid solution.
Un altro scopo dell'invenzione ? quello di fornire una composizione analgesica che partecipi a migliorare la suzione del neonato. Another object of the invention ? that of providing an analgesic composition which participates in improving the suction of the newborn.
Ancora un altro scopo ? quello di fornire una composizione analgesica che consenta una maggiore distrazione sensoriale dal dolore. Yet another purpose ? that of providing an analgesic composition which allows for greater sensory distraction from the pain.
Per raggiungere lo scopo sopra menzionato, la presente invenzione fornisce una composizione analgesica per neonato comprendente acqua, saccarosio, almeno un componente conservante, ed inoltre un componente addensante atto a dare una consistenza gelatinosa alla composizione. To achieve the above-mentioned object, the present invention provides an analgesic composition for infants comprising water, sucrose, at least one preservative component, and furthermore a thickening component capable of giving a gelatinous consistency to the composition.
Vantaggiosamente, la consistenza gelatinosa parifica la situazione dell?attaccamento al seno del neonato. Infatti, tale consistenza gelatinosa consente una pi? duratura adesione della composizione analgesica al ciuccio; anche se somministrata con cucchiaino, la soluzione analgesica sosta di pi? in bocca e quindi partecipa a migliorare la suzione ed a determinare una maggiore distrazione sensoriale del dolore. Advantageously, the gelatinous consistency equalizes the situation of attachment to the breast of the newborn. In fact, this gelatinous consistency allows a more? lasting adhesion of the analgesic composition to the pacifier; even if administered with a teaspoon, the analgesic solution stays longer? in the mouth and therefore participates in improving the suction and in determining a greater sensory distraction of the pain.
Con la consistenza gelatinosa, la durata del trattamento di saturazione sensoriale del dolore risulta essere potenziata da 4-5 minuti a 8-10 minuti. With the gelatinous consistency, the duration of the pain sensory saturation treatment is boosted from 4-5 minutes to 8-10 minutes.
Ulteriori caratteristiche e vantaggi del trovato risulteranno maggiormente chiari dalla descrizione che segue di una forma di realizzazione. Further characteristics and advantages of the invention will become clearer from the following description of an embodiment.
Una composizione analgesica per neonato comprende acqua, saccarosio, almeno un componente conservante, ed inoltre un componente addensante atto a dare una consistenza gelatinosa alla composizione. An analgesic composition for infants comprises water, sucrose, at least one preservative component, and further a thickener component adapted to give a gelatinous consistency to the composition.
Il componente addensante ? pectina alimentare. The thickening component? food pectin.
In particolare, la composizione secondo l?invenzione ha la seguente formulazione in peso: saccarosio 24,0 g, pectina alimentare 5,5 g, potassio sorbato 0,1 g, sodio benzoato 0,1 g, acido citrico 0,1 g, acqua q.b. a 100 ml. In particular, the composition according to the invention has the following formulation by weight: sucrose 24.0 g, food pectin 5.5 g, potassium sorbate 0.1 g, sodium benzoate 0.1 g, citric acid 0.1 g, water to taste to 100ml.
In aggiunta, la formulazione sopra indicata pu? comprendere acido citrico 0,1 g. In addition, the formulation indicated above pu? include citric acid 0.1 g.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102021000008465A IT202100008465A1 (en) | 2021-04-06 | 2021-04-06 | ANALGESIC COMPOSITION FOR NEWBORN |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102021000008465A IT202100008465A1 (en) | 2021-04-06 | 2021-04-06 | ANALGESIC COMPOSITION FOR NEWBORN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT202100008465A1 true IT202100008465A1 (en) | 2022-10-06 |
Family
ID=79018352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT102021000008465A IT202100008465A1 (en) | 2021-04-06 | 2021-04-06 | ANALGESIC COMPOSITION FOR NEWBORN |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT202100008465A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6475539B1 (en) * | 1998-05-07 | 2002-11-05 | Abbott Laboratories | Nutritionally complete low pH enteral formula |
| US20110117175A1 (en) * | 2009-11-18 | 2011-05-19 | Rosenbaum Richard J | Sweet analgesic for use in medical procedures or treatments |
| US20120039970A1 (en) * | 2009-03-30 | 2012-02-16 | Basf Se | Ready-to-use, stable suspension of partially amorphous carotenoid particles |
-
2021
- 2021-04-06 IT IT102021000008465A patent/IT202100008465A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6475539B1 (en) * | 1998-05-07 | 2002-11-05 | Abbott Laboratories | Nutritionally complete low pH enteral formula |
| US20120039970A1 (en) * | 2009-03-30 | 2012-02-16 | Basf Se | Ready-to-use, stable suspension of partially amorphous carotenoid particles |
| US20110117175A1 (en) * | 2009-11-18 | 2011-05-19 | Rosenbaum Richard J | Sweet analgesic for use in medical procedures or treatments |
Non-Patent Citations (2)
| Title |
|---|
| ANONYMOUS: "Label Children's Advil Cold", WWW.ACCESSDATA.FDA.GOV, 18 April 2002 (2002-04-18), XP055023727, Retrieved from the Internet <URL:http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21373lbl.pdf> [retrieved on 20120403] * |
| ROBERT G. STRICKLEY ET AL: "Pediatric drugs—a review of commercially available oral formulations", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 97, no. 5, 1 May 2008 (2008-05-01), pages 1731 - 1774, XP055121290, ISSN: 0022-3549, DOI: 10.1002/jps.21101 * |
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