IT201900010800A1 - COMPOSITION CONTAINING PRICKLY PEAR EXTRACT IN SERENOA OIL FOR THE MAINTENANCE OF PROSTATE FUNCTIONALITY - Google Patents
COMPOSITION CONTAINING PRICKLY PEAR EXTRACT IN SERENOA OIL FOR THE MAINTENANCE OF PROSTATE FUNCTIONALITY Download PDFInfo
- Publication number
- IT201900010800A1 IT201900010800A1 IT102019000010800A IT201900010800A IT201900010800A1 IT 201900010800 A1 IT201900010800 A1 IT 201900010800A1 IT 102019000010800 A IT102019000010800 A IT 102019000010800A IT 201900010800 A IT201900010800 A IT 201900010800A IT 201900010800 A1 IT201900010800 A1 IT 201900010800A1
- Authority
- IT
- Italy
- Prior art keywords
- extract
- composition according
- composition
- total
- oil
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 54
- 239000000284 extract Substances 0.000 title claims description 49
- 240000001439 Opuntia Species 0.000 title claims description 22
- 235000013389 Opuntia humifusa var. humifusa Nutrition 0.000 title claims description 22
- 210000002307 prostate Anatomy 0.000 title claims description 18
- 241000233910 Serenoa Species 0.000 title description 9
- 238000012423 maintenance Methods 0.000 title description 5
- 229920001661 Chitosan Polymers 0.000 claims description 22
- 240000007154 Coffea arabica Species 0.000 claims description 18
- 240000006661 Serenoa repens Species 0.000 claims description 17
- 235000005318 Serenoa repens Nutrition 0.000 claims description 17
- 235000001368 chlorogenic acid Nutrition 0.000 claims description 17
- 235000013824 polyphenols Nutrition 0.000 claims description 17
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 16
- 150000004676 glycans Chemical class 0.000 claims description 13
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
- 229920001282 polysaccharide Polymers 0.000 claims description 13
- 239000005017 polysaccharide Substances 0.000 claims description 13
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 12
- 229930195729 fatty acid Natural products 0.000 claims description 12
- 150000004665 fatty acids Chemical class 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000004480 active ingredient Substances 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims description 5
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 229940030275 epigallocatechin gallate Drugs 0.000 claims description 4
- 240000007551 Boswellia serrata Species 0.000 claims description 3
- 235000012035 Boswellia serrata Nutrition 0.000 claims description 3
- 239000000969 carrier Substances 0.000 claims description 3
- 229940094952 green tea extract Drugs 0.000 claims description 3
- 235000020688 green tea extract Nutrition 0.000 claims description 3
- 229940109529 pomegranate extract Drugs 0.000 claims description 3
- 239000006000 Garlic extract Substances 0.000 claims description 2
- 235000020706 garlic extract Nutrition 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 238000012546 transfer Methods 0.000 claims description 2
- 239000003921 oil Substances 0.000 description 21
- 230000000694 effects Effects 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 7
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 6
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 6
- 239000002775 capsule Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- -1 triglycerides Chemical class 0.000 description 5
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 4
- 239000011781 sodium selenite Substances 0.000 description 4
- 229960001471 sodium selenite Drugs 0.000 description 4
- 235000015921 sodium selenite Nutrition 0.000 description 4
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 4
- 235000005282 vitamin D3 Nutrition 0.000 description 4
- 239000011647 vitamin D3 Substances 0.000 description 4
- 229940021056 vitamin d3 Drugs 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 3
- 235000002566 Capsicum Nutrition 0.000 description 3
- 240000008574 Capsicum frutescens Species 0.000 description 3
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 229920000864 Punicalin Polymers 0.000 description 3
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 3
- 244000078534 Vaccinium myrtillus Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 229960003473 androstanolone Drugs 0.000 description 3
- 230000036765 blood level Effects 0.000 description 3
- 239000001390 capsicum minimum Substances 0.000 description 3
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000031891 intestinal absorption Effects 0.000 description 3
- 239000000419 plant extract Substances 0.000 description 3
- SSIRGMIVWUBXFB-UHFFFAOYSA-N punicalin Natural products OC1OC2COC(=O)c3cc(O)c(O)c(O)c3c4c(O)c(O)c5OC(=O)c6c(c(O)c(O)c7OC(=O)c4c5c67)c8cc(C(=O)OC2C(O)C1O)c(O)c(O)c8O SSIRGMIVWUBXFB-UHFFFAOYSA-N 0.000 description 3
- 229940042585 tocopherol acetate Drugs 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 244000294611 Punica granatum Species 0.000 description 2
- 235000014360 Punica granatum Nutrition 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 235000006468 Thea sinensis Nutrition 0.000 description 2
- 244000274883 Urtica dioica Species 0.000 description 2
- 235000009108 Urtica dioica Nutrition 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 244000273928 Zingiber officinale Species 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 description 2
- 229960002504 capsaicin Drugs 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Natural products COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
- 235000017663 capsaicin Nutrition 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
- 150000001765 catechin Chemical class 0.000 description 2
- 235000005487 catechin Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000004186 food analysis Methods 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 208000026423 prostatic infection Diseases 0.000 description 2
- IQHIEHIKNWLKFB-ITTSEVFZSA-N pumcalin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1OC(=O)C1=CC(O)=C(O)C(O)=C11)O)O)OC(=O)C2=CC(O)=C(O)C(O)=C2C2=C(O)C(O)=C(OC3=O)C4=C2C(=O)OC2=C4C3=C1C(O)=C2O IQHIEHIKNWLKFB-ITTSEVFZSA-N 0.000 description 2
- LMIBIMUSUFYFJN-RSVYENFWSA-N punicalagin Natural products O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3c4c(O)cc5OC(=O)c6c(c(O)c(O)c7OC(=O)c4c5c67)c8c(O)c(O)c(O)cc8C(=O)O[C@H]2[C@@H]9OC(=O)c%10cc(O)c(O)c(O)c%10c%11c(O)c(O)c(O)cc%11C(=O)O[C@@H]19 LMIBIMUSUFYFJN-RSVYENFWSA-N 0.000 description 2
- 230000000276 sedentary effect Effects 0.000 description 2
- 230000000391 smoking effect Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 229960003604 testosterone Drugs 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000007219 (+)-catechin Nutrition 0.000 description 1
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 229930014124 (-)-epigallocatechin gallate Natural products 0.000 description 1
- 235000004911 (-)-epigallocatechin gallate Nutrition 0.000 description 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 235000002567 Capsicum annuum Nutrition 0.000 description 1
- 235000007654 Capsicum sp Nutrition 0.000 description 1
- 235000007460 Coffea arabica Nutrition 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 235000004727 Opuntia ficus indica Nutrition 0.000 description 1
- 240000009297 Opuntia ficus-indica Species 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 206010050662 Prostate infection Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 235000000719 Prunus africana Nutrition 0.000 description 1
- 241000200478 Prunus africana Species 0.000 description 1
- 229920000241 Punicalagin Polymers 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000400688 Symmetrischema capsicum Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 102000001307 androgen receptors Human genes 0.000 description 1
- 108010080146 androgen receptors Proteins 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 230000001833 anti-estrogenic effect Effects 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229940055416 blueberry extract Drugs 0.000 description 1
- 235000019216 blueberry extract Nutrition 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 239000001511 capsicum annuum Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- VFSWRBJYBQXUTE-UHFFFAOYSA-N epi-Gallocatechin 3-O-gallate Natural products Oc1ccc2C(=O)C(OC(=O)c3cc(O)c(O)c(O)c3)C(Oc2c1)c4cc(O)c(O)c(O)c4 VFSWRBJYBQXUTE-UHFFFAOYSA-N 0.000 description 1
- 230000009986 erectile function Effects 0.000 description 1
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical class CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 239000000328 estrogen antagonist Substances 0.000 description 1
- 102000015694 estrogen receptors Human genes 0.000 description 1
- 108010038795 estrogen receptors Proteins 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000003953 foreskin Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 238000001030 gas--liquid chromatography Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000002780 gingerol Nutrition 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 229940070036 lycopene 10 mg Drugs 0.000 description 1
- 230000002879 macerating effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 229930000223 plant secondary metabolite Natural products 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001190 pomegranate ellagitannin Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000017497 prostate disease Diseases 0.000 description 1
- ZJVUMAFASBFUBG-OGJBWQGYSA-N punicalagin Chemical compound C([C@H]1O[C@@H]([C@@H]2OC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)O[C@H]2[C@@H]1OC(=O)C1=CC(O)=C(O)C(O)=C11)O)OC(=O)C2=CC(O)=C(O)C(O)=C2C2=C(O)C(O)=C(OC3=O)C4=C2C(=O)OC2=C4C3=C1C(O)=C2O ZJVUMAFASBFUBG-OGJBWQGYSA-N 0.000 description 1
- ZRKSVMFLACVUIU-UHFFFAOYSA-N punicalagin isomer Natural products OC1=C(O)C(=C2C3=4)OC(=O)C=4C4=C(O)C(O)=C3OC(=O)C2=C1C1=C(O)C(O)=C(O)C=C1C(=O)OC1C2OC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(O)OC1COC(=O)C1=CC4=C(O)C(O)=C1O ZRKSVMFLACVUIU-UHFFFAOYSA-N 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000006254 rheological additive Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000020755 serenoa repens extract Nutrition 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229940056069 zinc oxide 15 mg Drugs 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/33—Cactaceae (Cactus family), e.g. pricklypear or Cereus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Description
Titolo: COMPOSIZIONE CONTENENTE ESTRATTO DI FICO D'INDIA IN OLIO Title: COMPOSITION CONTAINING PRICKLY PEAR EXTRACT IN OIL
DESCRIZIONE DESCRIPTION
CAMPO DELL’INVENZIONE FIELD OF THE INVENTION
La presente invenzione riguarda una composizione, un metodo per la sua produzione ed un metodo di uso, in cui la composizione aiuta efficacemente a mantenere la funzionalità della prostata. La composizione comprende una miscela precisa di agenti altamente attivi, compresi: The present invention relates to a composition, a method for its production and a method of use, in which the composition effectively helps to maintain the functionality of the prostate. The composition includes a precise blend of highly active agents, including:
estratto di fiori di fico d'India in olio di serenoa microincapsulato, prickly pear flower extract in microencapsulated serenoa oil,
estratto di caffè verde contenente acidi clorogenici, chitosano. green coffee extract containing chlorogenic acids, chitosan.
SFONDO DELL’INVENZIONE BACKGROUND OF THE INVENTION
Un prodotto per il mantenimento delle funzionalità della prostata è un prodotto che ha la caratteristica di evitare l'insorgenza di disturbi della prostata quali iperplasia, infiammazione ed infezione prostatica. A product for the maintenance of prostate functions is a product that has the characteristic of avoiding the onset of prostate disorders such as hyperplasia, inflammation and prostatic infection.
L’iperplasia prostatica benigna (IPB) è caratterizzata dall'aumento di volume della ghiandola prostatica. Le cause non sono del tutto chiarite, ma sono state osservate correlazioni tra l'insorgenza di IPB e fattori quali: Benign prostatic hyperplasia (BPH) is characterized by an increase in the volume of the prostate gland. The causes are not fully understood, but correlations have been observed between the onset of BPH and factors such as:
- livelli ematici elevati di estrogeni; - elevated blood levels of estrogen;
- livelli ematici ridotti di testosterone libero; - reduced blood levels of free testosterone;
- livelli ematici elevati di diidrotestosterone; - elevated blood levels of dihydrotestosterone;
- età avanzata; - old age;
- ereditarietà; - inheritance;
- stile di vita, per esempio le abitudini al fumo e al consumo di alcol, e la sedentarietà. - lifestyle, for example smoking and alcohol consumption habits, and a sedentary lifestyle.
L’infiammazione prostatica è causata da: Prostate inflammation is caused by:
- infezioni batteriche; - bacterial infections;
- stili di vita come il fumo, il consumo di alcol e la sedentarietà; - lifestyles such as smoking, alcohol consumption and a sedentary lifestyle;
- sollecitazione muscolare eccessiva o troppo ridotta della zona prostatica. - excessive or too little muscle stress in the prostate area.
L’infezione prostatica è causata da: Prostate infection is caused by:
- colonizzazione da parte di microorganismi patogeni che risalgono l'uretra e si localizzano a livello prostatico; - colonization by pathogenic microorganisms that go up the urethra and are localized in the prostate;
- colonizzazione da parte di microorganismi patogeni localizzati a livellorettale che si diffondonoversola prostata; - colonization by pathogenic microorganisms localized at the rectal level that spread through the prostate;
- rapporti sessuali. - sexual intercourse.
Allo scopo di ottenere prodotti per il mantenimento della funzionalità della prostata, sono state sviluppate diverse sostanze, dotate di effetti e meccanismi d’azione diversi, che possono agire sulle numerose cause che danno origine all'iperplasia, all'infiammazione e all'infezione prostatica. Infatti, tali principi attivi possono esplicare effetti diversi quali: In order to obtain products for the maintenance of prostate functionality, various substances have been developed, with different effects and mechanisms of action, which can act on the numerous causes that give rise to hyperplasia, inflammation and prostatic infection. . In fact, these active ingredients can have different effects such as:
• effetto antiinfiammatorio; • anti-inflammatory effect;
• effetto antimicrobico; • antimicrobial effect;
• effetto antiiperplasia prostatica: tale azione è mediata dall'attività inibitoria nei confronti dell'enzima target 5-alfareduttasi. La 5-alfa-reduttasi (nota anche come 3-osso-5-alfasteroide 4-deidrogenasi) converte il testosterone in diidrotestosterone. Quest'ultimo è un ormone che stimola e controlla lo sviluppo ed il mantenimento delle caratteristiche maschili; • prostatic antihyperplasia effect: this action is mediated by the inhibitory activity against the target enzyme 5-alpha reductase. 5-alpha-reductase (also known as 3-oxo-5-alpha-asteroid 4-dehydrogenase) converts testosterone into dihydrotestosterone. The latter is a hormone that stimulates and controls the development and maintenance of male characteristics;
• effetto antiproliferativo su cellule tumorali della prostata; • antiproliferative effect on prostate cancer cells;
• effetto di miglioramento della funzione erettile. • effect of improving erectile function.
Diverse sostanze o prodotti mostrano proprietà utili al mantenimento della funzionalità della prostata, esplicando uno o più dei suddetti effetti. Inoltre, da prodotti presenti in commercio o dalla letteratura scientifica e brevettuale, sono noti numerosi tentativi di associare varie sostanze per cercare di ottenere composizioni per il mantenimento della funzionalità della prostata efficaci. Per esempio, è noto che: Several substances or products show properties useful for maintaining the functionality of the prostate, exerting one or more of the aforementioned effects. Furthermore, numerous attempts to associate various substances in order to obtain effective compositions for maintaining the functionality of the prostate are known from products available on the market or from the scientific and patent literature. For example, it is known that:
L’estratto di fiori di fico d'India contiene, tra i vari fitocomponenti, diversi polifenoli che sono particolarmente abbondanti nei fiori. Prickly pear flower extract contains, among the various phytocomponents, various polyphenols that are particularly abundant in flowers.
L’olio di serenoa (Serenoa repens) è un olio particolarmente ricco di acidi grassi e fitosteroli. I principi attivi della Serenoa stimolano a livello prostatico i recettori estrogenici e inibisconoquelli progestinici e sonoinoltre ingrado di produrre effetti antiestrogenici e antiandrogenici che si manifestano con blocco causato dall'inibizione della 5-alfa-reduttasi di tipo I e II del legame da parte del diidrotestosterone a livello dei recettori androgenici [Silverio et al. Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations andregional distributionof androgens andepidermal growthfactor in benign prostatic hyperplasia, in Prostate, vol. 37, 1998, pp. Serenoa oil (Serenoa repens) is an oil particularly rich in fatty acids and phytosterols. The active ingredients of Serenoa stimulate estrogen receptors in the prostate and inhibit progestogens and are also capable of producing anti-estrogenic and antiandrogenic effects which occur with blockage caused by the inhibition of type I and II 5-alpha-reductase of the binding by dihydrotestosterone. at the level of androgen receptors [Silverio et al. Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations andregional distribution of androgens andepidermal growthfactor in benign prostatic hyperplasia, in Prostate, vol. 37, 1998, pp.
77-83; Sultan et al. Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts, in J Steroid Biochem, vol. 20, 1984, pp. 77-83; Sultan et al. Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts, in J Steroid Biochem, vol. 20, 1984, pp.
515-519]. 515-519].
Gli acidi clorogenici contenuti nel caffè verde sono dei polifenoli e mostrano attività anti-iperplasia prostatica benigna [Huang Y, Chen H, Zhou X, Wu X, Hu E, Jiang Z. Inhibition effects of chlorogenic acid on benign prostatic hyperplasia in mice. Eur. J. Pharmacol. 2017;809:191-195. doi: 10.1016/j.ejphar.2017.04.017]. I dosaggi riportati sono da 1,6 mg/kg a 3,2 mg/kg nel ratto che corrispondono, per un uomo di 70 kg, a 112-224 mg. The chlorogenic acids contained in green coffee are polyphenols and show anti-benign prostatic hyperplasia [Huang Y, Chen H, Zhou X, Wu X, Hu E, Jiang Z. Inhibition effects of chlorogenic acid on benign prostatic hyperplasia in mice. Eur. J. Pharmacol. 2017; 809: 191-195. doi: 10.1016 / j.ejphar.2017.04.017]. The dosages reported are from 1.6 mg / kg to 3.2 mg / kg in rats which correspond to 112-224 mg for a 70 kg man.
Il chitosano ha la seguente struttura: Chitosan has the following structure:
È un polisaccaride lineare composto da D-glucosamina e N-acetil-D-glucosamina, legate tramite legami β(1-4). Il chitosano e suoi derivati aumentano l'assorbimento intestinale, e quindi la biodisponibilità, specialmente di macromolecole idrofile [Thanou M, Verhoef JC, Junginger HE. Chitosan and its derivatives as intestinal absorption enhancers. Adv. Drug. Deliv. Rev. 2001;50 Suppl. 1:S91-101] tra cui anche catechine/polifenoli [Dube A, Nicolazzo JA, Larson I. Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (−)-epigallocatechingallate. Eur. J. Pharm. Sci. 2010;41(2):219-225]. Generalmente i suoi dosaggi sono pari a 1/4 del dosaggio dei polifenoli totali ad esso associati. It is a linear polysaccharide composed of D-glucosamine and N-acetyl-D-glucosamine, linked via β (1-4) bonds. Chitosan and its derivatives increase intestinal absorption, and therefore bioavailability, especially of hydrophilic macromolecules [Thanou M, Verhoef JC, Junginger HE. Chitosan and its derivatives as intestinal absorption enhancers. Adv. Drug. Deliv. Rev. 2001; 50 Suppl. 1: S91-101] including catechins / polyphenols [Dube A, Nicolazzo JA, Larson I. Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+) - catechin and (-) - epigallocatechingallate. Eur. J. Pharm. Sci. 2010; 41 (2): 219-225]. Generally its dosages are equal to 1/4 of the dosage of the total polyphenols associated with it.
Nonostante, come dettosopra, sianonoti (daprodotti presenti in commercio o dalla letteratura scientifica e brevettuale) numerosi tentativi di associare varie sostanze per cercare di ottenere composizioni per il mantenimento della funzionalità della prostata efficaci, è ancora sentita l’esigenza di riuscire a combinare diverse sostanze con proprietà differenti, in proporzioni tali da esibire effetti sinergici in termini di efficacia per il mantenimento delle funzionalità della prostata e allo stesso tempo in grado di essere ben tollerate. Although, as mentioned above, there are known (from products on the market or from scientific and patent literature) numerous attempts to combine various substances to try to obtain effective compositions for the maintenance of prostate functionality, the need is still felt to be able to combine different substances with different properties, in such proportions as to exhibit synergistic effects in terms of efficacy for maintaining the functionality of the prostate and at the same time able to be well tolerated.
Infatti, ci sono vari problemi tecnici che una composizione ideale dovrebbe risolvere. In particolare, tali composizioni dovrebbero: In fact, there are various technical problems that an ideal composition should solve. In particular, such compositions should:
- essere efficaci, - avere una buona biodisponibilità dei principi attivi, - essere ben tollerate, - be effective, - have good bioavailability of the active ingredients, - be well tolerated,
- mostrare bassissima tossicità, - essere adatte anche per usi prolungati e ripetuti, - essere di facile somministrazione, per esempio in forma di capsule o di compresse, - avere un odore e un sapore non sgradevoli, - essere preferibilmente realizzate con ingredienti naturali - complessivamente quindi dovrebbero avere una buona compliance da parte dei soggetti che le assumono, per esempio fornendo una dose efficace di numerosi principi attivi che agiscono in sinergia, senza che la forma di somministrazione per via orale (per esempio compressa o capsula) abbia grosse dimensioni (per esempio dovrebbe avere un peso inferiore a 1,5 g), e senza che siano richieste numerose somministrazioni giornaliere, preferibilmente cioè siano somministrabili una sola volta al giorno. - show very low toxicity, - be suitable also for prolonged and repeated use, - be easy to administer, for example in capsule or tablet form, - have a non-unpleasant smell and taste, - be preferably made with natural ingredients - overall therefore they should have good compliance on the part of the subjects who take them, for example by providing an effective dose of numerous active ingredients that act in synergy, without the form of oral administration (for example tablet or capsule) having large dimensions (for example should have a weight of less than 1.5 g), and without requiring numerous daily administrations, that is, preferably they can be administered only once a day.
È una caratteristica delle presenti composizioni contenere solo una quantità relativamente piccola di additivi e/o eccipienti, dato il contenuto elevato di principi attivi. Questo permette la produzione di forme di dosaggio unitario fisicamente piccole. La quantità totale di additivi e/o eccipienti in un dato dosaggio unitario può essere circa il 70% in peso o inferiore in base al peso totale della composizione, più in particolare circa il 60% o inferiore. Preferibilmente, l’additivo contenuto è nell’intervallo circa dal 20% al 60% in peso, più in particolare l’additivo contenuto varia da circa il 30% a circa il 55% in peso. It is a characteristic of the present compositions to contain only a relatively small amount of additives and / or excipients, given the high content of active ingredients. This allows for the production of physically small unit dosage forms. The total amount of additives and / or excipients in a given unit dosage may be about 70% by weight or less based on the total weight of the composition, more particularly about 60% or less. Preferably, the additive contained is in the range from about 20% to 60% by weight, more particularly the additive contained varies from about 30% to about 55% by weight.
SOMMARIO DELL’INVENZIONE Lo scopo di cui sopra è stato raggiunto mediante una composizione comprendente una combinazione unica di ingredienti compresi: SUMMARY OF THE INVENTION The above purpose was achieved by means of a composition comprising a unique combination of ingredients including:
estratto di fiori di fico d'India in olio di Serenoa microincapsulato, estratto di caffè verde contenente acidi clorogenici, chitosano. prickly pear flower extract in microencapsulated Serenoa oil, green coffee extract containing chlorogenic acids, chitosan.
Gli inventori della presente invenzione hanno sorprendentemente trovato che i seguenti ingredienti: The inventors of the present invention have surprisingly found that the following ingredients:
estratto di fiori di fico d'India (OPUNTIA FICUS-INDICA) in olio di Serenoa (SERENOA REPENS) microincapsulato, estratto di caffè verde (COFFEA ARABICA) contenente acidi clorogenici, prickly pear flower extract (OPUNTIA FICUS-INDICA) in microencapsulated Serenoa oil (SERENOA REPENS), green coffee extract (COFFEA ARABICA) containing chlorogenic acids,
chitosano, chitosan,
mostrano attività sinergica tra di loro in termini di efficacia per il mantenimento delle funzionalità della prostata con ttività antimicrobica, antiinfiammatoria ed antiiperlasia prostatica. they show synergistic activity with each other in terms of efficacy for maintaining the functionality of the prostate with antimicrobial, anti-inflammatory and antihyperlasia prostatic activity.
Un oggetto della presente invenzione è quindi una composizione a base di: An object of the present invention is therefore a composition based on:
estratto di fiori di fico d'India in olio di Serenoa repens microincapsulato, prickly pear flower extract in microencapsulated Serenoa repens oil,
estratto di caffè verde contenente acidi clorogenici, chitosano, green coffee extract containing chlorogenic acids, chitosan,
come delineata nelle annesse rivendicazioni da 1 a 8. as outlined in the attached claims 1 to 8.
Un altro oggetto dell’invenzione è un processo di produzione della composizione, come delineato nell’annessa rivendicazione 9. Another object of the invention is a composition production process, as outlined in the attached claim 9.
Un ulteriore oggetto dell’invenzione sono le composizioni dell’invenzione per l’uso nel mantenimento della funzionalità della prostata, come delineato nell’annessa rivendicazione 10. A further object of the invention are the compositions of the invention for use in maintaining the functionality of the prostate, as outlined in the attached claim 10.
Il testo delle annesse rivendicazioni forma parte integrante della presente descrizione. The text of the attached claims forms an integral part of the present description.
Ulteriori caratteristiche e vantaggi delle composizioni e del processo secondo l’invenzione risulteranno dalla descrizione di seguito riportata di esempi di realizzazione, dati a titolo indicativo e non limitativo. Further characteristics and advantages of the compositions and of the process according to the invention will result from the following description of examples of embodiments, given for information only and not limitative.
DESCRIZIONE DETTAGLIATA DELL’INVENZIONE DETAILED DESCRIPTION OF THE INVENTION
Secondo una prima forma di realizzazione, la presente invenzione riguarda una composizione a base di: According to a first embodiment, the present invention relates to a composition based on:
estratto di fiori di fico d'India in olio di Serenoa repens microincapsulato, prickly pear flower extract in microencapsulated Serenoa repens oil,
estratto di caffè verde contenente acidi clorogenici, chitosano, green coffee extract containing chlorogenic acids, chitosan,
in cui: in which:
- L’estratto di fiori di fico d'India in olio di Serenoa repens microincapsulato è un estratto liposolubile di fiori di fico d'India in olio di Serenoa repens. Tale estratto viene poi microincapsulato per conferirgli una forma solida e poter essere utilizzato anche in forme farmaceutiche quali capsule, compresse e granulati. Tale estratto può essere ottenuto mediante macerazione dei fiori di fico d'India in olio di Serenoa repens, oppure assemblando un estratto liposolubile di fiori di fico d'India ottenuto, per esempio, in fluidi supercritici quali CO2 supercritica con l'olio di Serenoa repens, e successivamente microincapsulando la miscela. L’estratto di fiori di fico d'India in olio di Serenoa repens microincapsulato è caratterizzato da un contenuto di acidi grassi totali uguale o superiore al 60% p/p e un contenuto di polifenoli totali uguale o superiore a 10 ppm. - The extract of prickly pear flowers in microencapsulated Serenoa repens oil is a fat-soluble extract of prickly pear flowers in Serenoa repens oil. This extract is then microencapsulated to give it a solid form and can also be used in pharmaceutical forms such as capsules, tablets and granules. This extract can be obtained by macerating prickly pear flowers in Serenoa repens oil, or by assembling a fat-soluble extract of prickly pear flowers obtained, for example, in supercritical fluids such as supercritical CO2 with Serenoa repens oil. , and subsequently microencapsulating the mixture. The extract of prickly pear flowers in microencapsulated Serenoa repens oil is characterized by a total fatty acid content equal to or greater than 60% w / w and a total polyphenol content equal to or greater than 10 ppm.
- L'estratto di caffè verde contenente acidi clorogenici è un estratto di caffè verde caratterizzato da un contenuto di polifenoli totali espressi come acidi clorogenici uguale o superiore al 50%p/p. - Green coffee extract containing chlorogenic acids is a green coffee extract characterized by a content of total polyphenols expressed as chlorogenic acids equal to or greater than 50% w / w.
- Il chitosano (numero CAS 9012-76-4) è un polimero della D-glucosammina, che si può ottenere per deacetilazione alcalina della chitina. Il processo industriale attualmente utilizzato è quello di partire dalla chitina purificata ottenuta da crostacei. Il chitosano si solubilizza facilmente e velocemente in soluzione acida per effetto della salificazione dei gruppi funzionali amminici. - Chitosan (CAS number 9012-76-4) is a polymer of D-glucosamine, which can be obtained by alkaline deacetylation of chitin. The industrial process currently used is that of starting from purified chitin obtained from crustaceans. Chitosan solubilizes easily and quickly in an acid solution due to the salification of the amino functional groups.
Secondo una forma di realizzazione preferita dell’invenzione, la suddetta composizione comprende una quantità di estratto di fiori di fico d'India in olio di Serenoa repens microincapsulato, estratto di caffè verde contenente acidi clorogenici e chitosano tale da apportare per singola dose di somministrazione un contenuto di: According to a preferred embodiment of the invention, the aforesaid composition comprises a quantity of extract of prickly pear flowers in microencapsulated Serenoa repens oil, green coffee extract containing chlorogenic acids and chitosan such as to provide for a single dose of administration a content of:
- polifenoli totali uguale o superiore a 50 mg, - acidi grassi totali uguale o superiore a 150 mg, - total polyphenols equal to or greater than 50 mg, - total fatty acids equal to or greater than 150 mg,
- polisaccaridi totali uguale o superiore a 20 mg. - total polysaccharides equal to or greater than 20 mg.
Secondo una forma di realizzazione preferita dell’invenzione, la suddetta composizione comprende una quantità di estratto di fiori di fico d'India in olio di Serenoa repens microincapsulato, estratto di caffè verde contenente acidi clorogenici, estratto di melograno contenente punicalagine e punicaline e chitosano tale da apportare per singola dose di somministrazione un contenuto di: According to a preferred embodiment of the invention, the aforesaid composition comprises a quantity of extract of prickly pear flowers in microencapsulated Serenoa repens oil, green coffee extract containing chlorogenic acids, pomegranate extract containing punicalagin and punicalin and chitosan such as to be made for a single dose of administration a content of:
- polifenoli totali uguale o superiore a 50 mg, - acidi grassi totali uguale o superiore a 150 mg, - polisaccaridi totali uguale o superiore a 20 mg, - punicaline e punicalagine totali uguale o superiore a 30 mg. - total polyphenols equal to or greater than 50 mg, - total fatty acids equal to or greater than 150 mg, - total polysaccharides equal to or greater than 20 mg, - total punicalins and punicalagins equal to or greater than 30 mg.
Secondo una forma di realizzazione preferita dell’invenzione, la suddetta composizione comprende una quantità di estratto di fiori di fico d'India in olio di Serenoa repens microincapsulato, estratto di caffè verde contenente acidi clorogenici, polvere di Capsicum e chitosano tale da apportare per singola dose di somministrazione un contenuto di: According to a preferred embodiment of the invention, the aforesaid composition comprises a quantity of extract of prickly pear flowers in microencapsulated Serenoa repens oil, green coffee extract containing chlorogenic acids, Capsicum powder and chitosan such as to provide for each individual administration dose a content of:
- polifenoli totali uguale o superiore a 50 mg, - acidi grassi totali uguale o superiore a 150 mg, - polisaccaridi totali uguale o superiore a 20 mg, - total polyphenols equal to or greater than 50 mg, - total fatty acids equal to or greater than 150 mg, - total polysaccharides equal to or greater than 20 mg,
- capsaicina uguale o superiore a 1 ppm. - capsaicin equal to or greater than 1 ppm.
Secondo una forma di realizzazione preferita dell’invenzione, la suddetta composizione comprende una quantità di estratto di fiori di fico d'India in olio di Serenoa repens microincapsulato, estratto di caffè verde contenente acidi clorogenici, estratto di tè verde contenente epigallocatechina gallato e chitosano tale da apportare per singola dose di somministrazione un contenuto di: According to a preferred embodiment of the invention, the aforesaid composition comprises an amount of prickly pear flower extract in microencapsulated Serenoa repens oil, green coffee extract containing chlorogenic acids, green tea extract containing epigallocatechin gallate and chitosan such to be made for a single dose of administration a content of:
- polifenoli totali uguale o superiore a 100 mg, - acidi grassi totali uguale o superiore a 150 mg, - polisaccaridi totali uguale o superiore a 20 mg. - total polyphenols equal to or greater than 100 mg, - total fatty acids equal to or greater than 150 mg, - total polysaccharides equal to or greater than 20 mg.
Secondo una forma di realizzazione preferita dell’invenzione, la suddetta composizione comprende una quantità di estratto di fiori di fico d'India in olio di Serenoa repens microincapsulato, estratto di caffè verde contenente acidi clorogenici, polvere di Capsicum e chitosano tale da apportare per singola dose di somministrazione un contenuto di: According to a preferred embodiment of the invention, the aforesaid composition comprises a quantity of extract of prickly pear flowers in microencapsulated Serenoa repens oil, green coffee extract containing chlorogenic acids, Capsicum powder and chitosan such as to provide for each individual administration dose a content of:
- polifenoli totali uguale o superiore a 120 mg, - acidi grassi totali uguale o superiore a 150 mg, - polisaccaridi totali uguale o superiore a 20 mg, - capsaicina uguale o superiore a 1 ppm. - total polyphenols equal to or greater than 120 mg, - total fatty acids equal to or greater than 150 mg, - total polysaccharides equal to or greater than 20 mg, - capsaicin equal to or greater than 1 ppm.
Il termine “polifenoli totali”, come utilizzato qui, indica la quantità totale di composti a struttura polifenolica, espressi come equivalenti di acido caffeico e determinati analiticamente mediante il metodo di Folin-Ciocalteu [Ainsworth EA e Gillespie KM. Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin-Ciocalteu reagent. Nature Protocols 2007;2:875-875]. The term "total polyphenols", as used herein, indicates the total amount of compounds with a polyphenolic structure, expressed as caffeic acid equivalents and determined analytically by the Folin-Ciocalteu method [Ainsworth EA and Gillespie KM. Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin-Ciocalteu reagent. Nature Protocols 2007; 2: 875-875].
Il termine“acidi grassi totali”, come utilizzato qui, indica la quantità totale di acidi grassi liberi e provenienti dall'idrolisi di loro esteri quali trigliceridi, digliceridi, ecc.. Hanno una struttura di acido monocarbossilico alifatico, prevalentemente, ma non esclusivamente, a lunga catena, con un numero pari di atomi di carbonio, senza ramificazioni e aciclici; possono essere saturi o insaturi. Vengono determinati analiticamente mediante cromatografia gas-liquida [Horning EC, Arrens EH, Lipsky SR, Mattson FH, Mead JF, Turner DA, Goldwater WH. Quantitative Analysis of Fatty Acids by Gas-Liquid Chromatography. J. LipidRes., 1964;5:20-27]. Sono esempi di acidi grassi gli acidi miristico, palmitico, palmitoleico, stearico, oleico, linoleico, alfa-linolenico, arachidonico, eicosenoico, behenico, erucico e simili. The term "total fatty acids", as used here, indicates the total quantity of free fatty acids coming from the hydrolysis of their esters such as triglycerides, diglycerides, etc. They have a structure of aliphatic monocarboxylic acid, mainly, but not exclusively, long chain, with an even number of carbon atoms, without branching and acyclic; they can be saturated or unsaturated. They are determined analytically by gas-liquid chromatography [Horning EC, Arrens EH, Lipsky SR, Mattson FH, Mead JF, Turner DA, Goldwater WH. Quantitative Analysis of Fatty Acids by Gas-Liquid Chromatography. J. LipidRes., 1964; 5: 20-27]. Examples of fatty acids are myristic, palmitic, palmitoleic, stearic, oleic, linoleic, alpha-linolenic, arachidonic, eicosenoic, behenic, erucic acids and the like.
Il termine “polisaccaridi totali”, come utilizzato qui, indica la quantità totale di vari polisaccaridi. I polisaccaridi sono composti chimici organici che appartengono alla classe dei glucidi (carboidrati). Sono caratterizzati da un numero elevato (superiore a 20) di unità ripetitive (monosaccaridi), legate insieme per formare molecole grandi e complesse. I polisaccaridi possono essere lineari o ramificati. Vengono determinati analiticamente mediante metodi spettrofotometrici o HPLC [Food Analysis, a cura di S. Nielsen, 2010; Pomeranz Y, Meloan CE. Food Analysis - Theory and Practice, 2000]. In natura, i polisaccaridi si trovano comunemente nelle piante, dove costituiscono dal 50% al 90%del loro peso secco. The term "total polysaccharides", as used herein, means the total amount of various polysaccharides. Polysaccharides are organic chemical compounds that belong to the class of carbohydrates (carbohydrates). They are characterized by a large number (greater than 20) of repeating units (monosaccharides), bound together to form large and complex molecules. Polysaccharides can be linear or branched. They are determined analytically by spectrophotometric methods or HPLC [Food Analysis, edited by S. Nielsen, 2010; Pomeranz Y, Meloan CE. Food Analysis - Theory and Practice, 2000]. In nature, polysaccharides are commonly found in plants, where they make up 50% to 90% of their dry weight.
I termini "punicalagine" e"punicaline" indicano sostanze ad attività antiossidante presenti nel frutto del melograno (Punica granatum) e vengono determinate analiticamente mediante analisi cromatografiche (HPLC). The terms "punicalagine" and "punicalin" indicate substances with antioxidant activity present in the fruit of the pomegranate (Punica granatum) and are analytically determined by chromatographic analysis (HPLC).
Il termine "microincapsulazione", come utilizzato qui, indica un processo che consiste nel rivestire minute goccioline di liquido con una sottile pellicola, di solito costituita da polimeri naturali o sintetici, in modo da formare microcapsule. Questa tecnica permette di migliorare o modificare varie caratteristiche e proprietà del materiale microincapsulato, oltre a conferire protezione, stabilizzazione e ad ottimizzarne il rilascio e la biodisponibilità. Il termine “microincapsulato”, come utilizzato qui, indica un estratto vegetale o un olio essenziale sottoposto al processo di microincapsulazione. The term "microencapsulation", as used herein, refers to a process which consists of coating minute droplets of liquid with a thin film, usually made of natural or synthetic polymers, to form microcapsules. This technique allows to improve or modify various characteristics and properties of the microencapsulated material, as well as providing protection, stabilization and optimizing its release and bioavailability. The term "microencapsulated", as used herein, refers to a plant extract or essential oil that has undergone the microencapsulation process.
Il termine “singola dose di somministrazione”, come utilizzato qui, indica la dose di composizione in forma di capsula, compressa, granulato assunta con un'unica somministrazione orale. The term "single dose administration", as used herein, means the dose of composition in capsule, tablet, granulate form taken with a single oral administration.
La composizione dell’invenzione può comprendere anche ulteriori ingredienti ed eccipienti quali, ma senza limitazione, vitamine, minerali, altri estratti vegetali, eccipienti per la microincapsulazione, eccipienti di compressione, emollienti, umettanti, leganti, modificatori della reologia, regolatori di pH, acqua e simili. Per esempio, la composizione dell’invenzione può comprendere maltodestrine, cellulosa microcristallina, gomma arabica, magnesio stearato, silice, e simili. The composition of the invention may also comprise further ingredients and excipients such as, but not limited to, vitamins, minerals, other plant extracts, excipients for microencapsulation, compression excipients, emollients, humectants, binders, rheology modifiers, pH regulators, water and similar. For example, the composition of the invention may include maltodextrin, microcrystalline cellulose, gum arabic, magnesium stearate, silica, and the like.
Esempi nonlimitanti di vitamine che possonoessere utilizzate nella composizione della presente invenzione sono la vitamina D3 (colecalciferolo) e la vitamina E (tocoferolo) e suoi derivati quali la vitamina E acetato. Non-limiting examples of vitamins that can be used in the composition of the present invention are vitamin D3 (cholecalciferol) and vitamin E (tocopherol) and its derivatives such as vitamin E acetate.
Esempi nonlimitanti di minerali che possonoessere utilizzati nella composizione della presente invenzione sono magnesio, sotto forma, per esempio ma senza limitazione, di magnesio ossido, sodio, sotto forma, per esempio ma senza limitazione, di sodio selenito, e simili. Non-limiting examples of minerals which can be used in the composition of the present invention are magnesium, in the form, for example but without limitation, of magnesium oxide, sodium, in the form, for example but without limitation, of sodium selenite, and the like.
Esempi non limitanti di altri estratti vegetali che possono essere utilizzati nella composizione della presente invenzione sono: un estratto di tè verde (Camellia sinensis), un estratto di Boswellia serrata, un estratto di aglio (Allium sativum), un estratto di Serenoa repens, un estratto di mirtillo (Vaccinium myrtillus), un estratto di Capsicum sp. (per esempio Capsicum annuum), un olio essenziale di menta, un estratto di Pygeum africanum, e simili. Non-limiting examples of other plant extracts that can be used in the composition of the present invention are: a green tea extract (Camellia sinensis), a Boswellia serrata extract, a garlic extract (Allium sativum), a Serenoa repens extract, a blueberry extract (Vaccinium myrtillus), an extract of Capsicum sp. (e.g. Capsicum annuum), an essential oil of peppermint, an extract of Pygeum africanum, and the like.
Un esempio non limitante di eccipiente per la microincapsulazione che può essere utilizzato nella composizione della presente invenzione è gelatina. A non-limiting example of an excipient for microencapsulation that can be used in the composition of the present invention is gelatin.
La composizione può inoltre contenere ulteriori eccipienti o altri principi attivi a seconda della tipologia di formulazione che si desidera preparare. The composition may also contain further excipients or other active ingredients according to the type of formulation to be prepared.
In certe forme di realizzazione, la composizione è una capsula. In certain embodiments, the composition is a capsule.
In certe forme di realizzazione, la composizione è una compressa. In certain embodiments, the composition is a tablet.
In certe forme di realizzazione, la composizione è un granulato. In certain embodiments, the composition is a granulate.
Un altro oggetto dell’invenzione è un processo di produzione della composizione della presente invenzione. Il processo di produzione comprende le seguenti fasi (Schema 1): Another object of the invention is a production process of the composition of the present invention. The manufacturing process includes the following steps (Scheme 1):
Schema 1: Scheme 1:
cernita delle materie prime sorting of raw materials
miscelazione dei principi attivi contenenti polifenoli con chitosano mixing of the active ingredients containing polyphenols with chitosan
aggiunta degli altri principi attivi e miscelazione addition of the other active ingredients and mixing
aggiunta degli eccipienti e dei veicolati accettabili e addition of excipients and acceptable carriers e
miscelazione mixing
scarico e trasferimento in bulk bulk unloading and transfer
ripartizione e confezionamento distribution and packaging
ESEMPI EXAMPLES
Esempio 1 - composizione in capsule Example 1 - composition in capsules
Mediante il processo illustrato nello Schema 1, una composizione è stata preparata utilizzando i seguenti ingredienti (Tabella 1): By the process illustrated in Scheme 1, a composition was prepared using the following ingredients (Table 1):
Tabella 1. Table 1.
MATERIA PRIMA Quantità Vitamina D3 - colecalciferolo 0,05 mg Capsicumin polvere 5 mg Estratto di fiori di fico d'India in olio di 150 mg serenoa microincapsulato RAW MATERIAL Quantity Vitamin D3 - cholecalciferol 0.05 mg Capsicumin powder 5 mg Prickly pear flower extract in oil of 150 mg serenoa microencapsulated
Sodio selenito 0,1 mg Estratto secco di caffè verde titolato in acidi 240 mg clorogenici al 50% Sodium selenite 0.1 mg Dry extract of green coffee titrated in 240 mg chlorogenic acids at 50%
Chitosano 30 mg Eccipienti q.b. a 500 mg Totale 500 mg Chitosan 30 mg Excipients q.s. to 500 mg Total 500 mg
Esempio 2 - composizione in compresse Example 2 - tablet composition
Mediante il processo illustrato nello Schema 1, una composizione è stata preparata utilizzando i seguenti ingredienti (Tabella 2): By the process illustrated in Scheme 1, a composition was prepared using the following ingredients (Table 2):
Tabella 2. Table 2.
MATERIA PRIMA Quantità Vitamina D3 0,025 mg Licopene 20 mg Estratto di fiori di fico d'India in olio di 300 mg serenoa microincapsulato RAW MATERIAL Quantity Vitamin D3 0.025 mg Lycopene 20 mg Prickly pear flower extract in 300 mg serenoa microencapsulated oil
Zinco ossido 15 mg Olio essenziale di menta microincapsulato 7 mg Estratto di melograno 100 mg Sodio selenito 0,05 mg Vitamina E acetato 12 mg Estratto secco di caffè verde titolato in acidi 100 mg clorogenici al 50% Zinc oxide 15 mg Microencapsulated mint essential oil 7 mg Pomegranate extract 100 mg Sodium selenite 0.05 mg Vitamin E acetate 12 mg Dry extract of green coffee titrated in 100 mg chlorogenic acids at 50%
Chitosano 50 mg Eccipienti q.b. a 800 mg Totale 800 mg Esempio 3 - composizione in compresse Chitosan 50 mg Excipients q.s. at 800 mg Total 800 mg Example 3 - composition in tablets
Mediante il processo illustrato nello Schema 1, una composizione è stata preparata utilizzando i seguenti ingredienti (Tabella 3): By the process illustrated in Scheme 1, a composition was prepared using the following ingredients (Table 3):
Tabella 3. Table 3.
MATERIA PRIMA Quantità RAW MATERIAL Quantity
Estratto secco di Boswellia serrata titolato in 100 mg Boswellia serrata dry extract titrated in 100 mg
acidi boswellici al 65% 65% boswellic acids
Vitamina D3 0,125 mg Vitamin D3 0.125 mg
Licopene 10 mg Lycopene 10 mg
Estratto di fiori di fico d'India in olio di 230 mg Prickly pear flower extract in 230 mg oil
serenoa microincapsulato microencapsulated serenoa
Estratto secco di ortica (Urtica dioica) 75 mg Dry extract of nettle (Urtica dioica) 75 mg
Capsicumpolvere 4 mg Capsicum powder 4 mg
Estratto secco di bilberry (Vacciniummyrtillus) 10 mg Dry extract of bilberry (Vacciniummyrtillus) 10 mg
Estratto secco di zenzero (Zingiber officinale) 5 mg Dry extract of ginger (Zingiber officinale) 5 mg
titolato in gingeroli al 20% titrated in gingerols at 20%
Estratto secco di tè verde (Camellia sinensis) 50 mg Dry extract of green tea (Camellia sinensis) 50 mg
titolato in epigallocatechina gallato (EGCG) al titrated in epigallocatechin gallate (EGCG) al
95% 95%
Sodio selenito 0,014 mg Sodium selenite 0.014 mg
Zinco ossido 3,5 mg Zinc oxide 3.5 mg
Vitamina E acetato 3 mg Vitamin E acetate 3 mg
Estratto secco di caffè verde titolato in acidi 100 mg Dry extract of green coffee titrated in acids 100 mg
clorogenici al 50% 50% chlorogenic
Chitosano 22,5 mg Chitosan 22.5 mg
Eccipienti q.b. a 800 mg Totale 800 Excipients q.s. at 800 mg Total 800
È evidente che sono state descritte solo alcune forme particolari di realizzazione della presente invenzione, cui l’esperto dell’arte sarà in grado di apportare tutte quelle modifiche necessarie per il suo adattamento a particolari applicazioni, senza peraltro discostarsi dall’ambito di protezione della presente invenzione. It is evident that only some particular embodiments of the present invention have been described, to which the skilled in the art will be able to make all those modifications necessary for its adaptation to particular applications, without however departing from the scope of protection of the present invention. invention.
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102019000010800A IT201900010800A1 (en) | 2019-07-03 | 2019-07-03 | COMPOSITION CONTAINING PRICKLY PEAR EXTRACT IN SERENOA OIL FOR THE MAINTENANCE OF PROSTATE FUNCTIONALITY |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102019000010800A IT201900010800A1 (en) | 2019-07-03 | 2019-07-03 | COMPOSITION CONTAINING PRICKLY PEAR EXTRACT IN SERENOA OIL FOR THE MAINTENANCE OF PROSTATE FUNCTIONALITY |
Publications (1)
Publication Number | Publication Date |
---|---|
IT201900010800A1 true IT201900010800A1 (en) | 2021-01-03 |
Family
ID=68343344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT102019000010800A IT201900010800A1 (en) | 2019-07-03 | 2019-07-03 | COMPOSITION CONTAINING PRICKLY PEAR EXTRACT IN SERENOA OIL FOR THE MAINTENANCE OF PROSTATE FUNCTIONALITY |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT201900010800A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022269099A1 (en) * | 2021-06-25 | 2022-12-29 | Esserre Pharma Srl | Composition based on plant extracts and use thereof for the prevention and/or treatment of carbohydrate and lipid dysmetabolism |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100204319A1 (en) * | 2006-10-17 | 2010-08-12 | Summa Development Limited | Treatment for benign prostatic hyperplasia |
US20160136100A1 (en) * | 2002-04-10 | 2016-05-19 | Innercap Technologies, Inc. | Multi-phase, multi-compartment, capsular delivery apparatus and methods for using same |
-
2019
- 2019-07-03 IT IT102019000010800A patent/IT201900010800A1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160136100A1 (en) * | 2002-04-10 | 2016-05-19 | Innercap Technologies, Inc. | Multi-phase, multi-compartment, capsular delivery apparatus and methods for using same |
US20100204319A1 (en) * | 2006-10-17 | 2010-08-12 | Summa Development Limited | Treatment for benign prostatic hyperplasia |
Non-Patent Citations (25)
Title |
---|
"Food Analysis", 2010 |
AINSWORTH EAGILLESPIE KM: "Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin-Ciocalteu reagent", NATURE PROTOCOLS, vol. 2, 2007, pages 875 - 875 |
ANONYMOUS: "ARAMIS - Elekea srls", 1 January 2018 (2018-01-01), pages 1 - 3, XP055662982, Retrieved from the Internet <URL:http://www.elekea.it/specifici-per-uomo/3-aramis-8056746250027.html> [retrieved on 20200129] * |
ANONYMOUS: "Life Extension | Nutritional Interventions for BPH", 2 November 2017 (2017-11-02), pages 1 - 9, XP055662949, Retrieved from the Internet <URL:http://web.archive.org/web/20171102165031/http://www.lifeextension.com/Protocols/Male-Reproductive/Benign-Prostatic-Hyperplasia/Page-06> [retrieved on 20200129] * |
ANONYMOUS: "Prosta Guard - Combination tab", 25 February 2018 (2018-02-25), pages 1, XP055662658, Retrieved from the Internet <URL:http://web.archive.org/web/20180225222231/https://www.supherb.co.il/en/it-works-naturally/special-formulas/prosta-guard/#tab04> [retrieved on 20200128] * |
ANONYMOUS: "Prosta Guard - To help preserve the Health of the Prostate Gland - SupHerb", 25 February 2018 (2018-02-25), pages 1 - 2, XP055662603, Retrieved from the Internet <URL:http://web.archive.org/web/20180225222231/https://www.supherb.co.il/en/it-works-naturally/special-formulas/prosta-guard/> [retrieved on 20200128] * |
ANONYMOUS: "Prosta Guard For Guarding the Health of the Prostate Gland 60 tabs - SupHerb", 25 October 2016 (2016-10-25), pages 1 - 4, XP055662461, Retrieved from the Internet <URL:http://web.archive.org/web/20161025225659/http://www.vitaminglobal.com/prosta-guard-for-guarding-the-health-of-the-prostate-gland-60-tabs-supherb-p-1790-c-7_40_47.html> [retrieved on 20200128] * |
ANONYMOUS: "Prosta Guard", 25 February 2018 (2018-02-25), pages 1, XP055662615, Retrieved from the Internet <URL:http://web.archive.org/web/20180225222231im_/https://www.supherb.co.il/media/17760/prosta_guard_en_lable.jpg> [retrieved on 20200128] * |
ANONYMOUS: "PROSTAFLOR 40CPS 20G", 1 January 2018 (2018-01-01), pages 1 - 7, XP055663189, Retrieved from the Internet <URL:https://farmaciaammirati.it/avd-reform-srl/prostaflor-40cps-20g?limit=50> [retrieved on 20200129] * |
ANONYMOUS: "REGISTRO INTEGRATORI ELENCO IN ORDINE ALFABETICO PER IMPRESA", 2 September 2018 (2018-09-02), pages 1 - 2176, XP055663066, Retrieved from the Internet <URL:http://web.archive.org/web/20180902084536if_/http://www.salute.gov.it/imgs/C_17_pagineAree_3668_listaFile_itemName_1_file.pdf> [retrieved on 20200129] * |
ANONYMOUS: "SupHerb - Alpha Anti Oxidant", 27 February 2018 (2018-02-27), pages 1 - 2, XP055662839, Retrieved from the Internet <URL:http://web.archive.org/web/20180227042505/http://www.supherb.co.il/en/it-works-naturally/stress-anxiety/alpha-anti-oxidant/> [retrieved on 20200128] * |
ANY ET AL.: "Effects of long-term treatment with Serenoa repens (Permixon)on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia", PROSTATE, vol. 37, 1998, pages 77 - 83, XP009143666 |
AZIMI HANIEH ET AL: "A Review of Animal and Human Studies for Management of Benign Prostatic Hyperplasia with Natural Products: Perspective of New Pharmacological Agents", INFLAMMATION & ALLERGY DRUG TARGETS, BENTHAM SCIENCE PUBLISHERS, NL, vol. 11, no. 3, 1 June 2012 (2012-06-01), pages 207 - 221, XP009180305, ISSN: 1871-5281, DOI: 10.2174/187152812800392715 * |
DAN PALEVITCH ET AL: "Treatment of Benign Prostatic Hypertrophy with Opuntia ficus-indica (L.) Miller", INTERNATIONAL JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, vol. 21, 1 January 1994 (1994-01-01), pages 1 - 3, XP055662443 * |
DUBE ANICOLAZZO JALARSON I: "Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins ( + ) -Laid and ( - ) -epigallocatechin gallate", EUR. J. PHARM. SCI., vol. 41, no. 2, 2010, pages 219 - 225, XP027226313 |
HOMING ECARRENS EHLIPSKY SRMATTSON FHMEAD JF: "Quantitative analysis of Fatty Acids by Gas-Liquid Chromatography", J. LIPID RES., vol. 5, 1964, pages 20 - 27 |
HONG HEEOK ET AL: "Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia", NUTRITION RESEARCH AND PRACTICE,, vol. 3, no. 4, 1 January 2009 (2009-01-01), pages 323 - 327, XP009143661, DOI: 10.4162/NRP.2009.3.4.323 * |
HUANG YCHEN HZHOU XWU XHUJIANG Z: "Inhibition effects of chlorogenic acid on benign prostatic hyperplasia in mice", EUR. J. PHARMACOL., vol. 809, 2017, pages 191 - 195 |
JONAS A ET AL: "CACTUS FLOWER EXTRACTS MAY PROVE BENEFICIAL IN BENIGN PROSTATIC HYPERPLASIA DUE TO INHIBITION OF 5 ALPHA REDUCTASE ACTIVITY, AROMATASE ACTIVITY AND LIPID PEROXIDATION", UROLOGICAL RESEARCH, SPRINGER VERLAG, BERLIN, DE, vol. 26, no. 4, 1 January 1998 (1998-01-01), pages 265 - 270, XP002189154, ISSN: 0300-5623, DOI: 10.1007/S002400050055 * |
KHAN NAGHMA ET AL: "Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model", CARCINOGENESIS, OXFORD UNIVERSITY PRESS, GB, vol. 35, no. 2, 1 February 2014 (2014-02-01), pages 415 - 423, XP008183605, ISSN: 0143-3334, [retrieved on 20150926], DOI: 10.1093/CARCIN/BGT321 * |
POMERANZ YMELOAN CE, FOOD ANALYSIS - THEORY AND PRACTICE, 2000 |
SAMUEL OSCHIN: "Pepper Component Hot Enough To Trigger Suicide In Prostate Cancer Cells -- ScienceDaily", 19 March 2006 (2006-03-19), pages 1 - 5, XP055662864, Retrieved from the Internet <URL:https://www.sciencedaily.com/releases/2006/03/060319150754.htm> [retrieved on 20200128] * |
SULTAN ET AL.: "Inhibition of androgen metabolism and binding by a liposterolic extract of Serenoa repens ''B'' in human foreskin fibroblasts", J STEROID BIOCHEM, vol. 20, 1984, pages 515 - 519, XP023412935, DOI: 10.1016/0022-4731(84)90264-4 |
THANOU MVERHOEF JCJUNGINGER HE: "Chitosan and its derivatives as intestinal absorption enhancers", ADV. DRUG. DELIV. REV., vol. 50, no. 1, 2001, pages 91 - 101 |
YA HUANG ET AL: "Inhibition effects of chlorogenic acid on benign prostatic hyperplasia in mice", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 809, 1 August 2017 (2017-08-01), NL, pages 191 - 195, XP055662857, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2017.04.017 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022269099A1 (en) * | 2021-06-25 | 2022-12-29 | Esserre Pharma Srl | Composition based on plant extracts and use thereof for the prevention and/or treatment of carbohydrate and lipid dysmetabolism |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Jagetia | Phytochemical Composition and pleotropic pharmacological properties of jamun, Syzygium cumini skeels | |
Bijauliya et al. | A comprehensive review on herbal cosmetics | |
He et al. | Research progress on the health function of tea oil | |
AU2011285025B2 (en) | Formulations containing extracts of Echinacea angustifolia and Zingiber officinale which are useful in reducing inflammation and peripheral pain | |
US20190008907A1 (en) | Compositions for management of wounds, skin diseases, dehydration, chronic diseases, and respiratory diseases | |
Sagbo et al. | Plants used for cosmetics in the Eastern Cape Province of South Africa: A case study of skin care | |
US20080254135A1 (en) | Resveratrol-containing compositions for general health and vitality | |
Silva et al. | Hypericum genus cosmeceutical application–A decade comprehensive review on its multifunctional biological properties | |
US11964045B2 (en) | Natural skin penetrating moisturizer formulations | |
JP2016539183A5 (en) | ||
CA3082615A1 (en) | Topical compositions, process of manufacture and method of use | |
US11564963B2 (en) | Topical compositions, process of large-scale manufacture, and method of use | |
WO2010097643A1 (en) | Formulation based on micronized zeolite, green tea extract, and genistein as a therapeutic agent for reduction of body weight and cellulite | |
Amra et al. | Therapeutic benefits of natural oils along with permeation enhancing activity | |
US20220273015A1 (en) | Formulations and uses thereof | |
Chekka et al. | Momordica charantia: A natural medicinal plant | |
IT201900010800A1 (en) | COMPOSITION CONTAINING PRICKLY PEAR EXTRACT IN SERENOA OIL FOR THE MAINTENANCE OF PROSTATE FUNCTIONALITY | |
CA3188531A1 (en) | Topical compositions, process of large-scale manufacture, and method of use | |
CA2627021A1 (en) | Combination natural source/local anesthetic/dual component penetration enhancer topical formulation useful for treating pain, itching and/or inflammation of the skin | |
US20200085959A1 (en) | Cannabinoid and Terpene-Infused Topical Cream | |
IT201900010806A1 (en) | COMPOSITION CONTAINING SEQUOIA EXTRACT IN PUMPKIN OIL TO MAINTAIN PROSTATE FUNCTIONALITY | |
DE202013005637U1 (en) | Agent with tocotrienol for burns from the sun, radioactive rays or heat | |
Porębska | Medicinal plants in nutricosmetics | |
CA3149121A1 (en) | Treatment of inflammatory skin conditions | |
Dhawal et al. | Wound healing potential of Vakeri fortified Kampillakadi Taila |