IT201900002155A1 - Vescicole extracellulari da cellule geneticamente modificate iperesprimenti SerpinB3 per uso come agenti terapeutici - Google Patents
Vescicole extracellulari da cellule geneticamente modificate iperesprimenti SerpinB3 per uso come agenti terapeuticiInfo
- Publication number
- IT201900002155A1 IT201900002155A1 IT102019000002155A IT201900002155A IT201900002155A1 IT 201900002155 A1 IT201900002155 A1 IT 201900002155A1 IT 102019000002155 A IT102019000002155 A IT 102019000002155A IT 201900002155 A IT201900002155 A IT 201900002155A IT 201900002155 A1 IT201900002155 A1 IT 201900002155A1
- Authority
- IT
- Italy
- Prior art keywords
- serpinb3
- therapeutic agents
- genetically modified
- modified cells
- extracellular vesicles
- Prior art date
Links
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102019000002155A IT201900002155A1 (it) | 2019-02-14 | 2019-02-14 | Vescicole extracellulari da cellule geneticamente modificate iperesprimenti SerpinB3 per uso come agenti terapeutici |
EP20709715.5A EP3923961A1 (en) | 2019-02-14 | 2020-02-14 | Extracellular vesicles isolated from genetically modified cells over-expressing serpinb3 for use in medicine |
PCT/IB2020/051244 WO2020165851A1 (en) | 2019-02-14 | 2020-02-14 | Extracellular vesicles isolated from genetically modified cells over-expressing serpinb3 for use in medicine |
US17/430,739 US20220143098A1 (en) | 2019-02-14 | 2020-02-14 | Extracellular vsicles isolated from genetically modified cells over-expressing serpinb3 for use in medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102019000002155A IT201900002155A1 (it) | 2019-02-14 | 2019-02-14 | Vescicole extracellulari da cellule geneticamente modificate iperesprimenti SerpinB3 per uso come agenti terapeutici |
Publications (1)
Publication Number | Publication Date |
---|---|
IT201900002155A1 true IT201900002155A1 (it) | 2020-08-14 |
Family
ID=66589717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT102019000002155A IT201900002155A1 (it) | 2019-02-14 | 2019-02-14 | Vescicole extracellulari da cellule geneticamente modificate iperesprimenti SerpinB3 per uso come agenti terapeutici |
Country Status (4)
Country | Link |
---|---|
US (1) | US20220143098A1 (it) |
EP (1) | EP3923961A1 (it) |
IT (1) | IT201900002155A1 (it) |
WO (1) | WO2020165851A1 (it) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014013258A1 (en) * | 2012-07-19 | 2014-01-23 | Reneuron Limited | Stem cell microparticles |
US20180220642A1 (en) * | 2015-07-29 | 2018-08-09 | Indiana University Research And Technology Corporation | Materials and methods for treating and evaluating ischemic and/or reperfusion-injured tissue and/or tissue susceptible to same |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017097854A1 (en) * | 2015-12-08 | 2017-06-15 | Umc Utrecht Holding B.V. | Extracellular vesicle markers for stable angina and unstable angina |
-
2019
- 2019-02-14 IT IT102019000002155A patent/IT201900002155A1/it unknown
-
2020
- 2020-02-14 US US17/430,739 patent/US20220143098A1/en active Pending
- 2020-02-14 WO PCT/IB2020/051244 patent/WO2020165851A1/en unknown
- 2020-02-14 EP EP20709715.5A patent/EP3923961A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014013258A1 (en) * | 2012-07-19 | 2014-01-23 | Reneuron Limited | Stem cell microparticles |
US20180220642A1 (en) * | 2015-07-29 | 2018-08-09 | Indiana University Research And Technology Corporation | Materials and methods for treating and evaluating ischemic and/or reperfusion-injured tissue and/or tissue susceptible to same |
Non-Patent Citations (12)
Title |
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CANNITO STURATO CPATERNOSTRO CBIASIOLO ACOLOMBATTO SCAMBIERI THEFOURTH SVILLANO GFASOLATO SMUSSO T: "Hypoxya up-regola SerpinB3 through HIF-2a in human liver cancer cells", ONCOTARGET, vol. 6, 2015, pages 2206 - 2221 |
FOURTH SVIDALINO LTURATO CRUVOLETTO MCALABRESE FVALENT MCANNITO SFASSINA GWORD MGATTA A: "SerpinB3 induces epithelial-mesenchymal transition", J PATHOL, vol. 221, 2010, pages 343 - 356 |
G, TURATOVILLANO CFOURTH SRUVOLETTO MCISCATO FPATERNOSTRO CWORD MSEMERARO RALVARO DBERNARDI P: "Hepatic progenitor cells overexpress SerpinB3", BMC CELL BIOL, 2014 |
HALL JUSTIN ET AL: "Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson's Disease, Glioma, and Schwannoma", CELLULAR AND MOLECULAR NEUROBIOLOGY, SPRINGER NEW YORK, US, vol. 36, no. 3, 26 March 2016 (2016-03-26), pages 417 - 427, XP035904161, ISSN: 0272-4340, [retrieved on 20160326], DOI: 10.1007/S10571-015-0309-0 * |
JOSEPH M CATANZARO ET AL: "SerpinB3/B4: Mediators of Ras-driven inflammation and oncogenesis", CELL CYCLE, vol. 13, no. 20, 15 October 2014 (2014-10-15), US, pages 3155 - 3156, XP055629521, ISSN: 1538-4101, DOI: 10.4161/15384101.2014.969991 * |
KOUREMBANAS S: "Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and vectors of Cell Therapy", ANNU REV PHYSIOL, vol. 77, 2015, pages 13 - 27 |
MURACA MSMALL MFRANZIN CPTOLEMY AMJURGA MM, POZZOBON PERILONGO G: "diverging Concepts and Novel Perspectives in Regenerative Medicine", INT. J. MOL. SCI., vol. 18, no. 5, 2017, pages 1021 |
RUENN CHAI LAI ET AL: "Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome", INTERNATIONAL JOURNAL OF PROTEOMICS, vol. 91, no. 7, 1 January 2012 (2012-01-01), pages 2573 - 14, XP055155534, ISSN: 2090-2166, DOI: 10.1155/2012/971907 * |
SCIACOVELLI CISCATO F, G, MVILLANO TURATO CBERNARDI PRASOLA APONTISSO P: "SerpinB3 protects from oidative damage by chemotherapeutics through inhibition of mithocondrial respratory complex I", ONCOTARGET, vol. 5, 2014, pages 2418 - 2427 |
TURATO CCANNITO SIMONATO S, G, DTERRIN LFOURTH SBIASIOLO ARUVOLETTO MMARTINI AFASOLATO SZANUS GCILLO U: "SerpinB3 and Yap interplay increases Myc oncogenic activity", SKI REP, vol. 5, 2015, pages 17701 |
TURATO CKENT PSEBASTIANI GCANNITO STERRIN LBIASIOLO ASIMONATO DWORD MPANTOPOULOS KPONTISSO P: "SerpinB3 is overexpressed in the liver in presence of iron Overload", J INVEST MED, vol. 66, 2018, pages 32 - 38 |
VIAUD SC THERY PLOIXS, T, V TURSZ LAPIERRELANTZ ZITVOGEL, LN CHAPUT: "Dendritic cell-derived exosomes for cancer immunotherapy: what's next?", CANCER RES, vol. 70, 2010, pages 1281 - 1285, XP055108702, DOI: doi:10.1158/0008-5472.CAN-09-3276 |
Also Published As
Publication number | Publication date |
---|---|
WO2020165851A1 (en) | 2020-08-20 |
EP3923961A1 (en) | 2021-12-22 |
US20220143098A1 (en) | 2022-05-12 |
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IT201900002155A1 (it) | Vescicole extracellulari da cellule geneticamente modificate iperesprimenti SerpinB3 per uso come agenti terapeutici |