IT201800009683A1 - Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone) - Google Patents
Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone)Info
- Publication number
- IT201800009683A1 IT201800009683A1 IT102018000009683A IT201800009683A IT201800009683A1 IT 201800009683 A1 IT201800009683 A1 IT 201800009683A1 IT 102018000009683 A IT102018000009683 A IT 102018000009683A IT 201800009683 A IT201800009683 A IT 201800009683A IT 201800009683 A1 IT201800009683 A1 IT 201800009683A1
- Authority
- IT
- Italy
- Prior art keywords
- brexanolone
- pregnan
- hydroxy
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102018000009683A IT201800009683A1 (it) | 2018-10-22 | 2018-10-22 | Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone) |
FR1911134A FR3087439B1 (fr) | 2018-10-22 | 2019-10-08 | Procédé pour la préparation de 3α-hydroxy-5α-prégnan-20-one (brexanolone) |
PCT/EP2019/078580 WO2020083839A1 (en) | 2018-10-22 | 2019-10-21 | Process for the preparation of 3alpha-hydroxy-5αlpha-pregnan-20-one (brexanolone) |
GB2106894.5A GB2593352B (en) | 2018-10-22 | 2019-10-21 | Process for the preparation of 3alpha-hydroxy-5alpha-pregnan-20-one (brexanolone) |
CH00429/21A CH716822B1 (it) | 2018-10-22 | 2019-10-21 | Processo per la preparazione di 3alpha-idrossi-5alpha-pregnan-20-one (Brexanolone). |
BR112021007009-5A BR112021007009A2 (pt) | 2018-10-22 | 2019-10-21 | processo para a preparação de 3a-hidróxi-5a-pregnan-20-ona (brexanolona) |
CA3116467A CA3116467A1 (en) | 2018-10-22 | 2019-10-21 | Process for the preparation of 3.alpha.-hydroxy-5.alpha.-pregnan-20-one (brexanolone) |
CN201980069735.0A CN112888701A (zh) | 2018-10-22 | 2019-10-21 | 用于制备3α-羟基-5α-孕烷-20-酮(布瑞诺龙)的工艺 |
US17/282,772 US20210388020A1 (en) | 2018-10-22 | 2019-10-21 | Process for the preparation of 3alpha-hydroxy-5alpha-pregnan-20-0ne (brexanolone) |
DE112019005261.6T DE112019005261T5 (de) | 2018-10-22 | 2019-10-21 | Verfahren zur Herstellung von 3α-Hydroxy-5α-pregnan-20-on (Brexanolon) |
ES202190022A ES2837136B2 (es) | 2018-10-22 | 2019-10-21 | Proceso para la preparación de 3alfa-hidroxi-5alfa-pregnan-20-ona (Brexanolona) |
AU2019369041A AU2019369041B2 (en) | 2018-10-22 | 2019-10-21 | Process for the preparation of 3alpha-hydroxy-5alphalpha-pregnan-20-one (Brexanolone) |
ARP190103008A AR116790A1 (es) | 2018-10-22 | 2019-10-22 | PROCEDIMIENTO PARA LA PREPARACIÓN DE 3a-HIDROXI-5a-PREGNAN-20-ONA (BREXANOLONA) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102018000009683A IT201800009683A1 (it) | 2018-10-22 | 2018-10-22 | Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone) |
Publications (1)
Publication Number | Publication Date |
---|---|
IT201800009683A1 true IT201800009683A1 (it) | 2020-04-22 |
Family
ID=65324443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT102018000009683A IT201800009683A1 (it) | 2018-10-22 | 2018-10-22 | Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone) |
Country Status (13)
Country | Link |
---|---|
US (1) | US20210388020A1 (it) |
CN (1) | CN112888701A (it) |
AR (1) | AR116790A1 (it) |
AU (1) | AU2019369041B2 (it) |
BR (1) | BR112021007009A2 (it) |
CA (1) | CA3116467A1 (it) |
CH (1) | CH716822B1 (it) |
DE (1) | DE112019005261T5 (it) |
ES (1) | ES2837136B2 (it) |
FR (1) | FR3087439B1 (it) |
GB (1) | GB2593352B (it) |
IT (1) | IT201800009683A1 (it) |
WO (1) | WO2020083839A1 (it) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT202000021316A1 (it) | 2020-09-09 | 2022-03-09 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI (3α,5α)-3-IDROSSI-3-METIL-PREGNAN-20-ONE (GANAXOLONE) |
CN112501235B (zh) * | 2020-11-19 | 2022-12-02 | 华东师范大学 | 一种利用单烯醇酮醋酸酯制备布瑞诺龙的方法 |
CN112516086B (zh) * | 2020-12-08 | 2022-05-20 | 武汉久安药物研究院有限公司 | 注射用布瑞诺龙脂肪乳及其制备方法 |
CN114031660A (zh) * | 2021-11-24 | 2022-02-11 | 南京迈诺威医药科技有限公司 | 一种17α-孕烯醇酮的制备方法 |
CN113861255B (zh) * | 2021-11-24 | 2022-09-02 | 南京迈诺威医药科技有限公司 | 一种别孕烷醇酮有关物质的制备方法 |
IT202100030671A1 (it) | 2021-12-03 | 2023-06-03 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI (3a,5a)-20-OSSOPREGNAN-3-IL GLICIL-L-VALINATO CLORIDRATO |
CN115806577A (zh) * | 2023-02-03 | 2023-03-17 | 北京鑫开元医药科技有限公司 | 一种布瑞诺龙的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB442319A (en) | 1933-12-23 | 1936-02-06 | Schering Kahlbaum Ag | Process for the production of pregnanolones |
US5795982A (en) * | 1994-06-02 | 1998-08-18 | Roussel Uclaf | Intermediates for 16β-methyl steroids |
US20140058079A1 (en) * | 2011-03-23 | 2014-02-27 | Centre National De La Recherche Scientifique-Cnrs | Derivatives of allopregnanolone and of epiallopregnanolone and uses thereof for treating a neuropathological condition |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3152121A (en) * | 1962-03-16 | 1964-10-06 | Upjohn Co | 20-ketals of 3-hydroxy-5 beta-pregnan-20-one |
US5795985A (en) * | 1996-03-05 | 1998-08-18 | Ciba Specialty Chemicals Corporation | Phenyl alkyl ketone substituted by cyclic amine and a process for the preparation thereof |
WO2011019821A2 (en) * | 2009-08-13 | 2011-02-17 | Marinus Pharmaceuticals, Inc. | METHOD FOR MAKING 3α-HYDROXY, 3β- METHYL-5α-PREGNAN-20-ONE (GANAXOLONE) |
-
2018
- 2018-10-22 IT IT102018000009683A patent/IT201800009683A1/it unknown
-
2019
- 2019-10-08 FR FR1911134A patent/FR3087439B1/fr active Active
- 2019-10-21 CH CH00429/21A patent/CH716822B1/it not_active IP Right Cessation
- 2019-10-21 CA CA3116467A patent/CA3116467A1/en active Pending
- 2019-10-21 AU AU2019369041A patent/AU2019369041B2/en active Active
- 2019-10-21 US US17/282,772 patent/US20210388020A1/en active Pending
- 2019-10-21 CN CN201980069735.0A patent/CN112888701A/zh active Pending
- 2019-10-21 WO PCT/EP2019/078580 patent/WO2020083839A1/en active Application Filing
- 2019-10-21 DE DE112019005261.6T patent/DE112019005261T5/de active Pending
- 2019-10-21 BR BR112021007009-5A patent/BR112021007009A2/pt unknown
- 2019-10-21 GB GB2106894.5A patent/GB2593352B/en active Active
- 2019-10-21 ES ES202190022A patent/ES2837136B2/es active Active
- 2019-10-22 AR ARP190103008A patent/AR116790A1/es unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB442319A (en) | 1933-12-23 | 1936-02-06 | Schering Kahlbaum Ag | Process for the production of pregnanolones |
US5795982A (en) * | 1994-06-02 | 1998-08-18 | Roussel Uclaf | Intermediates for 16β-methyl steroids |
US20140058079A1 (en) * | 2011-03-23 | 2014-02-27 | Centre National De La Recherche Scientifique-Cnrs | Derivatives of allopregnanolone and of epiallopregnanolone and uses thereof for treating a neuropathological condition |
EP2688902B1 (fr) | 2011-03-23 | 2017-12-27 | Université de Strasbourg | Derives de l'allopregnanolone et de l'epiallopregnanolone et leurs utilisations pour traiter un etat neuropathologique |
Non-Patent Citations (5)
Title |
---|
CHRISTOPHER J. MACNEVIN ET AL: "Development and Screening of Water-Soluble Analogues of Progesterone and Allopregnanolone in Models of Brain Injury", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 19, 8 October 2009 (2009-10-08), pages 6012 - 6023, XP055046453, ISSN: 0022-2623, DOI: 10.1021/jm900712n * |
J. P. WIEBE ET AL., STEROIDS, 1985, pages 39 - 51 |
NEVES ET AL., TETRAHEDRON, vol. 55, 1999, pages 3255 - 64 |
R. H. PURDY ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 6, 1990, pages 1572 - 1581 |
SUBRATO DAS ET AL: "Molecular Iodine in Protection and Deprotection Chemistry", SYNLETT, vol. 2008, no. 18, 1 October 2008 (2008-10-01), DE, pages 2741 - 2762, XP055601247, ISSN: 0936-5214, DOI: 10.1055/s-0028-1083503 * |
Also Published As
Publication number | Publication date |
---|---|
DE112019005261T5 (de) | 2021-07-01 |
BR112021007009A2 (pt) | 2021-07-13 |
GB2593352B (en) | 2022-07-27 |
AU2019369041A1 (en) | 2021-06-10 |
GB2593352A (en) | 2021-09-22 |
CA3116467A1 (en) | 2020-04-30 |
AU2019369041B2 (en) | 2024-06-27 |
CN112888701A (zh) | 2021-06-01 |
FR3087439A1 (fr) | 2020-04-24 |
ES2837136A2 (es) | 2021-06-29 |
AR116790A1 (es) | 2021-06-16 |
FR3087439B1 (fr) | 2022-12-23 |
ES2837136R1 (es) | 2023-08-18 |
CH716822B1 (it) | 2023-01-13 |
US20210388020A1 (en) | 2021-12-16 |
ES2837136B2 (es) | 2024-02-12 |
WO2020083839A1 (en) | 2020-04-30 |
GB202106894D0 (en) | 2021-06-30 |
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