IT201600130538A1 - Processo per la produzione del delmopinolo - Google Patents

Processo per la produzione del delmopinolo

Info

Publication number
IT201600130538A1
IT201600130538A1 IT102016000130538A IT201600130538A IT201600130538A1 IT 201600130538 A1 IT201600130538 A1 IT 201600130538A1 IT 102016000130538 A IT102016000130538 A IT 102016000130538A IT 201600130538 A IT201600130538 A IT 201600130538A IT 201600130538 A1 IT201600130538 A1 IT 201600130538A1
Authority
IT
Italy
Prior art keywords
delmopinol
production
delmopinol production
Prior art date
Application number
IT102016000130538A
Other languages
English (en)
Inventor
Faveri Carla De
Mariano Stivanello
Original Assignee
Lundbeck Pharmaceuticals Italy S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck Pharmaceuticals Italy S P A filed Critical Lundbeck Pharmaceuticals Italy S P A
Priority to IT102016000130538A priority Critical patent/IT201600130538A1/it
Priority to PCT/EP2017/083768 priority patent/WO2018115096A1/en
Priority to DK17821624.8T priority patent/DK3558951T3/da
Priority to EP17821624.8A priority patent/EP3558951B1/en
Priority to US16/472,367 priority patent/US10894778B2/en
Priority to ES17821624T priority patent/ES2871824T3/es
Publication of IT201600130538A1 publication Critical patent/IT201600130538A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C21/00—Acyclic unsaturated compounds containing halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT102016000130538A 2016-12-23 2016-12-23 Processo per la produzione del delmopinolo IT201600130538A1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT102016000130538A IT201600130538A1 (it) 2016-12-23 2016-12-23 Processo per la produzione del delmopinolo
PCT/EP2017/083768 WO2018115096A1 (en) 2016-12-23 2017-12-20 Method for the manufacturing of delmopinol
DK17821624.8T DK3558951T3 (da) 2016-12-23 2017-12-20 Fremgangsmåde til fremstillingen af delmopinol
EP17821624.8A EP3558951B1 (en) 2016-12-23 2017-12-20 Method for the manufacturing of delmopinol
US16/472,367 US10894778B2 (en) 2016-12-23 2017-12-20 Method for the manufacturing of delmopinol
ES17821624T ES2871824T3 (es) 2016-12-23 2017-12-20 Método para la fabricación de delmopinol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102016000130538A IT201600130538A1 (it) 2016-12-23 2016-12-23 Processo per la produzione del delmopinolo

Publications (1)

Publication Number Publication Date
IT201600130538A1 true IT201600130538A1 (it) 2018-06-23

Family

ID=58609874

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102016000130538A IT201600130538A1 (it) 2016-12-23 2016-12-23 Processo per la produzione del delmopinolo

Country Status (6)

Country Link
US (1) US10894778B2 (it)
EP (1) EP3558951B1 (it)
DK (1) DK3558951T3 (it)
ES (1) ES2871824T3 (it)
IT (1) IT201600130538A1 (it)
WO (1) WO2018115096A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600130729A1 (it) * 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione degli intermedi del delmopinolo
WO2021155350A1 (en) * 2020-01-31 2021-08-05 You First Services, Inc. Methods of making delmopinol and salts thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014342A1 (en) * 1989-05-24 1990-11-29 Pharmacia Ab Substituted isoxazolidines and isoxazolines
WO2006120432A1 (en) * 2005-05-09 2006-11-16 Sinclair Pharmaceuticals Limited Formulation to prevent plaque formation
WO2007010294A2 (en) * 2005-07-22 2007-01-25 Sinclair Pharmaceuticals Limited Use of delmopinol in the treatment of acne
WO2007057681A1 (en) * 2005-11-17 2007-05-24 Sinclair Pharmaceuticals Limited Process for the preparation of delmopinol and derivatives thereof
WO2007091009A2 (en) * 2006-02-07 2007-08-16 Sinclair Pharmaceuticals Limited Preparation of delmopinol
WO2008139170A2 (en) * 2007-05-09 2008-11-20 Sinclair Pharmaceuticals Limited Transdermal and transmucosal drug delivery enhancers
WO2012131363A2 (en) * 2011-03-28 2012-10-04 Applisci Limited Deodorant formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE439011B (sv) 1980-03-21 1985-05-28 Ferrosan Ab Morfolinoforeningar, kompositioner innehallande dessa och anvendning derav
GB0604018D0 (en) 2006-02-28 2006-04-05 Sinclair Pharmaceuticals Ltd Method
IT201600130642A1 (it) 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione di 2(3 alchilmorfolino)-etan-1-olo
IT201600130729A1 (it) * 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione degli intermedi del delmopinolo

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014342A1 (en) * 1989-05-24 1990-11-29 Pharmacia Ab Substituted isoxazolidines and isoxazolines
WO2006120432A1 (en) * 2005-05-09 2006-11-16 Sinclair Pharmaceuticals Limited Formulation to prevent plaque formation
WO2007010294A2 (en) * 2005-07-22 2007-01-25 Sinclair Pharmaceuticals Limited Use of delmopinol in the treatment of acne
WO2007057681A1 (en) * 2005-11-17 2007-05-24 Sinclair Pharmaceuticals Limited Process for the preparation of delmopinol and derivatives thereof
WO2007091009A2 (en) * 2006-02-07 2007-08-16 Sinclair Pharmaceuticals Limited Preparation of delmopinol
WO2008139170A2 (en) * 2007-05-09 2008-11-20 Sinclair Pharmaceuticals Limited Transdermal and transmucosal drug delivery enhancers
WO2012131363A2 (en) * 2011-03-28 2012-10-04 Applisci Limited Deodorant formulations

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HUANG J-W ET AL: "Ring-opening reaction of methylenecyclopropanes with LiCl, LiBr or NaI in acetic acid", TETRAHE, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 60, no. 9, 23 February 2004 (2004-02-23), pages 2057 - 2062, XP004489808, ISSN: 0040-4020, DOI: 10.1016/J.TET.2003.12.061 *
KOSSANYI ET AL.: "Insect chemistry. Application of the Norrish type-I reaction to the synthesis of propylure, the sexual pheromone of Pectinophora gossypiella Saunders.", TETRAHEDRON LETTERS, vol. 14, no. 36, 1973, pages 3459 - 3462, XP002770932 *
SIRIWARDANA A I ET AL: "Addition of hydrogen halides to alkylidenecyclopropanes: a highly efficient and stereoselective method for the preparation of homoallylic halides", TETRAHEDRON LET, ELSEVIER, AMSTERDAM, NL, vol. 44, no. 5, 27 January 2003 (2003-01-27), pages 985 - 987, XP004408882, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(02)02722-3 *

Also Published As

Publication number Publication date
US20190375722A1 (en) 2019-12-12
DK3558951T3 (da) 2021-05-25
ES2871824T3 (es) 2021-11-02
EP3558951A1 (en) 2019-10-30
EP3558951B1 (en) 2021-04-14
US10894778B2 (en) 2021-01-19
WO2018115096A1 (en) 2018-06-28

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