IT1392492B1 - Processo per la purificazione del latanoprost, analogo sintetico della prostaglandina pgf2alfa. - Google Patents
Processo per la purificazione del latanoprost, analogo sintetico della prostaglandina pgf2alfa.Info
- Publication number
- IT1392492B1 IT1392492B1 ITMI2008A002330A ITMI20082330A IT1392492B1 IT 1392492 B1 IT1392492 B1 IT 1392492B1 IT MI2008A002330 A ITMI2008A002330 A IT MI2008A002330A IT MI20082330 A ITMI20082330 A IT MI20082330A IT 1392492 B1 IT1392492 B1 IT 1392492B1
- Authority
- IT
- Italy
- Prior art keywords
- latanoprost
- purification
- pgf2alfa
- prostaglandina
- synthetic analogue
- Prior art date
Links
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 title abstract 2
- 229960001160 latanoprost Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- -1 -isopropyl ester Chemical class 0.000 abstract 1
- 101000692466 Bos taurus Prostaglandin F synthase 2 Proteins 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2008A002330A IT1392492B1 (it) | 2008-12-24 | 2008-12-24 | Processo per la purificazione del latanoprost, analogo sintetico della prostaglandina pgf2alfa. |
| EP09180333A EP2208724B1 (en) | 2008-12-24 | 2009-12-22 | Process for purification of latanoprost, synthetic analogue of prostaglandin PGF 2alfa |
| AT09180333T ATE536341T1 (de) | 2008-12-24 | 2009-12-22 | Verfahren zur reinigung von latanoprost |
| HK11100478.8A HK1146267A1 (en) | 2008-12-24 | 2011-01-18 | Process for purification of latanoprost, synthetic analogue of prostaglandin pgf 2alfa |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2008A002330A IT1392492B1 (it) | 2008-12-24 | 2008-12-24 | Processo per la purificazione del latanoprost, analogo sintetico della prostaglandina pgf2alfa. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI20082330A1 ITMI20082330A1 (it) | 2010-06-25 |
| IT1392492B1 true IT1392492B1 (it) | 2012-03-09 |
Family
ID=41171094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI2008A002330A IT1392492B1 (it) | 2008-12-24 | 2008-12-24 | Processo per la purificazione del latanoprost, analogo sintetico della prostaglandina pgf2alfa. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2208724B1 (it) |
| AT (1) | ATE536341T1 (it) |
| HK (1) | HK1146267A1 (it) |
| IT (1) | IT1392492B1 (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU231214B1 (hu) | 2014-03-13 | 2021-11-29 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás nagytisztaságú prosztaglandinok előállítására |
| CN112832150B (zh) * | 2021-01-27 | 2022-06-24 | 中交第三公路工程局有限公司 | 一种涵洞通道等立面垂直凿毛装置 |
| CN115322094A (zh) * | 2021-01-27 | 2022-11-11 | Ａｇｃ株式会社 | 他氟前列素的纯化方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0569046B1 (en) | 1988-09-06 | 2002-11-13 | Pharmacia Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| HU212570B (en) | 1991-06-24 | 1996-08-29 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester |
| IL134241A (en) | 2000-01-27 | 2006-06-11 | Finetech Pharmaceutical Ltd | Process for the preparation of latanoprost |
| GB0112699D0 (en) * | 2001-05-24 | 2001-07-18 | Resolution Chemicals Ltd | Process for the preparation of prostglandins and analogues thereof |
| KR100581647B1 (ko) | 2001-07-17 | 2006-05-22 | 파마시아 앤드 업존 캄파니 엘엘씨 | 라타노프로스트 제조를 위한 방법 및 중간체 |
| PL212658B1 (pl) * | 2005-04-18 | 2012-11-30 | Inst Farmaceutyczny | Sposób otrzymywania pochodnych 13,14-dihydro-PGF<sub>2</sub><sub>α</sub> |
| ITRM20050231A1 (it) | 2005-05-13 | 2006-11-14 | Technopharma Sa | Procedimento per la sintesi di derivati delle prostaglandine f. |
-
2008
- 2008-12-24 IT ITMI2008A002330A patent/IT1392492B1/it active
-
2009
- 2009-12-22 EP EP09180333A patent/EP2208724B1/en active Active
- 2009-12-22 AT AT09180333T patent/ATE536341T1/de active
-
2011
- 2011-01-18 HK HK11100478.8A patent/HK1146267A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE536341T1 (de) | 2011-12-15 |
| EP2208724A1 (en) | 2010-07-21 |
| EP2208724B1 (en) | 2011-12-07 |
| ITMI20082330A1 (it) | 2010-06-25 |
| HK1146267A1 (en) | 2011-05-27 |
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