IT1318535B1 - Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina. - Google Patents

Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.

Info

Publication number
IT1318535B1
IT1318535B1 IT2000MI001158A ITMI20001158A IT1318535B1 IT 1318535 B1 IT1318535 B1 IT 1318535B1 IT 2000MI001158 A IT2000MI001158 A IT 2000MI001158A IT MI20001158 A ITMI20001158 A IT MI20001158A IT 1318535 B1 IT1318535 B1 IT 1318535B1
Authority
IT
Italy
Prior art keywords
adenosyl
methionine
preparation
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
IT2000MI001158A
Other languages
English (en)
Inventor
Marco Berna
Lino Sivieri
Gianni Santambrogio
Ermanno Valoti
Original Assignee
Chementecno Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chementecno Srl filed Critical Chementecno Srl
Publication of ITMI20001158A0 publication Critical patent/ITMI20001158A0/it
Priority to IT2000MI001158A priority Critical patent/IT1318535B1/it
Priority to CA002407559A priority patent/CA2407559C/en
Priority to AU6584801A priority patent/AU6584801A/xx
Priority to PCT/EP2001/003633 priority patent/WO2001090130A1/en
Priority to AT01943206T priority patent/ATE256695T1/de
Priority to DK01943206T priority patent/DK1283845T3/da
Priority to JP2001586317A priority patent/JP4777588B2/ja
Priority to PT01943206T priority patent/PT1283845E/pt
Priority to AU2001265848A priority patent/AU2001265848B8/en
Priority to ES01943206T priority patent/ES2208610T3/es
Priority to EP01943206A priority patent/EP1283845B1/en
Priority to TR2003/02297T priority patent/TR200302297T4/xx
Priority to DE60101575T priority patent/DE60101575T2/de
Priority to KR1020027015667A priority patent/KR100737193B1/ko
Priority to SI200130072T priority patent/SI1283845T1/xx
Priority to US09/829,906 priority patent/US20020010147A1/en
Publication of ITMI20001158A1 publication Critical patent/ITMI20001158A1/it
Priority to US10/142,876 priority patent/US6958233B2/en
Application granted granted Critical
Publication of IT1318535B1 publication Critical patent/IT1318535B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT2000MI001158A 2000-05-25 2000-05-25 Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina. IT1318535B1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT2000MI001158A IT1318535B1 (it) 2000-05-25 2000-05-25 Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.
AU2001265848A AU2001265848B8 (en) 2000-05-25 2001-03-30 Process for the preparation of pharmaceutically acceptable salts of (SS,RS)-S-adenosyl-L-methionine
EP01943206A EP1283845B1 (en) 2000-05-25 2001-03-30 Process for the preparation of pharmaceutically acceptable salts of (ss-rs)-s-adenosyl-l-methionine
PCT/EP2001/003633 WO2001090130A1 (en) 2000-05-25 2001-03-30 Process for the preparation of pharmaceutically acceptable salts of (ss-rs)-s-adenosyl-l-methionine
AT01943206T ATE256695T1 (de) 2000-05-25 2001-03-30 Verfahren zur herstellung von pharmazeutisch annehmbaren salzen des (ss,rs)-s-adenosyl-l- menthionin
DK01943206T DK1283845T3 (da) 2000-05-25 2001-03-30 Fremgangsmåde til fremstilling af farmaceutiske acceptable salte af (SS-RS)-S-adenosyl-L-methionin
JP2001586317A JP4777588B2 (ja) 2000-05-25 2001-03-30 （ｓｓ，ｒｓ）−ｓ−アデノシル−ｌ−メチオニンの薬剤として許容される塩の調製方法
PT01943206T PT1283845E (pt) 2000-05-25 2001-03-30 Processo para a preparacao de sais aceitaveis sob o ponto de vista farmaceutico de (ss-rs)-s-adenosil-l-metionina
CA002407559A CA2407559C (en) 2000-05-25 2001-03-30 Process for the preparation of pharmaceutically acceptable salts of (ss-rs)-s-adenosyl-l-methionine
ES01943206T ES2208610T3 (es) 2000-05-25 2001-03-30 Procedimiento para la preparacion de sales farmaceuticamente aceptables de (ss-rs)-s-adenosil-l-metionina.
AU6584801A AU6584801A (en) 2000-05-25 2001-03-30 Process for the preparation of pharmaceutically acceptable salts of (ss-rs)-s-adenosyl-l-methionine
TR2003/02297T TR200302297T4 (tr) 2000-05-25 2001-03-30 (SS, RS)-S-adenozil-L-metiyoninin farmasötik olarak kabul edilebilir tuzlarının hazırlanması için bir işlem
DE60101575T DE60101575T2 (de) 2000-05-25 2001-03-30 Verfahren zur herstellung von pharmazeutisch annehmbaren salzen des (ss,rs)-s-adenosyl-l-menthionin
KR1020027015667A KR100737193B1 (ko) 2000-05-25 2001-03-30 약제학적으로 허용되는(ｓｓ-ｒｓ)-ｓ-아데노실-ｌ-메티오닌 염의 제조방법
SI200130072T SI1283845T1 (en) 2000-05-25 2001-03-30 Process for the preparation of pharmaceutically acceptable salts of (ss-rs)-s-adenosyl-l-methionine
US09/829,906 US20020010147A1 (en) 2000-05-25 2001-04-11 Process for the preparation of pharmaceutically acceptable salts of (SS,RS) -s-adenosyl-l-methionine
US10/142,876 US6958233B2 (en) 2000-05-25 2002-05-13 Process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI001158A IT1318535B1 (it) 2000-05-25 2000-05-25 Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.

Publications (3)

Publication Number Publication Date
ITMI20001158A0 ITMI20001158A0 (it) 2000-05-25
ITMI20001158A1 ITMI20001158A1 (it) 2001-11-25
IT1318535B1 true IT1318535B1 (it) 2003-08-27

Family

ID=11445118

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI001158A IT1318535B1 (it) 2000-05-25 2000-05-25 Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.

Country Status (14)

Country Link
US (2) US20020010147A1 (it)
EP (1) EP1283845B1 (it)
JP (1) JP4777588B2 (it)
KR (1) KR100737193B1 (it)
AT (1) ATE256695T1 (it)
AU (2) AU6584801A (it)
CA (1) CA2407559C (it)
DE (1) DE60101575T2 (it)
DK (1) DK1283845T3 (it)
ES (1) ES2208610T3 (it)
IT (1) IT1318535B1 (it)
PT (1) PT1283845E (it)
TR (1) TR200302297T4 (it)
WO (1) WO2001090130A1 (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033815B2 (en) 2001-03-30 2006-04-25 Board Of Regents, The University Of Texas System Biosynthesis of S-adenosylmethionine in a recombinant yeast strain
CN100398659C (zh) * 2002-09-16 2008-07-02 上海青瑞生物医药技术有限公司 旋光纯(s,s)-腺甘甲硫氨酸制备的方法
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ES2406412T3 (es) 2005-06-09 2013-06-06 Gnosis S.P.A. Células de Saccharomyces cerevisiae secas, liofilizadas y/o microencapsuladas con un alto contenido de (S)-(+)-S-adenosil-metionina
ITRM20050344A1 (it) * 2005-06-30 2007-01-01 Luca Maria De Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi.
CN1955306B (zh) * 2005-10-28 2011-03-16 上海医药工业研究院 酵母菌生物合成、生产旋光纯腺苷甲硫氨酸的方法及其培养液
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
CN101437934B (zh) 2006-05-10 2013-03-20 三菱瓦斯化学株式会社 含s-腺苷-l-甲硫氨酸的干燥酵母的制备方法以及口服用组合物
US20070265211A1 (en) * 2006-05-12 2007-11-15 Matthias Rath Novel composition and method effective in inhibiting the atherogenic process
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
JP6479681B2 (ja) 2013-01-16 2019-03-06 ヘーベルト サム−イー エルエルシー Ｓ−アデノシル−ｌ−メチオニンの安定なインドール−３−プロピオネート塩
ITMI20130426A1 (it) * 2013-03-20 2014-09-21 Gnosis Spa S-adenosilmetionina sterile ad alto contenuto di isomero attivo per soluzioni iniettabili e procedimento per ottenerla
CN106349311B (zh) * 2016-08-23 2018-04-13 北京金阳利康医药有限公司 从酵母发酵液中提取s‑腺苷蛋氨酸的方法
IT201700074957A1 (it) * 2017-07-04 2019-01-04 Gnosis Spa Sale di (ss)-adenosil metionina con inositolo esafosfato e procedimento per ottenerlo
CN110396120B (zh) * 2019-02-13 2020-05-12 山东惠仕莱生物科技有限公司 一种从s-腺苷蛋氨酸发酵液中提取分离s-腺苷蛋氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
JPS56145299A (en) * 1980-04-11 1981-11-11 Kanegafuchi Chem Ind Co Ltd Purification of s-adenosyl-l-methionine
JPS5929700A (ja) * 1982-08-13 1984-02-16 Nippon Zeon Co Ltd Ｓ−アデノシル−ｌ−メチオニンの精製法
IT1169773B (it) 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale

Also Published As

Publication number Publication date
EP1283845A1 (en) 2003-02-19
DE60101575T2 (de) 2004-06-03
CA2407559C (en) 2009-12-22
US20020010147A1 (en) 2002-01-24
DE60101575D1 (de) 2004-01-29
AU6584801A (en) 2001-12-03
TR200302297T4 (tr) 2004-02-23
KR100737193B1 (ko) 2007-07-10
JP4777588B2 (ja) 2011-09-21
ATE256695T1 (de) 2004-01-15
AU2001265848B8 (en) 2006-05-04
US6958233B2 (en) 2005-10-25
ITMI20001158A1 (it) 2001-11-25
EP1283845B1 (en) 2003-12-17
CA2407559A1 (en) 2001-11-29
AU2001265848B2 (en) 2006-03-23
PT1283845E (pt) 2004-04-30
ES2208610T3 (es) 2004-06-16
KR20030036183A (ko) 2003-05-09
WO2001090130A1 (en) 2001-11-29
US20020173012A1 (en) 2002-11-21
DK1283845T3 (da) 2004-04-13
JP2003534349A (ja) 2003-11-18
ITMI20001158A0 (it) 2000-05-25

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