IT1304904B1 - ANTICOLINESTERASIC DERIVATIVES FOR THE TREATMENT OF FUNCTIONAL AND / OR ORGANIC SYNDROME - Google Patents

ANTICOLINESTERASIC DERIVATIVES FOR THE TREATMENT OF FUNCTIONAL AND / OR ORGANIC SYNDROME

Info

Publication number
IT1304904B1
IT1304904B1 IT1998FI000208A ITFI980208A IT1304904B1 IT 1304904 B1 IT1304904 B1 IT 1304904B1 IT 1998FI000208 A IT1998FI000208 A IT 1998FI000208A IT FI980208 A ITFI980208 A IT FI980208A IT 1304904 B1 IT1304904 B1 IT 1304904B1
Authority
IT
Italy
Prior art keywords
treatment
anticolinesterasic
derivatives
functional
organic
Prior art date
Application number
IT1998FI000208A
Other languages
Italian (it)
Inventor
Maria Nicolodi
Federigo Sicuteri
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ITFI980208A0 publication Critical patent/ITFI980208A0/en
Priority to IT1998FI000208A priority Critical patent/IT1304904B1/en
Priority to US09/763,751 priority patent/US6608088B1/en
Priority to ES99946150T priority patent/ES2265691T3/en
Priority to DK99946150T priority patent/DK1112067T3/en
Priority to JP2000569789A priority patent/JP3984787B2/en
Priority to PT99946150T priority patent/PT1112067E/en
Priority to AT99946150T priority patent/ATE327740T1/en
Priority to AU58617/99A priority patent/AU5861799A/en
Priority to EP99946150A priority patent/EP1112067B1/en
Priority to PCT/EP1999/006648 priority patent/WO2000015205A2/en
Priority to DE69931640T priority patent/DE69931640T2/en
Publication of ITFI980208A1 publication Critical patent/ITFI980208A1/en
Application granted granted Critical
Publication of IT1304904B1 publication Critical patent/IT1304904B1/en
Priority to CY20061101098T priority patent/CY1105125T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Abstract

Methods of use of donepezil having central action for the treatment of function (migraine and primary fibromyalgia) and/or organic (amputation, "phantom limb", tumoral or traumatic denervation or autoimmune mechanism) central pain syndromes are disclosed.
IT1998FI000208A 1998-09-11 1998-09-11 ANTICOLINESTERASIC DERIVATIVES FOR THE TREATMENT OF FUNCTIONAL AND / OR ORGANIC SYNDROME IT1304904B1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT1998FI000208A IT1304904B1 (en) 1998-09-11 1998-09-11 ANTICOLINESTERASIC DERIVATIVES FOR THE TREATMENT OF FUNCTIONAL AND / OR ORGANIC SYNDROME
AT99946150T ATE327740T1 (en) 1998-09-11 1999-09-09 USE OF ACETYLCHOLINESTERASE INHIBITORS FOR THE PRODUCTION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF FUNCTIONAL AND/OR ORGANIC PAIN SYNDROME
EP99946150A EP1112067B1 (en) 1998-09-11 1999-09-09 Use of acetylcholinesterase inhibitors for the preparation of pharmaceutical compositions for the treatment of functional and/or organic pain syndromes
DK99946150T DK1112067T3 (en) 1998-09-11 1999-09-09 Use of acetylcholinesterase inhibitors for the preparation of pharmaceutical compositions for the treatment of functional and / or organic pain syndromes
JP2000569789A JP3984787B2 (en) 1998-09-11 1999-09-09 Use of an acetylcholinesterase inhibitor for the preparation of a pharmaceutical composition for the treatment of functional and / or organic pain syndrome
PT99946150T PT1112067E (en) 1998-09-11 1999-09-09 USEFULNESS OF ACETILCOLINESTERASE INHIBITORS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FUNCTIONAL AND / OR ORGANIC PAIN SYNDROMES
US09/763,751 US6608088B1 (en) 1998-09-11 1999-09-09 Use of donerezil for the treatment of functional and/or organic pain syndromes
AU58617/99A AU5861799A (en) 1998-09-11 1999-09-09 Use of acetylcholinesterase inhibitors for the preparation of pharmaceutical compositions for the treatment of functional and/or organic pain syndromes
ES99946150T ES2265691T3 (en) 1998-09-11 1999-09-09 USE OF ACETILCOLINESTERASE INHIBITORS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FUNCTIONAL AND / OR ORGANIC PAINFUL SYNDROMES.
PCT/EP1999/006648 WO2000015205A2 (en) 1998-09-11 1999-09-09 Use of acetylcholinesterase inhibitors for the preparation of pharmaceutical compositions for the treatment of functional and/or organic pain syndromes
DE69931640T DE69931640T2 (en) 1998-09-11 1999-09-09 USE OF ACETYLCHOLINESTERASIS INHIBITORS FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF FUNCTIONAL AND / OR ORGANIC PAIN SYNDROME
CY20061101098T CY1105125T1 (en) 1998-09-11 2006-08-07 USE OF ACETYLCHOLINESTEPASE INHIBITORS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR THE THERAPEUTIC TREATMENT OF FUNCTIONAL AND/OR ORGANIC PAIN SYNDROMES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998FI000208A IT1304904B1 (en) 1998-09-11 1998-09-11 ANTICOLINESTERASIC DERIVATIVES FOR THE TREATMENT OF FUNCTIONAL AND / OR ORGANIC SYNDROME

Publications (3)

Publication Number Publication Date
ITFI980208A0 ITFI980208A0 (en) 1998-09-11
ITFI980208A1 ITFI980208A1 (en) 2000-03-11
IT1304904B1 true IT1304904B1 (en) 2001-04-05

Family

ID=11352669

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1998FI000208A IT1304904B1 (en) 1998-09-11 1998-09-11 ANTICOLINESTERASIC DERIVATIVES FOR THE TREATMENT OF FUNCTIONAL AND / OR ORGANIC SYNDROME

Country Status (12)

Country Link
US (1) US6608088B1 (en)
EP (1) EP1112067B1 (en)
JP (1) JP3984787B2 (en)
AT (1) ATE327740T1 (en)
AU (1) AU5861799A (en)
CY (1) CY1105125T1 (en)
DE (1) DE69931640T2 (en)
DK (1) DK1112067T3 (en)
ES (1) ES2265691T3 (en)
IT (1) IT1304904B1 (en)
PT (1) PT1112067E (en)
WO (1) WO2000015205A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060183776A9 (en) * 2000-03-03 2006-08-17 Eisai Co., Ltd. Liquid dosage formulations of donepezil
JP2003525903A (en) 2000-03-03 2003-09-02 エーザイ株式会社 New uses of cholinesterase inhibitors
CN1418099A (en) * 2000-04-21 2003-05-14 法玛西雅厄普约翰美国公司 Choice compound for treatment of fibromyalgia and chronic fatigue syndrome
WO2002083141A1 (en) * 2001-04-17 2002-10-24 Pharmacia & Upjohn Company Treatment of fibromyalgia and chronic fatigue syndrome
AT500143A1 (en) * 2004-04-22 2005-11-15 Sanochemia Pharmazeutika Ag CHOLINESTERASE INHIBITORS IN LIPOSOMES AND THEIR PREPARATION AND USE
JP5186219B2 (en) * 2005-01-25 2013-04-17 エピックス デラウェア， インコーポレイテッド Substituted arylamine compounds and their use as 5-HT6 modulators
JP5731094B2 (en) * 2005-02-11 2015-06-10 スティーブン・ウィルスＳｔｅｐｈｅｎ ＷＩＬＬＳ Treatment of microvascular diseases with acetylcholinesterase inhibitors
ME01224B (en) * 2005-04-04 2013-06-20 Eisai R&D Man Co Ltd Dihydropyridine compounds for neurodegenerative diseases and dementia
WO2008006286A1 (en) 2006-07-05 2008-01-17 Tianjin Hemay Bio-Tech Co. Ltd ANALGESIC 5, 9 - METHANOCYCLOOCTA (b) PYRIDIN - 2 (1H) - ONE DERIVATIVES, THEIR PREPARATION METHOD AND USE
US8012994B1 (en) 2006-09-22 2011-09-06 Sevastyanov Victor V Method for the treatment of sensorineural hearing loss with donepezil hydrochloride (ARICEPT®)
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
SI2091948T1 (en) 2006-11-30 2012-07-31 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
DK2142514T3 (en) 2007-04-18 2015-03-23 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US8138169B2 (en) 2008-04-11 2012-03-20 Comgenrx, Inc. Combination therapy for bipolar disorder
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
EA037187B1 (en) 2010-02-09 2021-02-17 Дзе Джонс Хопкинс Юниверсити Method and composition for treating a cognitive disorder
JP6026284B2 (en) 2010-03-03 2016-11-16 プロビオドルグ エージー Inhibitors of glutaminyl cyclase
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
WO2011151359A1 (en) 2010-06-02 2011-12-08 Noscira, S.A. Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative
JP6050264B2 (en) 2011-03-16 2016-12-21 プロビオドルグ エージー Benzimidazole derivatives as inhibitors of glutaminyl cyclase
JP2015078129A (en) * 2012-02-01 2015-04-23 株式会社新日本科学 Fibromyalgia therapeutic agent containing donepezil
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins Methods and compositions for improving cognitive function
AU2016268096B2 (en) 2015-05-22 2021-04-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
PL3461819T3 (en) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitors of glutaminyl cyclase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010083A (en) 1988-03-28 1991-04-23 Hoechst-Roussel Pharmaceuticals, Inc. 2,6-methano-1,3-benzodiazocine compounds which have useful pharmaceutical utility
DE3927049A1 (en) 1989-08-16 1991-02-21 Sandoz Ag HALOGENALKYL-PHENYL-KETONE AND THEIR HYDRATES, THEIR PRODUCTION AND USE
US5336675A (en) 1991-05-14 1994-08-09 Ernir Snorrason Method of treating mania in humans
GB9606736D0 (en) 1996-02-19 1996-06-05 Shire International Licensing Therapeutic method
WO1999008672A1 (en) 1997-08-15 1999-02-25 Shire International Licensing Bv Use of cholinesterase inhibitor for treating diseases associated with proteolytic enzyme activity

Also Published As

Publication number Publication date
ATE327740T1 (en) 2006-06-15
AU5861799A (en) 2000-04-03
JP2002524498A (en) 2002-08-06
DK1112067T3 (en) 2006-09-04
ITFI980208A1 (en) 2000-03-11
ES2265691T3 (en) 2007-02-16
CY1105125T1 (en) 2009-11-04
EP1112067A2 (en) 2001-07-04
WO2000015205A2 (en) 2000-03-23
ITFI980208A0 (en) 1998-09-11
JP3984787B2 (en) 2007-10-03
EP1112067B1 (en) 2006-05-31
DE69931640D1 (en) 2006-07-06
WO2000015205A3 (en) 2000-08-24
US6608088B1 (en) 2003-08-19
DE69931640T2 (en) 2007-03-08
PT1112067E (en) 2006-09-29

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