IT1298349B1 - Processo per la produzione di 1 - (3-trifluorometil) fenil-propan- 2-one intermedio nella sintesi della fenfluramina - Google Patents
Processo per la produzione di 1 - (3-trifluorometil) fenil-propan- 2-one intermedio nella sintesi della fenfluraminaInfo
- Publication number
- IT1298349B1 IT1298349B1 IT96BO000289A ITBO960289A IT1298349B1 IT 1298349 B1 IT1298349 B1 IT 1298349B1 IT 96BO000289 A IT96BO000289 A IT 96BO000289A IT BO960289 A ITBO960289 A IT BO960289A IT 1298349 B1 IT1298349 B1 IT 1298349B1
- Authority
- IT
- Italy
- Prior art keywords
- phenfluramine
- propan
- trifluoromethyl
- phenyl
- synthesis
- Prior art date
Links
- QCCDLTOVEPVEJK-UHFFFAOYSA-N benzyl methyl ketone Natural products CC(=O)CC1=CC=CC=C1 QCCDLTOVEPVEJK-UHFFFAOYSA-N 0.000 title 2
- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/227—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
- C07C49/233—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96BO000289A IT1298349B1 (it) | 1996-05-29 | 1996-05-29 | Processo per la produzione di 1 - (3-trifluorometil) fenil-propan- 2-one intermedio nella sintesi della fenfluramina |
| US08/837,436 US5811586A (en) | 1996-05-29 | 1997-04-17 | Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-one intermediate in the synthesis of the fenfluramine |
| KR1019970018740A KR970074738A (ko) | 1996-05-29 | 1997-05-15 | 펜풀루라민 제조용 1-(3-트리풀루오르메틸)페닐-프로판-2-온 중간체의 제조방법 |
| CA002205694A CA2205694A1 (en) | 1996-05-29 | 1997-05-20 | Process for manufacturing 1-(3-trifluoromethyl) phenyl-propan-2-one intermediate in the synthesis of the fenfluramine |
| EP97108370A EP0810195A1 (en) | 1996-05-29 | 1997-05-23 | Process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the fenfluramine |
| JP9138441A JP2824053B2 (ja) | 1996-05-29 | 1997-05-28 | １−（３−トリフルオロメチル）フェニル−２−プロパノンの製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96BO000289A IT1298349B1 (it) | 1996-05-29 | 1996-05-29 | Processo per la produzione di 1 - (3-trifluorometil) fenil-propan- 2-one intermedio nella sintesi della fenfluramina |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITBO960289A0 ITBO960289A0 (it) | 1996-05-29 |
| ITBO960289A1 ITBO960289A1 (it) | 1997-11-29 |
| IT1298349B1 true IT1298349B1 (it) | 2000-01-05 |
Family
ID=11341425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT96BO000289A IT1298349B1 (it) | 1996-05-29 | 1996-05-29 | Processo per la produzione di 1 - (3-trifluorometil) fenil-propan- 2-one intermedio nella sintesi della fenfluramina |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5811586A (it) |
| EP (1) | EP0810195A1 (it) |
| JP (1) | JP2824053B2 (it) |
| KR (1) | KR970074738A (it) |
| CA (1) | CA2205694A1 (it) |
| IT (1) | IT1298349B1 (it) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2819997T3 (en) * | 2012-02-28 | 2016-01-18 | Syngenta Participations Ag | Process for the preparation of phenyl-substituted 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-methoxy- [1-methyl-2-phenylethyl] amides |
| NZ730560A (en) | 2014-09-29 | 2020-05-29 | Zogenix International Ltd | Control system for control of distribution of medication |
| EP3170807B1 (en) | 2015-11-23 | 2019-12-11 | Frau Pharma S.r.l. | New method for synthesis of fenfluramine |
| US20170174614A1 (en) | 2015-12-22 | 2017-06-22 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| IL286391B (en) * | 2015-12-22 | 2022-08-01 | Zogenix International Ltd | Penfluramine preparations and methods for their preparation |
| EP4201427A1 (en) | 2016-08-24 | 2023-06-28 | Zogenix International Limited | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| EP3790537A1 (en) | 2018-05-11 | 2021-03-17 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| WO2023037182A2 (en) * | 2021-08-19 | 2023-03-16 | Biophore India Pharmaceuticals Pvt Ltd | AN IMPROVED PROCESS FOR THE PREPARATION OF N-ETHYL- α -METHYL-3-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL270984A (it) * | 1960-11-05 | |||
| US3652632A (en) * | 1968-11-06 | 1972-03-28 | Sherwin Williams Co | Organic sulfur compounds and method of production thereof |
-
1996
- 1996-05-29 IT IT96BO000289A patent/IT1298349B1/it active IP Right Grant
-
1997
- 1997-04-17 US US08/837,436 patent/US5811586A/en not_active Expired - Fee Related
- 1997-05-15 KR KR1019970018740A patent/KR970074738A/ko not_active Application Discontinuation
- 1997-05-20 CA CA002205694A patent/CA2205694A1/en not_active Abandoned
- 1997-05-23 EP EP97108370A patent/EP0810195A1/en not_active Ceased
- 1997-05-28 JP JP9138441A patent/JP2824053B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR970074738A (ko) | 1997-12-10 |
| EP0810195A1 (en) | 1997-12-03 |
| JP2824053B2 (ja) | 1998-11-11 |
| JPH1072396A (ja) | 1998-03-17 |
| ITBO960289A0 (it) | 1996-05-29 |
| US5811586A (en) | 1998-09-22 |
| CA2205694A1 (en) | 1997-11-29 |
| ITBO960289A1 (it) | 1997-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |