IT1276453B1 - HELYCOBACTER PYLORI VACCINE/THERAPEUTIC COMPOSITIONS, THEIR PREPARATION AND USE. - Google Patents

HELYCOBACTER PYLORI VACCINE/THERAPEUTIC COMPOSITIONS, THEIR PREPARATION AND USE.

Info

Publication number
IT1276453B1
IT1276453B1 IT95TO000545A ITTO950545A IT1276453B1 IT 1276453 B1 IT1276453 B1 IT 1276453B1 IT 95TO000545 A IT95TO000545 A IT 95TO000545A IT TO950545 A ITTO950545 A IT TO950545A IT 1276453 B1 IT1276453 B1 IT 1276453B1
Authority
IT
Italy
Prior art keywords
helycobacter
pylori
preparation
therapeutic compositions
protein
Prior art date
Application number
IT95TO000545A
Other languages
Italian (it)
Inventor
Peter William Dettmar
Andrew William Smith
Original Assignee
Reckitt & Colmann Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd
Publication of ITTO950545A0 publication Critical patent/ITTO950545A0/en
Publication of ITTO950545A1 publication Critical patent/ITTO950545A1/en
Application granted granted Critical
Publication of IT1276453B1 publication Critical patent/IT1276453B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

E' descritta una proteina di Helycobacter pylori, denominata HAP (emayglutinina/proteasi) come soggetto appropriato per un peptide/proteina vaccino o composizione terapeutica per prevenire contro l'infezione da H. pylori. Siti antigenici della proteina HAP di H. pylori, che determinano risposte anticorporali in pazienti includono la regione di legame con lo zinco e il sito attivo di proteasi.A Helycobacter pylori protein, called HAP (emayglutinin / protease) is described as the appropriate subject for a peptide / vaccine protein or therapeutic composition to prevent against H. pylori infection. Antigenic sites of the H. pylori HAP protein, which determine antibody responses in patients include the zinc binding region and the active protease site.

IT95TO000545A 1994-06-29 1995-06-29 HELYCOBACTER PYLORI VACCINE/THERAPEUTIC COMPOSITIONS, THEIR PREPARATION AND USE. IT1276453B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9413073A GB2290710B (en) 1994-06-29 1994-06-29 Protease from helicobacter pylori for use in vaccines/therapeutic compositions

Publications (3)

Publication Number Publication Date
ITTO950545A0 ITTO950545A0 (en) 1995-06-29
ITTO950545A1 ITTO950545A1 (en) 1996-12-29
IT1276453B1 true IT1276453B1 (en) 1997-10-31

Family

ID=10757523

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95TO000545A IT1276453B1 (en) 1994-06-29 1995-06-29 HELYCOBACTER PYLORI VACCINE/THERAPEUTIC COMPOSITIONS, THEIR PREPARATION AND USE.

Country Status (3)

Country Link
DE (1) DE19523554A1 (en)
GB (1) GB2290710B (en)
IT (1) IT1276453B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2252467A1 (en) * 1996-04-23 1997-10-30 Toray Industries, Inc. Antipylori agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2637612B1 (en) * 1988-10-06 1993-09-10 Pasteur Institut NUCLEOTIDE SEQUENCES ENCODING A PROTEIN WITH UREASIC ACTIVITY
CA2117490C (en) * 1992-02-26 2009-01-06 Timothy L. Cover Purified vacuolating toxin from helicobacter pylori and methods to use same
EP0967279B1 (en) * 1992-03-02 2008-01-02 Novartis Vaccines and Diagnostics S.r.l. Helicobacter pylori cytotoxin useful for vaccines and diagnostics

Also Published As

Publication number Publication date
ITTO950545A0 (en) 1995-06-29
DE19523554A1 (en) 1996-01-04
ITTO950545A1 (en) 1996-12-29
GB2290710B (en) 1998-03-25
GB2290710A (en) 1996-01-10
GB9413073D0 (en) 1994-08-17

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Legal Events

Date Code Title Description
0001 Granted