IT1266571B1 - Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari - Google Patents

Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari

Info

Publication number
IT1266571B1
IT1266571B1 IT93MI001723A ITMI931723A IT1266571B1 IT 1266571 B1 IT1266571 B1 IT 1266571B1 IT 93MI001723 A IT93MI001723 A IT 93MI001723A IT MI931723 A ITMI931723 A IT MI931723A IT 1266571 B1 IT1266571 B1 IT 1266571B1
Authority
IT
Italy
Prior art keywords
useful
treatment
cardiovascular diseases
propanamide
mercapto
Prior art date
Application number
IT93MI001723A
Other languages
English (en)
Inventor
Gabriele Norcini
Francesco Santangelo
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Priority to IT93MI001723A priority Critical patent/IT1266571B1/it
Publication of ITMI931723A0 publication Critical patent/ITMI931723A0/it
Priority to AT94111584T priority patent/ATE150019T1/de
Priority to DE69402004T priority patent/DE69402004T2/de
Priority to EP94111584A priority patent/EP0636621B1/en
Priority to US08/281,105 priority patent/US5506259A/en
Publication of ITMI931723A1 publication Critical patent/ITMI931723A1/it
Application granted granted Critical
Publication of IT1266571B1 publication Critical patent/IT1266571B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
IT93MI001723A 1993-07-30 1993-07-30 Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari IT1266571B1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT93MI001723A IT1266571B1 (it) 1993-07-30 1993-07-30 Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari
AT94111584T ATE150019T1 (de) 1993-07-30 1994-07-25 Beta-mercapto-propanamidderivate verwendbar zur behandlung kardiovaskularer krankheiten oder erkrankungen
DE69402004T DE69402004T2 (de) 1993-07-30 1994-07-25 Beta-mercapto-propanamidderivate verwendbar zur Behandlung kardiovaskularer Krankheiten oder Erkrankungen
EP94111584A EP0636621B1 (en) 1993-07-30 1994-07-25 Beta-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases
US08/281,105 US5506259A (en) 1993-07-30 1994-07-27 β-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI001723A IT1266571B1 (it) 1993-07-30 1993-07-30 Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari

Publications (3)

Publication Number Publication Date
ITMI931723A0 ITMI931723A0 (it) 1993-07-30
ITMI931723A1 ITMI931723A1 (it) 1995-01-30
IT1266571B1 true IT1266571B1 (it) 1997-01-09

Family

ID=11366739

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI001723A IT1266571B1 (it) 1993-07-30 1993-07-30 Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari

Country Status (5)

Country Link
US (1) US5506259A (it)
EP (1) EP0636621B1 (it)
AT (1) ATE150019T1 (it)
DE (1) DE69402004T2 (it)
IT (1) IT1266571B1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2745570B1 (fr) * 1996-03-04 1998-06-19 Roussel Uclaf Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
SE9901573D0 (sv) 1999-05-03 1999-05-03 Astra Ab New compounds
US7468390B2 (en) 2002-01-17 2008-12-23 Novartis Ag Methods of treatment and pharmaceutical composition
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
CA2882771C (en) 2012-08-24 2021-02-23 Novartis Ag Nep inhibitors for treating diseases characterized by atrial enlargement or remodeling
WO2017033128A1 (en) 2015-08-25 2017-03-02 Novartis Ag Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
WO2017072636A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical synergistic combination

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1191109B (it) * 1982-12-03 1988-02-24 Simes Derivati di acidi aminopiridincarbossilici,loro metodo di sintesi e composizioni farmaceutiche che li contengono
FR2540495B1 (fr) * 1983-02-07 1986-02-14 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
EP0136883B1 (en) * 1983-10-03 1987-11-25 E.R. Squibb & Sons, Inc. Enkephalinase inhibitors
FR2611712B1 (fr) * 1987-02-26 1989-06-23 Roussel Uclaf Nouveaux derives n-substitues de l'alpha-mercaptomethyl benzene propanamide, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
EP0318859A3 (en) * 1987-12-03 1990-08-16 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
EP0361365A1 (en) * 1988-09-30 1990-04-04 E.R. SQUIBB & SONS, INC. Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use
GB9123353D0 (en) * 1991-11-04 1991-12-18 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB2272435A (en) * 1992-11-16 1994-05-18 Fujisawa Pharmaceutical Co WS75624 substances from saccharothrix strain

Also Published As

Publication number Publication date
ITMI931723A1 (it) 1995-01-30
ITMI931723A0 (it) 1993-07-30
EP0636621A1 (en) 1995-02-01
EP0636621B1 (en) 1997-03-12
DE69402004T2 (de) 1997-06-19
US5506259A (en) 1996-04-09
DE69402004D1 (de) 1997-04-17
ATE150019T1 (de) 1997-03-15

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970311