IT1264901B1 - HETEROCYCLIC ANALOGUES OF 1,2,4-TRIAZOLE(15-C)PYRIMIDINES WITH ANTAGONIST ACTIVITY FOR THE ADENOSINE A2 RECEPTOR - Google Patents

HETEROCYCLIC ANALOGUES OF 1,2,4-TRIAZOLE(15-C)PYRIMIDINES WITH ANTAGONIST ACTIVITY FOR THE ADENOSINE A2 RECEPTOR

Info

Publication number
IT1264901B1
IT1264901B1 IT93MI001396A ITMI931396A IT1264901B1 IT 1264901 B1 IT1264901 B1 IT 1264901B1 IT 93MI001396 A IT93MI001396 A IT 93MI001396A IT MI931396 A ITMI931396 A IT MI931396A IT 1264901 B1 IT1264901 B1 IT 1264901B1
Authority
IT
Italy
Prior art keywords
adenosine
receptor
pyrimidines
triazole
antagonist activity
Prior art date
Application number
IT93MI001396A
Other languages
Italian (it)
Inventor
Pier Giovanni Baraldi
Laura Zappaterra
Ennio Ongini
Original Assignee
Schering Plough S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough S P A filed Critical Schering Plough S P A
Priority to IT93MI001396A priority Critical patent/IT1264901B1/en
Publication of ITMI931396A0 publication Critical patent/ITMI931396A0/en
Priority to AU70723/94A priority patent/AU7072394A/en
Priority to PCT/EP1994/002031 priority patent/WO1995001356A1/en
Publication of ITMI931396A1 publication Critical patent/ITMI931396A1/en
Application granted granted Critical
Publication of IT1264901B1 publication Critical patent/IT1264901B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Abstract

I composti di formula I, dove R e A hanno i significati dati nella descrizione, sono dotati di selettiva attività antagonista sul recettore A2 dell'adenosina.The compounds of formula I, where R and A have the meanings given in the description, are endowed with selective antagonist activity on the adenosine A2 receptor.

IT93MI001396A 1993-06-29 1993-06-29 HETEROCYCLIC ANALOGUES OF 1,2,4-TRIAZOLE(15-C)PYRIMIDINES WITH ANTAGONIST ACTIVITY FOR THE ADENOSINE A2 RECEPTOR IT1264901B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT93MI001396A IT1264901B1 (en) 1993-06-29 1993-06-29 HETEROCYCLIC ANALOGUES OF 1,2,4-TRIAZOLE(15-C)PYRIMIDINES WITH ANTAGONIST ACTIVITY FOR THE ADENOSINE A2 RECEPTOR
AU70723/94A AU7072394A (en) 1993-06-29 1994-06-22 1,2,4-triazolo(1,5-c)pyrimidine heterocyclic analogues having antagonistic activity on adenosine a2 receptor
PCT/EP1994/002031 WO1995001356A1 (en) 1993-06-29 1994-06-22 1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE HETEROCYCLIC ANALOGUES HAVING ANTAGONISTIC ACTIVITY ON ADENOSINE A2 RECEPTOR

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI001396A IT1264901B1 (en) 1993-06-29 1993-06-29 HETEROCYCLIC ANALOGUES OF 1,2,4-TRIAZOLE(15-C)PYRIMIDINES WITH ANTAGONIST ACTIVITY FOR THE ADENOSINE A2 RECEPTOR

Publications (3)

Publication Number Publication Date
ITMI931396A0 ITMI931396A0 (en) 1993-06-29
ITMI931396A1 ITMI931396A1 (en) 1994-12-29
IT1264901B1 true IT1264901B1 (en) 1996-10-17

Family

ID=11366495

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI001396A IT1264901B1 (en) 1993-06-29 1993-06-29 HETEROCYCLIC ANALOGUES OF 1,2,4-TRIAZOLE(15-C)PYRIMIDINES WITH ANTAGONIST ACTIVITY FOR THE ADENOSINE A2 RECEPTOR

Country Status (3)

Country Link
AU (1) AU7072394A (en)
IT (1) IT1264901B1 (en)
WO (1) WO1995001356A1 (en)

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IT1277392B1 (en) * 1995-07-28 1997-11-10 Schering Plough S P A HEROCYCLIC ANALOGS OF 1,2,4-TRIAZOLE (1,5-C] PYRIMIDINE WITH ANTAGONIST ACTIVITY FOR THE A2A RECEPTOR OF ADENOSINE
DE19629378A1 (en) * 1996-07-20 1998-01-29 Boehringer Ingelheim Kg New triazolopurines, process for their preparation and their use as medicaments
US6448253B1 (en) * 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
US6921825B2 (en) 1998-09-16 2005-07-26 King Pharmaceuticuals Research & Development, Inc. Adenosine A3 receptor modulators
AU4343500A (en) 1999-04-16 2000-11-02 Schering Corporation Use of azetidinone compounds
CZ303790B6 (en) 2000-05-26 2013-05-09 Merck Sharp & Dohme Corp. Pyrimidine derivatives, process of their preparation and pharmaceutical preparation containing them
WO2003028732A1 (en) * 2001-09-28 2003-04-10 Kyowa Hakko Kogyo Co., Ltd. Receptor antagonist
WO2003032996A1 (en) * 2001-10-15 2003-04-24 Schering Corporation Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pyrimidines as adenosine a2a receptor antagonists
CN1692116A (en) 2001-11-30 2005-11-02 先灵公司 Adenosine A2A receptor antagonists
TW200300686A (en) 2001-11-30 2003-06-16 Schering Corp Adenosine A2a receptor antagonists
JP4429724B2 (en) 2001-11-30 2010-03-10 シェーリング コーポレイション [1,2,4] -Triazole bicyclic adenosine A2a receptor antagonist
EP1549319A2 (en) * 2002-05-30 2005-07-06 King Pharmaceuticals Research and Development Inc. Pharmaceutically active compounds having a tricyclic pyrazolotriazolopyrimidine ring structure and methods of use
ES2354875T3 (en) 2002-12-19 2011-03-18 Schering Corporation USE OF ADENOSINE A2A RECEIVER ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF EXTRAPIRAMIDAL SYNDROME.
PE20050141A1 (en) 2003-04-23 2005-04-01 Schering Corp DERIVATIVES OF 2-ALKINYL-AND 2-ALKENYL-PIRAZOLO- [4,3-e] -1,2,4-TRIAZOLO- [1,5-c] -PYRIDINE AS ANTAGONISTS OF THE A2a ADENOSINE RECEPTOR
SI1678182T1 (en) 2003-10-28 2007-06-30 Schering Corp PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO- ?á4,3-E?å-1,2,4-TRIAZOLO ?á1,5-C?åPYRIMIDINES
JP2007513091A (en) 2003-12-01 2007-05-24 シェーリング　コーポレイション Process for the preparation of substituted 5-amino-pyrazolo- [4,3-e] -1,2,4-triazolo [1,5-c] pyrimidines
DE602005020127D1 (en) 2004-04-21 2010-05-06 Schering Corp PYRAZOLOÄ4,3-EÜ-1,2,4-TRIAZOLOÄ1,5-CÜPYRIMIDINE AS ANTAGONISTS OF THE ADENOSINE A2A RECEPTOR
US7465740B2 (en) 2005-09-19 2008-12-16 Schering Corporation 2-heteroaryl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
PE20070521A1 (en) 2005-09-23 2007-07-13 Schering Corp 7- [2- [4- (6-FLUORO-3-METHYL-1,2-BENZYSOXAZOL-5-IL) -1-PIPERAZINYL] ETHYL] -2- (1-PROPINYL) -7H-PIRAZOLE- [4, 3-E] - [1,2,4] -TRIAZOL- [1,5-C] -PYRIMIDIN-5-AMINE AS ANTAGONIST OF THE ADENOSINE A2a RECEPTOR
ES2273599B1 (en) 2005-10-14 2008-06-01 Universidad De Barcelona COMPOUNDS FOR THE TREATMENT OF HEADPHONE FIBRILATION.
US7691869B2 (en) 2007-03-30 2010-04-06 King Pharmaceuticals Research And Development, Inc. Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity
AU2009222047A1 (en) 2008-03-04 2009-09-11 Schering Corporation 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine A2a receptor antagonists
CA2812378C (en) * 2010-09-24 2016-11-29 Advinus Therapeutics Limited Fused tricyclic compounds as adenosine receptor antagonist
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
EP3220910B1 (en) 2014-11-18 2020-01-15 Merck Sharp & Dohme Corp. Aminopyrazine compounds with a2a antagonist properties
US10138212B2 (en) 2015-02-06 2018-11-27 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as A2A antagonist
EP3307067B1 (en) 2015-06-11 2022-11-02 Merck Sharp & Dohme LLC Aminopyrazine compounds with a2a antagonist properties
WO2017008205A1 (en) 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Substituted aminoquinazoline compounds as a2a antagonist
US11498923B2 (en) 2017-12-13 2022-11-15 Merck Sharp & Dohme Llc Substituted imidazo[1,2-c]quinazolines as A2A antagonists
CN108864114B (en) 2018-06-04 2020-11-06 应世生物科技(南京)有限公司 Selectivity A2AReceptor antagonists
DE102019116986A1 (en) 2019-06-24 2020-12-24 Helmholtz-Zentrum Dresden-Rossendorf E. V. Deuterated 7- (3- (4- (2 - ([18F] fluoro) ethoxy) phenyl) propyl) -2- (furan-2-yl) -7H-pyrazolo [4,3-e] [1,2, 4] triazolo [1,5-c] pyrimidin-5-amine derivatives

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US4713383A (en) * 1984-10-01 1987-12-15 Ciba-Geigy Corporation Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
EP0217748B1 (en) * 1985-09-30 1991-02-06 Ciba-Geigy Ag 2-Substituted-e-fused-[1,2,4,]triazolo-[1,5-c]pyrimidines pharmaceutical compositions and uses thereof
WO1988002370A1 (en) * 1986-09-30 1988-04-07 Ciba-Geigy Ag 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines pharmaceutical compositions and uses thereof

Also Published As

Publication number Publication date
AU7072394A (en) 1995-01-24
WO1995001356A1 (en) 1995-01-12
ITMI931396A1 (en) 1994-12-29
ITMI931396A0 (en) 1993-06-29

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Effective date: 19970530