IT1263022B - Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica. - Google Patents

Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica.

Info

Publication number
IT1263022B
IT1263022B ITRM920809A ITRM920809A IT1263022B IT 1263022 B IT1263022 B IT 1263022B IT RM920809 A ITRM920809 A IT RM920809A IT RM920809 A ITRM920809 A IT RM920809A IT 1263022 B IT1263022 B IT 1263022B
Authority
IT
Italy
Prior art keywords
interleuchina
wild
mutant
biological activity
interleukin
Prior art date
Application number
ITRM920809A
Other languages
English (en)
Inventor
Gennaro Ciliberto
Rocco Savino
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Publication of ITRM920809A0 publication Critical patent/ITRM920809A0/it
Priority to ITRM920809A priority Critical patent/IT1263022B/it
Priority to DK94900984T priority patent/DK0667872T3/da
Priority to DE69328437T priority patent/DE69328437T2/de
Priority to ES94900984T priority patent/ES2145819T3/es
Priority to PT94900984T priority patent/PT667872E/pt
Priority to CA002129824A priority patent/CA2129824C/en
Priority to JP6511903A priority patent/JP2515491B2/ja
Priority to EP94900984A priority patent/EP0667872B1/en
Priority to AT94900984T priority patent/ATE191923T1/de
Priority to PCT/IT1993/000114 priority patent/WO1994011402A1/en
Publication of ITRM920809A1 publication Critical patent/ITRM920809A1/it
Priority to US08/437,680 priority patent/US5681723A/en
Application granted granted Critical
Publication of IT1263022B publication Critical patent/IT1263022B/it
Priority to GR20000401372T priority patent/GR3033685T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Interleuchina-6 mutante, caratterizzata dal fatto di avere in posizione 176 l'amminoacido arginina invece dell'amminoacido serina come nell'interleuchina selvatica, e dal fatto di esibire un'attività biologica più elevata di quella dell'interleuchina-6 selvatica. La figura rappresenta la mappa genetica del plasmide pBKS IL-6 Ser176Arg contenente la sequenza nucleotidica che codifica per l'interleuchina 6 mutante secondo l'invenzione, non glicosilata. Questo plasmide è stato depositato in E. coli K12 presso The National Collection of Industrial and Marine Bacteria Ltd. in data 02/11/1992 con il numero di accesso NCIMB 40526.
ITRM920809A 1992-11-06 1992-11-06 Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica. IT1263022B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ITRM920809A IT1263022B (it) 1992-11-06 1992-11-06 Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica.
JP6511903A JP2515491B2 (ja) 1992-11-06 1993-11-02 野生インタ―ロイキン６より改良された生物学的活性を有する突然変異インタ―ロイキン６
AT94900984T ATE191923T1 (de) 1992-11-06 1993-11-02 Interleukine-6 mutante mit verbesserter biologischer aktivität im vergleich zu wildtyp il-6
ES94900984T ES2145819T3 (es) 1992-11-06 1993-11-02 Interleucina 6 mutante de actividad biologica mejorada con relacion a la de la interleucina 6 salvaje.
PT94900984T PT667872E (pt) 1992-11-06 1993-11-02 Interleucina-6 mutante com actividade biologica melhorada em relacao a da interleucina 6 selvagem
CA002129824A CA2129824C (en) 1992-11-06 1993-11-02 Mutant interleukin 6 with improved biological activity over wild interleukin 6
DK94900984T DK0667872T3 (da) 1992-11-06 1993-11-02 Mutantinterleukin 6 med forbedret biologisk aktivitet i forhold til vildtype-interleukin 6
EP94900984A EP0667872B1 (en) 1992-11-06 1993-11-02 Mutant interleukin 6 with improved biological activity over wild interleukin 6
DE69328437T DE69328437T2 (de) 1992-11-06 1993-11-02 Interleukine-6 Mutante mit verbesserter biologischer Aktivität im vergleich zu wildtyp IL-6
PCT/IT1993/000114 WO1994011402A1 (en) 1992-11-06 1993-11-02 Mutant interleukin 6 with improved biological activity over wild interleukin 6
US08/437,680 US5681723A (en) 1992-11-06 1995-05-05 Mutant interleukin 6 with improved biological activity over wild interleukin 6
GR20000401372T GR3033685T3 (en) 1992-11-06 2000-06-14 Mutant interleukin 6 with improved biological activity over wild interleukin 6.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920809A IT1263022B (it) 1992-11-06 1992-11-06 Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica.

Publications (3)

Publication Number Publication Date
ITRM920809A0 ITRM920809A0 (it) 1992-11-06
ITRM920809A1 ITRM920809A1 (it) 1994-05-06
IT1263022B true IT1263022B (it) 1996-07-23

Family

ID=11401276

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM920809A IT1263022B (it) 1992-11-06 1992-11-06 Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica.

Country Status (12)

Country Link
US (1) US5681723A (it)
EP (1) EP0667872B1 (it)
JP (1) JP2515491B2 (it)
AT (1) ATE191923T1 (it)
CA (1) CA2129824C (it)
DE (1) DE69328437T2 (it)
DK (1) DK0667872T3 (it)
ES (1) ES2145819T3 (it)
GR (1) GR3033685T3 (it)
IT (1) IT1263022B (it)
PT (1) PT667872E (it)
WO (1) WO1994011402A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1274782B (it) * 1994-12-14 1997-07-24 Angeletti P Ist Richerche Bio Metodo per selezionare superagonisti, antagonisti e superantagonisti di ormoni del cui complesso recettoriale fa parte gp 130
IT1277926B1 (it) * 1995-09-01 1997-11-12 Angeletti P Ist Richerche Bio Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire
WO1997010338A1 (en) * 1995-09-12 1997-03-20 Chiron Corporation Improved interleukin-6 receptor antagonist
AU7078200A (en) * 1999-08-27 2001-03-26 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use
IL161673A0 (en) 2004-04-29 2004-09-27 Applied Research Systems Compositions and methods for therapy of chemotherapy-induced neuropathy
WO2013147153A1 (ja) 2012-03-29 2013-10-03 株式会社未来創薬研究所 抗ｌａｍｐ５抗体およびその利用
WO2022256688A1 (en) 2021-06-04 2022-12-08 Sonnet BioTherapeutics, Inc. Methods of treating age-related frailty with interleukin-6

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT52962A (en) * 1988-03-04 1990-09-28 Sandoz Ag Process for production of medical compositions eliminating bone-absorption and promoting forming of bones
US5210075A (en) * 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides

Also Published As

Publication number Publication date
CA2129824C (en) 1997-03-04
US5681723A (en) 1997-10-28
DK0667872T3 (da) 2000-09-18
PT667872E (pt) 2000-08-31
CA2129824A1 (en) 1994-05-26
JP2515491B2 (ja) 1996-07-10
DE69328437T2 (de) 2000-11-02
WO1994011402A1 (en) 1994-05-26
ITRM920809A1 (it) 1994-05-06
DE69328437D1 (de) 2000-05-25
GR3033685T3 (en) 2000-10-31
ITRM920809A0 (it) 1992-11-06
EP0667872A1 (en) 1995-08-23
JPH07501947A (ja) 1995-03-02
ATE191923T1 (de) 2000-05-15
ES2145819T3 (es) 2000-07-16
EP0667872B1 (en) 2000-04-19

Similar Documents

Publication Publication Date Title
CA2163454A1 (en) Regulation of plant growth
IT1141977B (it) Polipeptide prodotto microbiologicamente con la sequenza di aminoacidi dell'interferone umano,dna e plasmidi che codificano per questa sequenza,microorganismi che contengono queste informazioni genetiche e processo per la loro preparazione
DE69739715D1 (de) Herstellungsverfahren von 1,3-propandiol durch rekombinante organismen
DE69636495D1 (de) Multi-tumor abweichende wachstumsgene
EP0305275A3 (en) Plants transformed with a dna sequence from bacillus thuringiensis
IT1263022B (it) Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica.
ATE264913T1 (de) Protease-resistente analoge des thrombomodulin
NO895028L (no) Ny chimerisk transformerende vekstfaktor-beta.
PL313445A1 (en) Grb3-3 gene, variants thereof and their use
FR2673644B1 (it)
ATE89317T1 (de) Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten.
ZA200102385B (en) Nucleotide sequences coding for the dapC gene and process for the production of L-lysine.
DK0672124T3 (da) Anvendelse af en DNA-sekvens, der koder for et oxalsyre-nedbrydende protein i form af et selektionsgen
MY104405A (en) Structural gene comprising dna coding for an endotoxin protein having toxic activity against insects.
HU9402670D0 (en) Transgenic plants displaying multiple virus resistance and process for their production
ATE386114T1 (de) Gene, die für lymphocyte spezifischen interferon- regulationsfaktor (lsirf) polypeptide kodiert
WO2003018805A1 (fr) Regulateurs de la proliferation de cellules souches hematopoietiques et polynucleotides codant ces regulateurs
Aleksiyeva et al. Organization of lysine operon in Bacillus subtilis.
NZ575248A (en) Glyphosate-n-acetyltransferase (gat) genes

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970923