IT1259188B - FORMULATIONS TO PROMOTE THE VAGINAL ABSORPTION OF POLYPEPTIDES - Google Patents
FORMULATIONS TO PROMOTE THE VAGINAL ABSORPTION OF POLYPEPTIDESInfo
- Publication number
- IT1259188B IT1259188B ITPD920214A ITPD920214A IT1259188B IT 1259188 B IT1259188 B IT 1259188B IT PD920214 A ITPD920214 A IT PD920214A IT PD920214 A ITPD920214 A IT PD920214A IT 1259188 B IT1259188 B IT 1259188B
- Authority
- IT
- Italy
- Prior art keywords
- formulations
- promote
- polypeptides
- vaginal
- polypeptide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 238000010521 absorption reaction Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000004005 microsphere Substances 0.000 abstract 2
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- 210000003038 endothelium Anatomy 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invenzione si riferisce a formulazioni farmaceutiche costituite da un polipeptide, ad esempio calcitonina, atte alla somministrazione per via vaginale. Dette formulazioni sono realizzate mediante l'impiego di polimeri semisintetici biocompatibili in forma di microsfere disperse omogeneamente in opportuni eccipienti scelti in modo da garantire la mucoadesivitĂ delle microsfere all'endotelio della mucosa vaginale e promuovere l'assorbimento transmucosale del polipeptide.The present invention relates to pharmaceutical formulations consisting of a polypeptide, for example calcitonin, suitable for vaginal administration. These formulations are made by using biocompatible semisynthetic polymers in the form of microspheres homogeneously dispersed in suitable excipients chosen so as to guarantee the mucoadhesivity of the microspheres to the endothelium of the vaginal mucosa and promote the transmucosal absorption of the polypeptide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD920214A IT1259188B (en) | 1992-11-25 | 1992-11-25 | FORMULATIONS TO PROMOTE THE VAGINAL ABSORPTION OF POLYPEPTIDES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD920214A IT1259188B (en) | 1992-11-25 | 1992-11-25 | FORMULATIONS TO PROMOTE THE VAGINAL ABSORPTION OF POLYPEPTIDES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITPD920214A0 ITPD920214A0 (en) | 1992-11-25 |
| ITPD920214A1 ITPD920214A1 (en) | 1994-05-25 |
| IT1259188B true IT1259188B (en) | 1996-03-11 |
Family
ID=11390105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITPD920214A IT1259188B (en) | 1992-11-25 | 1992-11-25 | FORMULATIONS TO PROMOTE THE VAGINAL ABSORPTION OF POLYPEPTIDES |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1259188B (en) |
-
1992
- 1992-11-25 IT ITPD920214A patent/IT1259188B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITPD920214A1 (en) | 1994-05-25 |
| ITPD920214A0 (en) | 1992-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19961024 |