IT1256705B - PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION. - Google Patents
PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION.Info
- Publication number
- IT1256705B IT1256705B ITRM920915A ITRM920915A IT1256705B IT 1256705 B IT1256705 B IT 1256705B IT RM920915 A ITRM920915 A IT RM920915A IT RM920915 A ITRM920915 A IT RM920915A IT 1256705 B IT1256705 B IT 1256705B
- Authority
- IT
- Italy
- Prior art keywords
- carnitine
- procedure
- preparation
- waste product
- opposite configuration
- Prior art date
Links
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical compound C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 title abstract 3
- 239000002699 waste material Substances 0.000 title abstract 2
- PHIQHXFUZVPYII-LURJTMIESA-N (S)-carnitine Chemical compound C[N+](C)(C)C[C@@H](O)CC([O-])=O PHIQHXFUZVPYII-LURJTMIESA-N 0.000 abstract 1
- -1 acyl D - (+) - carnitine ester Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
Abstract
Procedimento per produrre L-(-)-carnitina dal composto di scarto D-(+)-carnitinammide, consistente nel convertire la D-(+)-carnitinammide in D-(+)-carnitina, questa in un estere che viene acilato con un agente acilante che introduce un gruppo uscente fornendo un estere di acil D-(+)-carnitina che, una volta ripristinata la funzione carbossilica, per trattamento in ambiente basico dà L-(-)carnitina.Process for producing L - (-) - carnitine from the waste compound D - (+) - carnitinamide, consisting in converting D - (+) - carnitinamide to D - (+) - carnitine, this in an ester which is acylated with an acylating agent which introduces an outgoing group by supplying an acyl D - (+) - carnitine ester which, once the carboxylic function is restored, gives treatment in a basic environment to give L - (-) carnitine.
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM920915A IT1256705B (en) | 1992-12-21 | 1992-12-21 | PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION. |
ZA939444A ZA939444B (en) | 1992-12-21 | 1993-03-28 | Process for manfacturing L-(-) carnitine from a waste product having opposite configuration. |
ES93830506T ES2090945T3 (en) | 1992-12-21 | 1993-12-15 | PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT THAT HAS AN OPPOSING CONFIGURATION. |
DE69303807T DE69303807T2 (en) | 1992-12-21 | 1993-12-15 | Process for producing an L - (-) carnitine from a waste product with the opposite configuration |
DK93830506.7T DK0609643T3 (en) | 1992-12-21 | 1993-12-15 | Process for preparing L - (-) carnitine from a waste product of opposite configuration |
AT93830506T ATE140694T1 (en) | 1992-12-21 | 1993-12-15 | METHOD FOR PRODUCING L-(-)CARNITINE FROM A WASTE PRODUCT HAVING THE OPPOSITE CONFIGURATION |
EP93830506A EP0609643B1 (en) | 1992-12-21 | 1993-12-15 | Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration |
CA002111898A CA2111898C (en) | 1992-12-21 | 1993-12-20 | Process for manufacturing l-(-)-carnitine from a waste product having opposite configuration |
KR1019930028618A KR100294780B1 (en) | 1992-12-21 | 1993-12-20 | Process for the production of L-(-)-carnitine from wastes with opposite arrangement |
JP31979293A JP3502649B2 (en) | 1992-12-21 | 1993-12-20 | Method for producing L-(-)-carnitine from configurational isomer by-product |
US08/170,764 US5412113A (en) | 1992-12-21 | 1993-12-21 | Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration |
US08/367,863 US5599978A (en) | 1992-12-21 | 1995-01-03 | Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration |
GR960401768T GR3020617T3 (en) | 1992-12-21 | 1996-07-25 | Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration. |
HK98104936A HK1005861A1 (en) | 1992-12-21 | 1998-06-05 | Process for manufacturing l-(-)-carnitine from a waste product having opposite configuration |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM920915A IT1256705B (en) | 1992-12-21 | 1992-12-21 | PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM920915A0 ITRM920915A0 (en) | 1992-12-21 |
ITRM920915A1 ITRM920915A1 (en) | 1994-06-21 |
IT1256705B true IT1256705B (en) | 1995-12-12 |
Family
ID=11401346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM920915A IT1256705B (en) | 1992-12-21 | 1992-12-21 | PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINE FROM A WASTE PRODUCT WITH OPPOSITE CONFIGURATION. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5412113A (en) |
EP (1) | EP0609643B1 (en) |
JP (1) | JP3502649B2 (en) |
KR (1) | KR100294780B1 (en) |
AT (1) | ATE140694T1 (en) |
CA (1) | CA2111898C (en) |
DE (1) | DE69303807T2 (en) |
DK (1) | DK0609643T3 (en) |
ES (1) | ES2090945T3 (en) |
GR (1) | GR3020617T3 (en) |
HK (1) | HK1005861A1 (en) |
IT (1) | IT1256705B (en) |
ZA (1) | ZA939444B (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1240760B (en) * | 1990-02-12 | 1993-12-17 | Sigma Tau Ind Farmaceuti | ACYL-L-CARNITINE ESTERS WITH GAMMA-HYDROXYBUTIRRIC ACID AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM FOR THE INHIBITION OF NEURONAL DEGENERATION AND IN THE TREATMENT OF COMA. |
IT1261230B (en) * | 1993-04-08 | 1996-05-09 | Sigma Tau Ind Farmaceuti | IMPROVED PROCEDURE FOR THE PREPARATION OF L - (-) - CARNITINA STARTING FROM ITS PRECURSORS WITH OPPOSED CONFIGURATION. |
IT1261828B (en) | 1993-07-14 | 1996-06-03 | Sigma Tau Ind Farmaceuti | ACIL L-CARNITINE ESTERS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM FOR THE TREATMENT OF THE ENDOTOXIC SHOCK. |
IT1276207B1 (en) * | 1995-09-29 | 1997-10-27 | Sigma Tau Ind Farmaceuti | PROCEDURE FOR THE PREPARATION OF (S) -B-HYDROXY-GAMMA- BUTYROLACTONE |
IT1277953B1 (en) * | 1995-12-21 | 1997-11-12 | Sigma Tau Ind Farmaceuti | PHARMACEUTICAL COMPOSITION CONTAINING L-CARNITINE OR AN ALCANOYL L-CARNITINE AND A 3-OMEGA SERIES POLYUNSATURED ACID USEFUL |
IT1297120B1 (en) * | 1997-12-16 | 1999-08-03 | Sigma Tau Ind Farmaceuti | PROCEDURE FOR THE PRODUCTION OF (R) -3-HYDROXY-4-BUTYROLACTONE USEFUL IN THE PREPARATION OF (R) -CARNITINE |
IT1299182B1 (en) * | 1998-05-29 | 2000-02-29 | Sigma Tau Ind Farmaceuti | CHEMICAL PROCEDURE FOR THE STEREOSELECTIVE SYNTHESIS OF R - (-) - CARNITINE. |
IT1301977B1 (en) * | 1998-07-31 | 2000-07-20 | Sigma Tau Ind Farmaceuti | PROCEDURE FOR THE PREPARATION OF R - (-) - CARNITINA |
IT1307303B1 (en) * | 1999-12-23 | 2001-10-30 | Sigma Tau Ind Farmaceuti | STEREOSPECIFIC HYDROLYSIS OF OPTICALLY ACTIVE ESTERS. |
IT1306184B1 (en) * | 1999-08-05 | 2001-05-30 | Sigma Tau Ind Farmaceuti | NITRILOSSI DERIVATIVES OF (R) AND (S) -CARNITINE. |
CA2383814C (en) * | 1999-09-03 | 2010-08-17 | Sigma-Tau Healthscience S.P.A. | Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same |
DE10027393B4 (en) * | 2000-06-02 | 2007-05-16 | Wella Ag | Poly- and oligoesters of cationic hydroxy acids, process for their preparation and their use |
WO2012010297A1 (en) * | 2010-07-21 | 2012-01-26 | Lonza Ltd | A PROCESS FOR THE PRODUCTION OF CARNITINE FROM β-LACTONES |
HRP20231572T1 (en) | 2014-07-03 | 2024-03-15 | Silti Ag | Methods and compositions for treating obesity, preventing weight gain, promoting weight loss, promoting slimming, or treating or preventing the development of diabetes |
CN115057789B (en) * | 2022-06-30 | 2024-04-02 | 中科萱嘉医养(珠海)健康科技有限公司 | L-carnitine ionic liquid and preparation method and application thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1156852B (en) * | 1978-07-10 | 1987-02-04 | Sigma Tau Ind Farmaceuti | INDUSTRIAL PROCEDURE FOR THE PREPARATION OF THE L CARNITINAMIDE D'CANFORATE AND THE D CARNITINAMIDE D CANPHORATE AND ITS APPLICATIONS |
IT1136945B (en) * | 1981-03-18 | 1986-09-03 | Anic Spa | PROCESS FOR THE PREPARATION OF L-CARNITINA |
US5200526A (en) * | 1987-04-27 | 1993-04-06 | The Governors Of The University Of Alberta | Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts |
-
1992
- 1992-12-21 IT ITRM920915A patent/IT1256705B/en active IP Right Grant
-
1993
- 1993-03-28 ZA ZA939444A patent/ZA939444B/en unknown
- 1993-12-15 DK DK93830506.7T patent/DK0609643T3/en active
- 1993-12-15 EP EP93830506A patent/EP0609643B1/en not_active Expired - Lifetime
- 1993-12-15 AT AT93830506T patent/ATE140694T1/en not_active IP Right Cessation
- 1993-12-15 DE DE69303807T patent/DE69303807T2/en not_active Expired - Lifetime
- 1993-12-15 ES ES93830506T patent/ES2090945T3/en not_active Expired - Lifetime
- 1993-12-20 CA CA002111898A patent/CA2111898C/en not_active Expired - Fee Related
- 1993-12-20 JP JP31979293A patent/JP3502649B2/en not_active Expired - Fee Related
- 1993-12-20 KR KR1019930028618A patent/KR100294780B1/en not_active IP Right Cessation
- 1993-12-21 US US08/170,764 patent/US5412113A/en not_active Expired - Lifetime
-
1995
- 1995-01-03 US US08/367,863 patent/US5599978A/en not_active Expired - Lifetime
-
1996
- 1996-07-25 GR GR960401768T patent/GR3020617T3/en unknown
-
1998
- 1998-06-05 HK HK98104936A patent/HK1005861A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH06199751A (en) | 1994-07-19 |
HK1005861A1 (en) | 1999-01-29 |
KR100294780B1 (en) | 2001-09-17 |
JP3502649B2 (en) | 2004-03-02 |
ITRM920915A1 (en) | 1994-06-21 |
DE69303807T2 (en) | 1996-11-28 |
EP0609643A1 (en) | 1994-08-10 |
KR940014303A (en) | 1994-07-18 |
ITRM920915A0 (en) | 1992-12-21 |
US5599978A (en) | 1997-02-04 |
GR3020617T3 (en) | 1996-10-31 |
DK0609643T3 (en) | 1996-11-11 |
ZA939444B (en) | 1994-08-09 |
US5412113A (en) | 1995-05-02 |
CA2111898A1 (en) | 1994-06-22 |
ES2090945T3 (en) | 1996-10-16 |
ATE140694T1 (en) | 1996-08-15 |
CA2111898C (en) | 2004-04-27 |
DE69303807D1 (en) | 1996-08-29 |
EP0609643B1 (en) | 1996-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19951113 |