IT1256354B - ANTI-TUMORAL ACTIVITIES OF COMBRETASTATINA AND PROCEDURE FOR THEIR PREPARATION - Google Patents

ANTI-TUMORAL ACTIVITIES OF COMBRETASTATINA AND PROCEDURE FOR THEIR PREPARATION

Info

Publication number
IT1256354B
IT1256354B ITMI922033A ITMI922033A IT1256354B IT 1256354 B IT1256354 B IT 1256354B IT MI922033 A ITMI922033 A IT MI922033A IT MI922033 A ITMI922033 A IT MI922033A IT 1256354 B IT1256354 B IT 1256354B
Authority
IT
Italy
Prior art keywords
preparation
combretastatina
procedure
tumoral activities
tumoral
Prior art date
Application number
ITMI922033A
Other languages
Italian (it)
Inventor
Francesca Pelizzoni
Roberto Colombo
Luisella Verotta
Original Assignee
Francesca Pelizzoni
Roberto Colombo
Luisella Verotta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Francesca Pelizzoni, Roberto Colombo, Luisella Verotta filed Critical Francesca Pelizzoni
Priority to ITMI922033A priority Critical patent/IT1256354B/en
Publication of ITMI922033A0 publication Critical patent/ITMI922033A0/en
Priority to PCT/EP1993/002173 priority patent/WO1994005682A1/en
Priority to AU49479/93A priority patent/AU4947993A/en
Priority to ZA936311A priority patent/ZA936311B/en
Publication of ITMI922033A1 publication Critical patent/ITMI922033A1/en
Application granted granted Critical
Publication of IT1256354B publication Critical patent/IT1256354B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invenzione si riferisce a derivati della combretastatina ad attività anti-tumorale e ad un procedimento per la loro estrazione e il loro isolamento da Combretum krausii. L'invenzione si riferisce inoltre a composizioni farmaceutiche per uso anti-tumorale e alla preparazione di dette composizioni farmaceutiche.The invention relates to derivatives of combretastatin with anti-tumor activity and to a process for their extraction and isolation from Combretum krausii. The invention further relates to pharmaceutical compositions for anti-tumor use and to the preparation of said pharmaceutical compositions.

ITMI922033A 1992-08-31 1992-08-31 ANTI-TUMORAL ACTIVITIES OF COMBRETASTATINA AND PROCEDURE FOR THEIR PREPARATION IT1256354B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITMI922033A IT1256354B (en) 1992-08-31 1992-08-31 ANTI-TUMORAL ACTIVITIES OF COMBRETASTATINA AND PROCEDURE FOR THEIR PREPARATION
PCT/EP1993/002173 WO1994005682A1 (en) 1992-08-31 1993-08-16 Combretastatin derivatives with antitumoral activity and process for the preparation thereof
AU49479/93A AU4947993A (en) 1992-08-31 1993-08-16 Combretastatin derivatives with antitumoral activity and process for the preparation thereof
ZA936311A ZA936311B (en) 1992-08-31 1993-08-27 Combretastatin derivatives with antitumoral activity and process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922033A IT1256354B (en) 1992-08-31 1992-08-31 ANTI-TUMORAL ACTIVITIES OF COMBRETASTATINA AND PROCEDURE FOR THEIR PREPARATION

Publications (3)

Publication Number Publication Date
ITMI922033A0 ITMI922033A0 (en) 1992-08-31
ITMI922033A1 ITMI922033A1 (en) 1994-03-03
IT1256354B true IT1256354B (en) 1995-12-01

Family

ID=11363893

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI922033A IT1256354B (en) 1992-08-31 1992-08-31 ANTI-TUMORAL ACTIVITIES OF COMBRETASTATINA AND PROCEDURE FOR THEIR PREPARATION

Country Status (4)

Country Link
AU (1) AU4947993A (en)
IT (1) IT1256354B (en)
WO (1) WO1994005682A1 (en)
ZA (1) ZA936311B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2451844A1 (en) * 2001-06-27 2003-01-09 Unigen Pharmaceuticals, Inc. Method for generating, screening and dereplicating natural product libraries for the discovery of therapeutic agents
JP5128277B2 (en) 2004-05-28 2013-01-23 ユニジェン・インコーポレーテッド Diarylalkanes as potent inhibitors of binuclear enzymes
ES2740974T3 (en) 2008-07-21 2020-02-07 Unigen Inc Series of compounds for whitening (lightening) the skin
ES2859700T3 (en) 2011-03-24 2021-10-04 Unigen Inc Compounds and methods for the preparation of diarylpropanes
CN102219811B (en) * 2011-04-14 2013-07-03 中国药科大学 CA-4 derivatives and preparation method and medicinal application thereof
CN103421057B (en) * 2013-08-14 2016-03-30 合肥医工医药有限公司 Combretastatin aminosugar conjugate, its method for making and medicinal use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61171427A (en) * 1985-01-24 1986-08-02 Osaka Chem Lab Substance for preventing thrombosis or the like
CA1338645C (en) * 1987-01-06 1996-10-15 George R. Pettit Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins"
ATE167473T1 (en) * 1990-08-20 1998-07-15 Eisai Co Ltd SULFONAMIDE DERIVATIVES
GB9106177D0 (en) * 1991-03-22 1991-05-08 Aston Molecules Ltd Substituted diphenylethylenes and analogues or derivatives thereof

Also Published As

Publication number Publication date
ITMI922033A0 (en) 1992-08-31
AU4947993A (en) 1994-03-29
ZA936311B (en) 1994-03-23
ITMI922033A1 (en) 1994-03-03
WO1994005682A1 (en) 1994-03-17

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970828