IT1256320B - HETEROCYCLIC DERIVATIVES - Google Patents
HETEROCYCLIC DERIVATIVESInfo
- Publication number
- IT1256320B IT1256320B ITMI922661A ITMI922661A IT1256320B IT 1256320 B IT1256320 B IT 1256320B IT MI922661 A ITMI922661 A IT MI922661A IT MI922661 A ITMI922661 A IT MI922661A IT 1256320 B IT1256320 B IT 1256320B
- Authority
- IT
- Italy
- Prior art keywords
- compounds
- relates
- heterocyclic derivatives
- new compounds
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
L'invenzione riguarda composti farmaceuticamente utili di formula I, in cui R1, R2, R3, R4 e A1 hanno i diversi significati qui definiti, e loro sali non tossici e composizioni farmaceutiche che li contengono. I nuovi composti sono importanti nel trattamento di condizioni come ipertensione ed insufficienza cardiaca congestiva. L'invenzione riguarda inoltre procedimenti per la fabbricazione dei nuovi composti e l'impiego dei composti nel trattamento medico.The invention relates to pharmaceutically useful compounds of formula I, wherein R1, R2, R3, R4 and A1 have the different meanings defined herein, and their non-toxic salts and pharmaceutical compositions containing them. The new compounds are important in the treatment of conditions such as hypertension and congestive heart failure. The invention also relates to processes for the manufacture of the new compounds and the use of the compounds in medical treatment.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919125842A GB9125842D0 (en) | 1991-12-04 | 1991-12-04 | Heterocyclic derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI922661A0 ITMI922661A0 (en) | 1992-11-20 |
ITMI922661A1 ITMI922661A1 (en) | 1993-06-05 |
IT1256320B true IT1256320B (en) | 1995-11-30 |
Family
ID=10705730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI922661A IT1256320B (en) | 1991-12-04 | 1992-11-20 | HETEROCYCLIC DERIVATIVES |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPH05255327A (en) |
BE (1) | BE1005473A3 (en) |
CA (1) | CA2082668A1 (en) |
DE (1) | DE4239440A1 (en) |
FR (1) | FR2684672A1 (en) |
GB (2) | GB9125842D0 (en) |
IE (1) | IE922785A1 (en) |
IT (1) | IT1256320B (en) |
NL (1) | NL9202091A (en) |
ZA (1) | ZA928742B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5439911A (en) * | 1992-12-28 | 1995-08-08 | Shionogi & Co., Ltd. | Aminopyrimidine derivatives and their production and use |
EP0618207B1 (en) * | 1993-03-24 | 1999-01-07 | American Home Products Corporation | Substituted pyridopyrimidines as antihypertensives |
KR100300566B1 (en) * | 1994-09-17 | 2001-11-22 | 조생현 | Pyrimidinone derivative and method for preparation thereof |
US6440965B1 (en) * | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
US6583148B1 (en) | 1999-04-08 | 2003-06-24 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic substituted pyrimidines |
US7205297B2 (en) | 2000-07-24 | 2007-04-17 | Krenitsky Pharmaceuticals, Inc. | Substituted 5-alkynyl pyrimidines having neurotrophic activity |
GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
DK1471057T3 (en) * | 2003-04-25 | 2006-05-15 | Actimis Pharmaceuticals Inc | Pyrimidinylacetic acid derivatives suitable for the treatment of diseases mediated by CRTH2 |
SI1718649T1 (en) | 2004-01-31 | 2009-10-31 | Actimis Pharmaceuticals Inc | Imidazo 1,2-c pyrimidinylacetic acid derivatives |
AR068633A1 (en) | 2007-09-25 | 2009-11-25 | Actimis Pharmaceuticals Inc | PYRIMIDINES REPLACED WITH 2-S- BENCILO AS AN ANTHOGONIST OF CRTH2 |
DK2205569T3 (en) | 2007-09-25 | 2012-05-21 | Actimis Pharmaceuticals Inc | ALKYLTHIOPYRIMIDINES AS CRTH2 ANTAGONISTS |
KR102481705B1 (en) * | 2020-08-04 | 2022-12-27 | 연세대학교 산학협력단 | A Composition for Preventing or Treating Hepatic Fibrosis Comprising Triazole Derivatives as Active Ingredients |
CN117136189A (en) * | 2021-04-09 | 2023-11-28 | 先声再明医药有限公司 | Ubiquitin-specific protease 1 (USP 1) inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0424317A3 (en) * | 1989-10-19 | 1991-09-25 | Ciba-Geigy Ag | Pyrimidines |
IL99246A0 (en) * | 1990-09-10 | 1992-07-15 | Abbott Lab | Angiotensin ii receptor antagonists and pharmaceutical compositions containing them |
US5149699A (en) * | 1991-10-24 | 1992-09-22 | American Home Products Corporation | Substituted pyridopyrimidines useful as antgiotensin II antagonists |
-
1991
- 1991-12-04 GB GB919125842A patent/GB9125842D0/en active Pending
-
1992
- 1992-11-03 IE IE278592A patent/IE922785A1/en not_active IP Right Cessation
- 1992-11-12 CA CA002082668A patent/CA2082668A1/en not_active Abandoned
- 1992-11-12 ZA ZA928742A patent/ZA928742B/en unknown
- 1992-11-20 IT ITMI922661A patent/IT1256320B/en active IP Right Grant
- 1992-11-24 DE DE4239440A patent/DE4239440A1/de not_active Withdrawn
- 1992-11-30 FR FR9214376A patent/FR2684672A1/en active Pending
- 1992-12-02 NL NL9202091A patent/NL9202091A/en not_active Application Discontinuation
- 1992-12-03 GB GB9225283A patent/GB2262096A/en not_active Withdrawn
- 1992-12-03 BE BE9201065A patent/BE1005473A3/en not_active IP Right Cessation
- 1992-12-04 JP JP4325478A patent/JPH05255327A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
GB9225283D0 (en) | 1993-01-27 |
GB2262096A (en) | 1993-06-09 |
ZA928742B (en) | 1993-06-09 |
NL9202091A (en) | 1993-07-01 |
BE1005473A3 (en) | 1993-08-03 |
CA2082668A1 (en) | 1993-06-05 |
FR2684672A1 (en) | 1993-06-11 |
ITMI922661A1 (en) | 1993-06-05 |
JPH05255327A (en) | 1993-10-05 |
DE4239440A1 (en) | 1993-06-09 |
GB9125842D0 (en) | 1992-02-05 |
IE922785A1 (en) | 1993-06-16 |
ITMI922661A0 (en) | 1992-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |