IT1256023B - BENZOSSAZINONIC AND BENZOTHIAZINONIC DERIVATIVES WITH CARDIOVASCULAR ACTIVITY - Google Patents

BENZOSSAZINONIC AND BENZOTHIAZINONIC DERIVATIVES WITH CARDIOVASCULAR ACTIVITY

Info

Publication number
IT1256023B
IT1256023B ITMI921423A ITMI921423A IT1256023B IT 1256023 B IT1256023 B IT 1256023B IT MI921423 A ITMI921423 A IT MI921423A IT MI921423 A ITMI921423 A IT MI921423A IT 1256023 B IT1256023 B IT 1256023B
Authority
IT
Italy
Prior art keywords
benzothiazinonic
derivatives
benzossazinonic
cardiovascular activity
formula
Prior art date
Application number
ITMI921423A
Other languages
Italian (it)
Inventor
Silvio Levi
Francesca Benedini
Giorgio Bertolini
Giancarlo Dona
Gianni Gromo
Alberto Sala
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Priority to ITMI921423A priority Critical patent/IT1256023B/en
Publication of ITMI921423A0 publication Critical patent/ITMI921423A0/en
Priority to PCT/EP1993/001377 priority patent/WO1993025542A1/en
Publication of ITMI921423A1 publication Critical patent/ITMI921423A1/en
Application granted granted Critical
Publication of IT1256023B publication Critical patent/IT1256023B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems

Abstract

Derivati benzossazinonici e benzotiazinonici di formula (I) (FORMULA I) dove Y è alchilene o cicloalchilene; R è idrogeno, alogeno, idrossi, alchile, nitro, sulfo, ciano, ammino, alcossi, formile, trifluorometile, ecc.; e X e Z sono indipendentemente S oppure O, e i loro sali, possiedono attività cardiovascolare.Benzoxazinonic and benzothiazinonic derivatives of formula (I) (FORMULA I) where Y is alkylene or cycloalkylene; R is hydrogen, halogen, hydroxy, alkyl, nitro, sulfo, cyan, amino, alkoxy, formyl, trifluoromethyl, etc .; and X and Z are independently S or O, and their salts have cardiovascular activity.

ITMI921423A 1992-06-10 1992-06-10 BENZOSSAZINONIC AND BENZOTHIAZINONIC DERIVATIVES WITH CARDIOVASCULAR ACTIVITY IT1256023B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITMI921423A IT1256023B (en) 1992-06-10 1992-06-10 BENZOSSAZINONIC AND BENZOTHIAZINONIC DERIVATIVES WITH CARDIOVASCULAR ACTIVITY
PCT/EP1993/001377 WO1993025542A1 (en) 1992-06-10 1993-06-01 Benzoxazinone and benzothiazinone derivatives having cardiovascular activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921423A IT1256023B (en) 1992-06-10 1992-06-10 BENZOSSAZINONIC AND BENZOTHIAZINONIC DERIVATIVES WITH CARDIOVASCULAR ACTIVITY

Publications (3)

Publication Number Publication Date
ITMI921423A0 ITMI921423A0 (en) 1992-06-10
ITMI921423A1 ITMI921423A1 (en) 1993-12-10
IT1256023B true IT1256023B (en) 1995-11-20

Family

ID=11363482

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI921423A IT1256023B (en) 1992-06-10 1992-06-10 BENZOSSAZINONIC AND BENZOTHIAZINONIC DERIVATIVES WITH CARDIOVASCULAR ACTIVITY

Country Status (2)

Country Link
IT (1) IT1256023B (en)
WO (1) WO1993025542A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19708846A1 (en) * 1997-03-05 1998-09-17 Gruenenthal Gmbh New benzoxazinedione derivatives, process for their preparation and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3047573A (en) * 1962-07-31 N-alkylamido substituted
US2714105A (en) * 1953-12-31 1955-07-26 American Cyanamid Co Benzoxazine diones and methods of preparing the same
CH459211A (en) * 1965-01-25 1968-07-15 Robapharm Ag Process for the preparation of new basic derivatives of dihydro-1,3-benzoxazine-2,4-dione
IT1244472B (en) * 1990-12-14 1994-07-15 Italfarmaco Spa BENZOSSAZINONI AND BENZOTIAZINONI WITH CARDIOVASCULAR ACTIVITY

Also Published As

Publication number Publication date
ITMI921423A1 (en) 1993-12-10
ITMI921423A0 (en) 1992-06-10
WO1993025542A1 (en) 1993-12-23

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960610