IT1251743B - Drug comprising 2-iodo:melatonin, 2-bromo:melatonin and progestogen - for use as contraceptive, for controlling menstrual cycle and for treating mammary tumours and ovarian and bladder carcinomas - Google Patents
Drug comprising 2-iodo:melatonin, 2-bromo:melatonin and progestogen - for use as contraceptive, for controlling menstrual cycle and for treating mammary tumours and ovarian and bladder carcinomasInfo
- Publication number
- IT1251743B IT1251743B IT2233890A IT2233890A IT1251743B IT 1251743 B IT1251743 B IT 1251743B IT 2233890 A IT2233890 A IT 2233890A IT 2233890 A IT2233890 A IT 2233890A IT 1251743 B IT1251743 B IT 1251743B
- Authority
- IT
- Italy
- Prior art keywords
- melatonin
- contraceptive
- iodo
- drug
- progestogen
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000003433 contraceptive agent Substances 0.000 title abstract 2
- 230000002254 contraceptive effect Effects 0.000 title abstract 2
- FNHLXIXCQDGUCQ-UHFFFAOYSA-N n-[2-(2-bromo-5-methoxy-1h-indol-3-yl)ethyl]acetamide Chemical group COC1=CC=C2NC(Br)=C(CCNC(C)=O)C2=C1 FNHLXIXCQDGUCQ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000583 progesterone congener Substances 0.000 title abstract 2
- 206010005003 Bladder cancer Diseases 0.000 title 1
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title 1
- 206010033128 Ovarian cancer Diseases 0.000 title 1
- 201000001531 bladder carcinoma Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title 1
- 229960003987 melatonin Drugs 0.000 title 1
- 230000002611 ovarian Effects 0.000 title 1
- 230000027758 ovulation cycle Effects 0.000 title 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 title 1
- FJDDSMSDZHURBJ-UHFFFAOYSA-N N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1 FJDDSMSDZHURBJ-UHFFFAOYSA-N 0.000 abstract 3
- WAHQVRCNDCHDIB-QZYSPNBYSA-N [(3s,8r,9s,10r,13s,14s,17r)-17-acetyl-17-acetyloxy-6,10,13-trimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-yl] 3-cyclopentylpropanoate Chemical compound O([C@@H]1C=C2C(C)=C[C@H]3[C@@H]4CC[C@]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)(OC(=O)C)C(C)=O)C(=O)CCC1CCCC1 WAHQVRCNDCHDIB-QZYSPNBYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000001276 controlling effect Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002547 new drug Substances 0.000 abstract 1
- 230000000247 oncostatic effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Abstract
A new drug for human use, having contraceptive and menstural cycle controlling properties, oncostatic action is mammary tumours and melanomes, and antikinetosic action comprises N-acetyl-2-iodo-5-methoxy-triptamine (I) (2-iodomelatonin) or N-acetyl-2-komotryptamine (II) (2-bromomelatonin) and derivs. thereof in association with a progestagen. Also claimed are methods of synthesis for 2-iodomelatonin and 3-bromomelatonin.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2233890A IT1251743B (en) | 1990-12-11 | 1990-12-11 | Drug comprising 2-iodo:melatonin, 2-bromo:melatonin and progestogen - for use as contraceptive, for controlling menstrual cycle and for treating mammary tumours and ovarian and bladder carcinomas |
DE69132061T DE69132061D1 (en) | 1990-09-28 | 1991-09-27 | Contraceptive and menstrual cycle-regulating preparation with oncostatic properties |
DE69115221T DE69115221T2 (en) | 1990-09-28 | 1991-09-27 | Method for the synthesis of a preparation for regulating conception and the menstrual cycle with oncostatic, anti-kinetic, preventive and therapeutic properties for the treatment of breast cancer and melanoma. |
US07/767,084 US5272141A (en) | 1990-09-28 | 1991-09-27 | Contraceptive and menstrual cycle controlling drug having oncostatic therapeutic properties for treatment of mammary tumors and melanomas, and method therefor |
DK91830402.3T DK0483077T3 (en) | 1990-09-28 | 1991-09-27 | Process for the Synthesis of a Contraceptive and Menstrual Cycle Controlling Drug with Oncostatic, Antikinetosic, Preventive and Therapeutic Properties for the Treatment of Breast Tumors and Melanomas |
ES91830402T ES2082959T3 (en) | 1990-09-28 | 1991-09-27 | PROCEDURE TO DEVELOP THE SYNTHESIS OF A CONTRACEPTIVE AND CONTROL DRUG OF THE MENSTRUAL CYCLE THAT HAS ANTICINETOSIC, ONCOSTATIC AND THERAPEUTIC PROPERTIES FOR THE TREATMENT OF BREAST TUMORS AND MELANOMAS. |
AT91830402T ATE131058T1 (en) | 1990-09-28 | 1991-09-27 | METHOD FOR SYNTHESIS OF A PREPARATION FOR REGULATION OF CONCEPTION AND THE MENSTRUAL CYCLE WITH ONCOSTATIC ANTIKINETOSIC, PREVENTIVE AND THERAPEUTIC PROPERTIES FOR THE TREATMENT OF BREAST CANCER AND MELANOMA. |
AT94113848T ATE190490T1 (en) | 1990-09-28 | 1991-09-27 | CONTRACEPTIVE AND MENSTRUAL CYCLE REGULATING PREPARATION WITH ONCOSTATIC PROPERTIES |
EP91830402A EP0483077B1 (en) | 1990-09-28 | 1991-09-27 | A method for carrying out the synthesis of a contraceptive and menstrual cycle controlling drug having oncostatic, antikinetosic, preventive and therapeutic properties for treatment of mammary tumours and melanomas. |
EP94113848A EP0641565B1 (en) | 1990-09-28 | 1991-09-27 | Contraceptive and menstrual cycle controlling drug having oncostatic properties |
JP3251261A JP2849692B2 (en) | 1990-09-28 | 1991-09-30 | 2-Bromomelatonin, a contraceptive and menstrual cycle regulating agent having antitumor properties, and methods for producing the same |
GR960400577T GR3019175T3 (en) | 1990-09-28 | 1996-03-04 | A method for carrying out the synthesis of a contraceptive and menstrual cycle controlling drug having oncostatic, antikinetosic, preventive and therapeutic properties for treatment of mammary tumours and melanomas. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2233890A IT1251743B (en) | 1990-12-11 | 1990-12-11 | Drug comprising 2-iodo:melatonin, 2-bromo:melatonin and progestogen - for use as contraceptive, for controlling menstrual cycle and for treating mammary tumours and ovarian and bladder carcinomas |
Publications (3)
Publication Number | Publication Date |
---|---|
IT9022338A0 IT9022338A0 (en) | 1990-12-11 |
IT9022338A1 IT9022338A1 (en) | 1992-06-11 |
IT1251743B true IT1251743B (en) | 1995-05-23 |
Family
ID=11194889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2233890A IT1251743B (en) | 1990-09-28 | 1990-12-11 | Drug comprising 2-iodo:melatonin, 2-bromo:melatonin and progestogen - for use as contraceptive, for controlling menstrual cycle and for treating mammary tumours and ovarian and bladder carcinomas |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1251743B (en) |
-
1990
- 1990-12-11 IT IT2233890A patent/IT1251743B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
IT9022338A1 (en) | 1992-06-11 |
IT9022338A0 (en) | 1990-12-11 |
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