IT1251685B - PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN - Google Patents

PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN

Info

Publication number
IT1251685B
IT1251685B ITMI912703A ITMI912703A IT1251685B IT 1251685 B IT1251685 B IT 1251685B IT MI912703 A ITMI912703 A IT MI912703A IT MI912703 A ITMI912703 A IT MI912703A IT 1251685 B IT1251685 B IT 1251685B
Authority
IT
Italy
Prior art keywords
calcitonin
pharmaceutical compositions
compositions containing
glycyrrhizinate
absorption
Prior art date
Application number
ITMI912703A
Other languages
Italian (it)
Inventor
Laura Chiodini
Teodoro Fonio
Mario Pinza
Original Assignee
Isf Spa
Smithkline Beecham Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isf Spa, Smithkline Beecham Farma filed Critical Isf Spa
Publication of ITMI912703A0 publication Critical patent/ITMI912703A0/en
Priority to ITMI912703A priority Critical patent/IT1251685B/en
Priority to JP5506629A priority patent/JPH07500099A/en
Priority to AU26834/92A priority patent/AU2683492A/en
Priority to EP92920956A priority patent/EP0607229A1/en
Priority to PCT/EP1992/002321 priority patent/WO1993006854A1/en
Priority to CA002120755A priority patent/CA2120755A1/en
Priority to BR9206707A priority patent/BR9206707A/en
Priority to MX9205852A priority patent/MX9205852A/en
Priority to PT100946A priority patent/PT100946A/en
Publication of ITMI912703A1 publication Critical patent/ITMI912703A1/en
Application granted granted Critical
Publication of IT1251685B publication Critical patent/IT1251685B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

La presente invenzione si riferisce a nuove composizioni farmaceutiche contenenti calcitonine e a nuovo metodo per migliorare l'assorbimento di una calcitonina attraverso una membrana mucosa.Le composizioni farmaceutiche comprendono una calcitonina, una quantità efficace di un promotore dell'assorbimento che è un glicirrizinato, una quantità efficace di alcool benzilico e un veicolo farmaceuticamente accettabile; preferibilmente il glicirrizinato è glicirrizinato d'ammonio.The present invention relates to new pharmaceutical compositions containing calcitonins and to a new method for improving the absorption of a calcitonin through a mucous membrane. The pharmaceutical compositions comprise a calcitonin, an effective amount of an absorption promoter which is a glycyrrhizinate, a quantity effective benzyl alcohol and a pharmaceutically acceptable carrier; preferably the glycyrrhizinate is ammonium glycyrrhizinate.

ITMI912703A 1991-10-11 1991-10-11 PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN IT1251685B (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITMI912703A IT1251685B (en) 1991-10-11 1991-10-11 PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN
PCT/EP1992/002321 WO1993006854A1 (en) 1991-10-11 1992-10-08 Pharmaceutical compositions comprising a calcitonin, a glycyrrhizinate as absorption enhancer and benzyl
AU26834/92A AU2683492A (en) 1991-10-11 1992-10-08 Pharmaceutical compositions comprising a calcitonin, a glycyrrhizinate as absorption enhancer and benzyl
EP92920956A EP0607229A1 (en) 1991-10-11 1992-10-08 Pharmaceutical compositions comprising a calcitonin, a glycyrrhizinate as absorption enhancer and benzyl
JP5506629A JPH07500099A (en) 1991-10-11 1992-10-08 Pharmaceutical composition consisting of calcitonin, glycyrrhizinate as absorption enhancer and benzyl
CA002120755A CA2120755A1 (en) 1991-10-11 1992-10-08 Pharmaceutical compositions comprising a calcitonin, a glycyrrhizinate as absorption enhancer and benzyl
BR9206707A BR9206707A (en) 1991-10-11 1992-10-08 Pharmaceutical compounds containing a calcitonin
MX9205852A MX9205852A (en) 1991-10-11 1992-10-09 PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN
PT100946A PT100946A (en) 1991-10-11 1992-10-09 PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN AND ITS PREPARATION PROCESS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912703A IT1251685B (en) 1991-10-11 1991-10-11 PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN

Publications (3)

Publication Number Publication Date
ITMI912703A0 ITMI912703A0 (en) 1991-10-11
ITMI912703A1 ITMI912703A1 (en) 1993-04-11
IT1251685B true IT1251685B (en) 1995-05-19

Family

ID=11360856

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912703A IT1251685B (en) 1991-10-11 1991-10-11 PHARMACEUTICAL COMPOSITIONS CONTAINING A CALCITONIN

Country Status (9)

Country Link
EP (1) EP0607229A1 (en)
JP (1) JPH07500099A (en)
AU (1) AU2683492A (en)
BR (1) BR9206707A (en)
CA (1) CA2120755A1 (en)
IT (1) IT1251685B (en)
MX (1) MX9205852A (en)
PT (1) PT100946A (en)
WO (1) WO1993006854A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2285921A (en) * 1994-01-31 1995-08-02 Leilani Lea Sublingual administration of medicaments
EP0726075A1 (en) * 1995-02-08 1996-08-14 Therapicon Srl Pharmaceutical non-inorganic saline solutions for endonasal administration
WO1997021448A1 (en) * 1995-12-13 1997-06-19 Dullatur Limited A calcitonin preparation
IT1294191B1 (en) * 1997-09-05 1999-03-22 Alfa Wassermann Spa Composition for treating osteoporosis, Paget's disease or hypercalcemia, comprises calcitonin dissolved in acidic sodium chloride solution
GB2368792A (en) * 2000-10-06 2002-05-15 Roger Randal Charles New Absorption enhancers
ITRM20010048A1 (en) * 2001-01-30 2002-07-30 Gregorio Mauro De METHOD FOR PREPARING PHYSIOLOGICALLY ACCEPTABLE AQUEOUS SOLUTIONS SO OBTAINED.
GB0308732D0 (en) * 2003-04-15 2003-05-21 Axcess Ltd Absorption enhancers
GB0308734D0 (en) 2003-04-15 2003-05-21 Axcess Ltd Uptake of macromolecules

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60188315A (en) * 1984-03-07 1985-09-25 Yamanouchi Pharmaceut Co Ltd Antipruritic plaster containing glycyrretic acid
JPS61267528A (en) * 1984-11-26 1986-11-27 Yamanouchi Pharmaceut Co Ltd Transnasal calcitonin agent containing absorbefacient
ES2061688T3 (en) * 1987-11-13 1994-12-16 Smithkline Beecham Farma PHARMACEUTICAL COMPOSITIONS THAT INCLUDE A CALCITONINE AND A GLICIRRICINATE AS IMPROVER OF ABSORPTION.
JPH078806B2 (en) * 1990-08-16 1995-02-01 旭化成工業株式会社 Nasal emulsion containing calcitonin

Also Published As

Publication number Publication date
MX9205852A (en) 1993-06-01
JPH07500099A (en) 1995-01-05
WO1993006854A1 (en) 1993-04-15
CA2120755A1 (en) 1993-04-15
BR9206707A (en) 1995-10-31
PT100946A (en) 1993-10-29
ITMI912703A0 (en) 1991-10-11
AU2683492A (en) 1993-05-03
ITMI912703A1 (en) 1993-04-11
EP0607229A1 (en) 1994-07-27

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19951031