IT1249686B - Preparazioni farmaceutiche orali, a base di acidi biliari, a cessione protratta e controllata con le quali e' possibile adottare una sola somministrazione giornaliera - Google Patents
Preparazioni farmaceutiche orali, a base di acidi biliari, a cessione protratta e controllata con le quali e' possibile adottare una sola somministrazione giornalieraInfo
- Publication number
- IT1249686B IT1249686B ITRM910550A ITRM910550A IT1249686B IT 1249686 B IT1249686 B IT 1249686B IT RM910550 A ITRM910550 A IT RM910550A IT RM910550 A ITRM910550 A IT RM910550A IT 1249686 B IT1249686 B IT 1249686B
- Authority
- IT
- Italy
- Prior art keywords
- adopt
- bile acids
- pharmaceutical preparations
- daily administration
- protract
- Prior art date
Links
- 239000003613 bile acid Substances 0.000 title abstract 2
- 239000008183 oral pharmaceutical preparation Substances 0.000 title 1
- 239000001913 cellulose Substances 0.000 abstract 2
- 229920002678 cellulose Polymers 0.000 abstract 2
- 125000005395 methacrylic acid group Chemical group 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 abstract 1
- 229920001817 Agar Polymers 0.000 abstract 1
- 229920000569 Gum karaya Polymers 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 241000934878 Sterculia Species 0.000 abstract 1
- 229920001615 Tragacanth Polymers 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000008272 agar Substances 0.000 abstract 1
- 235000010419 agar Nutrition 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 239000000305 astragalus gummifer gum Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 abstract 1
- 201000001883 cholelithiasis Diseases 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 208000001130 gallstones Diseases 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 235000010494 karaya gum Nutrition 0.000 abstract 1
- 239000000231 karaya gum Substances 0.000 abstract 1
- 229940039371 karaya gum Drugs 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 229940069328 povidone Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 abstract 1
- 229960001661 ursodiol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Vengono descritte preparazioni farmaceutiche uso orale, a base di acidi biliari, in particolare acido ursodesossicolico, caratterizzate dal fatto che cedono la sostanza attiva in modo controllato e per un periodo esteso (6-12 ore).Detti preparati trovano impiego nella terapia delle calcolosi biliari sia in senso curativo (lisi) che preventivo e permettono di adottare una posologia particolarmente vantaggiosa (monosomministrazione giornaliera).L'effetto ritardo viene ottenuto con geli a base di agar, alginati, gomma adragante, gomma arabica, gomma karaya, polimeri metacrilici. Nella formulazione possono essere compresi tamponi, additivi (sali di calcio, cellulosa, amido), leganti (povidone, metacrilati), lubrificanti (talco, stearati), sostanze filmanti (polimeri metacrilici, derivati cellulosici od altri equivalenti).
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910550A IT1249686B (it) | 1991-07-22 | 1991-07-22 | Preparazioni farmaceutiche orali, a base di acidi biliari, a cessione protratta e controllata con le quali e' possibile adottare una sola somministrazione giornaliera |
| EP92108382A EP0524395B1 (en) | 1991-07-22 | 1992-05-18 | Sustained release compositions containing bile acids |
| DE69208171T DE69208171T2 (de) | 1991-07-22 | 1992-05-18 | Gallensäuren enthaltende Arzneimittel mit verzögerter Wirkstoffabgabe |
| AT92108382T ATE133864T1 (de) | 1991-07-22 | 1992-05-18 | Gallensäuren enthaltende arzneimittel mit verzögerter wirkstoffabgabe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910550A IT1249686B (it) | 1991-07-22 | 1991-07-22 | Preparazioni farmaceutiche orali, a base di acidi biliari, a cessione protratta e controllata con le quali e' possibile adottare una sola somministrazione giornaliera |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM910550A0 ITRM910550A0 (it) | 1991-07-22 |
| ITRM910550A1 ITRM910550A1 (it) | 1993-01-22 |
| IT1249686B true IT1249686B (it) | 1995-03-09 |
Family
ID=11400282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM910550A IT1249686B (it) | 1991-07-22 | 1991-07-22 | Preparazioni farmaceutiche orali, a base di acidi biliari, a cessione protratta e controllata con le quali e' possibile adottare una sola somministrazione giornaliera |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0524395B1 (it) |
| AT (1) | ATE133864T1 (it) |
| DE (1) | DE69208171T2 (it) |
| IT (1) | IT1249686B (it) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5262172A (en) * | 1992-06-19 | 1993-11-16 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing buffered bile acids |
| ES2059262B1 (es) * | 1992-10-13 | 1995-10-01 | Boniscontro E Gazzone S R L | Composiciones farmaceuticas orales de liberacion sostenida conteniendo acidos biliares. |
| IT1265074B1 (it) * | 1993-05-18 | 1996-10-30 | Istituto Biochimico Italiano | Composizione farmaceutica a lento rilascio contenente come sostanza attiva un acido biliare |
| AU693483B2 (en) * | 1993-10-22 | 1998-07-02 | Tsumura & Co. | Base for sustained-release preparation, sustained-release preparation, and process for producing the preparation |
| DE19906290A1 (de) * | 1999-02-15 | 2000-08-17 | Falk Pharma Gmbh | Arzneimittel zur Behandlung bzw. Prävention von Darmkrebs |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1101649B (it) * | 1978-12-15 | 1985-10-07 | Lehner Ag | Composizione farmaceutica ad azione prolungata contenente acidi biliari |
| IT1212141B (it) * | 1987-06-03 | 1989-11-08 | So Ri Far S R L | Composizioni farmaceutiche per la prevenzione e terapia della calcolosi delle vie biliari e della dispepsia biliare. |
-
1991
- 1991-07-22 IT ITRM910550A patent/IT1249686B/it active IP Right Grant
-
1992
- 1992-05-18 AT AT92108382T patent/ATE133864T1/de not_active IP Right Cessation
- 1992-05-18 DE DE69208171T patent/DE69208171T2/de not_active Expired - Fee Related
- 1992-05-18 EP EP92108382A patent/EP0524395B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69208171D1 (de) | 1996-03-21 |
| ATE133864T1 (de) | 1996-02-15 |
| ITRM910550A0 (it) | 1991-07-22 |
| DE69208171T2 (de) | 1996-10-02 |
| ITRM910550A1 (it) | 1993-01-22 |
| EP0524395B1 (en) | 1996-02-07 |
| EP0524395A1 (en) | 1993-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960711 |