IT1245867B - Vaccini utilizzanti eritrociti come veicoli di antigeni - Google Patents

Vaccini utilizzanti eritrociti come veicoli di antigeni

Info

Publication number
IT1245867B
IT1245867B ITRM910385A ITRM910385A IT1245867B IT 1245867 B IT1245867 B IT 1245867B IT RM910385 A ITRM910385 A IT RM910385A IT RM910385 A ITRM910385 A IT RM910385A IT 1245867 B IT1245867 B IT 1245867B
Authority
IT
Italy
Prior art keywords
vaccines
vehicles
erythrocytes
antigen
neutralizers
Prior art date
Application number
ITRM910385A
Other languages
English (en)
Inventor
Umberto Benatti
Flora Antonio De
Carolina Polvani
Luciano Nencioni
Sergio Silvestri
Original Assignee
Consiglio Nazionale Ricerche
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale Ricerche, Sclavo Spa filed Critical Consiglio Nazionale Ricerche
Priority to ITRM910385A priority Critical patent/IT1245867B/it
Publication of ITRM910385A0 publication Critical patent/ITRM910385A0/it
Priority to AU21510/92A priority patent/AU2151092A/en
Priority to PCT/IT1992/000061 priority patent/WO1992021378A1/en
Publication of ITRM910385A1 publication Critical patent/ITRM910385A1/it
Application granted granted Critical
Publication of IT1245867B publication Critical patent/IT1245867B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6006—Cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invenzione descrive vaccini ottenuti utilizzando come veicoli di antigeni, nonché come adiuvanti, cellule della linea eritrocitaria, in particolare eritrociti che inducano, iniettati per via endovena nell'organismo da immunizzare, la produzione di anticorpi specifici e neutralizzanti.In particolare sono descritti vaccini contro la pertosse, la difterite e il tetano.
ITRM910385A 1991-06-03 1991-06-03 Vaccini utilizzanti eritrociti come veicoli di antigeni IT1245867B (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITRM910385A IT1245867B (it) 1991-06-03 1991-06-03 Vaccini utilizzanti eritrociti come veicoli di antigeni
AU21510/92A AU2151092A (en) 1991-06-03 1992-06-02 Vaccines with erythrocytes as antigen carriers
PCT/IT1992/000061 WO1992021378A1 (en) 1991-06-03 1992-06-02 Vaccines with erythrocytes as antigen carriers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910385A IT1245867B (it) 1991-06-03 1991-06-03 Vaccini utilizzanti eritrociti come veicoli di antigeni

Publications (3)

Publication Number Publication Date
ITRM910385A0 ITRM910385A0 (it) 1991-06-03
ITRM910385A1 ITRM910385A1 (it) 1992-12-03
IT1245867B true IT1245867B (it) 1994-10-25

Family

ID=11400177

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM910385A IT1245867B (it) 1991-06-03 1991-06-03 Vaccini utilizzanti eritrociti come veicoli di antigeni

Country Status (3)

Country Link
AU (1) AU2151092A (it)
IT (1) IT1245867B (it)
WO (1) WO1992021378A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1355656A2 (en) * 2000-07-24 2003-10-29 Gendel Limited Red blood cell as vehicle for agent-membrane translocation sequence conjugate
WO2013040547A2 (en) * 2011-09-15 2013-03-21 The Research Foundation Of State University Of New York Compounds and methods of immunization with tumor antigens
BR112016022814A8 (pt) 2014-04-01 2021-07-06 Rubius Therapeutics Inc composição farmacêutica e seu método de preparação, ácido nucleico, e dispositivo médico ou kit médico
CN115120714A (zh) * 2021-03-29 2022-09-30 华中科技大学 免疫制剂、包含免疫制剂的组合物及其用途、制备方法
CN114432261B (zh) * 2022-02-24 2023-11-28 初源汇企业管理(深圳)合伙企业(有限合伙) 一种靶向递送疫苗的制备方法及红细胞疫苗

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144131A (en) * 1974-05-23 1979-03-13 Wisconsin Alumni Research Foundation Immobilization of enzymes on human tissue or erythrocytes
FR2529463B1 (fr) * 1982-07-05 1986-01-10 Centre Nat Rech Scient Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus
CA1327174C (en) * 1988-10-05 1994-02-22 Youssef Mouneimne Electro-insertion of proteins into animal cell membranes

Also Published As

Publication number Publication date
ITRM910385A1 (it) 1992-12-03
WO1992021378A1 (en) 1992-12-10
ITRM910385A0 (it) 1991-06-03
AU2151092A (en) 1993-01-08

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970626