IT1245867B - Vaccini utilizzanti eritrociti come veicoli di antigeni - Google Patents
Vaccini utilizzanti eritrociti come veicoli di antigeniInfo
- Publication number
- IT1245867B IT1245867B ITRM910385A ITRM910385A IT1245867B IT 1245867 B IT1245867 B IT 1245867B IT RM910385 A ITRM910385 A IT RM910385A IT RM910385 A ITRM910385 A IT RM910385A IT 1245867 B IT1245867 B IT 1245867B
- Authority
- IT
- Italy
- Prior art keywords
- vaccines
- vehicles
- erythrocytes
- antigen
- neutralizers
- Prior art date
Links
- 210000003743 erythrocyte Anatomy 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 201000005702 Pertussis Diseases 0.000 abstract 1
- 206010043376 Tetanus Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 206010013023 diphtheria Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6006—Cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Botany (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invenzione descrive vaccini ottenuti utilizzando come veicoli di antigeni, nonché come adiuvanti, cellule della linea eritrocitaria, in particolare eritrociti che inducano, iniettati per via endovena nell'organismo da immunizzare, la produzione di anticorpi specifici e neutralizzanti.In particolare sono descritti vaccini contro la pertosse, la difterite e il tetano.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910385A IT1245867B (it) | 1991-06-03 | 1991-06-03 | Vaccini utilizzanti eritrociti come veicoli di antigeni |
AU21510/92A AU2151092A (en) | 1991-06-03 | 1992-06-02 | Vaccines with erythrocytes as antigen carriers |
PCT/IT1992/000061 WO1992021378A1 (en) | 1991-06-03 | 1992-06-02 | Vaccines with erythrocytes as antigen carriers |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910385A IT1245867B (it) | 1991-06-03 | 1991-06-03 | Vaccini utilizzanti eritrociti come veicoli di antigeni |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM910385A0 ITRM910385A0 (it) | 1991-06-03 |
ITRM910385A1 ITRM910385A1 (it) | 1992-12-03 |
IT1245867B true IT1245867B (it) | 1994-10-25 |
Family
ID=11400177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM910385A IT1245867B (it) | 1991-06-03 | 1991-06-03 | Vaccini utilizzanti eritrociti come veicoli di antigeni |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2151092A (it) |
IT (1) | IT1245867B (it) |
WO (1) | WO1992021378A1 (it) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1355656A2 (en) * | 2000-07-24 | 2003-10-29 | Gendel Limited | Red blood cell as vehicle for agent-membrane translocation sequence conjugate |
WO2013040547A2 (en) * | 2011-09-15 | 2013-03-21 | The Research Foundation Of State University Of New York | Compounds and methods of immunization with tumor antigens |
BR112016022814A8 (pt) | 2014-04-01 | 2021-07-06 | Rubius Therapeutics Inc | composição farmacêutica e seu método de preparação, ácido nucleico, e dispositivo médico ou kit médico |
CN115120714A (zh) * | 2021-03-29 | 2022-09-30 | 华中科技大学 | 免疫制剂、包含免疫制剂的组合物及其用途、制备方法 |
CN114432261B (zh) * | 2022-02-24 | 2023-11-28 | 初源汇企业管理(深圳)合伙企业(有限合伙) | 一种靶向递送疫苗的制备方法及红细胞疫苗 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4144131A (en) * | 1974-05-23 | 1979-03-13 | Wisconsin Alumni Research Foundation | Immobilization of enzymes on human tissue or erythrocytes |
FR2529463B1 (fr) * | 1982-07-05 | 1986-01-10 | Centre Nat Rech Scient | Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus |
CA1327174C (en) * | 1988-10-05 | 1994-02-22 | Youssef Mouneimne | Electro-insertion of proteins into animal cell membranes |
-
1991
- 1991-06-03 IT ITRM910385A patent/IT1245867B/it active IP Right Grant
-
1992
- 1992-06-02 WO PCT/IT1992/000061 patent/WO1992021378A1/en active Application Filing
- 1992-06-02 AU AU21510/92A patent/AU2151092A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ITRM910385A1 (it) | 1992-12-03 |
WO1992021378A1 (en) | 1992-12-10 |
ITRM910385A0 (it) | 1991-06-03 |
AU2151092A (en) | 1993-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970626 |