IT1244546B - Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica - Google Patents

Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica

Info

Publication number
IT1244546B
IT1244546B ITMI910251A ITMI910251A IT1244546B IT 1244546 B IT1244546 B IT 1244546B IT MI910251 A ITMI910251 A IT MI910251A IT MI910251 A ITMI910251 A IT MI910251A IT 1244546 B IT1244546 B IT 1244546B
Authority
IT
Italy
Prior art keywords
phosphatidylinititol
inhibitors
analogues
phospholipase
specific
Prior art date
Application number
ITMI910251A
Other languages
English (en)
Inventor
Mario Brufani
Maria Candida Cesta
Enrico Ferrari
Luigi Filocamo
Sperandina Lappa
Stefano Maiorana
Pier Giuseppe Pagella
Original Assignee
Mediolanum Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici Spa filed Critical Mediolanum Farmaceutici Spa
Publication of ITMI910251A0 publication Critical patent/ITMI910251A0/it
Priority to ITMI910251A priority Critical patent/IT1244546B/it
Priority to US07/824,318 priority patent/US5352810A/en
Priority to CA002060083A priority patent/CA2060083A1/en
Priority to EP19920101226 priority patent/EP0497234A3/en
Priority to ZA92584A priority patent/ZA92584B/xx
Priority to IE031292A priority patent/IE920312A1/en
Priority to AU10648/92A priority patent/AU651658B2/en
Priority to NO92920394A priority patent/NO920394L/no
Priority to KR1019920001516A priority patent/KR920016460A/ko
Priority to JP4042426A priority patent/JPH05213974A/ja
Publication of ITMI910251A1 publication Critical patent/ITMI910251A1/it
Application granted granted Critical
Publication of IT1244546B publication Critical patent/IT1244546B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/177—Esters of thiophosphoric acids with cycloaliphatic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Tioanaloghi del fosfatidilinositolo inibitori della fosfolipasi C fosfatidilinositolo-specifica aventi la formula generale (I) (FORMULA I) (I) nella quale R ha i significati specificati nella descrizione, atti alla preparazione di composizioni farmaceutiche per il trattamento di patologie di tipo tumorale, trombotico e infiammatorio.
ITMI910251A 1991-02-01 1991-02-01 Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica IT1244546B (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ITMI910251A IT1244546B (it) 1991-02-01 1991-02-01 Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica
US07/824,318 US5352810A (en) 1991-02-01 1992-01-23 Phosphatidylinositol analogues, inhibitors of phosphatidylinositol specific phospholipase C
CA002060083A CA2060083A1 (en) 1991-02-01 1992-01-27 Phosphatidylinositol analogues, inhibitors of phosphatidylinositol-specific phospholipase c
EP19920101226 EP0497234A3 (en) 1991-02-01 1992-01-27 Phosphatidylinositol analogues, inhibitors of phosphatidyl-inositol-specific phospholipase c
ZA92584A ZA92584B (en) 1991-02-01 1992-01-28 Phosphatidylinositol analogues,inhibitors of phosphatidylinositol-specific phospholipase c
IE031292A IE920312A1 (en) 1991-02-01 1992-01-30 Phosphatidylinositol analogues, inhibitors of¹phosphatidylinositol-specific phospholipase c
AU10648/92A AU651658B2 (en) 1991-02-01 1992-01-30 Phosphatidylinositol analogues, inhibitors of phosphatidylinositol - specific phospholipase C
NO92920394A NO920394L (no) 1991-02-01 1992-01-30 Terapeutisk aktive inositol-analoger og fremgangsmaate forderes fremstilling
KR1019920001516A KR920016460A (ko) 1991-02-01 1992-01-31 포스파티딜이노시톨-특이 포스포리파제 c 억제제로서의 포스파티딜이노시톨 동족체
JP4042426A JPH05213974A (ja) 1991-02-01 1992-01-31 ホスファチジルイノシトール特異的ホスホリパーゼｃ阻害物質であるホスファチジルイノシトール同族体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910251A IT1244546B (it) 1991-02-01 1991-02-01 Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica

Publications (3)

Publication Number Publication Date
ITMI910251A0 ITMI910251A0 (it) 1991-02-01
ITMI910251A1 ITMI910251A1 (it) 1992-08-01
IT1244546B true IT1244546B (it) 1994-07-15

Family

ID=11358370

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI910251A IT1244546B (it) 1991-02-01 1991-02-01 Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica

Country Status (10)

Country Link
US (1) US5352810A (it)
EP (1) EP0497234A3 (it)
JP (1) JPH05213974A (it)
KR (1) KR920016460A (it)
AU (1) AU651658B2 (it)
CA (1) CA2060083A1 (it)
IE (1) IE920312A1 (it)
IT (1) IT1244546B (it)
NO (1) NO920394L (it)
ZA (1) ZA92584B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2694936B1 (fr) * 1992-08-18 1994-11-25 Bayer Pharma Dérivés substitués du désoxy-myoinositol, procédé pour leur préparation et leur utilisation dans des médicaments.
US20020107193A1 (en) * 2000-11-09 2002-08-08 Glazner Gordon W. Therapeutic uses for IP3 receptor-mediated calcium channel modulators
GB0127206D0 (en) * 2001-11-13 2002-01-02 Univ Liverpool Treatment of inflammatory conditions
US7943594B2 (en) * 2002-07-10 2011-05-17 Massachusetts Institute Of Technology Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans
EP1566447A1 (en) * 2004-02-20 2005-08-24 Aventis Pharma Deutschland GmbH Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
CN104974024B (zh) * 2008-03-21 2017-11-14 综合医院公司 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物
CN114460203B (zh) * 2022-02-15 2023-12-22 浙江海正药业股份有限公司 一种同时检测药物中对甲苯亚磺酸甲酯、对甲苯亚磺酸乙酯、对甲苯亚磺酸异丙酯的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2287901A1 (fr) * 1974-10-14 1976-05-14 Pasteur Institut Medicament immunostimulant contenant un derive d'ose ou de polyose phosphoryle
DE2659048A1 (de) * 1976-12-27 1978-07-06 Nattermann A & Cie Neue inositphosphatid-derivate und verfahren zur herstellung dieser verbindungen
US4515722A (en) * 1982-03-30 1985-05-07 Merck & Co., Inc. Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents
DE3239817A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue glycerinderivate zur synthese von phospholipiden
US4585762A (en) * 1982-07-30 1986-04-29 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same

Also Published As

Publication number Publication date
IE920312A1 (en) 1992-08-12
EP0497234A2 (en) 1992-08-05
ITMI910251A0 (it) 1991-02-01
NO920394L (no) 1992-08-03
CA2060083A1 (en) 1992-08-02
ZA92584B (en) 1992-10-28
ITMI910251A1 (it) 1992-08-01
AU1064892A (en) 1992-08-06
EP0497234A3 (en) 1993-06-02
NO920394D0 (no) 1992-01-30
KR920016460A (ko) 1992-09-24
US5352810A (en) 1994-10-04
JPH05213974A (ja) 1993-08-24
AU651658B2 (en) 1994-07-28

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970227