IT1243859B - Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids. - Google Patents
Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids.Info
- Publication number
- IT1243859B IT1243859B IT02183390A IT2183390A IT1243859B IT 1243859 B IT1243859 B IT 1243859B IT 02183390 A IT02183390 A IT 02183390A IT 2183390 A IT2183390 A IT 2183390A IT 1243859 B IT1243859 B IT 1243859B
- Authority
- IT
- Italy
- Prior art keywords
- adenosyl
- acid
- formyl
- methyl
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02183390A IT1243859B (it) | 1990-10-23 | 1990-10-23 | Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids. |
EP91117638A EP0482493B1 (en) | 1990-10-23 | 1991-10-15 | Pharmaceutical compositions active in the therapy of neurological affections in aids patients, containing as an active principle at least S-adenosyl-L-methionine salt. |
DE69132542T DE69132542T2 (de) | 1990-10-23 | 1991-10-15 | Pharmazeutische Zusammensetzung mit therapeutischer Wirkung auf die neuronalen Schädigungen in Aids-Patienten, enthaltend als Wirkstoff wenigstens ein Salz von S-Adenosyl-L-methionine. |
AT91117638T ATE199319T1 (de) | 1990-10-23 | 1991-10-15 | Pharmazeutische zusammensetzung mit therapeutischer wirkung auf die neuronalen schädigungen in aids-patienten, enthaltend als wirkstoff wenigstens ein salz von s-adenosyl-l- methionine. |
ZA918355A ZA918355B (en) | 1990-10-23 | 1991-10-18 | Pharmaceutical compositions active in the therapy of neurological affections in aids patients,containing as an active principle at least one compound selected from the group consisting of s-adenosyl-l-methionine salt,5-methyl-tetrahydrofolic acid,5-formyltetrahydrofolic acid |
FI914919A FI914919A (fi) | 1990-10-23 | 1991-10-18 | Farmaceutiska kompositioner som aer aktiva vid behandling av aids-patienters neurologiska sjukdomar, vilka kompositioner innehaoller, som ett paoverkande aemne aotminstone en foerening som valts fraon en grupp som bestaor av s-adenosyl-l-metioninsalt, 5- metyltetrahydrofolsyra och 5-formyltetrahydrofolsyra |
CA002053826A CA2053826C (en) | 1990-10-23 | 1991-10-21 | Pharmaceutical compositions active in the therapy of neurological affections in aids patients |
AU86708/91A AU645854B2 (en) | 1990-10-23 | 1991-10-22 | Pharmaceutical compositions active in the therapy of neurological affections in aids patients, containing as an active principle at least one compound selected from the group consisting of S-adenosyl-L-methionine salt, 5-methyl- tetrahydrofolic acid, 5-formyltetrahydrofolic acid |
PT99300A PT99300B (pt) | 1990-10-23 | 1991-10-22 | Processo para a preparacao de composicoes farmaceuticas para a terapia de afeccoes neurologicas em doentes com sida que contem, como ingrediente activo, pelo menos um composto escolhido do grupo que consiste em sais de s-adenosilmetionina, acido 5-metiltetra-hidrofolico e acido 5-formiltetra-hidrofolico e os seus sais |
KR1019910018639A KR100187992B1 (ko) | 1990-10-23 | 1991-10-23 | S-아데노실-l-메티오닌 염, 5-메틸테트라하이드로폴산 및 5-포르밀테트라하이드로폴산으로 이루어진 그룹으로부터 선택된 하나 이상의 화합물을 활성 성분으로서 함유하는, aids환자의 신경학적 질환의 치료시 활성을 나타내는 약제학적 조성물 |
NO914157A NO914157D0 (no) | 1990-10-23 | 1991-10-23 | Fremgangsmaate for fremstilling av et farmasoeytisk preparat |
JP30260091A JP3289928B2 (ja) | 1990-10-23 | 1991-10-23 | S−アデノシル−l−メチオニン塩、5−メチル−テトラヒドロ葉酸、5−ホルミルテトラヒドロ葉酸から成る群から選択される少なくとも1つの化合物を活性成分として含む、aids患者の神経障害の治療に有効な医薬組成物 |
US08/108,005 US6093703A (en) | 1990-10-23 | 1993-08-18 | Pharmaceutical compositions, containing S-adenosyl-L-methionine salt, 5-methyl-tetrahydrofolic acid and 5-formyltetrahydrofolic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT02183390A IT1243859B (it) | 1990-10-23 | 1990-10-23 | Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids. |
Publications (3)
Publication Number | Publication Date |
---|---|
IT9021833A0 IT9021833A0 (it) | 1990-10-23 |
IT9021833A1 IT9021833A1 (it) | 1992-04-23 |
IT1243859B true IT1243859B (it) | 1994-06-28 |
Family
ID=11187495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT02183390A IT1243859B (it) | 1990-10-23 | 1990-10-23 | Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6093703A (it) |
EP (1) | EP0482493B1 (it) |
JP (1) | JP3289928B2 (it) |
KR (1) | KR100187992B1 (it) |
AT (1) | ATE199319T1 (it) |
AU (1) | AU645854B2 (it) |
CA (1) | CA2053826C (it) |
DE (1) | DE69132542T2 (it) |
FI (1) | FI914919A (it) |
IT (1) | IT1243859B (it) |
NO (1) | NO914157D0 (it) |
PT (1) | PT99300B (it) |
ZA (1) | ZA918355B (it) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5660835A (en) * | 1995-02-24 | 1997-08-26 | East Carolina University | Method of treating adenosine depletion |
ATE262799T1 (de) * | 1996-01-31 | 2004-04-15 | Univ South Alabama | Lebensmittel und vitamin herstellungen mit natürlichem isomeren von reduzierten folaten |
DE19628514C1 (de) * | 1996-07-05 | 1997-09-25 | E Dr Grundmann | Kombination von S-Adenosylmethionin und Azidothymidin zur Hemmung der HIV-Replikation |
DE19632823C1 (de) * | 1996-08-14 | 1997-11-20 | Symbio Herborn Group Gmbh & Co | Komplexe zwischen S-(+)-Adenosylmethionin und 3'-Azido-2',3'-didesoxynucleosid als potente Inhibitoren der HIV-Replikation |
US7071230B2 (en) | 1997-10-02 | 2006-07-04 | Board Of Trustees Of Southern Illinois University | Therapeutic use of D-methionine to reduce the toxicity of noise |
US8642581B1 (en) | 2000-02-11 | 2014-02-04 | Brian D. Halevie-Goldman | Compositions and methods for the production of S-adenosylmethionine within the body |
IT1317920B1 (it) * | 2000-10-20 | 2003-07-15 | Univ Roma | S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer. |
US6759395B2 (en) | 2000-12-18 | 2004-07-06 | Orchid Chemicals & Pharmaceuticals, Ltd. | Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same |
ITMI20012462A1 (it) * | 2001-11-22 | 2003-05-22 | Gnosis Srl | Processo per la preparazione di compresse comprendenti s-adenosilmetionina |
US20030155045A1 (en) * | 2002-02-05 | 2003-08-21 | Williams Peter C. | Lubricated low temperature carburized stainless steel parts |
KR20060051135A (ko) * | 2004-09-15 | 2006-05-19 | 니프로 가부시키가이샤 | 안정화된 주사용 수용액 제재 |
JP4956942B2 (ja) * | 2004-09-15 | 2012-06-20 | ニプロ株式会社 | 安定化された注射用水溶液製剤 |
ITMI20050485A1 (it) * | 2005-03-23 | 2006-09-24 | Truffini & Regge Farmaceutici | Formulazioni granulari rivestite |
FR2884421B1 (fr) | 2005-04-15 | 2007-08-10 | Virbac Sa | Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie |
WO2006111541A2 (en) * | 2005-04-20 | 2006-10-26 | Basf Plant Science Gmbh | Expression cassettes for seed-preferential expression in plants |
WO2006119589A2 (en) * | 2005-05-11 | 2006-11-16 | Ramaekers, Vincent | Prevention and therapy of cerebral folate deficiency |
ITMI20060629A1 (it) | 2006-03-31 | 2007-10-01 | Daniele Giovannone | Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento |
US20090088404A1 (en) * | 2007-01-31 | 2009-04-02 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
EP2189154A1 (en) * | 2008-11-25 | 2010-05-26 | Gnosis S.p.A. | Effervescent tablets and mouth-soluble granulates of S-adenosyl methionine and process for the preparation thereof |
CN101862333B (zh) * | 2009-04-20 | 2013-07-24 | 天津药物研究院 | 左亚叶酸钠稳定的口服制剂及其制备方法 |
US20110027342A1 (en) * | 2009-07-28 | 2011-02-03 | Msi Methylation Sciences, Inc. | S-adenosylmethionine formulations with enhanced bioavailability |
WO2012012902A1 (en) * | 2010-07-28 | 2012-02-02 | Msi Methylation Sciences Inc. | S-adenosylmethionine formulations with enhanced bioavailability |
US8329208B2 (en) | 2009-07-28 | 2012-12-11 | Methylation Sciences International Srl | Pharmacokinetics of S-adenosylmethionine formulations |
WO2011100550A2 (en) | 2010-02-12 | 2011-08-18 | Alexander Vuckovic, M.D., Llc | Compositions and methods for treating depression |
WO2016185413A1 (en) | 2015-05-20 | 2016-11-24 | Nestec S.A. | Modified release formulations |
CA3042699A1 (en) | 2016-11-03 | 2018-08-09 | Alexander Vuckovic, M.D., Llc | Compositions and methods for treating depression |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1227049B (it) * | 1988-07-29 | 1991-03-14 | Bioresearch Spa | Impiego di derivati adenosinici per la preparazione di composizioni farmaceutiche aventi attivita' immunostimolante. |
GB8900812D0 (en) * | 1989-01-14 | 1989-03-08 | Univ Manchester | Pharmaceutical method and compositions |
JPH04503286A (ja) * | 1989-02-09 | 1992-06-11 | バートン・ジェフリー・ジェームズ | ステレオシステムのための信号増補プロセッサ |
IT1229203B (it) * | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
DE4005275A1 (de) * | 1990-02-20 | 1991-08-22 | Grundmann Ewald | Verwendung von s-adenosylmethionin als mittel gegen virale infektionen durch retroviren |
-
1990
- 1990-10-23 IT IT02183390A patent/IT1243859B/it active IP Right Grant
-
1991
- 1991-10-15 AT AT91117638T patent/ATE199319T1/de not_active IP Right Cessation
- 1991-10-15 EP EP91117638A patent/EP0482493B1/en not_active Expired - Lifetime
- 1991-10-15 DE DE69132542T patent/DE69132542T2/de not_active Expired - Fee Related
- 1991-10-18 ZA ZA918355A patent/ZA918355B/xx unknown
- 1991-10-18 FI FI914919A patent/FI914919A/fi unknown
- 1991-10-21 CA CA002053826A patent/CA2053826C/en not_active Expired - Fee Related
- 1991-10-22 AU AU86708/91A patent/AU645854B2/en not_active Ceased
- 1991-10-22 PT PT99300A patent/PT99300B/pt not_active IP Right Cessation
- 1991-10-23 JP JP30260091A patent/JP3289928B2/ja not_active Expired - Fee Related
- 1991-10-23 KR KR1019910018639A patent/KR100187992B1/ko not_active IP Right Cessation
- 1991-10-23 NO NO914157A patent/NO914157D0/no unknown
-
1993
- 1993-08-18 US US08/108,005 patent/US6093703A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2053826A1 (en) | 1992-04-24 |
PT99300B (pt) | 1999-04-30 |
EP0482493A2 (en) | 1992-04-29 |
ZA918355B (en) | 1992-07-29 |
FI914919A0 (fi) | 1991-10-18 |
FI914919A (fi) | 1992-04-24 |
AU8670891A (en) | 1992-04-30 |
KR100187992B1 (ko) | 1999-06-01 |
EP0482493B1 (en) | 2001-02-28 |
ATE199319T1 (de) | 2001-03-15 |
US6093703A (en) | 2000-07-25 |
DE69132542T2 (de) | 2001-06-21 |
EP0482493A3 (en) | 1992-09-02 |
CA2053826C (en) | 2002-12-17 |
IT9021833A1 (it) | 1992-04-23 |
AU645854B2 (en) | 1994-01-27 |
NO914157D0 (no) | 1991-10-23 |
JP3289928B2 (ja) | 2002-06-10 |
DE69132542D1 (de) | 2001-04-05 |
KR920007629A (ko) | 1992-05-27 |
IT9021833A0 (it) | 1990-10-23 |
JPH04264031A (ja) | 1992-09-18 |
PT99300A (pt) | 1992-08-31 |
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Legal Events
Date | Code | Title | Description |
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0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971030 |