IT1243774B - Derivati della prourochinasi - Google Patents

Derivati della prourochinasi

Info

Publication number
IT1243774B
IT1243774B IT02117890A IT2117890A IT1243774B IT 1243774 B IT1243774 B IT 1243774B IT 02117890 A IT02117890 A IT 02117890A IT 2117890 A IT2117890 A IT 2117890A IT 1243774 B IT1243774 B IT 1243774B
Authority
IT
Italy
Prior art keywords
prourokinase
derivatives
prourokinase derivatives
Prior art date
Application number
IT02117890A
Other languages
English (en)
Other versions
IT9021178A0 (it
IT9021178A1 (it
Inventor
Anna Brandazza
Jacqueline Lansen
Gaetano Orsini
Paolo Sarmientos
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Priority to IT02117890A priority Critical patent/IT1243774B/it
Publication of IT9021178A0 publication Critical patent/IT9021178A0/it
Priority to GB9116457A priority patent/GB2247022A/en
Priority to DE4125193A priority patent/DE4125193A1/de
Priority to JP3190333A priority patent/JPH04252184A/ja
Publication of IT9021178A1 publication Critical patent/IT9021178A1/it
Application granted granted Critical
Publication of IT1243774B publication Critical patent/IT1243774B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT02117890A 1990-08-02 1990-08-02 Derivati della prourochinasi IT1243774B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT02117890A IT1243774B (it) 1990-08-02 1990-08-02 Derivati della prourochinasi
GB9116457A GB2247022A (en) 1990-08-02 1991-07-30 Pro-urokinase derivatives
DE4125193A DE4125193A1 (de) 1990-08-02 1991-07-30 Pro-urokinasederivate
JP3190333A JPH04252184A (ja) 1990-08-02 1991-07-30 プロウロキナーゼ誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02117890A IT1243774B (it) 1990-08-02 1990-08-02 Derivati della prourochinasi

Publications (3)

Publication Number Publication Date
IT9021178A0 IT9021178A0 (it) 1990-08-02
IT9021178A1 IT9021178A1 (it) 1992-02-02
IT1243774B true IT1243774B (it) 1994-06-28

Family

ID=11177958

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02117890A IT1243774B (it) 1990-08-02 1990-08-02 Derivati della prourochinasi

Country Status (4)

Country Link
JP (1) JPH04252184A (it)
DE (1) DE4125193A1 (it)
GB (1) GB2247022A (it)
IT (1) IT1243774B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2426115A1 (en) * 2003-04-18 2004-10-18 Victor Gurewich Methods, devices, and compositions for lysis of occlusive blood clots while sparing wound sealing clots

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605124B2 (en) * 1985-12-23 1991-01-10 Behringwerke Aktiengesellschaft Novel peptide plasminogen activators
JPS63105675A (ja) * 1986-10-23 1988-05-10 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
EP0336508A1 (en) * 1988-04-06 1989-10-11 K.U. Leuven Research & Development Recombinant human single-chain urokinase-type plasminogen activator mutant produced by site-specific mutagenesis of lysine 158 to histidine 158

Also Published As

Publication number Publication date
DE4125193A1 (de) 1992-02-06
IT9021178A0 (it) 1990-08-02
JPH04252184A (ja) 1992-09-08
GB9116457D0 (en) 1991-09-11
IT9021178A1 (it) 1992-02-02
GB2247022A (en) 1992-02-19

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Legal Events

Date Code Title Description
0001 Granted