IT1243742B - Calcitonin-based pharmaceutical compositions - Google Patents
Calcitonin-based pharmaceutical compositionsInfo
- Publication number
- IT1243742B IT1243742B IT02173590A IT2173590A IT1243742B IT 1243742 B IT1243742 B IT 1243742B IT 02173590 A IT02173590 A IT 02173590A IT 2173590 A IT2173590 A IT 2173590A IT 1243742 B IT1243742 B IT 1243742B
- Authority
- IT
- Italy
- Prior art keywords
- calcitonin
- pharmaceutical compositions
- based pharmaceutical
- monobasic
- citrate
- Prior art date
Links
- 102000055006 Calcitonin Human genes 0.000 title abstract 3
- 108060001064 Calcitonin Proteins 0.000 title abstract 3
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title abstract 3
- 229960004015 calcitonin Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229960003194 meglumine Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000002850 nasal mucosa Anatomy 0.000 abstract 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 1
- 229960000281 trometamol Drugs 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention concerns pharmaceutical compositions based on calcitonin in aqueous solution at pH lying between 3.5 and 4.5, comprising: a calcitonin, alkyl esters of p-hydroxybenzoic acid, monobasic tromethamine citrate, monobasic meglumine citrate and citric acid in defined proportions. These compositions are particularly suitable for application to the nasal mucosa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT02173590A IT1243742B (en) | 1990-10-12 | 1990-10-12 | Calcitonin-based pharmaceutical compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT02173590A IT1243742B (en) | 1990-10-12 | 1990-10-12 | Calcitonin-based pharmaceutical compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9021735A0 IT9021735A0 (en) | 1990-10-12 |
| IT9021735A1 IT9021735A1 (en) | 1992-04-12 |
| IT1243742B true IT1243742B (en) | 1994-06-21 |
Family
ID=11186136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT02173590A IT1243742B (en) | 1990-10-12 | 1990-10-12 | Calcitonin-based pharmaceutical compositions |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1243742B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004014411A1 (en) * | 2002-07-29 | 2004-02-19 | Therapicon Srl | Nasal peptide pharmaceutical formulation |
-
1990
- 1990-10-12 IT IT02173590A patent/IT1243742B/en active IP Right Grant
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004014411A1 (en) * | 2002-07-29 | 2004-02-19 | Therapicon Srl | Nasal peptide pharmaceutical formulation |
Also Published As
| Publication number | Publication date |
|---|---|
| IT9021735A1 (en) | 1992-04-12 |
| IT9021735A0 (en) | 1990-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971030 |