IT1241581B - Synthetic peptides containing amino acid sequences defining immunoreactive epitopes against anti-HCV human antibodies which are useful for the preparation of immunological assays - Google Patents
Synthetic peptides containing amino acid sequences defining immunoreactive epitopes against anti-HCV human antibodies which are useful for the preparation of immunological assaysInfo
- Publication number
- IT1241581B IT1241581B IT67703A IT6770390A IT1241581B IT 1241581 B IT1241581 B IT 1241581B IT 67703 A IT67703 A IT 67703A IT 6770390 A IT6770390 A IT 6770390A IT 1241581 B IT1241581 B IT 1241581B
- Authority
- IT
- Italy
- Prior art keywords
- glu
- ser
- immunological assays
- asp
- preparation
- Prior art date
Links
- 238000010324 immunological assay Methods 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 title 1
- 239000000758 substrate Substances 0.000 abstract 2
- SKTGPBFTMNLIHQ-KKUMJFAQSA-N Arg-Glu-Phe Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O SKTGPBFTMNLIHQ-KKUMJFAQSA-N 0.000 abstract 1
- WVNFNPGXYADPPO-BQBZGAKWSA-N Arg-Gly-Ser Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CO)C(O)=O WVNFNPGXYADPPO-BQBZGAKWSA-N 0.000 abstract 1
- NLDNNZKUSLAYFW-NHCYSSNCSA-N Asn-Lys-Val Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O NLDNNZKUSLAYFW-NHCYSSNCSA-N 0.000 abstract 1
- WSWYMRLTJVKRCE-ZLUOBGJFSA-N Asp-Ala-Asp Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(O)=O WSWYMRLTJVKRCE-ZLUOBGJFSA-N 0.000 abstract 1
- WSOKZUVWBXVJHX-CIUDSAMLSA-N Asp-Arg-Glu Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(O)=O WSOKZUVWBXVJHX-CIUDSAMLSA-N 0.000 abstract 1
- HRVQDZOWMLFAOD-BIIVOSGPSA-N Asp-Ser-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)N)C(=O)O HRVQDZOWMLFAOD-BIIVOSGPSA-N 0.000 abstract 1
- GMVCSRBOSIUTFC-FXQIFTODSA-N Glu-Ser-Glu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(O)=O GMVCSRBOSIUTFC-FXQIFTODSA-N 0.000 abstract 1
- RUDRIZRGOLQSMX-IUCAKERBSA-N Gly-Met-Met Chemical compound [H]NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(O)=O RUDRIZRGOLQSMX-IUCAKERBSA-N 0.000 abstract 1
- LGMUPVWZEYYUMU-YVNDNENWSA-N Ile-Glu-Gln Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)O)N LGMUPVWZEYYUMU-YVNDNENWSA-N 0.000 abstract 1
- UWLHDGMRWXHFFY-HPCHECBXSA-N Ile-Ile-Pro Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@@H]1C(=O)O)N UWLHDGMRWXHFFY-HPCHECBXSA-N 0.000 abstract 1
- UCXQIIIFOOGYEM-ULQDDVLXSA-N Leu-Pro-Tyr Chemical compound CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 UCXQIIIFOOGYEM-ULQDDVLXSA-N 0.000 abstract 1
- SITLTJHOQZFJGG-UHFFFAOYSA-N N-L-alpha-glutamyl-L-valine Natural products CC(C)C(C(O)=O)NC(=O)C(N)CCC(O)=O SITLTJHOQZFJGG-UHFFFAOYSA-N 0.000 abstract 1
- 101100205189 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) leu-5 gene Proteins 0.000 abstract 1
- FDMKYQQYJKYCLV-GUBZILKMSA-N Pro-Pro-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCCC1 FDMKYQQYJKYCLV-GUBZILKMSA-N 0.000 abstract 1
- DGHFNYXVIXNNMC-GUBZILKMSA-N Ser-Gln-His Chemical compound C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)N DGHFNYXVIXNNMC-GUBZILKMSA-N 0.000 abstract 1
- MIJWOJAXARLEHA-WDSKDSINSA-N Ser-Gly-Glu Chemical compound OC[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CCC(O)=O MIJWOJAXARLEHA-WDSKDSINSA-N 0.000 abstract 1
- HYLXOQURIOCKIH-VQVTYTSYSA-N Thr-Arg Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=N HYLXOQURIOCKIH-VQVTYTSYSA-N 0.000 abstract 1
- JNQZPAWOPBZGIX-RCWTZXSCSA-N Thr-Arg-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)O)CCCN=C(N)N JNQZPAWOPBZGIX-RCWTZXSCSA-N 0.000 abstract 1
- MGJLBZFUXUGMML-VOAKCMCISA-N Thr-Lys-Lys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)N)O MGJLBZFUXUGMML-VOAKCMCISA-N 0.000 abstract 1
- WDIWOIRFNMLNKO-ULQDDVLXSA-N Val-Leu-Tyr Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 WDIWOIRFNMLNKO-ULQDDVLXSA-N 0.000 abstract 1
- 108010069926 arginyl-glycyl-serine Proteins 0.000 abstract 1
- 108010038633 aspartylglutamate Proteins 0.000 abstract 1
- 238000007385 chemical modification Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 108010078144 glutaminyl-glycine Proteins 0.000 abstract 1
- 108010025306 histidylleucine Proteins 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 108010053037 kyotorphin Proteins 0.000 abstract 1
- 108010071185 leucyl-alanine Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to the identification and utilization of peptides which can be synthesized by chemical methods which reproduce and assemble epitopes which are immunologically and specifically reactive with anti-HCV antibodies and which are used in reagents in immunological assays for the detection of such antibodies in the serum or plasma of patients exposed to HCV infection, permitting the preparation of tests with improved sensitivity and specificity characteristics and therefore of greater predictive value. The invention provides new polypeptides having the formula: 1) THR LYS LYS SER GLY GLU ASN 2) ILE ILE PRO ASP ARG GLU VAL LEU TYR ARG GLU PHE ASP GLU 3) SER GLN HIS LEU PRO TYR ILE GLU GLN GLY MET MET LEU ALA 4) ARG GLY SER PRO PRO SER LEU 5) THR ARG HYS ASP SER PRO ASP ALA ASP 6) THR ARG VAL GLU SER GLU ASN LYS VAL and others derived from these by chemical modification, through condensation or conjugation with protein substrates which are effective in facilitating availability for immunological interaction and for immobilization on the insoluble substrates frequently used in immunological assays.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT67703A IT1241581B (en) | 1990-09-20 | 1990-09-20 | Synthetic peptides containing amino acid sequences defining immunoreactive epitopes against anti-HCV human antibodies which are useful for the preparation of immunological assays |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT67703A IT1241581B (en) | 1990-09-20 | 1990-09-20 | Synthetic peptides containing amino acid sequences defining immunoreactive epitopes against anti-HCV human antibodies which are useful for the preparation of immunological assays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9067703A0 IT9067703A0 (en) | 1990-09-20 |
| IT9067703A1 IT9067703A1 (en) | 1992-03-20 |
| IT1241581B true IT1241581B (en) | 1994-01-18 |
Family
ID=11304639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT67703A IT1241581B (en) | 1990-09-20 | 1990-09-20 | Synthetic peptides containing amino acid sequences defining immunoreactive epitopes against anti-HCV human antibodies which are useful for the preparation of immunological assays |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1241581B (en) |
-
1990
- 1990-09-20 IT IT67703A patent/IT1241581B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IT9067703A0 (en) | 1990-09-20 |
| IT9067703A1 (en) | 1992-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950929 |