IT1224225B - New 4-oxo:quinoline-3-carboxylic acid cpds. - Google Patents

New 4-oxo:quinoline-3-carboxylic acid cpds.

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Publication number
IT1224225B
IT1224225B IT8767130A IT6713087A IT1224225B IT 1224225 B IT1224225 B IT 1224225B IT 8767130 A IT8767130 A IT 8767130A IT 6713087 A IT6713087 A IT 6713087A IT 1224225 B IT1224225 B IT 1224225B
Authority
IT
Italy
Prior art keywords
carboxylic acid
substd
oxo
new
thiomorpholino
Prior art date
Application number
IT8767130A
Other languages
Italian (it)
Other versions
IT8767130A0 (en
Inventor
Ueda Hisashi Miyamoto Hiraki
Aki Shinji
Otsuka Tatsuya
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of IT8767130A0 publication Critical patent/IT8767130A0/en
Application granted granted Critical
Publication of IT1224225B publication Critical patent/IT1224225B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(+8.5.86, 22.5.86, 23.7.86, 19.8.86, 30.9.86, 15.10.86, 18.12.86-JP-105655, 118568, 173370, 193838, 233837, 246050, 303515) (1703KM) 4-Oxoquinoline-3-carboxylic acid cpds. of formula (I) and their salts are new. R1 is cyclopropyl opt. substd. by 1-3 substits. selected from lower alkyl and halogen; R2 is 5-9 membered opt. unsatd. heterocyclic ring which may be substd. R3 is lower alkyl which may be substd. by 1-3 substits. selected from a 5- or 6-membered satd. heterocyclic ring, lower alkylthio, amino, lower-alkylamino, lower alkanoyloxy, OH, lower alkoxy and halogen; and X is halogen. Pref. R2 is opt. substd. 1-piperidinyl, 1-pyrrolidinyl, 1-homopiperazinyl, thiomorpholino, 1,4-diazabicyclo (4.3.0) nona-4-yl, thiomorpholino-4-oxide, thiomorpholino-4,4-dioxide, 1-hexahydropyridazinyl, 2-thiazolidinyl, 1-imidazolidinyl or 3,7-diazabicyclo (4.3.0) nona-3-yl. 10 Cpds. of (I) including 7-(4-(5-methyl) 2-oxo-1,3-dioxolen -4-yl) methyl-1-piperazinyl) -1-cyclopropyl-6-fluoro- 8-methyl-1,4-dihydro-4-oxoquinoline -3-carboxylic acid are described.
IT8767130A 1986-02-25 1987-02-24 New 4-oxo:quinoline-3-carboxylic acid cpds. IT1224225B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP4092186 1986-02-25
JP10565586 1986-05-08
JP11856886 1986-05-22
JP17337086 1986-07-23
JP19383886 1986-08-19

Publications (2)

Publication Number Publication Date
IT8767130A0 IT8767130A0 (en) 1987-02-24
IT1224225B true IT1224225B (en) 1990-09-26

Family

ID=27522123

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8767130A IT1224225B (en) 1986-02-25 1987-02-24 New 4-oxo:quinoline-3-carboxylic acid cpds.

Country Status (1)

Country Link
IT (1) IT1224225B (en)

Also Published As

Publication number Publication date
IT8767130A0 (en) 1987-02-24

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